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CiRA - Center for iPS Cell Research and Application

Research Activities

Research Activities

Home　›　Research Activities　›　Principal Investigators　›　Shinya Yamanaka (Director Emeritus & Professor)

Principal Investigators

Dept. of Life Science Frontiers　
Shinya Yamanaka (Director Emeritus & Professor)

Publications
  • 2022
    • Sakuma K, Tsubooka-Yamazoe N, Hashimoto K, Sakai N, Asano S, Watanabe-Matsumoto S, Watanabe T, Saito B, Matsumoto H, Ueno H, Ito R, Toyoda T
      • CDK8/19 inhibition plays an important role in pancreatic β-cell induction from human iPSCs.
      • Stem Cell Research & Therapy. 14(1):1
    • Kunitomi A, Hirohata R, Arreola V, Osawa M, Kato TM, Nomura M, Kawaguchi J, Hara H, Kusano K, Takashima Y, Takahashi K, Fukuda K, Takasu N, Yamanaka S
      • Improved Sendai viral system for reprogramming to naive pluripotency.
      • Cell Rep Methods. 2(11):100317
    • Suzuki T, Aizawa K, Shibuya K, Yamanaka S, Anzai Y, Kurokawa K, Nagai R
      • Prevalence of Asymptomatic SARS-CoV-2 Infection in Japan.
      • JAMA Netw Open. 5(12):e2247704
    • Yoshida S, Kato TM, Sato Y, Umekage M, Ichisaka T, Tsukahara M, Takasu N, Yamanaka S
      • A clinical-grade HLA haplobank of human induced pluripotent stem cells matching approximately 40% of the Japanese population.
      • Med. 4(1):51-66.e10
    • Iwasaki M, Kawahara Y, Okubo C, Yamakawa T, Nakamura M, Tabata T, Nishi Y, Narita M, Ohta A, Saito H, Yamamoto T, Nakagawa M, Yamanaka S, Takahashi K
      • Multi-omics approach reveals posttranscriptionally regulated genes are essential for human pluripotent stem cells.
      • iScience. 25(5):104289



  • 2021
    • Takahashi K, Okubo C, Nakamura M, Iwasaki M, Kawahara Y, Tabata T, Miyamoto Y, Woltjen K,
      Yamanaka S
      • A stress-reduced passaging technique improves the viability of human pluripotent cells.
      • Cell Reports Methods. 2(2):100155
    • Hashimoto R, Sakamoto A, Deguchi S, Yi R, Sano E, Hotta A, Takahashi K, Yamanaka S, Takayama K
      • Dual inhibition of TMPRSS2 and Cathepsin B prevents SARS-CoV-2 infection in iPS cells.
      • Molecular Therapy Nucleic Acids. 26:1107-1114
    • Takahashi K, Nakamura M, Narita M, Ueda M, Takashima Y, Watanabe A, Yamanaka S
      • The pluripotent stem cell-specific transcript ESRG is dispensable for human pluripotency.
      • PLoS Genetics. 17(5):e1009587
    • Karagiannis, P., and Yamanaka, S.
      • Konnichiwa: Japanese scientists and their struggle to speak English: More research careers in Japan need less English.
      • EMBO Reports. 22:e52558



  • 2020
    • Shinya Yamanaka.
      • Pluripotent Stem Cell-Based Cell Therapy-Promise and Challenges.
      • Cell Stem Cell 27(4), 523-531
    • Takahashi, K., Jeong, D., Wang, S., Narita, M., Jin X., Iwasaki, M., Perli, S.D., Conklin, B.R., and
      Yamanaka, S.
      • Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells.
      • Cell Reports 31(9), 107715



  • 2019
    • Araki, H., Miura, F., Watanabe, A., Morinaga, C., Kitaoka, F., Kitano, Y., Sakai, N., Shibata, Y., Terada, M., Goto, S., Yamanaka, S., Takahashi, M., Ito, T.
      • Base-Resolution Methylome of Retinal Pigment Epithelial Cells Used in the First Trial of Human Induced Pluripotent Stem Cell-Based Autologous Transplantation.
      • Stem Cell Reports 13(4), 761-774
    • Kime, C., Kiyonari, H., Ohtsuka, S., Kohbayashi, E., Asahi, M., Yamanaka, S., Takahashi, M., Tomoda, K.
      • Induced 2C Expression and Implantation-Competent Blastocyst-like Cysts from Primed Pluripotent Stem Cells.
      • Stem Cell Reports 13(3), 485-498
    • Wu, J.C., Garg, P., Yoshida, Y., Yamanaka, S., Gepstein, L., Hulot, J.-S., Knollmann, B.C., Schwartz, P.J.
      • Towards Precision Medicine With Human iPSCs for Cardiac Channelopathies.
      • Circulation research 125(6), 653-658
    • Suga, M., Kondo, T., Imamura, K., Shibukawa, R., Okanishi, Y., Sagara, Y., Tsukita, K., Enami, T., Furujo, M., Saijo, K., Nakamura, Y., Osawa, M., Saito, M.K., Yamanaka, S., Inoue, H.
      • Generation of a human induced pluripotent stem cell line, BRCi001-A, derived from a patient with mucopolysaccharidosis type I.
      • Stem Cell Research 36: 101406
    • Karagiannis, P., Yamanaka, S., Saito, M. K.
      • Application of induced pluripotent stem cells to primary immunodeficiency diseases.
      • Experimental Hematology 71, 43-50
    • Tsuji, O., Sugai, K., Yamaguchi, R., Tashiro, S., Nagoshi, N., Kohyama, J., Iida, T., Ohkubo, T., Itakura, G., Isoda, M., Shinozaki, M., Fujiyoshi, K., Kanemura, Y., Yamanaka, S., Nakamura, M., Okano, H.
      • Laying the Groundwork for a First-In-Human Study of an induced Pluripotent Stem Cell-Based Intervention for Spinal Cord Injury.
      • STEM CELLS 37(1): 6-13



