Research Activities

Research Activities

Home › Research Activities › Principal Investigators › Shinya Yamanaka (Professor)

Principal Investigators

Dept. of Life Science Frontiers 
Shinya Yamanaka (Professor)

Publications
  • 2017
    • Sugiyama, H., Takahashi, K., Yamamoto, T., Iwasaki, M., Narita, M., Nakamura, M., Rand, TA., Nakagawa, M., Watanabe, A., and Yamanaka, S.
      • Nat1 promotes translation of specific proteins that induce differentiation of mouse embryonic stem cells.
      • Proc Natl Acad Sci U S A 114, 340-345.



  • 2016
    • Hayashi, Y., Hsiao, E.C., Sami, S., Lancero, M., Schlieve, C.R., Nguyen, T., Yano, K, Nagahashi, A., Ikeya, M., Matsumoto, Y., Nishimura, K., Fukuda, A., Hisatake, K., Tomoda, K., Asaka, I., Toguchida, J., Conklin, B.R., and Yamanaka, S.
      • BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence.
      • Proc Natl Acad Sci U S A 113, 13057-13062.
    • Kime, C., Sakaki-Yumoto, M., Goodrich, L., Hayashi, Y., Sami, S., Derynck, R., Asahi, M., Panning, B., Yamanaka, S., and Tomoda, K.
      • Autotaxin-mediated lipid signaling intersects with LIF and BMP signaling to promote the naive pluripotency transcription factor program.
      • Proc Natl Acad Sci U S A 113, 12478-12483.
    • Funakoshi, S., Miki, K., Takaki, T., Okubo, C., Hatani, T., Chonabayashi, K., Nishikawa, M., Takei, I., Oishi, A., Narita, M., Hoshijima, M., Kimura, T., Yamanaka, S., and Yoshida, Y.
      • Enhanced engraftment, proliferation, and therapeutic potential in heart using optimized human iPSC-derived cardiomyocytes.
      • Scientific Reports 6, 19111.



  • 2015
    • Kim, SI., Oceguera-Yanez, F., Hirohata., R., Linker, S., Okita, K., Yamada, Y., Yamamoto, T., Yamanaka, S., and Woltjen, K.
      • KLF4 N-Terminal Variance Modulates Induced Reprogramming to Pluripotency.
      • Stem Cell Reports 4, 727-743.
    • Hayashi, Y., Caboni, L., Das, D., Yumoto, F., Clayton, T., Deller, MC., Nguyen, P., Farr, CL., Chiu, HJ., Miller, MD., Elsliger, MA., Deacon, AM., Godzik, A., Lesley, SA., Tomoda, K., Conklin, BR., Wilson, IA., Yamanaka, S., and Fletterick, RJ.
      • Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.
      • Proc Natl Acad Sci U S A 112, 4666-4671.
    • Miki, K., Endo, K., Takahashi, S., Funakoshi, S., Takei, I., Katayama, S., Toyoda, T., Kotaka, M., Takaki, T., Umeda, M., Okubo, C., Nishikawa, M., Oishi, A., Narita, M., Miyashita, I., Asano, K., Hayashi, K., Osafune, K., Yamanaka, S., Saito, H., and Yoshida, Y.
      • Efficient Detection and Purification of Cell Populations Using Synthetic MicroRNA Switches.
      • Cell Stem Cell 16, 699-711.
    • Sasaki, K., Yokobayashi, S., Nakamura, T., Okamoto, I., Yabuta, Y., Kurimoto, K., Ohta, H., Moritoki, Y., Iwatani, C., Tsuchiya, H., Nakamura, S., Sekiguchi, K., Sakuma, T., Yamamoto, T., Mori, T., Woltjen, K., Nakagawa, M., Yamamoto, T., Takahashi, K., Yamanaka, S., and Saitou, M.
      • Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells.
      • Cell Stem Cell 17, 178-194.
    • Toyohara, T., Mae, SI., Sueta, SI., Inoue, T., Yamagishi, Y., Kawamoto, T., Kasahara, T., Hoshina, A., Toyoda, T., Tanaka, H., Araoka, T., Sato-Otsubo, A., Takahashi, K., Sato, Y., Yamaji, N., Ogawa, S., Yamanaka, S., and Osafune, K.
      • Cell Therapy Using Human Induced Pluripotent Stem Cell-Derived Renal Progenitors Ameliorates Acute Kidney Injury in Mice.
      • Stem Cells Translational Medicine 4, 980-992.



