発表論文

GoTo 2016 / 2014 / 2012 / 2010 / 2008 / 2004 / 2002

2018

Low Cell-Matrix Adhesion Reveals Two Subtypes of Human Pluripotent Stem Cells
Leqian Yu, Junjun Li, Jiayin Hong, Yasuhiro Takashima, Nanae Fujimoto, Minako Nakajima, Akihisa Yamamoto, Xiaofeng Dong, Yujiao Dang, Yu Hou, Wei Yang, Itsunari Minami, Keisuke Okita, Motomu Tanaka, Chunxiong Luo, Fuchou Tang, Yong Chen, Chao Tang, Hidetoshi Kotera, Li Liu.
Stem Cell Reports, e-pub, https://doi.org/10.1016/j.stemcr.2018.06.003

Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs
Ikeda T, Hikichi T, Miura H, Shibata H, Mitsunaga K, Yamada Y, Woltjen K, Miyamoto K, Hiratani I, Yamada Y, Hotta A, Yamamoto T, Okita K, Masui S.
Nat Commun. 9(1):1387. (CiRA News) (Editors’ Highlights)

Human AK2 links intracellular bioenergetic redistribution to the fate of hematopoietic progenitors
Oshima K, Saiki N, Tanaka M, Imamura H, Niwa A, Tanimura A, Nagahashi A, Hirayama A, Okita K, Hotta A, Kitayama S, Osawa M, Kaneko S, Watanabe A, Asaka I, Fujibuchi W, Imai K, Yabe H, Kamachi Y, Hara J, Kojima S, Tomita M, Soga T, Noma T, Nonoyama S, Nakahata T, Saito MK.
Biochem Biophys Res Commun. 497(2):719-725. (CiRA News)

2017

MHC matching improves engraftment of iPSC-derived neurons in non-human primates
Morizane A, Kikuchi T, Hayashi T, Mizuma H, Takara S, Doi H, Mawatari A, Glasser MF, Shiina T, Ishigaki H, Itoh Y, Okita K, Yamasaki E, Doi D, Onoe H, Ogasawara K, Yamanaka S, Takahashi J.
Nature Communications 8, 385. (CiRA News)

Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model
Kikuchi T, Morizane A, Doi D, Magotani H, Onoe H, Hayashi T, Mizuma H, Takara S, Takahashi R, Inoue H, Morita S, Yamamoto M, Okita K, Nakagawa M, Parmar M, Takahashi J.
Nature 548, 592–596. (CiRA News)

Artificial acceleration of mammalian cell reprogramming by bacterial proteins.
Ikeda T, Uchiyama I, Iwasaki M, Sasaki T, Nakagawa M, Okita K, Masui S.
Genes Cells. 22(10):918-928.

Hybrid Cellular Metabolism Coordinated by Zic3 and Esrrb Synergistically Enhances Induction of Naive Pluripotency.
Sone M, Morone N, Nakamura T, Tanaka A, Okita K, Woltjen K, Nakagawa M, Heuser JE, Yamada Y, Yamanaka S, Yamamoto T.
Cell Metab. 2017 May 2;25(5):1103-1117.e6. (CiRA News)

Clonal Variation of Human Induced Pluripotent Stem Cells for Induction into the Germ Cell Fate.
Yokobayashi S, Okita K, Nakagawa M, Nakamura T, Yabuta Y, Yamamoto T, Saitou M.
Biol Reprod. 96(6):1154-1166.

Modelling urea-cycle disorder citrullinemia type 1 with disease-specific iPSCs.
Yoshitoshi-Uebayashi EY, Toyoda T, Yasuda K, Kotaka M, Nomoto K, Okita K, Yasuchika K, Okamoto S, Takubo N, Nishikubo T, Soga T, Uemoto S, Osafune K.
Biochem Biophys Res Commun. 486(3):613-619.

Idiopathic Parkinson’s disease patient-derived induced pluripotent stem cells function as midbrain dopaminergic neurons in rodent brains.
Kikuchi T, Morizane A, Doi D, Okita K, Nakagawa M, Yamakado H, Inoue H, Takahashi R, Takahashi J.
J Neurosci Res. 95(9):1829-1837.