  • 2018
    • Karagiannis, P., Takahashi, K., Saito, M., Yoshida, Y., Okita, K., Watanabe, A., Inoue, H., Yamashita, J., Todani, M., Nakagawa, M., Osawa, M., Yashiro, Y., Yamanaka, S., and Osafune, K.
      • Induced Pluripotent Stem Cells and Their Use in Human Models of Disease and Development.
      • Physiological Reviews 99(1): 79-114
    • Allison, TF., Andrews, PW., Avior, Y., Barbaric, I., Benvenisty, N., Bock, C., Brehm, J., Brüstle, O.,
      Damjanov, I., Elefanty, A., Felkner, D., Gokhale, PJ., Halbritter, F., Healy, LE., Hu, TX., Knowles, BB.,
      Loring, JF., Ludwig, TE., Mayberry, R., Micallef, S., Mohamed, JS., Müller, FJ., Mummery, CL., Nakatsuji, N.,
      Ng, ES., Oh, SKW., O'Shea, O., Pera, MF., Reubinoff, B., Robson, P., Rossant, J., Schuldt, BM., Solter, D.,
      Sourris, K., Stacey, G., Stanley, EG., Suemori, H., Takahashi, K., and Yamanaka, S.
      • Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells.
      • Nature Communications 9(1): 1925
    • Rand, TA., Sutou, K., Tanabe, K., Jeong, D., Nomura, M., Kitaoka, F., Tomoda, E., Narita, M., Nakamura, M., Nakamura, M., Watanabe, A., Rulifson, E., Yamanaka, S., and Takahashi, K.
      • MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition.
      • Cell Reports 23(2): 361-375



  • 2017
    • Ikeda, H., Sone, M., Yamanaka, S., and Yamamoto, T.
      • Structural and spatial chromatin features at developmental gene loci in human pluripotent stem cells.
      • Nature Communications 8(1): 1616
    • Morizane, A., Kikuchi, T., Hayashi, T., Mizuma, H., Takara, S., Doi, H., Mawatari, A., Glasser, M.F., Shiina, T., Ishigaki, H., Itoh, Y., Okita, K., Yamasaki, E., Doi, D., Ono,e H., Ogasawara, K., Yamanaka, S., and
      Takahashi, .J.
      • MHC matching improves engraftment of iPSC-derived neurons in non-human primates.
      • Nature Communications 8(1): 385
    • Kawamura, M., Miyagawa, S., Fukushima, S., Saito, A., Miki, K., Funakoshi, S., Yoshida, Y., Yamanaka, S., Shimizu, T., Okano, T., Daimon, T., Toda, K., and Sawa, Y.
      • Enhanced Therapeutic Effects of Human iPS Cell Derived-Cardiomyocyte by Combined Cell-Sheets with Omental Flap Technique in Porcine Ischemic Cardiomyopathy Model.
      • Scientific Reports 7: 8824
    • Imamura, K., Izumi, Y., Watanabe, A., Tsukita, K., Woltjen, K., Yamamoto, T., Hotta, A., Kondo, T., Kitaoka, S., Ohta, A., Tanaka, A., Watanabe, D., Morita, M., Takuma, H., Tamaoka, A., Kunath, T., Wray, S., Furuya, H., Era, T., Makioka, K., Okamoto, K., Fujisawa, T., Nishitoh, H., Homma, K., Ichijo, H., Julien, J.P., Obata, N., Hosokawa, M., Akiyama, H., Kaneko, S., Ayaki, T., Ito, H., Kaji, R., Takahashi, R., Yamanaka, S., and
      Inoue, H.
      • The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis.
      • Science Translational Medicine 9(391): eaaf3962
    • Sone, M. Morone, N., Nakamura, T., Tanaka, A., Okita, K., Woltjen, K., Nakagawa, M., Heuser, J.E.,
      Yamada, Y., Yamanaka, S., and Yamamoto, T.
      • Hybrid Cellular Metabolism Coordinated by Zic3 and Esrrb Synergistically Enhances Induction of Naive Pluripotency.
      • Cell Metabolism 25(5): 1103-111
    • Yagi, M., Yamanaka, S., Yamada, Y.
      • Epigenetic foundations of pluripotent stem cells that recapitulate in vivo pluripotency.
      • Laboratory Investigation 97, 1133-1141
    • Yoshida, Y., and Yamanaka, S.
      • Induced Pluripotent Stem Cells 10 Years Later: For Cardiac Applications.
      • Circulation Research 120: 1958-1968
    • Parr, C.J., Yamanaka, S., and Saito, H.
      • An update on stem cell biology and engineering for brain development.
      • Molecular Psychiatry 6: 808-819
    • Mandai, M., Watanabe, A., Kurimoto, Y., Hirami, Y., Morinaga, C., Daimon, T., Fujihara, M., Akimaru, H., Sakai, N., Shibata, Y., Terada, M., Nomiya, Y., Tanishima, S., Nakamura, M., Kamao, H., Sugita, S., Onishi, A., Ito, T., Fujita, K., Kawamata, S., Go, M.J., Shinohara, C., Hata, K., Sawada, M., Yamamoto, M., Ohta, S., Ohara, Y., Yoshida, K., Kuwahara, J., Kitano, Y., Amano, N., Umekage, M., Kitaoka, F., Tanaka, A., Okada, C., Takasu, N., Ogawa, S., Yamanaka, S., and Takahashi, M.
      • First-in-human Clinical Study of Transplantation of Autologous iPSC-Retinal Pigment Epithelial Cell Sheet for Wet Age Related Macular Degeneration.
      • The New England Journal of Medicine 376(11): 1038-1046
    • Karagiannis, P., Onodera, A., and Yamanaka, S.
      • New Models for Therapeutic Innovation from Japan.
      • EBioMedicine 18: 3-4
    • Shi, Y., Inoue, H., Wu, J.C., and Yamanaka, S.
      • Induced pluripotent stem cell technology: a decade of progress.
      • Nature Reviews Drug Discovery 16(2):115-130
    • Sugiyama, H., Takahashi, K., Yamamoto, T., Iwasaki, M., Narita, M., Nakamura, M., Rand, TA.,
      Nakagawa, M., Watanabe, A., and Yamanaka, S.
      • Nat1 promotes translation of specific proteins that induce differentiation of mouse embryonic stem cells.
      • Proc Natl Acad Sci U S A 114(2), 340-345.



