京都大学iPS細胞研究所 未来生命科学開拓部門 渡辺研究室

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Publication

2010~2016

  • Mandai M, Watanabe A, Kurimoto Y et al., Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration. N Engl. J. Med. 2017; 376:1038-1046
  • Ueki J, Nakamori M, Nakamura M, Nishikawa M, Yoshida Y, Tanaka A, Morizane A, Kamon M, Araki T, Takahashi MP, Watanabe A, Inagaki N, Sakurai H. Myotonic dystrophy type 1 patient-derived iPSCs for the investigation of CTG repeat instability.  Sci. Rep. in press.
  • Shirane K, Kurimoto K, Yabuta Y, Yamaji M, Satoh J, Ito S, Watanabe A, Hayashi K, Saitou M, Sasaki H. Global Landscape and Regulatory Principles of DNA Methylation Reprogramming for Germ Cell Specification by Mouse Pluripotent Stem Cells.  Dev. Cell, in press.
  • Matsuno K, Mae SI, Okada C, Nakamura M, Watanabe A, Toyoda T, Uchida E, Osafune K. Redefining definitive endoderm subtypes by robust induction of human induced pluripotent stem cells. Differentiation, in press.
  • Sugiyama H, Takahashi K, Yamamoto T, Iwasaki M, Narita M, Nakamura M, Rand TA, Nakagawa M, Watanabe A, Yamanaka S. Nat1 promotes translation of specific proteins that induce differentiation of mouse embryonic stem cells.  Proc. Natl. Acad. Sci. USA. 2017; 114(2):340-345.
  • Kawasaki Y, Oda H, Ito J, Niwa A, Tanaka T, Hijikata A, Seki R, Nagahashi A, Osawa M, Asaka I, Watanabe A, Nishimata S, Shirai T, Kawashima H, Ohara O, Nakahata T, Nishikomori R, Heike T, Saito MK. Identification of a High-Frequency Somatic NLRC4 Mutation as a Cause of Autoinflammation by Pluripotent Cell-Based Phenotype Dissection.  Arthritis Rheumatol. 2017;69(2):447-459.
  • Ameku T, Taura D, Sone M, Numata T, Nakamura M, Shiota F, Toyoda T, Matsui S, Araoka T, Yasuno T, Mae S, Kobayashi H, Kondo N, Kitaoka F, Amano N, Arai S, Ichisaka T, Matsuura N, Inoue S, Yamamoto T, Takahashi K, Asaka I, Yamada Y, Ubara Y, Muso E, Fukatsu A, Watanabe A, Sato Y, Nakahata T, Mori Y, Koizumi A, Nakao K, Yamanaka S, Osafune K.Identification of MMP1 as a novel risk factor for intracranial aneurysms in ADPKD using iPSC models.  Sci. Rep. 2016;6:30013.
  • Nishizawa M, Chonabayashi K, Nomura M, Tanaka A, Nakamura M, Inagaki A, Nishikawa M, Takei I, Oishi A, Tanabe K, Ohnuki M, Yokota H, Koyanagi-Aoi M, Okita K, Watanabe A, Takaori-Kondo A, Yamanaka S, Yoshida Y. Epigenetic Variation between Human Induced Pluripotent Stem Cell Lines Is an Indicator of Differentiation Capacity. Cell Stem Cell. 2016; 19(3):341-54.
  • Hasegawa A, Kaneko H, Ishihara D, Nakamura M, Watanabe A, Yamamoto M, Trainor CD, Shimizu R. GATA1 Binding Kinetics on Conformation-Specific Binding Sites Elicit Differential Transcriptional Regulation.  Mol Cell Biol. 2016;36(16):2151-2167.
  • Yahara Y, Takemori H, Okada M, Kosai A, Yamashita A, Kobayashi T, Fujita K, Itoh Y, Nakamura M, Fuchino H, Kawahara N, Fukui N, Watanabe A, Kimura T, Tsumaki N. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3. Nat Commun. 2016;7:10959
  • Ikeda K, Mizoro Y, Ameku T, Nomiya Y, Mae SI, Matsui S, Kuchitsu Y, Suzuki C, Hamaoka-Okamoto A, Yahata T, Sone M, Okita K, Watanabe A, Osafune K, Hamaoka K.Transcriptional Analysis of Intravenous Immunoglobulin Resistance in Kawasaki Disease Using an Induced Pluripotent Stem Cell Disease Model.  Circ. J. 2016;81(1):110-118.
  • Kitayama S, Zhang R, Liu TY, Ueda N, Iriguchi S, Yasui Y, Kawai Y, Tatsumi M, Hirai N, Mizoro Y, Iwama T, Watanabe A, Nakanishi M, Kuzushima K, Uemura Y, Kaneko S.Cellular Adjuvant Properties, Direct Cytotoxicity of Re-differentiated Valpha24 Invariant NKT-like Cells from Human Induced Pluripotent Stem Cells.  Stem Cell Rep. 2016;6(2):213-227.
  • Kitazawa K, Hikichi T, Nakamura T, Mitsunaga K, Tanaka A, Nakamura M, Yamakawa T, Furukawa S, Takasaka M, Goshima N, Watanabe A, Okita K, Kawasaki S, Ueno M, Kinoshita S, Masui S. OVOL2 Maintains the Transcriptional Program of Human Corneal Epithelium by Suppressing Epithelial-to-Mesenchymal Transition. Cell Rep. 2016;15(6):1359-1368.
  • Nakamura S, Takayama N, Hirata S, Seo H, Endo H, Ochi K, Fujita K, Koike T, Harimoto K, Dohda T, Watanabe A, Okita K, Takahashi N, Sawaguchi A, Yamanaka S, Nakauchi H, Nishimura S, Eto K. Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cells.  Cell Stem Cell. 2014;14(4):535-548.
  • Ohnuki M, Tanabe K, Sutou K, Teramoto I, Sawamura Y, Narita M, Nakamura M, Tokunaga Y, Nakamura M, Watanabe A, Yamanaka S, Takahashi K. Dynamic regulation of human endogenous retroviruses mediates factor-induced reprogramming and differentiation potential.  Proc Natl Acad Sci U S A. 2014;111(34):12426-12431.
  • Koyanagi-Aoi M, Ohnuki M, Takahashi K, Okita K, Noma H, Sawamura Y, Teramoto I, Narita M, Sato Y, Ichisaka T, Amano N, Watanabe A, Morizane A, Yamada Y, Sato T, Takahashi J, Yamanaka S.
    Differentiation-defective phenotypes revealed by large-scale analyses of human pluripotent stem cells. Proc Natl Acad Sci USA. 17;110(51):20569-74 (2013)

