Center for iPS Cell Research and Application (CiRA) Kyoto University Department of
Life Science Frontiers Hotta Lab
Welcome to Hotta Lab!
Our research group has established on March 2010 at Center for iPS Cell Research and Application (CiRA) in Kyoto University.
iPS cell technology provides a way to isolate any cell type from a donor in a minimally invasive fashion. Two attractive features of iPS cells are that they can grow indefinitely on culture dish by keeping their pluripotency and be differentiated into any cell type. Thus, iPS cells have enormous potential for drug testing and future stem cell therapy. They also offer transplantation that is free of immune rejection and independent of donor supply. However, when iPS cells are derived from patients with congenital genetic disorders, such as hemophilia or muscular dystrophy, the genetic mutations must be repaired before transplantation. For this reason, our research group aims to develop novel iPS cell based therapies for genetic disorders using non-viral transposon-mediated gene delivery methods and genome editing technologies, such as the CRISPR-Cas9 system.
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