  • 2016
    • Hayashi, Y., Hsiao, E.C., Sami, S., Lancero, M., Schlieve, C.R., Nguyen, T., Yano, K, Nagahashi, A., Ikeya, M., Matsumoto, Y., Nishimura, K., Fukuda, A., Hisatake, K., Tomoda, K., Asaka, I., Toguchida, J., Conklin, B.R., and Yamanaka, S.
      • BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence.
      • Proc Natl Acad Sci U S A 113, 13057-13062.
    • Kime, C., Sakaki-Yumoto, M., Goodrich, L., Hayashi, Y., Sami, S., Derynck, R., Asahi, M., Panning, B., Yamanaka, S., and Tomoda, K.
      • Autotaxin-mediated lipid signaling intersects with LIF and BMP signaling to promote the naive pluripotency transcription factor program.
      • Proc Natl Acad Sci U S A 113, 12478-12483.
    • Funakoshi, S., Miki, K., Takaki, T., Okubo, C., Hatani, T., Chonabayashi, K., Nishikawa, M., Takei, I., Oishi, A., Narita, M., Hoshijima, M., Kimura, T., Yamanaka, S., and Yoshida, Y.
      • Enhanced engraftment, proliferation, and therapeutic potential in heart using optimized human iPSC-derived cardiomyocytes.
      • Scientific Reports 6, 19111.



  • 2015
    • Kim, SI., Oceguera-Yanez, F., Hirohata., R., Linker, S., Okita, K., Yamada, Y., Yamamoto, T., Yamanaka, S., and Woltjen, K.
      • KLF4 N-Terminal Variance Modulates Induced Reprogramming to Pluripotency.
      • Stem Cell Reports 4, 727-743.
    • Hayashi, Y., Caboni, L., Das, D., Yumoto, F., Clayton, T., Deller, MC., Nguyen, P., Farr, CL., Chiu, HJ., Miller, MD., Elsliger, MA., Deacon, AM., Godzik, A., Lesley, SA., Tomoda, K., Conklin, BR., Wilson, IA., Yamanaka, S., and Fletterick, RJ.
      • Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.
      • Proc Natl Acad Sci U S A 112, 4666-4671.
    • Miki, K., Endo, K., Takahashi, S., Funakoshi, S., Takei, I., Katayama, S., Toyoda, T., Kotaka, M., Takaki, T., Umeda, M., Okubo, C., Nishikawa, M., Oishi, A., Narita, M., Miyashita, I., Asano, K., Hayashi, K., Osafune, K., Yamanaka, S., Saito, H., and Yoshida, Y.
      • Efficient Detection and Purification of Cell Populations Using Synthetic MicroRNA Switches.
      • Cell Stem Cell 16, 699-711.
    • Sasaki, K., Yokobayashi, S., Nakamura, T., Okamoto, I., Yabuta, Y., Kurimoto, K., Ohta, H., Moritoki, Y., Iwatani, C., Tsuchiya, H., Nakamura, S., Sekiguchi, K., Sakuma, T., Yamamoto, T., Mori, T., Woltjen, K., Nakagawa, M., Yamamoto, T., Takahashi, K., Yamanaka, S., and Saitou, M.
      • Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells.
      • Cell Stem Cell 17, 178-194.
    • Toyohara, T., Mae, SI., Sueta, SI., Inoue, T., Yamagishi, Y., Kawamoto, T., Kasahara, T., Hoshina, A., Toyoda, T., Tanaka, H., Araoka, T., Sato-Otsubo, A., Takahashi, K., Sato, Y., Yamaji, N., Ogawa, S., Yamanaka, S., and Osafune, K.
      • Cell Therapy Using Human Induced Pluripotent Stem Cell-Derived Renal Progenitors Ameliorates Acute Kidney Injury in Mice.
      • Stem Cells Translational Medicine 4, 980-992.



  • 2014
    • Ohnuki, M., Tanabe, K., Sutou, K., Teramoto, I., Sawamura, Y., Narita, M., Nakamura, M., Tokunaga, Y., Nakamura, M., Watanabe, A., Yamanaka, S., and Takahashi, K.
      • Dynamic regulation of human endogenous retroviruses mediates factor-induced reprogramming and differentiation potential.
      • Proc Natl Acad Sci U S A 111, 12426-12431.
    • Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Sasaki, A., Yamamoto, M., Nakamura, M., Sutou, K., Osafune, K., and Yamanaka, S.
      • Induction of pluripotency in human somatic cells via a transient state resembling primitive streak-like mesendoderm.
      • Nature Communications 5, 3678.
    • Shimamoto, R., Amano, N., Ichisaka, T., Watanabe, A., Yamanaka, S., and Okita, K.
      • Generation and Characterization of Induced Pluripotent Stem Cells from Aid-Deficient Mice.
      • PLoS ONE 9, e94735.
    • Nakagawa, M., Taniguchi, Y., Senda, S., Takizawa, N., Ichisaka, T., Asano, K., Morizane, A., Doi, D., Takahashi, J., Nishizawa, M., Yoshida, Y., Toyoda, T., Osafune, K., Sekiguchi, K., and Yamanaka, S.
      • A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cells.
      • Scientific Reports 4, 3594.



  • 2013
    • Koyanagi-Aoi, M., Ohnuki, M., Takahashi, K., Okita, K., Noma, H., Sawamura, Y., Teramoto, I., Narita, M., Sato, Y., Ichisaka, T., Amano, N., Watanabe, A., Morizane, A., Yamada, Y., Sato, T., Takahashi, J., and Yamanaka, S.
      • Differentiation defective phenotypes revealed by large scale analysis of human pluripotent stem cells.
      • Proc Natl Acad Sci U S A 110, 20569-20574.
    • Tanabe, K., Nakamura, M., Narita, M., Takahashi, K., and Yamanaka, S.
      • Maturation, not initiation, is the major roadblock during reprogramming toward pluripotency from human fibroblasts.
      • Proc Natl Acad Sci U S A 110, 12172-12179.
    • Okita, K., Yamakawa, T., Matsumura, Y., Sato, Y., Amano, N., Watanabe, A., Goshima, N., and Yamanaka, S.
      • An Efficient Non-viral Method to Generate Integration-Free Human iPS Cells from Cord Blood and Peripheral Blood Cells.
      • Stem Cells 31, 458-466.



  • 2012
    • Tomoda, K., Takahashi, K., Leung, K., Okada, A., Narita, M., Yamada, N.A., Eilertson, K.E., Tsang, P., Baba, S., White, M.P., Sami, S., Srivastava, D., Conklin, B.R., Panning, B., and Yamanaka, S.
      • Derivation conditions impact x-inactivation status in female human induced pluripotent stem cells.
      • Cell Stem Cell 11, 91-99.
    • Kajiwara, M., Aoi, T., Okita, K., Takahashi, R., Inoue, H., Takayama, N., Endo, H., Eto, K., Toguchida, J., Uemoto, S., and Yamanaka, S.
      • Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells.
      • Proc Natl Acad Sci U S A 109, 12538-12543.
    • Miki, K., Uenaka, H., Saito, A., Miyagawa, S., Sakaguchi, T., Higuchi, T., Shimizu, T., Okano, T., Yamanaka, S., and Sawa, Y.
      • Bioengineered myocardium derived from induced pluripotent stem cells improves cardiac function and attenuates cardiac remodeling following chronic myocardial infarction in rats.
      • Stem Cells Transl Med 1, 430-437.