 

  • Watanabe A, Yamada Y, Yamanaka S.
    Epigenetic regulation in pluripotent stem cells: a key to breaking the epigenetic barrier. Philos. Trans. R. Soc. B; Biol. Sci. 368, 20120292 (2013)

 

  • Okita K, Yamakawa T, Matsumura Y, Sato Y, Amano N, Watanabe A, Goshima N, Yamanaka S.
    An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells. Stem Cells. 31, 458-66 (2013)

 

  • Hiratsuka S, Ishibashi S, Tomita T, Watanabe A, Akashi-Takamura S, Murakami M, Kijima H, Miyake K, Aburatani H, Maru Y.
    Primary tumours modulate innate immune signalling to create pre-metastatic vascular hyperpermeability foci.
    Nat Commun., 4, 1853 (2013)

 

  • Kondo T, Asai M, Tsukita K, Kutoku Y, Ohsawa Y, Sunada Y, Imamura K, Egawa N, Yahata N, Okita K, Takahashi K, Asaka I, Aoi T, Watanabe A, Watanabe K, Kadoya C, Nakano R, Watanabe D, Maruyama K, Hori O, Hibino S, Choshi T, Nakahata T, Hioki H, Kaneko T, Naitoh M, Yoshikawa K, Yamawaki S, Suzuki S, Hata R, Ueno S, Seki T, Kobayashi K, Toda T, Murakami K, Irie K, Klein WL, Mori H, Asada T, Takahashi R, Iwata N, Yamanaka S, Inoue H.
    Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness.
    Cell Stem Cell. 12, 487-96 (2013)

 

  • Gupta BK, Maher DM, Ebeling MC, Sundram V, Koch MD, Lynch DW, Bohlmeyer T, Watanabe A, Aburatani H, Puumala SE, Jaggi M, Chauhan SC.
    Increased Expression and Aberrant Localization of Mucin 13 in Metastatic Colon Cancer.
    PLoS One, 7, e45031 (2012)

 