2016

Transcriptional Analysis of Intravenous Immunoglobulin Resistance in Kawasaki Disease Using an Induced Pluripotent Stem Cell Disease Model.
Ikeda K, Mizoro Y, Ameku T, Nomiya Y, Mae SI, Matsui S, Kuchitsu Y, Suzuki C, Hamaoka-Okamoto A, Yahata T, Sone M, Okita K, Watanabe A, Osafune K, Hamaoka K.
Circ J. 81 (1) 110-118. (CiRA News)

Differences and similarities between human and chimpanzee neural progenitors during cerebral cortex development.
Mora-Bermúdez F, Badsha F, Kanton S, Camp JG, Vernot B, Köhler K, Voigt B, Okita K, Maricic T, He Z, Lachmann R, Pääbo S, Treutlein B, Huttner WB.
eLife. 2016;5;e18683.

Epigenetic Variationbetween Human Induced Pluripotent Stem Cell Lines Is an Indicator of Differentiation Capacity.
Nishizawa M, Chonabayashi K, Nomura M, Tanaka A, Nakamura M, Inagaki A, Nishikawa M, Takei I, Oishi A, Tanabe K, Ohnuki M, Yokota H, Koyanagi-Aoi M, Okita K, Watanabe A, Takaori-Kondo A, Yamanaka S, Yoshida Y.
Cell Stem Cell. 19 (3) 341-54. (CiRA News)

Cardiomyocytes Derived from MHC-Homozygous Induced Pluripotent Stem Cells Exhibit Reduced Allogeneic Immunogenicity in MHC-Matched Non-human Primates.
Kawamura T, Miyagawa S, Fukushima S, Maeda A, Kashiyama N, Kawamura A, Miki K, Okita K, Yoshida Y, Shiina T, Ogasawara K, Miyagawa S, Toda K, Okuyama H, Sawa Y.
Stem Cell Reports. 6 (3) 312-20.

Screening of Human cDNA Library Reveals Two differentiation-Related Genes, HHEX and HLX, as Promoters of Early Phase Reprogramming toward Pluripotency.
Yamakawa T, Sato Y, Matsumura Y, Kobayashi Y, Kawamura Y, Goshima N, Yamanaka S, Okita K.
Stem Cells. 34 (11) 2661-2669. (CiRA News)

Adoptive Transfer of CD8+ T Cells Generated from Induced Pluripotent Stem Cells Triggers Regressions of Large Tumors Along with Immunological Memory.
Saito H, Okita K, Chang AE, Ito F.
Cancer Res. 76 (12) 3473-3483.      [Cover]

Rewinding the process of mammalian extinction
Saragusty J, Diecke S, Drukker M, Durrant B, Ben-Nun IF, Galli C, Göritz F, Hayashi K, Hermes R, Holtze S, Johnson S, Lazzari G, Loi P, Loring JF, Okita K, Renfree MB, Seet S, Voracek T, Stejskal J, Ryder OA, Hildebrandt TB
Zoo Biology. 35: 280-292. DOI: 10.1002/zoo.21292 (CiRA News)

OVOL2 Maintains the Transcriptional Program of Human Corneal Epithelium by Suppressing Epithelial-to-Mesenchymal Transition.
Kitazawa K, Hikichi T, Nakamura T, Mitsunaga K, Tanaka A, Nakamura M, Yamakawa T, Furukawa S, Takasaka M, Goshima N, Watanabe A, Okita K, Kawasaki S, Ueno M, Kinoshita S, Masui S.
Cell Rep. 2016 Apr 27. pii: S2211-1247(16)30433-8. (CiRA News)

Establishment of Human Neural Progenitor Cells from Human Induced Pluripotent Stem Cells with Diverse Tissue Origins.
Fukusumi H, Shofuda T, Bamba Y, Yamamoto A, Kanematsu D, Handa Y, Okita K, Nakamura M, Yamanaka S, Okano H, Kanemura Y.
Stem Cells International, 2016, Article ID 7235757.

Reprogramming of Melanoma Tumor-Infiltrating Lymphocytes to Induced Pluripotent Stem Cells.
Saito H, Okita K, Fusaki N, Sabel MS, Chang AE, Ito F.
Stem Cells International, 2016, Article ID 8394960.

Gingival Fibroblasts as Autologous Feeders for Induced Pluripotent Stem Cells.
Yu G, Okawa H, Okita K, Kamano Y, Wang F, Saeki M, Yatani H, Egusa H.
J Dent Res. 95(1):110-8.

2015

SCIREP_top100readbadge_01sEpigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects.
Hashizume O, Ohnishi S, Mito T, Shimizu A, Iashikawa K, Nakada K, Soda M, Mano H, Togayachi S, Miyoshi H, Okita K, Hayashi J.
Sci Rep. 5:10434.