  • 2011
    • Nakamura, T., Nakagawa, M., Ichisaka, T., Shiota, A., and Yamanaka, S.
      • Essential roles of ECAT15-2/Dppa2 in functional lung development.
      • Mol Cell Biol 31, 4366-4378.
    • Maekawa, M., Yamaguchi, K., Nakamura, T., Shibukawa, R., Kodanaka, I., Ichisaka, T., Kawamura, Y., Mochizuki, H., Goshima, N., and Yamanaka, S.
      • Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1.
      • Nature 474, 225-229.
    • Iwabuchi, K., Yamakawa, T., Sato, Y., Ichisaka, T., Takahashi, K., Okita, K., and Yamanaka, S.
      • ECAT11/L1td1 is enriched in ESCs and rapidly activated during iPSC generation, but it is dispensable for the pluripotency.
      • PLoS ONE 6, e20461.
    • Okita, K., Matsumura, Y., Sato, Y., Okada, A., Morizane, A., Okamoto, S., Hong, H., Nakagawa, M., Tanabe, K., Tezuka, K., Shibata, T., Kunisada, T., Takahashi, M., Takahashi, J., Saji, H., and Yamanaka, S.
      • A more efficient method to generate integration-free human iPS cells.
      • Nature Methods 8, 409-412.



  • 2010
    • Egusa, H., Okita, K., Kayashima, H., Yu, G., Fukuyasu, S., Saeki, M., Matsumoto, T., Yamanaka, S., and Yatani, H.
      • Gingival fibroblasts as a promising source of induced pluripotent stem cells.
      • PLoS One 5, e12743.
    • Nakagawa, M., Takizawa, N., Narita, M., Ichisaka, T., and Yamanaka, S.
      • Promotion of direct reprogramming by transformation-deficient Myc.
      • Proc Natl Acad Sci U S A 107, 14152-14157.
    • Tsuji, O., Miura, K., Okada, Y., Fujiyoshi, K., Mukaino, M., Nagoshi, N., Kitamura, K., Kumagai, G., Nishino, M., Tomisato, S., Higashi, H., Nagai, T., Katoh, H., Kohda, K., Matsuzaki, Y., Yuzaki, M., Ikeda, E., Toyama, Y., Nakamura, M., Yamanaka, S., and Okano, H. (2010).
      • Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury.
      • Proc Natl Acad Sci U S A 107, 12704-12709.
    • Saunders, L.R., Sharma, A.D., Tawney, J., Nakagawa, M., Okita, K., Yamanaka, S., Willenbring, H., and Verdin, E. (2010).
      • miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues.
      • Aging (Albany NY).
    • Tamaoki, N., Takahashi, K., Tanaka, T., Ichisaka, T., Aoki, H., Takeda-Kawaguchi, T., Iida, K., Kunisada, T., Shibata, T., Yamanaka, S., and Tezuka, K. (2010).
      • Dental Pulp Cells for Induced Pluripotent Stem Cell Banking.
      • J Dent Res.
    • Kaichi, S., Hasegawa, K., Takaya, T., Yokoo, N., Mima, T., Kawamura, T., Morimoto, T., Ono, K., Baba, S., Doi, H., Yamanaka, S., Nakahata, T., and Heike, T. (2010).
      • Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice.
      • Cardiovasc Res.
    • Yamanaka, S., and Blau, H.M. (2010).
      • Nuclear reprogramming to a pluripotent state by three approaches.
      • Nature 465, 704-712.
    • Okita, K., and Yamanaka, S. (2010).
      • Induction of pluripotency by defined factors.
      • Exp Cell Res.
    • Sato, S., Yagi, S., Arai, Y., Hirabayashi, K., Hattori, N., Iwatani, M., Okita, K., Ohgane, J., Tanaka, S., Wakayama, T., Yamanaka, S. & Shiota, K.
      • Genome-wide DNA methylation profile of tissue-dependent and differentially methylated regions (T-DMRs) residing in mouse pluripotent stem cells.
      • Genes Cells (2010).
    • Kazuki, Y., Hiratsuka, M., Takiguchi, M., Osaki, M., Kajitani, N., Hoshiya, H., Hiramatsu, K., Yoshino, T., Kazuki, K., Ishihara, C., Takehara, S., Higaki, K., Nakagawa, M., Takahashi, K., Yamanaka, S., and Oshimura, M.
      • Complete genetic correction of ips cells from Duchenne muscular dystrophy.
      • Mol Ther 18, 386-393. (2010)
    • Mizuno, Y., Chang, H., Umeda, K., Niwa, A., Iwasa, T., Awaya, T., Fukada, S.I., Yamamoto, H., Yamanaka, S., Nakahata, T., and Heike, T
      • Generation of skeletal muscle stem/progenitor cells from murine induced pluripotent stem cells.
      • FASEB J. (2010)
    • Okita, K., Hong, H., Takahashi, K., and Yamanaka, S.
      • Generation of mouse-induced pluripotent stem cells with plasmid vectors.
      • Nat Protoc 5, 418-428. (2010)