  • Arioka Y, Watanabe A, Saito K, Yamada Y.
    Activation-induced cytidine deaminase alters the subcellular localization of Tet family proteins.
    PLoS One, 7, e45031 (2012)
  • Egawa N, Kitaoka S, Tsukita K, Naitoh M, Takahashi K, Yamamoto T, Adachi F, Kondo T, Okita K, Asaka I, Aoi T, Watanabe A, Yamada Y, Morizane A, Takahashi J, Ayaki T, Ito H, Yoshikawa K, Yamawaki S, Suzuki S, Watanabe D, Hioki H, Kaneko T, Makioka K, Okamoto K, Takuma H, Tamaoka A, Hasegawa K, Nonaka T, Hasegawa M, Kawata A, Yoshida M, Nakahata T, Takahashi R, Marchetto MC, Gage FH, Yamanaka S, Inoue H.
    Drug screening for ALS using patient-specific induced pluripotent stem cells.
    Sci. Transl. Med. 4, 145ra104 (2012)

 

  • Tanaka T, Takahashi K, Yamane M, Tomida S, Nakamura S, Oshima K, Niwa A, Nishikomori R, Kambe N, Hara H, Mitsuyama M, Morone N, Heuser JE, Yamamoto T, Watanabe A, Sato-Otsubo A, Ogawa S, Asaka I, Heike T, Yamanaka S, Nakahata T, Saito MK.
    Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery.
    Blood 120, 1299-1308 (2012)

 

  • Chauhan SC, Ebeling MC, Maher DM, Koch MD, Watanabe A, Aburatani H, Lio Y, Jaggi M
    MUC13 mucin augments pancreatic tumorigenesis.
    Mol. Cancer Ther. 11, 24-33 (2012)
  • Gupta BK, Maher DM, Ebeling MC, Sundram V, Koch MD, Lynch DW, Bohlmeyer T, Watanabe A, Aburatani H, Puumala SE, Jaggi M, Chauhan SC.
    Increased expression and aberrant localization of mucin 13 in metastatic colon cancer.
    J Histochem Cytochem. 60, 822-31(2012)

 

  • Pandian GN, Shinohara K, Ohtsuki A, Nakano Y, Masafumi M, Bando T, Nagase H, Yamada Y, Watanabe A, Terada N, Sato S, Morinaga H, Sugiyama H.
    Synthetic small molecules for epigenetic activation of pluripotency genes in mouse embryonic fibroblasts.
    ChemBioChem, 12, 2822-2828 (2011)

 

  • Watanabe A., Ogiwara H., Ehata S., MUkasa A., Ishikawa S., Maeda D., Ueki K., Ino Y., Todo T., Yamada Y., Fukayama M., Saito N., Miyazono K., Aburatani H.
    A homozygously deleted gene DACH1 regulates tumor-initiating activity of glioma cells.
    Proc. Natl. Acad. Sci. USA 108, 12384-12389 (2011)

 

  • Ehata S., Johansson E., Katayama R., Koike S., Watanabe A., Hoshino Y., Katsuno Y., Komuro A., Koinuma D., Kano M.R., Yashiro M., Hirakawa K., Aburatani H., Fujita N., Miyazono K.
    Transforming growth factor-beta decreases the cancer-initiating cellpopulation within diffuse-type gastric carcinoma cells.
    Oncogene 30, 1693-1705 (2011)

 

  • Johansson E., Komuro A., Iwata C., Hagiwara A., Fuse Y., Watanabe A., Morishita Y., Aburatani H., Funa K., Kano M.R., Miyazono K.
    Exogenous introduction of tissue inhibitor of metalloproteinase 2 reduces accelerated growth of TGF-beta-disrupted diffuse-type gastric carcinoma.
    Cancer Sci. 101, 2398-2403 (2010)

 

  • Seki M., Watanabe A., Enomoto S., Kawamura T., Ito H., Kodama T., Hamakubo H., Aburatani H.
    Human ROBO1 is cleaved by metalloproteinases and gamma-secretase and migrates to the nucleus in cancer cells.
    FEBS Lett. 584, 2909-2915 (2010)

 

  • Yamada Y. Watanabe A.
    Epigenetic codes in stem cells and cancer stem cells.
    Adv Genet. 70, 177-199 (2010)

 

  • 渡辺 亮、山田 泰広
    体細胞リプログラミングにおけるエピジェネティック制御.
    実験医学増刊「エピジェネティクスと疾患」 2010 Vol. 28, 2552-2557

 

2004~2009

  • Komuro A., Yashiro M., Iwata C., Morishita Y., Johansson E., Matsumoto Y., Watanabe A., Aburatani H., Miyoshi H., Kiyono K., Shirai Y., Suzuki H.I., Hirakawa K., Kano M.R., Miyazono K.
    Progression of Tumors by Disrupting TGF-β Signaling in Diffuse-type Gastric Carcinoma via Accelerated Angiogenesis.
    J. Natl. Cancer Inst. 101. 592-604 (2009)

