Publications

Home > Research Activities > Research Divisions > Tatsutoshi Nakahata (Professor) > Publications

Iida M., Heike T., Yoshimoto M., Baba S., Doi H., Nakahata T.: Identification of cardiac stem cells with FLK1 expression during embryonic stem cell differentiation. FASEB J. 19:371-378, 2005
Tsuchiya A., Heike T., Fujino H., Shiota M., Umeda K., Yoshimoto M., Matsuda Y., Ichida T., Aoyagi Y., Nakahata T.: Long-term extensive expansion of mouse hepatic stem/progenytor cells in a novel culture system. Gastroenterology 128:2089-2104,2005.
Yoshimoto M., Heike T., Shiota M., Kobatashi H., Umeda K., Nakahata T.: Two different role of purified CD45+ hematopoietic stem cells after transplantation in muscles. Stem Cells 23:610-618, 2005.
Yasumi T, Katamura K., Okafuji I., Yoshioka T., Meguro T., Nishikomori R., Kusunoki T., Heike T., Nakahata T.: limited ability of antigen-specific Th1 responses to inhibit Th2 cell development in vivo. J. Immunol. 174:1325-1331. 2005.
Tanaka A., Konno M., Muto S., Kambe N., Morii E., Nakahata T., Itai A., Matsuda H.: A novel NF-kB inhibitor, IMD-0354, suppresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors.Blood 105:2324-2331, 2005.
Kawamura T., Ono K., Morimoto T., Wada H., Hirai M., Hidaka K., Morisaki T., Heike T., Nakahata T., Kita T., Hasegawa K.: Acetylation of GATA-4 is involved in the differentiation of embryonic stem cells into cardiac myocytes. J. Biol. Chem. 280:19682-19688,2005.
Saito M., Fujisawa A., Nishikomori R., Kambe N., Nakata-Hizume M., Yoshimoto M., Ohmori K., Okafuji I., Yoshioka T., Kusunoki T., Miyachi Y., Heike T.,Nakahata T.: Somatic mosaicism of CIAS1 in a patient with chronic infantile neurologic, cutaneous, articular syndrome.Arthritis & Rheumatism 52:3579-3585,2005.
OhtsukaY.,ManabeA.,KawasakiH.,HasegawaD.,ZaikeY.,WatanabeS.,TanizawaT,NakahataT.,Tsuji K.: RAS-bloking bisphosphonate zoledronic acid inhibits the abnormal proliferation and differentiation of juvenile myelomonocytic leukemia cells.Blood 106:3134-3141,2005.
Kanazawa N, Okafuji I, Kambe N, Nishikomori R, Nakata-Hizume M, Nagai S, Fuji A, Yuasa T, Manki A, Sakurai Y, Nakajima M, Kobayashi H, Fujiwara I, Tsutsumi H, Utani A, Nishigori C, Heike T, Nakahata T,Miyachi Y.: Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-kappaB activation: common genetic etiology with Blau syndrome.Blood. 105:1195-7. 2005.
Kato T, Heike T, Okawa K. haruyama M, Shiraishi K. Yshimoto M, Nagato M, Shibata M, Kumada T, Yamanaka Y, Hattori H, Nakahata T.: A neurosphere-derived factor, cyctatin C, supports differentiation of ES cells into neural stem cells.Proc. Natl. Acad. Sci. USA 103:6019-6024 2006.
