研究活動
Research Activities

研究活動
Research Activities

Home › 研究活動 › 主任研究者 › 沖田 圭介 講師

主任研究者
Principal Investigator

未来生命科学開拓部門 沖田 圭介 講師

発表論文

Sone M, Morone N, Nakamura T, Tanaka A, Okita K, Woltjen K, Nakagawa M, Heuser JE, Yamada Y, Yamanaka S, Yamamoto T.

Hybrid Cellular Metabolism Coordinated by Zic3 and Esrrb Synergistically Enhances Induction of Naive Pluripotency. Cell Metab. 2017 May 2;25(5):1103-1117.e6.

Yokobayashi S, Okita K, Nakagawa M, Nakamura T, Yabuta Y, Yamamoto T, Saitou M.

Clonal Variation of Human Induced Pluripotent Stem Cells for Induction into the Germ Cell Fate. Biol Reprod. 2017 Apr 27. doi: 10.1093/biolre/iox038. [Epub ahead of print]

Yoshitoshi-Uebayashi EY, Toyoda T, Yasuda K, Kotaka M, Nomoto K, Okita K, Yasuchika K, Okamoto S, Takubo N, Nishikubo T, Soga T, Uemoto S, Osafune K.

Modelling urea-cycle disorder citrullinemia type 1 with disease-specific iPSCs. Biochem Biophys Res Commun. 2017 Mar 14. pii: S0006-291X(17)30494-1. doi:10.1016/j.bbrc.2017.03.037. [Epub ahead of print]

Kikuchi T, Morizane A, Doi D, Okita K, Nakagawa M, Yamakado H, Inoue H, Takahashi R, Takahashi J.

Idiopathic Parkinson's disease patient-derived induced pluripotent stem cells function as midbrain dopaminergic neurons in rodent brains. J Neurosci Res. 2017 Feb 24. doi: 10.1002/jnr.24014. [Epub ahead of print]

Ikeda K, Mizoro Y, Ameku T, Nomiya Y, Mae SI, Matsui S, Kuchitsu Y, Suzuki C, Hamaoka-Okamoto A, Yahata T, Sone M, Okita K, Watanabe A, Osafune K, Hamaoka K.

Transcriptional Analysis of Intravenous Immunoglobulin Resistance in Kawasaki Disease Using an Induced Pluripotent Stem Cell Disease Model. Circ J. 81 (1) 110-118. (2016)

Mora-Bermúdez F, Badsha F, Kanton S, Camp JG, Vernot B, Köhler K, Voigt B, Okita K, Maricic T, He Z, Lachmann R, Pääbo S, Treutlein B, Huttner WB.

Differences and similarities between human and chimpanzee neural progenitors during cerebral cortex development. eLife. 2016;5;e18683.

Nishizawa M, Chonabayashi K, Nomura M, Tanaka A, Nakamura M, Inagaki A, Nishikawa M, Takei I, Oishi A, Tanabe K, Ohnuki M, Yokota H, Koyanagi-Aoi M, Okita K, Watanabe A, Takaori-Kondo A, Yamanaka S, Yoshida Y.

Epigenetic Variationbetween Human Induced Pluripotent Stem Cell Lines Is an Indicator of Differentiation Capacity. Cell Stem Cell. 19 (3) 341-54. (2016)

Kawamura T, Miyagawa S, Fukushima S, Maeda A, Kashiyama N, Kawamura A, Miki K, Okita K, Yoshida Y, Shiina T, Ogasawara K, Miyagawa S, Toda K, Okuyama H, Sawa Y.

Cardiomyocytes Derived from MHC-Homozygous Induced Pluripotent Stem Cells Exhibit Reduced Allogeneic Immunogenicity in MHC-Matched Non-human Primates. Stem Cell Reports. 6 (3) 312-20. (2016)

Yamakawa T, Sato Y, Matsumura Y, Kobayashi Y, Kawamura Y, Goshima N, Yamanaka S, Okita K.

Screening of Human cDNA Library Reveals Two differentiation-Related Genes, HHEX and HLX, as Promoters of Early Phase Reprogramming toward Pluripotency. Stem Cells. 34 (11) 2661-2669. (2016)

Saito H, Okita K, Chang AE, Ito F.

Adoptive Transfer of CD8+ T Cells Generated from Induced Pluripotent Stem Cells Triggers Regressions of Large Tumors Along with Immunological Memory. Cancer Res. 76 (12) 3473-3483. (2016)

Saragusty J, Diecke S, Drukker M, Durrant B, Ben-Nun IF, Galli C, Göritz F, Hayashi K, Hermes R, Holtze S, Johnson S, Lazzari G, Loi P, Loring JF, Okita K, Renfree MB, Seet S, Voracek T, Stejskal J, Ryder OA, Hildebrandt TB

Rewinding the process of mammalian extinction Zoo Biology. 35: 280-292. DOI: 10.1002/zoo.21292 (2016)

Kitazawa K, Hikichi T, Nakamura T, Mitsunaga K, Tanaka A, Nakamura M, Yamakawa T, Furukawa S, Takasaka M, Goshima N, Watanabe A, Okita K, Kawasaki S, Ueno M, Kinoshita S, Masui S.

OVOL2 Maintains the Transcriptional Program of Human Corneal Epithelium by Suppressing Epithelial-to-Mesenchymal Transition. Cell Rep. 2016 Apr 27. pii: S2211-1247(16)30433-8.

Fukusumi H, Shofuda T, Bamba Y, Yamamoto A, Kanematsu D, Handa Y, Okita K, Nakamura M, Yamanaka S, Okano H, Kanemura Y.

Establishment of Human Neural Progenitor Cells from Human Induced Pluripotent Stem Cells with Diverse Tissue Origins. Stem Cells International. 2016, Article ID 7235757.