 

  • Takanaga H., Tsuchida-Straeten N., Nishide K., Watanabe A., Aburatani H., Kondo T.
    Gli2 is a novel regulator of Sox2 expression in telencephalic neuroepithelial cells.
    Stem Cells 27, 165-174 (2008)

 

  • Hiratsuka S., Watanabe A., Sakurai, Y., Akashi-Takamura S., Ishibashi S., Miyake K., Akira S., Aburatani H., Maru Y.
    The S100A8-Serum amyloid A3-TLR4 paracrine cascade establishes pre-metastatic phase.
    Nat. Cell Biol. 10, 1349-1355 (2008)

 

  • Onuma Y., Watanabe A., Aburatani H., Asashima M., Whitman, M.
    TRIQK, a novel family of small proteins localized to the endoplasmic-reticulum membrane, is conserved across vertebrates.
    Zool. Sci. 25, 706-713 (2008)

 

  • Torisu Y., Watanabe A., Nonaka A. Midorikawa Y., Makuuchi M., Shimamura T., Sugimura H., Niida A., Akiyama T., Iwanari H., Kodama T., Zeniya M., Aburatani H.
    A human homolog of Notum, overexpressed in colorectal and hepatocellular carcinoma, is transcriptionally regulated by β-catenin/TCF.
    Cancer Sci. 99, 1139-1146 (2008)

 

  • Li C.P., Goto A., Watanabe A., Murata K., Ota S., Niki T., Aburatani H., Fukayama M.
    AKR1B10 in usual interstitial pneumonia (UIP): Expression in squamous metaplasia in association with smoking and lung cancer.
    Pathol. Res. Pract. 204, 295-304 (2008)

 

  • Yoshitake H., Takahashi M., Ishikawa H., Nojima M., Iwanari H., Watanabe A., Aburatani H., Yoshida K., Ishi K., Takamori K., Ogawa H., Hamakubo T., Kodama T., Araki Y.
    Aldo-keto reductase family 1, member B10 in uterine carcinomas: a potential risk factor of recurrence after surgical therapy in cervical cancer.
    Int. J. Gynecol. Cancer 17, 1300-1306 (2007)

 

  • Yamamoto Y., Uehara A., Miura K., Watanabe A., Aburatani H., Komiyama M.
    Development of artificial restriction DNA cutter composed of Ce(Iv)/EDTA and PNA.
    Nucleosides Nucleotides Nucleic Acids. 26, 1265-1268 (2007)

 

  • Hiratsuka S., Watanabe A., Aburatani H., Maru Y.
    Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis.
    Nat. Cell Biol. 8, 1369-1375 (2006)

 

  • Guo Y., Chen Y., Itoh H., Watanabe A., Ge X., Kodama T., Aburatani H.
    Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma.
    Gene 384, 51-61 (2006)

 

  • Ito H., Funahashi S., Yamauchi N., Shibahara J., Midorikawa Y., Kawai S., Kinoshita Y., Watanabe A., Hippo Y., Ohtomo T., Iwanari H., Nakajima A., Makuuchi M., Fukayama M., Hirata Y., Hamakubo T., Kodama T., Tsuchiya M., Aburatani H.
    Identification of ROBO1 as a novel hepatocellular carcinoma antigen and a potential therapeutic and diagnostic target.
    Clin. Cancer Res. 12, 3257-3264 (2006)

 

  • Watanabe N., Zmijewski J.W., Takabe W., Umezu-Goto M., Goffe C.L., Sekine A., Lamdar A., Watanabe A., Aoki J., Arai H., Kodama T., Murphy M.P., Kalyanaraman R., Darley-Usmar V.M., Noguchi, N.
    Activation of MAP Kinases by Lysophosphatidylcholine-induced mitochondrial reactive oxygen species generation in endothelial cells.
    Am. J. Pathol. 168, 1737-1748 (2006)

 

  • Yamamoto Y., Uehara A., Watanabe A., Aburatani H., Komiyama M.
    Chemical reaction-based site-selective DNA cutter for PCR-free gene manipulation.
    ChemBioChem 7, 673-677 (2006)

 

  • Tanaka T., Jiang S., Hotta H., Takano K., Iwanari H., Sumi K., Daigo K., Ohashi R., Sugai M., Ikegame C., Umezu H., Hirayama Y., Midorikawa Y., Hippo Y., Watanabe A., Uchiyama Y., Hasegawa G., Reid P., Aburatani H., Hamakubo T., Sakai J., Naito M., Kodama T.
    Dysregulated expression of P1 and P2 promoter-driven hepatocyte nuclear factor-4alpha in the pathogenesis of human cancer.
    J. Pathol. 208, 662-672 (2006)