  • 2014
    • Ohnuki, M., Tanabe, K., Sutou, K., Teramoto, I., Sawamura, Y., Narita, M., Nakamura, M., Tokunaga, Y., Nakamura, M., Watanabe, A., Yamanaka, S., and Takahashi, K.
      • Dynamic regulation of human endogenous retroviruses mediates factor-induced reprogramming and differentiation potential.
      • Proc Natl Acad Sci U S A 111, 12426-12431.
    • Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Sasaki, A., Yamamoto, M., Nakamura, M., Sutou, K., Osafune, K., and Yamanaka, S.
      • Induction of pluripotency in human somatic cells via a transient state resembling primitive streak-like mesendoderm.
      • Nature Communications 5, 3678.
    • Shimamoto, R., Amano, N., Ichisaka, T., Watanabe, A., Yamanaka, S., and Okita, K.
      • Generation and Characterization of Induced Pluripotent Stem Cells from Aid-Deficient Mice.
      • PLoS ONE 9, e94735.
    • Nakagawa, M., Taniguchi, Y., Senda, S., Takizawa, N., Ichisaka, T., Asano, K., Morizane, A., Doi, D., Takahashi, J., Nishizawa, M., Yoshida, Y., Toyoda, T., Osafune, K., Sekiguchi, K., and Yamanaka, S.
      • A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cells.
      • Scientific Reports 4, 3594.



  • 2013
    • Koyanagi-Aoi, M., Ohnuki, M., Takahashi, K., Okita, K., Noma, H., Sawamura, Y., Teramoto, I., Narita, M., Sato, Y., Ichisaka, T., Amano, N., Watanabe, A., Morizane, A., Yamada, Y., Sato, T., Takahashi, J., and Yamanaka, S.
      • Differentiation defective phenotypes revealed by large scale analysis of human pluripotent stem cells.
      • Proc Natl Acad Sci U S A 110, 20569-20574.
    • Tanabe, K., Nakamura, M., Narita, M., Takahashi, K., and Yamanaka, S.
      • Maturation, not initiation, is the major roadblock during reprogramming toward pluripotency from human fibroblasts.
      • Proc Natl Acad Sci U S A 110, 12172-12179.
    • Okita, K., Yamakawa, T., Matsumura, Y., Sato, Y., Amano, N., Watanabe, A., Goshima, N., and Yamanaka, S.
      • An Efficient Non-viral Method to Generate Integration-Free Human iPS Cells from Cord Blood and Peripheral Blood Cells.
      • Stem Cells 31, 458-466.



  • 2012
    • Tomoda, K., Takahashi, K., Leung, K., Okada, A., Narita, M., Yamada, N.A., Eilertson, K.E., Tsang, P., Baba, S., White, M.P., Sami, S., Srivastava, D., Conklin, B.R., Panning, B., and Yamanaka, S.
      • Derivation conditions impact x-inactivation status in female human induced pluripotent stem cells.
      • Cell Stem Cell 11, 91-99.
    • Kajiwara, M., Aoi, T., Okita, K., Takahashi, R., Inoue, H., Takayama, N., Endo, H., Eto, K., Toguchida, J., Uemoto, S., and Yamanaka, S.
      • Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells.
      • Proc Natl Acad Sci U S A 109, 12538-12543.
    • Miki, K., Uenaka, H., Saito, A., Miyagawa, S., Sakaguchi, T., Higuchi, T., Shimizu, T., Okano, T., Yamanaka, S., and Sawa, Y.
      • Bioengineered myocardium derived from induced pluripotent stem cells improves cardiac function and attenuates cardiac remodeling following chronic myocardial infarction in rats.
      • Stem Cells Transl Med 1, 430-437.



  • 2011
    • Nakamura, T., Nakagawa, M., Ichisaka, T., Shiota, A., and Yamanaka, S.
      • Essential roles of ECAT15-2/Dppa2 in functional lung development.
      • Mol Cell Biol 31, 4366-4378.
    • Maekawa, M., Yamaguchi, K., Nakamura, T., Shibukawa, R., Kodanaka, I., Ichisaka, T., Kawamura, Y., Mochizuki, H., Goshima, N., and Yamanaka, S.
      • Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1.
      • Nature 474, 225-229.
    • Iwabuchi, K., Yamakawa, T., Sato, Y., Ichisaka, T., Takahashi, K., Okita, K., and Yamanaka, S.
      • ECAT11/L1td1 is enriched in ESCs and rapidly activated during iPSC generation, but it is dispensable for the pluripotency.
      • PLoS ONE 6, e20461.
    • Okita, K., Matsumura, Y., Sato, Y., Okada, A., Morizane, A., Okamoto, S., Hong, H., Nakagawa, M., Tanabe, K., Tezuka, K., Shibata, T., Kunisada, T., Takahashi, M., Takahashi, J., Saji, H., and Yamanaka, S.
      • A more efficient method to generate integration-free human iPS cells.
      • Nature Methods 8, 409-412.