  • 2009
    • Takahashi, K., Narita, M., Yokura, M., Ichisaka, T., and Yamanaka, S. (2009).
      • Human induced pluripotent stem cells on autologous feeders.
      • PLoS One 4, e8067.
    • Nagata, S., Toyoda, M., Yamaguchi, S., Hirano, K., Makino, H., Nishino, K., Miyagawa, Y., Okita, H., Kiyokawa, N., Nakagawa, M., Yamanaka, S., Akutsu, H., Umezawa, A., and Tada, T. (2009)
      • Efficient reprogramming of human and mouse primary extra-embryonic cells to pluripotent stem cells.
      • Genes Cells 14, 1395-1404.
    • Kazuki, Y., Hiratsuka, M., Takiguchi, M., Osaki, M., Kajitani, N., Hoshiya, H., Hiramatsu, K., Yoshino, T., Kazuki, K., Ishihara, C., Takehara, S., Higaki, K., Nakagawa, M., Takahashi, K., Yamanaka, S., and Oshimura, M. (2009).
      • Complete Genetic Correction of iPS Cells From Duchenne Muscular Dystrophy.
      • Mol Ther.
    • Nagata, S., Toyoda, M., Yamaguchi, S., Hirano, K., Makino, H., Nishino, K., Miyagawa, Y., Okita, H., Kiyokawa, N., Nakagawa, M., Yamanaka, S., Akutsu, H., Umezawa, A., and Tada, T. (2009)
      • Efficient reprogramming of human and mouse primary extra-embryonic cells to pluripotent stem cells.
      • Genes Cells.
    • Yoshida, Y., Takahashi, K., Okita, K., Ichisaka, T., and Yamanaka, S. (2009).
      • Hypoxia enhances the generation of induced pluripotent stem cells.
      • Cell Stem Cell 5, 237-241.
    • Hong, H., Takahashi, K., Ichisaka, T., Aoi, T., Kanagawa, O., Nakagawa, M., Okita, K., and Yamanaka, S. (2009)
      • Suppression of induced pluripotent stem cell generation by the p53-p21 pathway.
      • Nature 460, 1132-1135.
    • Nishimura, K., Nakagawa, T., Ono, K., Ogita, H., Sakamoto, T., Yamamoto, N., Okita, K., Yamanaka, S., and Ito, J. (2009).
      • Transplantation of mouse induced pluripotent stem cells into the cochlea.
      • Neuroreport.
    • Miura, K., Okada, Y., Aoi, T., Okada. A., Takahashi, K., Okita, K., Nakagawa, M., Koyanagi, M., Tanabe, K., Ohnuki, M., Ogawa, D., Ikeda, E., Okano, H., Yamanaka, S. (2009).
      • Variation in the safety of induced pluripotent stem cell lines.
      • Nat Biotechnol 27, 743-745.
    • Niwa, A., Umeda, K., Chang, H., Saito, M., Okita, K., Takahashi, K., Nakagawa, M., Yamanaka, S., Nakahata, T., Heike, T. (2009).
      • Orderly hematopoietic development of induced pluripotent stem cells via Flk-1+ hemoangiogenic progenitors.
      • J Cell Phys, Epub ahead of print.
    • Ohnuki, M., Takahashi, K., and Yamanaka, S. (2009).
      • Generation and characterization of human induced pluripotent stem cells.
      • Curr Protoc Stem Cell Biol Chapter 4, Unit 4A 2.
    • Yamanaka, S. (2009).
      • A fresh look at iPS cells.
      • Cell 137, 13-17.
    • Tsubooka, N., Ichisaka, T., Okita, K., Takahashi, K., Nakagawa, M., and Yamanaka, S. (2009).
      • Roles of Sall4 in the generation of pluripotent stem cells from blastocysts and fibroblasts.
      • Genes Cells.
    • Taura, D., Sone, M., Homma, K., Oyamada, N., Takahashi, K., Tamura, N., Yamanaka, S., and Nakao, K. (2009a)
      • Induction and Isolation of Vascular Cells From Human-Induced Pluripotent Stem Cells.
      • Arterioscler Thromb Vasc Biol.
    • Taura, D., Noguchi, M., Sone, M., Hosoda, K., Mori, E., Okada, Y., Takahashi, K., Homma, K., Oyamada, N., Inuzuka, M., Sonoyama, T., Ebihara, K., Tamura, N., Itoh, H., Suemori, H., Nakatsuji, N., Okano, H., Yamanaka, S., and Nakao, K. (2009b).
      • Adipogenic differentiation of human induced pluripotent stem cells: comparison with that of human embryonic stem cells.
      • FEBS Lett 583, 1029-1033.
    • Tanaka, T., Tohyama, S., Murata, M., Nomura, F., Kaneko, T., Chen, H., Hattori, F., Egashira, T., Seki, T., Ohno, Y., Koshimizu, U., Yuasa, S., Ogawa, S., Yamanaka, S., Yasuda, K., and Fukuda, K. (2009).
      • In vitro pharmacologic testing using human induced pluripotent stem cell-derived cardiomyocytes.
      • Biochem Biophys Res Commun.
    • Senju, S., Haruta, M., Matsunaga, Y., Fukushima, S., Ikeda, T., Takahashi, K., Okita, K., Yamanaka, S., and Nishimura, Y. (2009)
      • Characterization of Dendritic Cells and Macrophages Generated by Directed Differentiation from Mouse Induced Pluripotent Stem Cells.
      • Stem Cells 27, 1021-1031.
    • Hirami, Y., Osakada, F., Takahashi, K., Okita, K., Yamanaka, S., Ikeda, H., Yoshimura, N., and Takahashi, M. (2009).
      • Generation of retinal cells from mouse and human induced pluripotent stem cells.
      • Neurosci Lett.
    • Daley, G.Q., Lensch, M.W., Jaenisch, R., Meissner, A., Plath, K., and Yamanaka, S. (2009).
      • Broader implications of defining standards for the pluripotency of iPSCs.
      • Cell Stem Cell 4, 200-201; author reply 202.
    • Aoyama, Y., Nomura, M., Yamanaka, S., Ogawa, Y., and Kitajima, Y. (2009).
      • Subcutaneous phaeohyphomycosis caused by Exophiala xenobiotica in a non-Hodgkin lymphoma patient.
      • Med Mycol 47, 95-99.
    • Aiba, K., Nedorezov, T., Piao, Y., Nishiyama, A., Matoba, R., Sharova, L.V., Sharov, A.A., Yamanaka, S., Niwa, H., and Ko, M.S. (2009).
      • Defining developmental potency and cell lineage trajectories by expression profiling of differentiating mouse embryonic stem cells.
      • DNA Res 16, 73-80.



