発表論文リスト

2017

  • Ayako Aihara, Tomo Koike, Natsuki Abe, Sou Nakamura, Akira Sawaguchi, Takanori Nakamura, Naoshi Sugimoto, Hiromitsu Nakauchi, Taito Nishino and Koji Eto. Novel TPO receptor agonist TA-316 contributes to platelet biogenesis from human iPS cells. Blood Advances 2017 1:468-476; doi: https://doi.org/10.1182/bloodadvances.2016000844

2016

  • Hirata S, Murata T, Suzuki D, Nakamura S, Jono-Ohnishi R, Hirose H, Sawaguchi A, Nishimura S, Sugimoto N, Eto K. Selective Inhibition of ADAM17 Efficiently Mediates Glycoprotein Ibα Retention During Ex Vivo Generation of Human Induced Pluripotent Stem Cell-Derived Platelets. Stem Cells Transl Med. 2016 Oct 5. pii: sctm.2016-0104. [Epub ahead of print]
  • Eto K, Kunishima S. Linkage between the mechanisms of thrombocytopenia and thrombosis. Blood. 2016 Mar 10;127(10)1234-41

2015

  • Toshihiro Fujii, Asuka Sakata, Satoshi Nishimura, Koji Eto, and Shigekazu Nagata. TMEM16F is required for phosphatidylserine exposure and microparticle release in activated mouse platelets. PNAS. 2015 Oct 13;112(41):12800-5. doi: 10.1073/pnas.1516594112. Epub 2015 Sep 28.2
  • Karagiannis P, Eto K. Manipulating megakaryocytes to manufacture platelets ex vivo. J Thromb Haemost. 2015 Jun;13 Suppl 1:S47-53. doi: 10.1111/jth.12946
  • Nishimura S, Nagasaki M, Kunishima S, Sawaguchi A, Sakata A, Sakaguchi H, Ohmori T, Manabe I, Italiano JE Jr, Ryu T, Takayama N, Komuro I, Kadowaki T, Eto K, Nagai R. IL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs. J Cell Biol. 2015 May 11;209(3):453-66. doi: 10.1083/jcb.201410052
  • Eto K. Platelet biogenesis wears silkworm cocoons. Blood. 2015 April 2 ; 125 (14)2181-83
  • Taku TORIUMI, Naoya TAKAYAMA, Miyako MURAKAMI, Momoko SATO, Maki YUGUCHI, Yosuke YAMAZAKI, Koji ETO, Makoto OTSU, Hiromitsu NAKAUCHI, Tetsuo SHIRAKAWA, Keitaro ISOKAWA, Masaki J. HONDA. Characterization of mesenchymal progenitor cells in the crown and root pulp of primary teeth. Biomedical Research. 2015 Feb 28; Vol. 36 ( 1 ): 31-45

2014

  • Nishimura S, Nagasaki M, Okudaira S, Aoki J, Ohmori 4, Ohkawa R, Nakamura K, Igarashi K, Yamashita H, Eto K, Uno K, Hayashi N, Kadowaki T, Komuro I, Yatomi Y, Nagai R. ENPP2 contributes to adipose tissue expansion and insulin resistance in Diet-Induced obesity. Diabetes. 2014 Dec; 63(12):4154-64.
  • IshiiT, Eto K.“Fetal stem cell transplantation: Past, present, and future.”World J Stem Cells. 2014 Sept. 26; 6(4): 404-420.
  • Hosoi M, Kumano K, Taoka K, Arai S, Kataoka K, Ueda K, Kamikubo Y, Takayama N, Otsu M, Eto K, Nakauchi H, Kurokawa M.Generation of induced pluripotent stem cells derived from primary and secondary myelofibrosis patient samples.Exp Hematol. 2014 Sep;42(9):816-25.
  • Ochi K, Takayama N, Hirose S, Nakahata T, Nakauchi H, Eto K.Multicolor staining of globin subtypes reveals impaired globin switching during erythropoiesis in human pluripotent stem cells.Stem Cells Transl Med. 2014 Jul;3(7):792-800.
  • Higuchi T, Kawagoe S, Otsu M, Shimada Y, Kobayashi H, Hirayama R, Eto K, Ida H, Ohashi T, Nakauchi H, Eto K.The generation of induced pluripotent stem cells (iPSCs) from patients with infantile and late-onset types of Pompe disease and the effects of treatment with acid-α-glucosidase in Pompe’s iPSCs.Mol Genet Metab. 2014 May;112(1):44-8.
  • Nakamura S, Takayama N, Hirata S, Seo H, Endo H, Ochi K, Fujita KI, Koike T, Harimoto KI, Watanabe A, Okita K, Takahashi N, Sawaguchi A, Yamanaka S, Nakauchi H, Nishimura S, Eto K. Expandable megakaryocyte cell lines enable clinically-aplicable generation of platelets from human induced pluripotent stem cells. Cell Stem Cell. 2014 Feb 12;14(4):535-548. doi: 10.1016/j.stem.2014.01.011.

