Woltjen Lab

Stem Cells and Genome Engineering

Archive for February, 2015

Collaborator employs piggyBac for synthetic gene cascade

Collaborator Miki Ebisuya (RIKEN Unit Leader and JST PRESTO member) employed multiple piggyBac transposons to deliver components of the Notch-Delta cascade to mammalian cells without such inherent cell-cell signalling. By recreating the gene network artificially, her research team was able to break cellular symmetry, and generate an asymmetric population of cells in an appropriate ratio. […]