  • 2008
    • Aoi, T., Yae, K., Nakagawa, M., Ichisaka, T., Okita, K., Takahashi, K., Chiba, T., and Yamanaka, S. (2008).
      • Generation of pluripotent stem cells from adult mouse liver and stomach cells.
      • Science 321, 699-702.
    • Nakagawa, M., Koyanagi, M., Tanabe, K., Takahashi, K., Ichisaka, T., Aoi, T., Okita, K., Mochiduki, Y., Takizawa, N., and Yamanaka, S. (2008).
      • Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts.
      • Nat Biotechnol 26, 101-106.
    • Narazaki, G., Uosaki, H., Teranishi, M., Okita, K., Kim, B., Matsuoka, S., Yamanaka, S., and Yamashita, J.K. (2008).
      • Directed and systematic differentiation of cardiovascular cells from mouse induced pluripotent stem cells.
      • Circulation 118, 498-506.
    • Okita, K., Nakagawa, M., Hyenjong, H., Ichisaka, T., and Yamanaka, S. (2008).
      • Generation of mouse induced pluripotent stem cells without viral vectors.
      • Science 322, 949-953.
    • Yamanaka, S. (2008).
      • Induction of pluripotent stem cells from mouse fibroblasts by four transcription factors.
      • Cell Prolif 41 Suppl 1, 51-56.



  • 2007
    • Hyun, I., Hochedlinger, K., Jaenisch, R., and Yamanaka, S. (2007).
      • New advances in iPS cell research do not obviate the need for human embryonic stem cells.
      • Cell Stem Cell 1, 367-368.
    • Okita, K., Ichisaka, T., and Yamanaka, S. (2007).
      • Generation of germline-competent induced pluripotent stem cells.
      • Nature 448, 313-317.
    • Takahashi, K., Okita, K., Nakagawa, M., and Yamanaka, S. (2007a).
      • Induction of pluripotent stem cells from fibroblast cultures.
      • Nat Protoc 2, 3081-3089.
    • Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., and Yamanaka, S. (2007b)
      • Induction of pluripotent stem cells from adult human fibroblasts by defined factors.
      • Cell 131, 861-872.
    • Yamanaka, S. (2007).
      • Strategies and new developments in the generation of patient-specific pluripotent stem cells.
      • Cell Stem Cell 1, 39-49.
    • Lewitzky M, Yamanaka S.
      • Reprogramming somatic cells towards pluripotency by defined factors.
      • Curr Opin Biotechnol. 2007 Oct;18(5):467-73.
    • Yoshikane N, Nakamura N, Ueda R, Ueno N, Yamanaka S, Nakamura M.
      • Drosophila NAT1, a homolog of the vertebrate translational regulator NAT1/DAP5/p97, is required for embryonic germband extension and metamorphosis.
      • Dev Growth Differ. 2007 Sep;49(7):623-34.
    • Uemoto, Y., Suzuki, S., Terada, N., Ohno, N., Ohno, S., Yamanaka S., and Komada, M.
      • Specific role of the truncated betaIV-spectrin Sigma6 in sodium channel clustering at axon initial segments and nodes of Ranvier.
      • J Biol Chem 282:6548-6555, 2007



  • 2006
    • Nimura, K., Ishida, C., Koriyama, H., Hata, K., Yamanaka S., Li, E., Ura, K., and Kaneda, Y.
      • Dnmt3a2 targets endogenous Dnmt3L to ES cell chromatin and induces regional DNA methylation.
      • Genes Cells 11:1225-1237, 2006.
    • Takahashi K, Yamanaka S.
      • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
      • Cell, 126:663-676, 2006.
    • Tanaka TS, Lopez de Silanes I, Sharova LV, Akutsu H, Yoshikawa T, Amano H, Yamanaka S, Gorospe M, Ko MS.
      • Esg1, expressed exclusively in preimplantation embryos, germline, and embryonic stem cells, is a putative RNA-binding protein with broad RNA targets.
      • Dev Growth Differ. 48: 381-90, 2006.
    • Imamura M, Miura K, Iwabuchi K, Ichisaka T, Nakagawa M, Lee J, Kanatsu-Shinohara M, Shinohara T, Yamanaka S.
      • Transcriptional repression and DNA hypermethylation of a small set of ES cell marker genes in male germline stem cells.
      • BMC Dev Biol. 6: 34, 2006
    • Takahashi K, Ichisaka T, Yamanaka S.
      • Identification of genes involved in tumor-like properties of embryonic stem cells.
      • Methods Mol Biol. 329: 449-58, 2006.
    • Amano H., Itakura K., Maruyama M., Ichisaka T., Nakagawa M. and Yamanaka STokuzawa Y, Maruyama M, Yamanaka S.
      • Utilization of digital differential display to identify novel targets of Oct3/4.
      • Methods Mol Biol. 329: 223-31, 2006.
    • Identification and targeted disruption of the mouse gene encoding ESG1 (PH34/ECAT2/DPPA5).
      • BMC Developmental Biology, 6: 11 , 2006.
    • Okita K. and Yamanaka S.
      • Intracellular signaling pathways regulating pluripotency of embryonic stem cells.
      • Cur. Stem Cell Res. Ther., 1: 103-11, 2006



  • 2005
    • Takahashi K., Murakami M. and Yamanaka S.
      • Role of the phosphoinositide 3-kinase pathway in mouse embryonic stem (ES) cells.
      • Biochem Soc Trans. 33: 1522-5, 2005
    • Takahashi K., Nakagawa M., Young S.G. and Yamanaka S.
      • Differential membrane localization of ERas and Rheb, Two Ras-related proteins involved in the PI3 kinase / mTOR pathway.
      • J. Biol. Chem. 280: 32768-74, 2005
    • Maruyama M., Ichisaka T., Nakagawa M. and Yamanaka S.
      • Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells.
      • J. Biol. Chem. 280: 24371-9, 2005
    • Wang X, Beugnet A., Murakami M., Yamanaka S. and Proud C.G.
      • Distinct signaling events downstream of mTOR co-operate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins.
      • Mol. Cell. Biol. 25: 2558-72, 2005
    • Takahashi K., Maruyama M., Tokuzawa Y, Murakami M, Oda Y, Yoshikane N, Makabe KW, Ichisaka T, Yamanaka S. (The first two authors equally contributed)
      • Evolutionarily Conserved Non-AUG Translation Initiation in NAT1/p97/DAP5 (EIF4G2),
      • Genomics 85:360-71, 2005