2013

  • Hirose S, Takayama N, Nakamura S, Nagasawa K, Ochi K, Hirata S, Yamazaki S, Yamaguchi T, Otsu M, Sano S, Takahashi N, Sawaguchi A, Ito M, Kato T, Nakauchi H, Eto K. Immortalization of erythroblasts by c-MYC and BCL-XL enables large-scale erythrocyte production from human pluripotent stem cells. Stem Cell Reports. 2013 Dec 5;1(6):499-508. doi: 10.1016/j.stemcr.2013.10.010. eCollection 2013.
  • Nishimura S, Manabe I, Takaki S, Nagasaki M, Otsu M, Yamashita H, Sugita J, Yoshimura K, Eto K, Komuro I, Kadowaki T, Nagai R. Adipose natural regulatory B cells negatively control adipose tissue inflammation. Cell Metab. 2013 Oct 22. pii: S1550-4131(13)00386-0. doi: 10.1016/j.cmet.2013.09.017. [Epub ahead of print]
  • Hirata S, Takayama N, Jono-Ohnishi R, Endo H, Nakamura S, Dohda T, Nishi M, Hamazaki Y, Ishii EI, Kaneko S, Otsu M, Nakauchi H, Kunishima S, Eto K. Congenital amegakaryocytic thrombocytopenia iPS cells exhibit defective MPL-mediated signaling. J Clin Invest. 2013 Sep 3;123(9):3802-14. doi: 10.1172/JCI64721. Epub 2013 Aug 1.
  • Nakagawa Y, Nakamura S, Nakajima M, Endo H, Dohda T, Takayama N, Nakauchi H, Arai F, Fukuda T, Eto K. Two differential flows in a bioreactor promoted platelet generation from human pluripotent stem cell-derived megakaryocytes. Exp Hematol. 2013 Aug;41(8):742-8. doi: 10.1016/j.exphem.2013.04.007. Epub 2013 Apr 22
  • Oda A, Eto K. WASPs and WAVEs: from molecular function to physiology in hematopoietic cells. Semin Cell Dev Biol. 2013 Apr;24(4):308-13. doi: 10.1016/j.semcdb.2013.03.002. Epub 2013 Mar 14
  • Nishimura T, Kaneko S, Kawana-Tachikawa A, Tajima Y, Goto H, Zhu D, Nakayama-Hosoya K, Iriguchi S, Uemura Y, Shimizu T, Takayama N, Yamada D, Nishimura K, Ohtaka M, Watanabe N, Takahashi S, Iwamoto A, Koseki H, Nakanishi M, Eto K, Nakauchi H. Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation. Cell Stem Cell. 2013 Jan 3;12(1):114-26. doi: 10.1016/j.stem.2012.11.002.

2012

  • Kumano K, Arai S, Hosoi M, Taoka K, Takayama N, Otsu M, Nagae G, Ueda K, Nakazaki K, Kamikubo Y, Eto K, Aburatani H, Nakauchi H, Kurokawa M. Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples. Blood. 119(26):6234-42.
  • Takayama N, Eto K. Pluripotent stem cells reveal the developmental biology of human megakaryocytes and provide a source of platelets for clinical application. Cell Mol Life Sci. 2012 Oct;69(20):3419-28. doi: 10.1007/s00018-012-0995-4.
  • Takayama N, Eto K. In vitro generation of megakaryocytes and platelets from human embryonic stem cells and induced pluripotent stem cells. Methods Mol Biol. 788:205-17.