  • 2010
    • Egusa, H., Okita, K., Kayashima, H., Yu, G., Fukuyasu, S., Saeki, M., Matsumoto, T., Yamanaka, S., and Yatani, H.
      • Gingival fibroblasts as a promising source of induced pluripotent stem cells.
      • PLoS One 5, e12743.
    • Nakagawa, M., Takizawa, N., Narita, M., Ichisaka, T., and Yamanaka, S.
      • Promotion of direct reprogramming by transformation-deficient Myc.
      • Proc Natl Acad Sci U S A 107, 14152-14157.
    • Tsuji, O., Miura, K., Okada, Y., Fujiyoshi, K., Mukaino, M., Nagoshi, N., Kitamura, K., Kumagai, G., Nishino, M., Tomisato, S., Higashi, H., Nagai, T., Katoh, H., Kohda, K., Matsuzaki, Y., Yuzaki, M., Ikeda, E., Toyama, Y., Nakamura, M., Yamanaka, S., and Okano, H. (2010).
      • Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury.
      • Proc Natl Acad Sci U S A 107, 12704-12709.
    • Saunders, L.R., Sharma, A.D., Tawney, J., Nakagawa, M., Okita, K., Yamanaka, S., Willenbring, H., and Verdin, E. (2010).
      • miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues.
      • Aging (Albany NY).
    • Tamaoki, N., Takahashi, K., Tanaka, T., Ichisaka, T., Aoki, H., Takeda-Kawaguchi, T., Iida, K., Kunisada, T., Shibata, T., Yamanaka, S., and Tezuka, K. (2010).
      • Dental Pulp Cells for Induced Pluripotent Stem Cell Banking.
      • J Dent Res.
    • Kaichi, S., Hasegawa, K., Takaya, T., Yokoo, N., Mima, T., Kawamura, T., Morimoto, T., Ono, K., Baba, S., Doi, H., Yamanaka, S., Nakahata, T., and Heike, T. (2010).
      • Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice.
      • Cardiovasc Res.
    • Yamanaka, S., and Blau, H.M. (2010).
      • Nuclear reprogramming to a pluripotent state by three approaches.
      • Nature 465, 704-712.
    • Okita, K., and Yamanaka, S. (2010).
      • Induction of pluripotency by defined factors.
      • Exp Cell Res.
    • Sato, S., Yagi, S., Arai, Y., Hirabayashi, K., Hattori, N., Iwatani, M., Okita, K., Ohgane, J., Tanaka, S., Wakayama, T., Yamanaka, S. & Shiota, K.
      • Genome-wide DNA methylation profile of tissue-dependent and differentially methylated regions (T-DMRs) residing in mouse pluripotent stem cells.
      • Genes Cells (2010).
    • Kazuki, Y., Hiratsuka, M., Takiguchi, M., Osaki, M., Kajitani, N., Hoshiya, H., Hiramatsu, K., Yoshino, T., Kazuki, K., Ishihara, C., Takehara, S., Higaki, K., Nakagawa, M., Takahashi, K., Yamanaka, S., and Oshimura, M.
      • Complete genetic correction of ips cells from Duchenne muscular dystrophy.
      • Mol Ther 18, 386-393. (2010)
    • Mizuno, Y., Chang, H., Umeda, K., Niwa, A., Iwasa, T., Awaya, T., Fukada, S.I., Yamamoto, H., Yamanaka, S., Nakahata, T., and Heike, T
      • Generation of skeletal muscle stem/progenitor cells from murine induced pluripotent stem cells.
      • FASEB J. (2010)
    • Okita, K., Hong, H., Takahashi, K., and Yamanaka, S.
      • Generation of mouse-induced pluripotent stem cells with plasmid vectors.
      • Nat Protoc 5, 418-428. (2010)