  • 2004
    • Hamazaki T., Oka M., Yamanaka S. & Terada N.
      • Aggregation of Embryonic Stem Cells Induces Nanog Repression and Primitive Endoderm Differentiation.
      • J. Cell Sci. 117: 5681-5686, 2004
    • Tomoda K., Kato-Yoneda N., Fukumoto A., Yamanaka S. & Kato J.Y.
      • Multiple Functions of Jab1 Are Required for Early Embryonic Development and Growth Potential in Mice.
      • J. Biol. Chem. 279: 43013-8, 2004
    • Murakami M., Ichisaka T., Maeda M., Oshiro N., Hara K., Edenhofer F., Kiyama H., Yonezawa K. & Yamanaka S.
      • mTOR is essential for Growth and Proliferation in Early Mouse Embryos and Embryonic Stem Cells.
      • Mol. Cell. Biol. 24: 6710-6718, 2004
    • Matsuda E., Shigeoka , Iida R., Tocharus C., Yamanaka S., Kawaichi M. & Ishida Y.
      • Expression Profiling with Arrays of Randomly Disrupted Genes in Mouse ES Cells Leads to in Vivo Functional Analysis.
      • Proc. Natl. Acad. Sci. U S A 101:4170-4, 2004
    • Mak W., Nesterova TB., de Napoles M., Appanah R., Yamanaka S., Otte AP, and Neil Brockdorff N.
      • Reactivation of the Paternal X Chromosome in Early Mouse Embryos.
      • Science 303: 666-669, 2004



  • 2003
    • Mitsui K, Tokuzawa Y, Itoh H., Segawa K, Murakami M, Takahashi K, Maruyama M, Maeda M and Yamanaka S.
      • The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cell.
      • Cell 113: 631-642, 2003
    • Takahashi K, Mitusi K. and Yamanaka S.
      • Role of ERas in promoting tumor-like properties in mouse embronic stem cells.
      • Nature 423: 541-545, 2003
    • Tokuzawa Y., Kaiho E., Maruyama M., Takahashi K., Mitsui K., Maeda M., Niwa H., and Yamanaka S.
      • Fbx15 is a novel target of Oct3/4 but is dispensable for ES cell self-renewal and mouse development.
      • Mol. Cell. Biol. 23: 2699-2708, 2003



  • ~2002
    • Taniguchi, M., Miura, K., Iwao, H., and Yamanaka S.
      • Quantitative Assessment of DNA Microarrays – Comparison with Northern Blot Analyses.
      • Genomics 71: 34-39, 2001
    • Yamanaka S., Zhang, X. Y., Maeda, M., Miura, K., Wang, S., Farese, R. V. Jr., Iwao, H., and Innerarity. T. L.
      • Essential role of NAT1/p97/DAP5 in embryonic differentiation and retinoic acid pathway.
      • EMBO 19: 5533-5541, 2000
    • Nakamura, Y., Miura, K., Fujino, Y., Iwao, H., Ogita S. and Yamanaka S.
      • Evolution, Structure, and Expression of GNPI/Oscillin Orthologous Genes.
      • Genomics 68: 179-186, 2000



  • ~1999
    • Yamanaka S., Zhang, X. Y., Miura, K., Kim, S. and Iwao, H.
      • The human gene encoding the lectin-type oxidized LDL receptor (OLR1) is a novel member of the natural killer gene complex with a unique expression profile.
      • Genomics 54: 191-199, 1998.
    • Qian, X., Balestra, M. E., Yamanaka S., Boren, J., Lee, I. and Innerarity, T. L.
      • Low expression of the apolipoprotein B mRNA-editing transgene in mice reduces LDL levels but does not cause liver dysplasia or tumors.
      • Arterioscler Thromb Vasc Biol 18:1013-1020, 1998.
    • Yamanaka S., Poksay, K.S., Arnold, K.S., and Innerarity, T.L.
      • A novel translational repressor mRNA is extensively edited in livers containing tumors caused by the transgene expression of an apoB mRNA editing enzyme.
      • Genes Dev.11: 321-333, 1997.
    • Yamanaka S., Poksay, K.S., Driscoll, D.M., and Innerarity, T.L.
      • Hyperediting of multiple cytidines of apolipoprotein B mRNA by APOBEC-1 requires auxiliary protein(s) but not a mooring sequence motif.
      • J. Biol.Chem. 271: 11506-11510, 1996.
    • Yamanaka S., Balestra, M.E., Ferrell, L.D., Fan, J., Arnold, K.S., Taylor, S., Taylor, J.M., and Innerarity, T.L.
      • Apolipoprotein B mRNA-editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals.
      • Proc. Natl. Acad. Sci. U S A 92:8483-8487, 1995.
    • Yamanaka S., Poksay, K.S., Balestra, M.E., Zeng, G.-Q., and Innerarity, T.L.
      • Cloning and mutagenesis of the rabbit apoB mRNA editing protein: A zinc motif is essential for catalytic activity, and non-catalytic auxiliary factor(s) of the editing complex are widely distributed.
      • J. Biol. Chem. 269:21725-21734, 1994.
    • Yamanaka S., K. Miura, T. Yukimura, and K. Yamamoto.
      • 11-Dehydro thromboxane B2: a reliable parameter of thromboxane A2 production in dogs.
      • Prostaglandins 45: 221-8, 1993.
    • Yamanaka S., H. Iwao, T. Yukimura, S. Kim, and K. Miura.
      • Effect of NG-nitro-L-arginine on effective vascular stiffness in dogs.
      • Jpn J Pharmacol 63: 41-5, 1993.
    • Yamanaka S., H. Iwao, T. Yukimura, S. Kim, and K. Miura.
      • Effect of the platelet-activating factor antagonist, TCV-309, and the cyclo-oxygenase inhibitor, ibuprofen, on the haemodynamic changes in canine experimental endotoxic shock.
      • Br J Pharmacol 110: 1501-7, 1993.
    • Yamanaka S., K. Miura, T. Yukimura, M. Okumura, and K. Yamamoto.
      • Putative mechanism of hypotensive action of platelet-activating factor in dogs.
      • Circ Res 70: 893-901, 1992.



