Woltjen Lab

Stem Cells and Genome Engineering

Written by: on February 5, 2015 @ 12:00

Collaborator Miki Ebisuya (RIKEN Unit Leader and JST PRESTO member) employed multiple piggyBac transposons to deliver components of the Notch-Delta cascade to mammalian cells without such inherent cell-cell signalling. By recreating the gene network artificially, her research team was able to break cellular symmetry, and generate an asymmetric population of cells in an appropriate ratio. This is an important step towards re-creating in vitro the patterned cell diversification that exists in vivo.

Read about the study in the Official RIKEN Press Release. Japanese only!
Or jump directly to the article in Nature Communications.

Categories: Publications