  • 2009
    • Takahashi, K., Narita, M., Yokura, M., Ichisaka, T., and Yamanaka, S. (2009).
      • Human induced pluripotent stem cells on autologous feeders.
      • PLoS One 4, e8067.
    • Nagata, S., Toyoda, M., Yamaguchi, S., Hirano, K., Makino, H., Nishino, K., Miyagawa, Y., Okita, H., Kiyokawa, N., Nakagawa, M., Yamanaka, S., Akutsu, H., Umezawa, A., and Tada, T. (2009)
      • Efficient reprogramming of human and mouse primary extra-embryonic cells to pluripotent stem cells.
      • Genes Cells 14, 1395-1404.
    • Kazuki, Y., Hiratsuka, M., Takiguchi, M., Osaki, M., Kajitani, N., Hoshiya, H., Hiramatsu, K., Yoshino, T., Kazuki, K., Ishihara, C., Takehara, S., Higaki, K., Nakagawa, M., Takahashi, K., Yamanaka, S., and Oshimura, M. (2009).
      • Complete Genetic Correction of iPS Cells From Duchenne Muscular Dystrophy.
      • Mol Ther.
    • Nagata, S., Toyoda, M., Yamaguchi, S., Hirano, K., Makino, H., Nishino, K., Miyagawa, Y., Okita, H., Kiyokawa, N., Nakagawa, M., Yamanaka, S., Akutsu, H., Umezawa, A., and Tada, T. (2009)
      • Efficient reprogramming of human and mouse primary extra-embryonic cells to pluripotent stem cells.
      • Genes Cells.
    • Yoshida, Y., Takahashi, K., Okita, K., Ichisaka, T., and Yamanaka, S. (2009).
      • Hypoxia enhances the generation of induced pluripotent stem cells.
      • Cell Stem Cell 5, 237-241.
    • Hong, H., Takahashi, K., Ichisaka, T., Aoi, T., Kanagawa, O., Nakagawa, M., Okita, K., and Yamanaka, S. (2009)
      • Suppression of induced pluripotent stem cell generation by the p53-p21 pathway.
      • Nature 460, 1132-1135.
    • Nishimura, K., Nakagawa, T., Ono, K., Ogita, H., Sakamoto, T., Yamamoto, N., Okita, K., Yamanaka, S., and Ito, J. (2009).
      • Transplantation of mouse induced pluripotent stem cells into the cochlea.
      • Neuroreport.
    • Miura, K., Okada, Y., Aoi, T., Okada. A., Takahashi, K., Okita, K., Nakagawa, M., Koyanagi, M., Tanabe, K., Ohnuki, M., Ogawa, D., Ikeda, E., Okano, H., Yamanaka, S. (2009).
      • Variation in the safety of induced pluripotent stem cell lines.
      • Nat Biotechnol 27, 743-745.
    • Niwa, A., Umeda, K., Chang, H., Saito, M., Okita, K., Takahashi, K., Nakagawa, M., Yamanaka, S., Nakahata, T., Heike, T. (2009).
      • Orderly hematopoietic development of induced pluripotent stem cells via Flk-1+ hemoangiogenic progenitors.
      • J Cell Phys, Epub ahead of print.
    • Ohnuki, M., Takahashi, K., and Yamanaka, S. (2009).
      • Generation and characterization of human induced pluripotent stem cells.
      • Curr Protoc Stem Cell Biol Chapter 4, Unit 4A 2.
    • Yamanaka, S. (2009).
      • A fresh look at iPS cells.
      • Cell 137, 13-17.
    • Tsubooka, N., Ichisaka, T., Okita, K., Takahashi, K., Nakagawa, M., and Yamanaka, S. (2009).
      • Roles of Sall4 in the generation of pluripotent stem cells from blastocysts and fibroblasts.
      • Genes Cells.
    • Taura, D., Sone, M., Homma, K., Oyamada, N., Takahashi, K., Tamura, N., Yamanaka, S., and Nakao, K. (2009a)
      • Induction and Isolation of Vascular Cells From Human-Induced Pluripotent Stem Cells.
      • Arterioscler Thromb Vasc Biol.
    • Taura, D., Noguchi, M., Sone, M., Hosoda, K., Mori, E., Okada, Y., Takahashi, K., Homma, K., Oyamada, N., Inuzuka, M., Sonoyama, T., Ebihara, K., Tamura, N., Itoh, H., Suemori, H., Nakatsuji, N., Okano, H., Yamanaka, S., and Nakao, K. (2009b).
      • Adipogenic differentiation of human induced pluripotent stem cells: comparison with that of human embryonic stem cells.
      • FEBS Lett 583, 1029-1033.
    • Tanaka, T., Tohyama, S., Murata, M., Nomura, F., Kaneko, T., Chen, H., Hattori, F., Egashira, T., Seki, T., Ohno, Y., Koshimizu, U., Yuasa, S., Ogawa, S., Yamanaka, S., Yasuda, K., and Fukuda, K. (2009).
      • In vitro pharmacologic testing using human induced pluripotent stem cell-derived cardiomyocytes.
      • Biochem Biophys Res Commun.
    • Senju, S., Haruta, M., Matsunaga, Y., Fukushima, S., Ikeda, T., Takahashi, K., Okita, K., Yamanaka, S., and Nishimura, Y. (2009)
      • Characterization of Dendritic Cells and Macrophages Generated by Directed Differentiation from Mouse Induced Pluripotent Stem Cells.
      • Stem Cells 27, 1021-1031.
    • Hirami, Y., Osakada, F., Takahashi, K., Okita, K., Yamanaka, S., Ikeda, H., Yoshimura, N., and Takahashi, M. (2009).
      • Generation of retinal cells from mouse and human induced pluripotent stem cells.
      • Neurosci Lett.
    • Daley, G.Q., Lensch, M.W., Jaenisch, R., Meissner, A., Plath, K., and Yamanaka, S. (2009).
      • Broader implications of defining standards for the pluripotency of iPSCs.
      • Cell Stem Cell 4, 200-201; author reply 202.
    • Aoyama, Y., Nomura, M., Yamanaka, S., Ogawa, Y., and Kitajima, Y. (2009).
      • Subcutaneous phaeohyphomycosis caused by Exophiala xenobiotica in a non-Hodgkin lymphoma patient.
      • Med Mycol 47, 95-99.
    • Aiba, K., Nedorezov, T., Piao, Y., Nishiyama, A., Matoba, R., Sharova, L.V., Sharov, A.A., Yamanaka, S., Niwa, H., and Ko, M.S. (2009).
      • Defining developmental potency and cell lineage trajectories by expression profiling of differentiating mouse embryonic stem cells.
      • DNA Res 16, 73-80.