KLF4 N-terminal variance modulates induced reprogramming to pluripotency.
Kim SI, Oceguera-Yanez F, Hirohata R, Linker S, Okita K, Yamada Y, Yamamoto T, Yamanaka S, Woltjen K.
Cell Stem Cell.14(4):535-48. (CiRA News)

X-linked severe combined immunodeficiency (X-SCID) rats for xeno-transplantation and behavioral evaluation.
Samata B, Kikuchi T, Miyawaki Y, Morizane A, Mashimo T, Nakagawa M, Okita K, Takahashi J.
J Neurosci Methods. 243:68-77. (CiRA News)

2014

Generation and Characterization of Induced Pluripotent Stem Cells from Aid-Deficient Mice.
Shimamoto R, Amano N, Ichisaka T, Watanabe A, Yamanaka S, Okita K.
PLOS ONE. 10.1371/journal.pone.0094735

Expandable Megakaryocyte Cell Lines Enable Clinically Applicable Generation of Platelets from Human Induced Pluripotent Stem Cells.
Nakamura S, Takayama N, Hirata S, Seo H, Endo H, Ochi K, Fujita KI, Koike T, Harimoto KI, Dohda T, Watanabe A, Okita K, Takahashi N, Sawaguchi A, Yamanaka S, Nakauchi H, Nishimura S, Eto K.
Cell Stem Cell.14(4):535-48.

Premature termination of reprogramming in vivo leads to cancer development through altered epigenetic regulation.
Ohnishi K, Semi K, Yamamoto T, Shimizu M, Tanaka A, Mitsunaga K, Okita K, Osafune K, Arioka Y, Maeda T, Soejima H, Moriwaki H, Yamanaka S, Woltjen K, Yamada Y.
Cell. 156(4):663-77.

2013

Differentiation-defective phenotypes revealed by large-scale analyses of human pluripotent stem cells.
Koyanagi-Aoi M, Ohnuki M, Takahashi K, Okita K, Noma H, Sawamura Y, Teramoto I, Narita M, Sato Y, Ichisaka T, Amano N, Watanabe A, Morizane A, Yamada Y, Sato T, Takahashi J, Yamanaka S.
Proc Natl Acad Sci U S A. 110(51):20569-74.

Direct Comparison of Autologous and Allogeneic Transplantation of iPSC-Derived Neural Cells in the Brain of a Nonhuman Primate.
Morizane A, Doi D, Kikuchi T, Okita K, Hotta A, Kawasaki T, Hayashi T, Onoe H, Shiina T, Yamanaka S, Takahashi J.
Stem Cell Reports. 1(4):283-92.

Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a.
Kuroki S, Matoba S, Akiyoshi M, Matsumura Y, Miyachi H, Mise N, Abe K, Ogura A, Wilhelm D, Koopman P, Nozaki M, Kanai Y, Shinkai Y, Tachibana M.
Science. 341(6150):1106-9.

Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness.
Kondo T, Asai M, Tsukita K, Kutoku Y, Ohsawa Y, Sunada Y, Imamura K, Egawa N, Yahata N, Okita K, Takahashi K, Asaka I, Aoi T, Watanabe A, Watanabe K, Kadoya C, Nakano R, Watanabe D, Maruyama K, Hori O, Hibino S, Choshi T, Nakahata T, Hioki H, Kaneko T, Naitoh M, Yoshikawa K, Yamawaki S, Suzuki S, Hata R, Ueno SI, Seki T, Kobayashi K, Toda T, Murakami K, Irie K, Klein WL, Mori H, Asada T, Takahashi R, Iwata N, Yamanaka S, Inoue H.
Cell Stem Cell. 12(4):487-96.

An Efficient Non-viral Method to Generate Integration-Free Human iPS Cells from Cord Blood and Peripheral Blood Cells.
Okita K, Yamakawa T, Matsumura Y, Sato Y, Amano N, Watanabe A, Goshima N, Yamanaka S
Stem Cells. 31(3):458-66.

2012

Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells.
Egawa N, Kitaoka S, Tsukita K, Naitoh M, Takahashi K, Yamamoto T, Adachi F, Kondo T, Okita K, Asaka I, Aoi T, Watanabe A, Yamada Y, Morizane A, Takahashi J, Ayaki T, Ito H, Yoshikawa K, Yamawaki S, Suzuki S, Watanabe D, Hioki H, Kaneko T, Makioka K, Okamoto K, Takuma H, Tamaoka A, Hasegawa K, Nonaka T, Hasegawa M, Kawata A, Yoshida M, Nakahata T, Takahashi R, Marchetto MC, Gage FH, Yamanaka S, Inoue H.
Sci Transl Med. 4(145):145ra104.

Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells.
Kajiwara M, Aoi T, Okita K, Takahashi R, Inoue H, Takayama N, Endo H, Eto K, Toguchida J, Uemoto S, Yamanaka S.
Proc Natl Acad Sci U S A. 109(31):12538-43.

2011

Human and mouse induced pluripotent stem cells are differentially reprogrammed in response to kinase inhibitors.
Hirano K, Nagata S, Yamaguchi S, Nakagawa M, Okita K, Kotera H, Ainscough J, Tada T.
Stem Cells Dev. 21(8):1287-98.

ECAT11/L1td1 is enriched in ESCs and rapidly activated during iPSC generation, but it is dispensable for the maintenance and induction of pluripotency.
Iwabuchi KA, Yamakawa T, Sato Y, Ichisaka T, Takahashi K, Okita K, Yamanaka S.
PLoS One. 6(5):e20461.

A more efficient method to generate integration-free human iPS cells.
Okita K, Matsumura Y, Sato Y, Okada A, Morizane A, Okamoto S, Hong H, Nakagawa M, Tanabe K, Tezuka KI, Shibata T, Kunisada T, Takahashi M, Takahashi J, Saji H, Yamanaka S.
Nat Methods. 8(5):409-12.

Induction and enhancement of cardiac cell differentiation from mouse and human induced pluripotent stem cells with cyclosporin-A.
Fujiwara M, Yan P, Otsuji TG, Narazaki G, Uosaki H, Fukushima H, Kuwahara K, Harada M, Matsuda H, Matsuoka S, Okita K, Takahashi K, Nakagawa M, Ikeda T, Sakata R, Mummery CL, Nakatsuji N, Yamanaka S, Nakao K, Yamashita JK.
PLoS One. 6(2):e16734.

2010

Gingival fibroblasts as a promising source of induced pluripotent stem cells.
Egusa H, Okita K, Kayashima H, Yu G, Fukuyasu S, Saeki M, Matsumoto T, Yamanaka S, Yatani H.
PLoS One. 5(9):e12743.

Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice.
Espejel S, Roll GR, McLaughlin KJ, Lee AY, Zhang JY, Laird DJ, Okita K, Yamanaka S, Willenbring H.
J Clin Invest. 120(9):3120-6.

miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues
Laura R. Saunders, Amar Deep Sharma, Jaime Tawney, Masato Nakagawa, Keisuke Okita, Shinya Yamanaka, Holger Willenbring, Eric Verdin
Aging. 2(7):415-31.

Generation of mouse-induced pluripotent stem cells with plasmid vectors.
Okita K, Hong H, Takahashi K, Yamanaka S.
Nat Protoc. 5(3):418-28.

Genome-wide DNA methylation profile of tissue-dependent and differentially methylated regions (T-DMRs) residing in mouse pluripotent stem cells.
Sato S, Yagi S, Arai Y, Hirabayashi K, Hattori N, Iwatani M, Okita K, Ohgane J, Tanaka S, Wakayama T, Yamanaka S, Shiota K.
Genes Cells. 15(6):607-18.

2009

Hypoxia enhances the generation of induced pluripotent stem cells.
Yoshida Y, Takahashi K, Okita K, Ichisaka T, Yamanaka S.
Cell Stem Cell. 5(3):237-41.

Suppression of induced pluripotent stem cell generation by the p53–p21 pathway.
Hyenjong Hong, Kazutoshi Takahashi, Tomoko Ichisaka, Takashi Aoi, Osami Kanagawa, Masato Nakagawa, Keisuke Okita & Shinya Yamanaka
Nature. 460(7259):1132-5

Characterization of Dendritic Cells and Macrophages Generated by Directed Differentiation from Mouse Induced Pluripotent Stem Cells.
Senju, S., Haruta, M., Matsunaga, Y., Fukushima, S., Ikeda, T., Takahashi, K., Okita, K., Yamanaka, S., and Nishimura, Y.
Stem Cells 27, 1021-1031.

Sall4 in the generation of pluripotent stem cells from blastocysts and fibroblasts.
Tsubooka, N., Ichisaka, T., Okita, K., Takahashi, K., Nakagawa, M., and Yamanaka, S.
Genes Cells. 14(6):683-94.