 

  • Chen Y., Guo Y., Ge X., Itoh H., Watanabe A., Fujiwara T., Kodama T., Aburatani H.
    Elevated expression and potential roles of human Sp5, a member of Sp transcription factor family, in human cancers.
    Biochem. Biophys. Res. Commun. 340, 758-766 (2006)

 

  • Yamauchi N., Watanabe A., Hishinuma M., Ohashi K., Midorikawa Y., Morishita Y., Niki T., Shibahara J., Mori M., Makuuchi M., Hippo Y., Kodama T., Iwanari H., Aburatani H., Fukayama M.
    The Glypican 3 oncofetal protein is a promising diagnostic marker for hepatocellular carcinoma.
    Modern Pathol. 18, 1591-1598 (2005)

 

  • Shimamura T., Ito H., Shibahara J., Watanabe A., Hippo Y., Taniguchi H., Chen Y., Kashima T., Ohtomo T., Tokioka F., Iwanari H., Kodama T., Kazui T., Sugimura H., Fukayama M., Aburatani H.
    Over-expression of MUC13 is associated with intestinal type gastric cancer.
    Cancer Sci. 96, 265-273 (2005)

 

  • Fukumoto S., Yamauchi N., Moriguchi H., Hippo Y., Watanabe A., Shibahara J., Taniguchi H., Ishikawa S., Ito H., Yamamoto S., Iwanari H., Hironaka M., Ishikawa Y., Niki T., Sohara Y., Kodama T., Nishimura M., Fukayama M., Dosaka-Akita H., Aburatani H.
    Overexpression of the aldo-keto reductase family protein AKR1B10 is highly correlated with smokers’ non-small cell lung carcinomas.
    Clin. Cancer Res. 11, 1776-1185 (2005)

 

  • Hippo Y., Watanabe K., Watanabe A., Midorikawa Y., Yamamoto S., Ihara S., Tokita S., Iwanari H., Ito Y., Nakano K., Nezu J., Tsunoda H., Yoshino T., Ohizumi I., Tsuchiya M., Ohnishi S., Makuuchi M., Hamakubo T., Kodama T., Aburatani H.
    Identification of soluble NH2-terminal fragment of glypican-3 as a serological marker for early-stage hepatocellular carcinoma.
    Cancer Res. 64, 2418-2423 (2004)

 

  • Watanabe A, Aburatani H.
    AKR1B10 in non-small cell lung carcinoma.
    Biotherapy 3, 329 (2006)

 

~2003

  • Watanabe A., Hippo Y., Taniguchi H., Iwanari H., Yashiro M., Hirakawa K., Kodama T., Aburatani H.
    An opposing view on WWOX protein function as a tumor suppressor.
    Cancer Res. 63, 8629-8633 (2003)

 

  • Yoshida Y., Noguchi N., Watanabe A., Iwaki Y., Yanagisawa M., Kodama T., Cynshi O., Niki E.
    Antioxidant action of 2,2,4,6-tetra-substituted 2,3-dihydro-5-hydroxybenzofuran against lipid peroxidation: Effects of substituents and side chain.
    Free Radic. Res. 36, 1171-1178 (2002)

 

  • Noguchi N., Watanabe A., Shi H.
    Diverse functions of antioxidants.
    Free Radic. Res. 33, 809-817 (2001)

 

  • Okimoto Y., Watanabe A., Yamashita T., Niki E., Noguchi N.
    A novel fluorescent probe diphenyl-1- pyrenylphosphine to follow lipid peroxidation in cell membranes.
    FEBS Lett. 474, 137-140 (2000)

 

  • Watanabe A., Noguchi N., Fujisawa A., Kodama T., Tamura K., Cynshi O., Niki E.
    Stability and reactivity of aryloxyl radicals derived from a novel antioxidant BO-653 and related compounds. Effects of substituent and side chain in solution and membranes.
    J. Am. Chem. Soc. 122, 5438-5442 (2000)

 

  • Watanabe A., Noguchi N., Takahashi M., Niki E.
    Rate constants for hydrogen atom abstraction by α-tocopheroxyl radical from lipid, hydroperoxide and ascorbic acid.
    Chem. Lett. 613-614 (1999)

 

  • 渡辺亮, 二木鋭雄
    フリーラジカルとは何か
    日本病院薬剤師会雑誌 37, 13 (2001)
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