  • 2008
    • Aoi, T., Yae, K., Nakagawa, M., Ichisaka, T., Okita, K., Takahashi, K., Chiba, T., and Yamanaka, S. (2008).
      • Generation of pluripotent stem cells from adult mouse liver and stomach cells.
      • Science 321, 699-702.
    • Nakagawa, M., Koyanagi, M., Tanabe, K., Takahashi, K., Ichisaka, T., Aoi, T., Okita, K., Mochiduki, Y., Takizawa, N., and Yamanaka, S. (2008).
      • Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts.
      • Nat Biotechnol 26, 101-106.
    • Narazaki, G., Uosaki, H., Teranishi, M., Okita, K., Kim, B., Matsuoka, S., Yamanaka, S., and Yamashita, J.K. (2008).
      • Directed and systematic differentiation of cardiovascular cells from mouse induced pluripotent stem cells.
      • Circulation 118, 498-506.
    • Okita, K., Nakagawa, M., Hyenjong, H., Ichisaka, T., and Yamanaka, S. (2008).
      • Generation of mouse induced pluripotent stem cells without viral vectors.
      • Science 322, 949-953.
    • Yamanaka, S. (2008).
      • Induction of pluripotent stem cells from mouse fibroblasts by four transcription factors.
      • Cell Prolif 41 Suppl 1, 51-56.



  • 2007
    • Hyun, I., Hochedlinger, K., Jaenisch, R., and Yamanaka, S. (2007).
      • New advances in iPS cell research do not obviate the need for human embryonic stem cells.
      • Cell Stem Cell 1, 367-368.
    • Okita, K., Ichisaka, T., and Yamanaka, S. (2007).
      • Generation of germline-competent induced pluripotent stem cells.
      • Nature 448, 313-317.
    • Takahashi, K., Okita, K., Nakagawa, M., and Yamanaka, S. (2007a).
      • Induction of pluripotent stem cells from fibroblast cultures.
      • Nat Protoc 2, 3081-3089.
    • Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., and Yamanaka, S. (2007b)
      • Induction of pluripotent stem cells from adult human fibroblasts by defined factors.
      • Cell 131, 861-872.
    • Yamanaka, S. (2007).
      • Strategies and new developments in the generation of patient-specific pluripotent stem cells.
      • Cell Stem Cell 1, 39-49.
    • Lewitzky M, Yamanaka S.
      • Reprogramming somatic cells towards pluripotency by defined factors.
      • Curr Opin Biotechnol. 2007 Oct;18(5):467-73.
    • Yoshikane N, Nakamura N, Ueda R, Ueno N, Yamanaka S, Nakamura M.
      • Drosophila NAT1, a homolog of the vertebrate translational regulator NAT1/DAP5/p97, is required for embryonic germband extension and metamorphosis.
      • Dev Growth Differ. 2007 Sep;49(7):623-34.
    • Uemoto, Y., Suzuki, S., Terada, N., Ohno, N., Ohno, S., Yamanaka S., and Komada, M.
      • Specific role of the truncated betaIV-spectrin Sigma6 in sodium channel clustering at axon initial segments and nodes of Ranvier.
      • J Biol Chem 282:6548-6555, 2007



  • 2006
    • Nimura, K., Ishida, C., Koriyama, H., Hata, K., Yamanaka S., Li, E., Ura, K., and Kaneda, Y.
      • Dnmt3a2 targets endogenous Dnmt3L to ES cell chromatin and induces regional DNA methylation.
      • Genes Cells 11:1225-1237, 2006.
    • Takahashi K, Yamanaka S.
      • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
      • Cell, 126:663-676, 2006.
    • Tanaka TS, Lopez de Silanes I, Sharova LV, Akutsu H, Yoshikawa T, Amano H, Yamanaka S, Gorospe M, Ko MS.
      • Esg1, expressed exclusively in preimplantation embryos, germline, and embryonic stem cells, is a putative RNA-binding protein with broad RNA targets.
      • Dev Growth Differ. 48: 381-90, 2006.
    • Imamura M, Miura K, Iwabuchi K, Ichisaka T, Nakagawa M, Lee J, Kanatsu-Shinohara M, Shinohara T, Yamanaka S.
      • Transcriptional repression and DNA hypermethylation of a small set of ES cell marker genes in male germline stem cells.
      • BMC Dev Biol. 6: 34, 2006
    • Takahashi K, Ichisaka T, Yamanaka S.
      • Identification of genes involved in tumor-like properties of embryonic stem cells.
      • Methods Mol Biol. 329: 449-58, 2006.
    • Amano H., Itakura K., Maruyama M., Ichisaka T., Nakagawa M. and Yamanaka STokuzawa Y, Maruyama M, Yamanaka S.
      • Utilization of digital differential display to identify novel targets of Oct3/4.
      • Methods Mol Biol. 329: 223-31, 2006.
    • Identification and targeted disruption of the mouse gene encoding ESG1 (PH34/ECAT2/DPPA5).
      • BMC Developmental Biology, 6: 11 , 2006.
    • Okita K. and Yamanaka S.
      • Intracellular signaling pathways regulating pluripotency of embryonic stem cells.
      • Cur. Stem Cell Res. Ther., 1: 103-11, 2006