Umeda K, Heike T, Yoshimoto M, Shinoda G, Shiota M, Suemori H, Hong Yuan Luo, Danid H.K., Torii Ryuzo, Shibuya M, Nakatsuji N, Nakahata T.: Indentification and characterization of hemoangiogenic progenitors during cynomolgus monkey embryonic stem cell diffrentiation.Stem Cells 24;1348-1358,2006
Tanaka H.,Matsumura I.,Itoh K.,Hatsuyama A.,Satoh Y.,Nakahata T.,Kanakura Y.: HOX decoy peptide enhances the ex vivo expansion of human umbilical cord blood HSCs.Stem Cells 24:2592-2602,2006
Suzuki T, Yokoyama Y, Kumano K, Takanashi M, Kozuma S, Takano T, Nakahata T, Nishikawa M, Sakano S, Kurokawa M, Ogawa S, Chiba S.: Highly Efficient Ex Vivo Expansion of human hematopoietic stem cells using Delta1-Fc chimeric protein.Stem Cells 24:2456-2465,2006
Umeda K,Heike T,Nakata-Hizume M, Niwa A, Arai M, Shinoda G, Ma F, Suemori H, Luo HY,Chui DH,Torii R,Shibuya M, Nakatsuji N, Nakahata T: Sequential analysis of α-and β -globin gene expression during erythropoietic differentiation from primate embryonic stem cells.Stem cells 24:2627-2636 2006
Shiota M,Heike T,Haruyama M,Baba S,Tsuchiya A,Fujino H,Kobayashi H,Umeda K,Yoshimoto M,Nakahata T: Isolation and characterization of bone marrow-derived mesenchymal progenitor cells with myogenic and neuronal properties.Exp Cell Res.10;313(5)1008-1023 2007
Shinoda G, Umeda K,Heike T, Arai M, Niwa A, Ma F, Suemori H, Luo HY,Chui DH,Torii R,Shibuya M, Nakatsuji N, Nakahata T: a4-Integrin+endothelium deriverd from primate embryonic stem cells generates primitive and definitive hematopoietic cells.Blood 109(6)2406-2415 2007
Baba S, Heike T, Umeda K, Iwasa T, Kaichi S, Hiraumi T, Doi H, Yoshimoto M, Kanatsu-Shinohata M, Shinohara T, Nakahata T.: Generation of cardiac and endothelial cells from neonatal mouse testis-derived multipotent germline stem cells.Stem Cells 25:1375-1383 2007
Fujisawa A, Kambe N, Saito M, Nishikomori R, Tanizaki H, Kanazawa N, Adachi S, Heike T, Sagara J, Suda T, Nakahata T, Miyachi Y.: Disease-associated mutations in CIAS1 induce cathepsin B-dependent rapid cell death of human THP-1 monocytic cells.Blood 109(7)2903-2911,2007
Tsuchiya A, Heike T, Baba S, Fujino H, Umeda K, Matsuda Y, Nomoto M, Ichida T, AoyagiY, Nakahata T.: Long-term culture of postnatal mouse hepatic stem/progenitor cells and their relative development hierarchy.Stem Cells 25:895-902,2007.
Baba S, Heike T, Yoshimoto M, Umeda K, Doi H, Iwasa T, Lin X, Matsuoka S, Komeda M,Nakahata T: Flk1+ cardiac stem/progenitor cells derived from embryonic stem cells improve cardiac function in a dilated cardiomyopathy mouse model.Cardiiovascular Res. 76:119-131, 2007
Miyazaki M,Yasunaga J, Taniguchi Y, Tamiya S, Nakahata T, Matsuoka M.: Preferential selection of human T-Cell leukemia virus type 1 provirus lacking the 5' long terminal repeat during oncogenesis.J. Virol. 81:5714-5723, 2007
Fujino H, Hiramatsu H, Tsuchiya A, Niwa A, Noma H, Shiota M, Umeda K, Yoshimoto M, Ito M, Heike T, Nakahata T.: Human cord blood CD34+ cells develop into hepatocytes in the livers of NOD/SCID/gcnull mice through cell fusion.FASEB J. 21:3499-3510,2007.
Ma F, Kambe N, Dan W, Shinoda G, Fujino H, Umeda K, Fujisawa A, Ma L, Suemori H, Nakatsuji N, Miyachi Y, Torii R, Tsuji K, Heike T, Nakahata T: Direct development of functionary mature tryptase/chymase double-positive connective tissue-type mast cells from primate embryonic stem cells.Stem Cells 26:706-714, 2008.
Ito M, Kobayashi K, Nakahata T: NOD/Shi-scid IL2rγnull (NOG)Mice More appropriate for humanized mouse models.Curr. Top. Microbiol. Immunol. 324:54-76, 2008.
Ma F, Ebihara Y, Umeda K, Sakai H, Hanada S, Hong Z, Zaike Y, Tsuchida E, Nakahata T, Nakauchi H, Tsuji K.: Generatuion of functional erythrocytes from human embryonic stem cell-derived definitive hematopoiesis.Proc. Natl. Acad. Sci. USA 105: 13087-13092,2008.
KamitsujiY, Kuroda J, Kimura S, Toyokuni S, Watanabe K, Ashihara E, Tanaka H, Yui Y, Watanabe M, Matsubara H, Mizushima Y, Hiraumi Y, KawataE, Yoshikawa T, Maekawa T, Nakahata T, Adachi A: The Bcr-Abl kinase inhibitor INNO-406 induces autophagyand different modes of cell death execution in Bcr-Abl-positive luekemias.Cell Death and Differ. 15,1712-1722, 2008.
