A research team led by Lecturer Hidetoshi Sakurai of CiRA and Akihito Tanaka, a graduate student at Nagoya University Graduate School of Medicine who is currently engaged in external research at CiRA has developed a technique for producing myocytes from human iPS cells which is superior to existing methods in efficiency, reproducibility, and speed. […]
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The research group led by Associate Professor Kenji Osafune and his colleague Shin-ichi Mae, both from CiRA, Kyoto University, has succeeded in developing a highly efficient method of inducing human induced pluripotent stem (iPS) cells to differentiate into intermediate mesoderm, the precursor of kidney, gonad, and other cell lineages. This represents a major step toward realizing renal […]
A research group at the CiRA at Japan’s Kyoto University has successfully recapitulated amyotrophic lateral sclerosis (ALS)-associated abnormalities in motor neurons differentiated from induced pluripotent stem cells obtained from patients with familial ALS, a late-onset, fatal disorder which is also known for Lou Gehrig’s disease. In a drug screening assay using the disease model, the team further found that the chemical compound anacardic acid can rescue some ALS phenotypes in vitro.
Hepatocytes generated from human induced pluripotent stem cells (iPS cells) constitute an unprecedented resource in the field of drug discovery and cell therapy, but the successful generation of mature hepatocytes from human iPS cells remains a challenge.