  • 2005
    • Takahashi K., Murakami M. and Yamanaka S.
      • Role of the phosphoinositide 3-kinase pathway in mouse embryonic stem (ES) cells.
      • Biochem Soc Trans. 33: 1522-5, 2005
    • Takahashi K., Nakagawa M., Young S.G. and Yamanaka S.
      • Differential membrane localization of ERas and Rheb, Two Ras-related proteins involved in the PI3 kinase / mTOR pathway.
      • J. Biol. Chem. 280: 32768-74, 2005
    • Maruyama M., Ichisaka T., Nakagawa M. and Yamanaka S.
      • Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells.
      • J. Biol. Chem. 280: 24371-9, 2005
    • Wang X, Beugnet A., Murakami M., Yamanaka S. and Proud C.G.
      • Distinct signaling events downstream of mTOR co-operate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins.
      • Mol. Cell. Biol. 25: 2558-72, 2005
    • Takahashi K., Maruyama M., Tokuzawa Y, Murakami M, Oda Y, Yoshikane N, Makabe KW, Ichisaka T, Yamanaka S. (The first two authors equally contributed)
      • Evolutionarily Conserved Non-AUG Translation Initiation in NAT1/p97/DAP5 (EIF4G2),
      • Genomics 85:360-71, 2005
    • Fukuhara A, Matsuda M, Nishizawa M, Tanaka M, Matsuki Y, Murakami M, Ichisaka T, Murakami H, Watanabe E, Takagi T, Akiyoshi M, Ohtsubo T, Kihara S, Yamashita S, Makishima M, Funahashi T, Yamanaka S, Hiramatsu R, Matsuzawa Y & Shimomura I.
      • Visfatin: A Protein Secreted by Visceral Fat that Mimics the Effects of Insulin.
      • Science 307: 426-430, 2005



  • 2004
    • Hamazaki T., Oka M., Yamanaka S. & Terada N.
      • Aggregation of Embryonic Stem Cells Induces Nanog Repression and Primitive Endoderm Differentiation.
      • J. Cell Sci. 117: 5681-5686, 2004
    • Tomoda K., Kato-Yoneda N., Fukumoto A., Yamanaka S. & Kato J.Y.
      • Multiple Functions of Jab1 Are Required for Early Embryonic Development and Growth Potential in Mice.
      • J. Biol. Chem. 279: 43013-8, 2004
    • Murakami M., Ichisaka T., Maeda M., Oshiro N., Hara K., Edenhofer F., Kiyama H., Yonezawa K. & Yamanaka S.
      • mTOR is essential for Growth and Proliferation in Early Mouse Embryos and Embryonic Stem Cells.
      • Mol. Cell. Biol. 24: 6710-6718, 2004
    • Matsuda E., Shigeoka , Iida R., Tocharus C., Yamanaka S., Kawaichi M. & Ishida Y.
      • Expression Profiling with Arrays of Randomly Disrupted Genes in Mouse ES Cells Leads to in Vivo Functional Analysis.
      • Proc. Natl. Acad. Sci. U S A 101:4170-4, 2004
    • Mak W., Nesterova TB., de Napoles M., Appanah R., Yamanaka S., Otte AP, and Neil Brockdorff N.
      • Reactivation of the Paternal X Chromosome in Early Mouse Embryos.
      • Science 303: 666-669, 2004



  • 2003
    • Mitsui K, Tokuzawa Y, Itoh H., Segawa K, Murakami M, Takahashi K, Maruyama M, Maeda M and Yamanaka S.
      • The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cell.
      • Cell 113: 631-642, 2003
    • Takahashi K, Mitusi K. and Yamanaka S.
      • Role of ERas in promoting tumor-like properties in mouse embronic stem cells.
      • Nature 423: 541-545, 2003
    • Tokuzawa Y., Kaiho E., Maruyama M., Takahashi K., Mitsui K., Maeda M., Niwa H., and Yamanaka S.
      • Fbx15 is a novel target of Oct3/4 but is dispensable for ES cell self-renewal and mouse development.
      • Mol. Cell. Biol. 23: 2699-2708, 2003



  • ~2002
    • Taniguchi, M., Miura, K., Iwao, H., and Yamanaka S.
      • Quantitative Assessment of DNA Microarrays – Comparison with Northern Blot Analyses.
      • Genomics 71: 34-39, 2001
    • Yamanaka S., Zhang, X. Y., Maeda, M., Miura, K., Wang, S., Farese, R. V. Jr., Iwao, H., and Innerarity. T. L.
      • Essential role of NAT1/p97/DAP5 in embryonic differentiation and retinoic acid pathway.
      • EMBO 19: 5533-5541, 2000
    • Nakamura, Y., Miura, K., Fujino, Y., Iwao, H., Ogita S. and Yamanaka S.
      • Evolution, Structure, and Expression of GNPI/Oscillin Orthologous Genes.
      • Genomics 68: 179-186, 2000