Orderly hematopoietic development of induced pluripotent stem cells via Flk-1+ hemoangiogenic progenitors.
Niwa, A., Umeda, K., Chang, H., Saito, M., Okita, K., Takahashi, K., Nakagawa, M., Yamanaka, S., Nakahata, T., Heike, T.
J Cell Phys. 221(2):367-77.

Generation of retinal cells from mouse and human induced pluripotent stem cells.
Hirami, Y., Osakada, F., Takahashi, K., Okita, K., Yamanaka, S., Ikeda, H., Yoshimura, N., and Takahashi, M.
Neurosci Lett. 458(3):126-31.

Transplantation of mouse induced pluripotent stem cells into the cochlea.
Nishimura, K., Nakagawa, T., Ono, K., Ogita, H., Sakamoto, T., Yamamoto, N., Okita, K., Yamanaka, S., and Ito, J.
Neuroreport. 20(14):1250-4.

Variation in the safety of induced pluripotent stem cell lines.
Kyoko Miura, Yohei Okada, Takashi Aoi, Aki Okada, Kazutoshi Takahashi, Keisuke Okita, Masato Nakagawa, Michiyo Koyanagi, Koji Tanabe, Mari Ohnuki, Daisuke Ogawa, Eiji Ikeda, Hideyuki Okano, Shinya Yamanaka
Nature Biotechnology. 27, 743 – 745

2008

Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors.
Okita K, Nakagawa M, Hyenjong H, Ichisaka T, Yamanaka S.
Science . 322: 949-953

Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells.
Aoi T, Yae K, Nakagawa M, Ichisaka T, Okita K, Takahashi K, Chiba T, Yamanaka S.
Science. 321:699-702.

Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts.
Nakagawa M, Koyanagi M, Tanabe K, Takahashi K, Ichisaka T, Aoi T, Okita K, Mochiduki Y, Takizawa N, Yamanaka S.
Nat Biotechnol. 26(1):101-6.

2007

Induction of pluripotent stem cells from fibroblast cultures.
Takahashi K, Okita K, Nakagawa M, Yamanaka S.
Nat Protoc. 2(12):3081-9.

Generation of germline-competent induced pluripotent stem cells.
Keisuke Okita, Tomoko Ichisaka, Shinya Yamanaka.
Nature. 448(7151):313-7

2004

Targeted disruption of the mouse ELYS gene results in embryonic lethality at peri-implantation development.
Keisuke Okita, Hiroshi Kiyonari, Ikuo Nobuhisa, Naoki Kimura, Shinichi Aizawa, Tetsuya Taga.
Genes Cells. 11, 1083-1091.

Spred-2 suppresses aorta-gonad-mesonephros hematopoiesis by inhibiting MAP kinase activation.
Ikuo Nobuhisa, Reiko Kato, Hirofumi Inoue, Makiko Takizawa, Keisuke Okita, Akihiko Yoshimura,  Tetsuya Taga.
J Exp Med. 199, 737–742.

Negative regulation of hematopoiesis by the fused in myeloproliferative disorders gene product.
Hirofumi Inoue, Ikuo Nobuhisa, Keisuke Okita, Makiko Takizawa, Pébusque Marie-Josèphe, Tetsuya Taga.
Biochem Biophys Res Commun. 313, 125-128.

2003

Regulation of Hematopoietic Development in the Aorta-Gonad-Mesonephros Region Mediated by Lnk Adaptor Protein.
Ikuo Nobuhisa, Makiko Takizawa, Satoshi Takaki, Hirofumi Inoue, Keisuke Okita, Masaya Ueno, Kiyoshi Takatsu, Tetsuya Taga.
Mol Cell Biol. 23, 8486-8494.

Genomic organization and characterization of the mouse ELYS gene.
Keisuke Okita, Ikuo Nobuhisa, Makiko Takizawa, Masaya Ueno, Naoki Kimura, Tetsuya Taga.
Biochem Biophys Res Commun. 305, 327-332.

2002

Identification of a novel transcription factor, ELYS, expressed predominantly in mouse foetal haematopoietic tissues.
Naoki Kimura, Makiko Takizawa,Keisuke Okita, Osamu Natori, Katsuhide Igarashi, Masaya Ueno, Kin-ichi Nakashima, Ikuo Nobuhisa, Tetsuya Taga.
Genes Cells. 7, 435-446