2011

  • Nishimura S, Manabe I, Nagasaki M, Kakuta S, Iwakura Y, Takayama N, Ooehara J, Otsu M, Kamiya K, Petrich B, Urano T, Kadono T, Sato S, Aiba A, Yamashita H, Sugiura S, Kadowaki T, Nakauchi H, Eto K, Nagai R. In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling. Blood 119, 45-56.
  • Umemoto T, Yamato M, Ishihara J, Shiratsuchi Y, Utsumi M, Morita Y, Tsukui H, Terasawa M, Shibata T, Nishida K, Kobayashi Y, Petrich B, Hiromitsu Nakauchi , Koji Eto and Teruo Okano. Integrin αvβ3 regulates thrombopoietin-mediated maintenance of hematopoietic stem cells. Blood 119, 83-94.
  • Kunishima S, Kashiwagi H, Otsu M, Takayama N, Eto K, Onodera M, Miyajima Y, Takamatsu Y, Suzumiya J, Matsubara K, Tomiyama Y, Saito H. Heterozygous ITGA2B R995W mutation inducing constitutive activation of the aIIbβ3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia. Blood 117, 5479-5484.

2010

  • Takayama N, Nishimura S, Nakamura S, Shimizu T, Ohnishi R, Endo H, Yamaguchi T, Otsu M, Nishimura K, Nakanishi M, Sawaguchi A, Nagai R, Takahashi K, Yamanaka S, Nakauchi H, Eto K. Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells. J Exp Med 207, 2817-30.
  • Takizawa H, Nishimura S, Takayama N, Oda A, Nishikii H, Morita Y, Kakinuma S, Yamazaki S, Okamura S, Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu K, Nakauchi H, Takaki S, Eto K. Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo. J Clin Invest 120, 179-90.
  • Hayashi Y, Chan T, Warashina M, Fukuda M, Ariizumi T, Okabayashi K, Takayama N, Otsu M, Eto K, Furue MK, Michiue T, Ohnuma K, Nakauchi H, Asashima M. Reduction of N-glycolylneuraminic acid in human induced pluripotent stem cells generated or cultured under feeder- and serum-free defined conditions. PLoS One. 5(11):e14099.

2009

  • Oki T, Eto K, Izawa K, Yamanishi Y, Inagaki N, Frampton J, Kitamura T, Kitaura J. Evidence that integrin aIIbβ3-dependent interaction of mast cells with fibrinogen exacerbates chronic inflammation. J Biol Chem 284, 31463-72.
  • Okabe M, Otsu M, Ahn DH, Kobayashi T, Wakiyama Y, Morita Y, Onodera M, Eto K, Ema H, Nakauchi H. Definitive proof for direct reprogramming of hematopoietic cells to pluripotency. Blood 114, 1764-7.
  • Ogaeri T, Eto K, Otsu M, Ema H, Nakauchi H. The actin polymerization regulator WAVE2 is required for early bone marrow repopulation by hematopoietic stem cells. Stem Cells 27, 1120-9.
  • Yamazaki S, Iwama A, Takayanagi S, Eto K, Ema H, Nakauchi H. TGF-β induces hibernation of hematopoietic stem cells in the bone marrow niche. Blood 113, 1250-6.

2008

  • Nishikii H, Eto K, Tamura N, Hattori K, Heissig B, Kanaji T, Sawaguchi A, Goto S, Ware J, Nakauchi H. Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells. J Exp Med 205, 1917-27.
  • Takayama N, Nishikii H, Usui J, Tsukui H, Sawaguchi A, Hiroyama T, Eto K, Nakauchi H. Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors. Blood 111, 5298-5306.

2007

  • Eto K, Nishikii H, Ogaeri T, Suetsugu S, Kamiya A, Kobayashi T, Yamazaki D, Oda A, Takenawa T, Nakauchi H. The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery. Blood 110, 3637-3647.

2006

  • Yamazaki S, Iwama A, Takayanagi SI, Morita Y, Eto K, Ema H, Nakauchi H. Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells. EMBO J 25, 3515-3523.

2005

  • Matsubara A, Iwama A, Yamazaki S, Furuta C, Hirasawa R, Morita Y, Osawa M, Motohashi T, Eto K, Ema H, Kitamura T, Vestwever D, Nakauchi H. Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development. J Exp Med 202, 1483-1492.