  • ~1999
    • Yamanaka S., Zhang, X. Y., Miura, K., Kim, S. and Iwao, H.
      • The human gene encoding the lectin-type oxidized LDL receptor (OLR1) is a novel member of the natural killer gene complex with a unique expression profile.
      • Genomics 54: 191-199, 1998.
    • Qian, X., Balestra, M. E., Yamanaka S., Boren, J., Lee, I. and Innerarity, T. L.
      • Low expression of the apolipoprotein B mRNA-editing transgene in mice reduces LDL levels but does not cause liver dysplasia or tumors.
      • Arterioscler Thromb Vasc Biol 18:1013-1020, 1998.
    • Yamanaka S., Poksay, K.S., Arnold, K.S., and Innerarity, T.L.
      • A novel translational repressor mRNA is extensively edited in livers containing tumors caused by the transgene expression of an apoB mRNA editing enzyme.
      • Genes Dev.11: 321-333, 1997.
    • Yamanaka S., Poksay, K.S., Driscoll, D.M., and Innerarity, T.L.
      • Hyperediting of multiple cytidines of apolipoprotein B mRNA by APOBEC-1 requires auxiliary protein(s) but not a mooring sequence motif.
      • J. Biol.Chem. 271: 11506-11510, 1996.
    • Yamanaka S., Balestra, M.E., Ferrell, L.D., Fan, J., Arnold, K.S., Taylor, S., Taylor, J.M., and Innerarity, T.L.
      • Apolipoprotein B mRNA-editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals.
      • Proc. Natl. Acad. Sci. U S A 92:8483-8487, 1995.
    • Yamanaka S., Poksay, K.S., Balestra, M.E., Zeng, G.-Q., and Innerarity, T.L.
      • Cloning and mutagenesis of the rabbit apoB mRNA editing protein: A zinc motif is essential for catalytic activity, and non-catalytic auxiliary factor(s) of the editing complex are widely distributed.
      • J. Biol. Chem. 269:21725-21734, 1994.
    • Yamanaka S., K. Miura, T. Yukimura, and K. Yamamoto.
      • 11-Dehydro thromboxane B2: a reliable parameter of thromboxane A2 production in dogs.
      • Prostaglandins 45: 221-8, 1993.
    • Yamanaka S., H. Iwao, T. Yukimura, S. Kim, and K. Miura.
      • Effect of NG-nitro-L-arginine on effective vascular stiffness in dogs.
      • Jpn J Pharmacol 63: 41-5, 1993.
    • Yamanaka S., H. Iwao, T. Yukimura, S. Kim, and K. Miura.
      • Effect of the platelet-activating factor antagonist, TCV-309, and the cyclo-oxygenase inhibitor, ibuprofen, on the haemodynamic changes in canine experimental endotoxic shock.
      • Br J Pharmacol 110: 1501-7, 1993.
    • Yamanaka S., K. Miura, T. Yukimura, M. Okumura, and K. Yamamoto.
      • Putative mechanism of hypotensive action of platelet-activating factor in dogs.
      • Circ Res 70: 893-901, 1992.