  • Other publications
    • Tamada S., Nakatani T., Asai T., Tashiro T., Komiya T., Sumi T., Okamura M., Kim S., Iwao H., Kishimoto T., Yamanaka S., and Miura K.
      • Inhibition of NF-κB activation by pyrrolidine dithiocarbamate prevents chronic FK506 nephropathy.
      • Kidney International. 63: 306-314, 2003
    • Asai, T., Nakatani T., Yamanaka S., Tamada S., Kishimoto T., Tashiro K., Nakao N., Okamura M., Kim S., Iwao H. & Miura K.
      • Magnesium supplementation prevents experimental chronic cyclosporine a nephrotoxicity via renin-angiotensin system independent mechanism.
      • Transplantation 74:784-791, 2002
    • Miura,K., Nakatani,T., Asai,T., Yamanaka S., Tamada,S., Tashiro,K., Kim,S., Okamura, M. & Iwao, H.
      • Role of hypomagnesemia in chronic cyclosporine A nephropathy.
      • Transplantation 73: 340-7, 2002
    • Miura, K., Yamanaka S., Ebara T., Okumura, M., Imanishi M., Kim, S., Nakatani T. & Iwao, H.
      • Effects of Nitric Oxide Scavenger, Carboxy-PTIO on endotoxin-induced alterations in systemic hemodyamics in rats.
      • Jpn J Pharmacol 82: 261-4, 2000
    • Miura, K., Yamanaka S., Ebara T., Okumura, M., Imanishi M., Kim, S., Nakatani T. & Iwao, H.
      • Effects of Nitric Oxide Scavenger, Carboxy-PTIO on endotoxin-induced alterations in systemic hemodyamics in rats.
      • Jpn J Pharmacol 82: 261-4, 2000
    • Miura, K., Okumura, M., Yamanaka S., Kim, S. & Iwao, H.
      • No participation of Adenosine A1 receptor in acute nephrotoxicity by 4-pentenoic acid administration in dogs.
      • Jpn J Pharmacol 80: 223-8, 1999
    • Miura, K., Okumura, M., Yamanaka S., Kim, S. and Iwao, H.
      • Effects of activation of renal adenosine A2 receptor on renal function and renin release in dogs.
      • Jpn J Pharmacol 80: 173-176, 1999.
    • Hamaguchi A, Kim S, Izumi Y, Zhan Y, Yamanaka S, and Iwao H.
      • Contribution of extracellular signal-regulated kinase to angiotensin II-induced transforming growth factor-beta1 expression in vascular smooth muscle cells.
      • Hypertension 34:126-31, 1999.
    • Yano, M., Kim, S., Izumi, Y., Yamanaka S. and Iwao, H.
      • Differential activation of cardiac c-jun amino-terminal kinase and extracellular signal-regulated kinase in angiotensin II-mediated hypertension.
      • Circ Res 83: 752-760, 1998.
    • Seto, M., Kim, S., Yoshifusa, H., Nakamura, Y., Masuda, T., Hamaguchi, A., Yamanaka S. and Iwao, H.
      • Effects of prednisolone on glomerular signal transduction cascades in experimental glomerulonephritis.
      • J Am Soc Nephrol 9: 1367-1376, 1998.
    • Izumi, Y., S. Kim, T. Murakami, S. Yamanaka, and H. Iwao.
      • Cardiac mitogen-activated protein kinase activities are chronically increased in stroke-prone hypertensive rats.
      • Hypertension 31: 50-6, 1998.
    • Kim, S., Y. Izumi, M. Yano, A. Hamaguchi, K. Miura, S. Yamanaka, H. Miyazaki, and H. Iwao.
      • Angiotensin blockade inhibits activation of mitogen-activated protein kinases in rat balloon-injured artery.
      • Circulation 97: 1731-7, 1998.
    • Hamaguchi, A., S. Kim, M. Yano, S. Yamanaka, and H. Iwao.
      • Activation of glomerular mitogen-activated protein kinases in angiotensin II-mediated hypertension.
      • J Am Soc Nephrol 9: 372-80, 1998.
    • Uchida, J., K. Miura, S. Yamanaka S. Kim, H. Iwao, T. Nakatani, and T. Kishimoto.
      • Renal endothelin in FK506-induced nephrotoxicity in spontaneously hypertensive rats.
      • Jpn J Pharmacol 76: 39-49, 1998.
    • Kim, S., H. Wanibuchi, A. Hamaguchi, K. Miura, S. Yamanaka, and H. Iwao.
      • Angiotensin blockade improves cardiac and renal complications of type II diabetic rats.
      • Hypertension 30: 1054-61, 1997.
    • Matsuura, T., K. Miura, T. Ebara, T. Yukimura, S. Yamanaka S. Kim, and H. Iwao.
      • Renal vascular effects of the selective endothelin receptor antagonists in anaesthetized rats.
      • Br J Pharmacol 122: 81-6, 1997.
    • Kim, S., T. Murakami, Y. Izumi, M. Yano, K. Miura, S. Yamanaka, and H. Iwao.
      • Extracellular signal-regulated kinase and c-Jun NH2-terminal kinase activities are continuously and differentially increased in aorta of hypertensive rats.
      • Biochem Biophys Res Commun 236: 199-204, 1997.
    • Kim, S., T. Sada, M. Mizuno, M. Ikeda, M. Yano, K. Miura, S. Yamanaka, H. Koike, and H. Iwao.
      • Effects of angiotensin AT1 receptor antagonist on volume overload- induced cardiac gene expression in rats.
      • Hypertens Res 20: 133-42, 1997.
    • Yukimura, T., Y. Yamashita, K. Miura, M. Okumura, S. Yamanaka, and K. Yamamoto.
      • Renal effects of the nitric oxide synthase inhibitor, L-NG- nitroarginine, in dogs.
      • Am J Hypertens 5: 484-7, 1992.
    • Yukimura, T., K. Miura, Y. Yamashita, T. Shimmen, M. Okumura, S. Yamanaka, M. Saito, and K. Yamamoto.
      • Effects of the calcium channel antagonist nicardipine on renal action of endothelin in dogs.
      • Contrib Nephrol 90: 105-10, 1991.
    • Yamashita, Y., T. Yukimura, K. Miura, M. Okumura, S. Yamanaka, and K. Yamamoto.
      • Effects of NG-nitro-L-arginine on renal hemodynamic responses to endothelin-3 in anesthetized dogs.
      • J Cardiovasc Pharmacol 17: S332-4, 1991.
    • Miura, K., T. Yukimura, Y. Yamashita, T. Shimmen, M. Okumura, S. Yamanaka, M. Imanishi, and K. Yamamoto.
      • Renal and femoral vascular responses to endothelin-1 in dogs: role of prostaglandins.
      • J Pharmacol Exp Ther 256: 11-7, 1991.
    • Miura, K., T. Yukimura, Y. Yamashita, K. Shichino, T. Shimmen, M. Saito, M. Okumura, M. Imanishi, S. Yamanaka, and K. Yamamoto
      • Effects of endothelin on renal hemodynamics and renal function in anesthetized dogs.
      • Am J Hypertens 3: 632-4, 1990.
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