Tsuji S, Yoshimoto M, Takahashi K, Noda Y, Nakahata T, Heike T.: Side population cells contribute to the genesis of human endometrium.Fertil. Steril. 90:1528-1537,2008.
Tsuchiya A., Heike T., Baba S., Fujino H., Umeda K., Matsuda Y., Nomoto M., Ichida T., Aoyagi Y., Nakahata T.: Sca-1+ endothelial cells (SPECs) reside in the portal area of the liver and contribute to rapid recovery from acute liver disease.Biochem. Biophys. Res. Com.365:595-601,2008.
Saito M., Nishikomori R., Kambe N., Fujisawa A., Tanizaki H., Takeichi K., Imagawa T., Iehara T., Takada H., Matsubayashi T., TanakaH., Kawashima K., Kagami S., Kawai T., Okafuji I., Yoshioka T., Adachi S., Heike T., Miyachi Y., Nakahata T.: Disease-associated CIAS1 mutations induce monocyte death, revealing low-level mosaicism in mutation-negative cryopyrin-associated periodic syndrome patients.Blood 111:2132-2141,2008.
Kosaka Y., Sano K., Kobayashi R., Ayukawa H., Kaneko T., Yabe H., Tsuchida H., Mugishima M., Ohara A., Morimoto A., Otsuka Y., Ohga S., Bessho F., Nakahata T., Tsukimoto I., Kojima S.: rospective multicenter trial comparing repeated immunosuppressive therapy with stem cell transplantation from an alternative donor as second-line treatment for children with severe and very severe aplastic anemia.Blood 111:1054-1059,2008.
Yamanaka Y., Kumada T., Heike T., Shibata M., Takaoka Y., Kitano A., Shiraishi K., Kato T., Nagato M., Okawa K., Furushima K., Nakao K., Aizawa S., Nakamura Y., Taketo M.M. Nakahata T.: Loss of Borealin/DasraB leads to defective cell proliferation, p53 accumulation and early embryonic lethality.Mech. Develop. 125:4441-450,2008.
Okafuji I, Nishikomori R, Kanazawa N, Kambe N, Fujisawa A, Yamazaki S, Saito M, Yoshioka T, Kawai T, Sakai H, Tanizaki H, Heike T, Miyachi Y, Nakahata T.: Role of the NOD2 genotype in the clinical phenotype of Blau syndrome and early-onset sarcoidosis. Arthritis Rheum. 60:242-50 2009.
Kato M, Sanada M, Kato I, Sato Y, Takita J, Takeuchi K, Niwa A, Chen Y, Nakazaki K, Nomoto J, Asakura Y, Muto S, Tamura A, Iio M, Akatsuka Y, Hayashi Y, Mori H, Igarashi T, Kurokawa M, Chiba S, Mori S, Ishikawa Y, Okamoto K, Tobinai K, Nakagama H, Nakahata T, Yoshino T, Kobayashi Y, Ogawa S: Frequent inactivation of A20 in B-cell lymphomas.Nature 459:712-716,2009.
Higashi A.Y., Ikawa T, Muramatsu M, Economides A.N., Niwa A, Okuda T, Murphy AJ., Rojas J, Heike T, Nakahata T, Kawamoto H, Kita T, Yanagita M.: Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic activation of CreER^T2.J Immunol. in press
Niwa A., Umeda K., Chang H., Saito M., Okita K., Takahashi K., Nakagawa M., Yamanaka S., Nakahata T., Heike T.: Orderly Hematopoietic Development of Induced Pluripotent Stem Cells via Flk-1+ Hemoangiogenic Progenitors.J. Cell. Physiol. in press.
Yokoo N., Baba S., Kaichi S., Niwa A., Mima T., Doi H., Yamanaka S., Nakahata T., Heike T.: The effects of cardioactive drugs on cardiomyocytes derived from human induced pluripotent stem cells. Biochem. Biophys. Res. Com. in press.
Chang H, Yoshimoto M, Umeda K, Iwasa T, Mizuno Y, Fukada SI, Yamamoto H, Motohashi N, Suzuki YM, Takeda S, Heike T, Nakahata T.: Generation of transplantable, functional satellite-like cells from mouse embryonic stem cells.FASEB J. in press

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