  • Other publications
    • Tamada S., Nakatani T., Asai T., Tashiro T., Komiya T., Sumi T., Okamura M., Kim S., Iwao H., Kishimoto T., Yamanaka S., and Miura K.
      • Inhibition of NF-κB activation by pyrrolidine dithiocarbamate prevents chronic FK506 nephropathy.
      • Kidney International. 63: 306-314, 2003
    • Asai, T., Nakatani T., Yamanaka S., Tamada S., Kishimoto T., Tashiro K., Nakao N., Okamura M., Kim S., Iwao H. & Miura K.
      • Magnesium supplementation prevents experimental chronic cyclosporine a nephrotoxicity via renin-angiotensin system independent mechanism.
      • Transplantation 74:784-791, 2002
    • Miura,K., Nakatani,T., Asai,T., Yamanaka S., Tamada,S., Tashiro,K., Kim,S., Okamura, M. & Iwao, H.
      • Role of hypomagnesemia in chronic cyclosporine A nephropathy.
      • Transplantation 73: 340-7, 2002
    • Miura, K., Yamanaka S., Ebara T., Okumura, M., Imanishi M., Kim, S., Nakatani T. & Iwao, H.
      • Effects of Nitric Oxide Scavenger, Carboxy-PTIO on endotoxin-induced alterations in systemic hemodyamics in rats.
      • Jpn J Pharmacol 82: 261-4, 2000
    • Miura, K., Yamanaka S., Ebara T., Okumura, M., Imanishi M., Kim, S., Nakatani T. & Iwao, H.
      • Effects of Nitric Oxide Scavenger, Carboxy-PTIO on endotoxin-induced alterations in systemic hemodyamics in rats.
      • Jpn J Pharmacol 82: 261-4, 2000
    • Miura, K., Okumura, M., Yamanaka S., Kim, S. & Iwao, H.
      • No participation of Adenosine A1 receptor in acute nephrotoxicity by 4-pentenoic acid administration in dogs.
      • Jpn J Pharmacol 80: 223-8, 1999
    • Miura, K., Okumura, M., Yamanaka S., Kim, S. and Iwao, H.
      • Effects of activation of renal adenosine A2 receptor on renal function and renin release in dogs.
      • Jpn J Pharmacol 80: 173-176, 1999.
    • Hamaguchi A, Kim S, Izumi Y, Zhan Y, Yamanaka S, and Iwao H.
      • Contribution of extracellular signal-regulated kinase to angiotensin II-induced transforming growth factor-beta1 expression in vascular smooth muscle cells.
      • Hypertension 34:126-31, 1999.
    • Yano, M., Kim, S., Izumi, Y., Yamanaka S. and Iwao, H.
      • Differential activation of cardiac c-jun amino-terminal kinase and extracellular signal-regulated kinase in angiotensin II-mediated hypertension.
      • Circ Res 83: 752-760, 1998.
    • Seto, M., Kim, S., Yoshifusa, H., Nakamura, Y., Masuda, T., Hamaguchi, A., Yamanaka S. and Iwao, H.
      • Effects of prednisolone on glomerular signal transduction cascades in experimental glomerulonephritis.
      • J Am Soc Nephrol 9: 1367-1376, 1998.
    • Izumi, Y., S. Kim, T. Murakami, S. Yamanaka, and H. Iwao.
      • Cardiac mitogen-activated protein kinase activities are chronically increased in stroke-prone hypertensive rats.
      • Hypertension 31: 50-6, 1998.
    • Kim, S., Y. Izumi, M. Yano, A. Hamaguchi, K. Miura, S. Yamanaka, H. Miyazaki, and H. Iwao.
      • Angiotensin blockade inhibits activation of mitogen-activated protein kinases in rat balloon-injured artery.
      • Circulation 97: 1731-7, 1998.
    • Hamaguchi, A., S. Kim, M. Yano, S. Yamanaka, and H. Iwao.
      • Activation of glomerular mitogen-activated protein kinases in angiotensin II-mediated hypertension.
      • J Am Soc Nephrol 9: 372-80, 1998.
    • Uchida, J., K. Miura, S. Yamanaka S. Kim, H. Iwao, T. Nakatani, and T. Kishimoto.
      • Renal endothelin in FK506-induced nephrotoxicity in spontaneously hypertensive rats.
      • Jpn J Pharmacol 76: 39-49, 1998.
    • Kim, S., H. Wanibuchi, A. Hamaguchi, K. Miura, S. Yamanaka, and H. Iwao.
      • Angiotensin blockade improves cardiac and renal complications of type II diabetic rats.
      • Hypertension 30: 1054-61, 1997.
    • Matsuura, T., K. Miura, T. Ebara, T. Yukimura, S. Yamanaka S. Kim, and H. Iwao.
      • Renal vascular effects of the selective endothelin receptor antagonists in anaesthetized rats.
      • Br J Pharmacol 122: 81-6, 1997.
    • Kim, S., T. Murakami, Y. Izumi, M. Yano, K. Miura, S. Yamanaka, and H. Iwao.
      • Extracellular signal-regulated kinase and c-Jun NH2-terminal kinase activities are continuously and differentially increased in aorta of hypertensive rats.
      • Biochem Biophys Res Commun 236: 199-204, 1997.
    • Kim, S., T. Sada, M. Mizuno, M. Ikeda, M. Yano, K. Miura, S. Yamanaka, H. Koike, and H. Iwao.
      • Effects of angiotensin AT1 receptor antagonist on volume overload- induced cardiac gene expression in rats.
      • Hypertens Res 20: 133-42, 1997.
    • Yukimura, T., Y. Yamashita, K. Miura, M. Okumura, S. Yamanaka, and K. Yamamoto.
      • Renal effects of the nitric oxide synthase inhibitor, L-NG- nitroarginine, in dogs.
      • Am J Hypertens 5: 484-7, 1992.
    • Yukimura, T., K. Miura, Y. Yamashita, T. Shimmen, M. Okumura, S. Yamanaka, M. Saito, and K. Yamamoto.
      • Effects of the calcium channel antagonist nicardipine on renal action of endothelin in dogs.
      • Contrib Nephrol 90: 105-10, 1991.
    • Yamashita, Y., T. Yukimura, K. Miura, M. Okumura, S. Yamanaka, and K. Yamamoto.
      • Effects of NG-nitro-L-arginine on renal hemodynamic responses to endothelin-3 in anesthetized dogs.
      • J Cardiovasc Pharmacol 17: S332-4, 1991.
    • Miura, K., T. Yukimura, Y. Yamashita, T. Shimmen, M. Okumura, S. Yamanaka, M. Imanishi, and K. Yamamoto.
      • Renal and femoral vascular responses to endothelin-1 in dogs: role of prostaglandins.
      • J Pharmacol Exp Ther 256: 11-7, 1991.
    • Miura, K., T. Yukimura, Y. Yamashita, K. Shichino, T. Shimmen, M. Saito, M. Okumura, M. Imanishi, S. Yamanaka, and K. Yamamoto
      • Effects of endothelin on renal hemodynamics and renal function in anesthetized dogs.
      • Am J Hypertens 3: 632-4, 1990.
go top