Saito H, Okita K, Fusaki N, Sabel MS, Chang AE, Ito F.

Reprogramming of Melanoma Tumor-Infiltrating Lymphocytes to Induced Pluripotent Stem Cells. Stem Cells International. 2016, Article ID 8394960.

Yu G, Okawa H, Okita K, Kamano Y, Wang F, Saeki M, Yatani H, Egusa H.

Gingival Fibroblasts as Autologous Feeders for Induced Pluripotent Stem Cells. J Dent Res. 95(1):110-8. (2016)

Hashizume O, Ohnishi S, Mito T, Shimizu A, Iashikawa K, Nakada K, Soda M, Mano H, Togayachi S, Miyoshi H, Okita K, Hayashi J.

Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects. Sci Rep. 5:10434. (2015)

Kim SI, Oceguera-Yanez F, Hirohata R, Linker S, Okita K, Yamada Y, Yamamoto T, Yamanaka S, Woltjen K.

KLF4 N-terminal variance modulates induced reprogramming to pluripotency. Cell Stem Cell. 14(4):535-48. (2015)

Samata B, Kikuchi T, Miyawaki Y, Morizane A, Mashimo T, Nakagawa M, Okita K, Takahashi J.

X-linked severe combined immunodeficiency (X-SCID) rats for xeno-transplantation and behavioral evaluation. J Neurosci Methods. 243:68-77. (2015)

Shimamoto R, Amano N, Ichisaka T, Watanabe A, Yamanaka S, Okita K.

Generation and Characterization of Induced Pluripotent Stem Cells from Aid-Deficient Mice. PLoS ONE 10.1371/journal.pone.0094735 (2014)

Nakamura S, Takayama N, Hirata S, Seo H, Endo H, Ochi K, Fujita KI, Koike T, Harimoto KI, Dohda T, Watanabe A, Okita K, Takahashi N, Sawaguchi A, Yamanaka S, Nakauchi H, Nishimura S, Eto K.

Expandable Megakaryocyte Cell Lines Enable Clinically Applicable Generation of Platelets from Human Induced Pluripotent Stem Cells. Cell Stem Cell. 14(4):535-48. (2014)

Ohnishi K, Semi K, Yamamoto T, Shimizu M, Tanaka A, Mitsunaga K, Okita K, Osafune K, Arioka Y, Maeda T, Soejima H, Moriwaki H, Yamanaka S, Woltjen K, Yamada Y.

Premature termination of reprogramming in vivo leads to cancer development through altered epigenetic regulation. Cell. 156(4):663-77. (2014)

Koyanagi-Aoi M, Ohnuki M, Takahashi K, Okita K, Noma H, Sawamura Y, Teramoto I, Narita M, Sato Y, Ichisaka T, Amano N, Watanabe A, Morizane A, Yamada Y, Sato T, Takahashi J, Yamanaka S.

Differentiation-defective phenotypes revealed by large-scale analyses of human pluripotent stem cells. Proc Natl Acad Sci U S A. 110(51):20569-74. (2013)

Morizane A, Doi D, Kikuchi T, Okita K, Hotta A, Kawasaki T, Hayashi T, Onoe H, Shiina T, Yamanaka S, Takahashi J.

Direct Comparison of Autologous and Allogeneic Transplantation of iPSC-Derived Neural Cells in the Brain of a Nonhuman Primate. Stem Cell Reports. 1(4):283-92. (2013)

Kuroki S, Matoba S, Akiyoshi M, Matsumura Y, Miyachi H, Mise N, Abe K, Ogura A, Wilhelm D, Koopman P, Nozaki M, Kanai Y, Shinkai Y, Tachibana M.

Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a. Science. 341(6150):1106-9. (2013)

Kondo T, Asai M, Tsukita K, Kutoku Y, Ohsawa Y, Sunada Y, Imamura K, Egawa N, Yahata N, Okita K, Takahashi K, Asaka I, Aoi T, Watanabe A, Watanabe K, Kadoya C, Nakano R, Watanabe D, Maruyama K, Hori O, Hibino S, Choshi T, Nakahata T, Hioki H, Kaneko T, Naitoh M, Yoshikawa K, Yamawaki S, Suzuki S, Hata R, Ueno SI, Seki T, Kobayashi K, Toda T, Murakami K, Irie K, Klein WL, Mori H, Asada T, Takahashi R, Iwata N, Yamanaka S, Inoue H.

Modeling Alzheimer's Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness. Cell Stem Cell. 12(4):487-96. (2013)

Okita K, Yamakawa T, Matsumura Y, Sato Y, Amano N, Watanabe A, Goshima N, Yamanaka S.

An Efficient Non-viral Method to Generate Integration-Free Human iPS Cells from Cord Blood and Peripheral Blood Cells. Stem Cells. 31(3):458-66. (2013)

Egawa N, Kitaoka S, Tsukita K, Naitoh M, Takahashi K, Yamamoto T, Adachi F, Kondo T, Okita K, Asaka I, Aoi T, Watanabe A, Yamada Y, Morizane A, Takahashi J, Ayaki T, Ito H, Yoshikawa K, Yamawaki S, Suzuki S, Watanabe D, Hioki H, Kaneko T, Makioka K, Okamoto K, Takuma H, Tamaoka A, Hasegawa K, Nonaka T, Hasegawa M, Kawata A, Yoshida M, Nakahata T, Takahashi R, Marchetto MC, Gage FH, Yamanaka S, Inoue H.

Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells. Sci Transl Med. 4(145):145ra104. (2012)

Kajiwara M, Aoi T, Okita K, Takahashi R, Inoue H, Takayama N, Endo H, Eto K, Toguchida J, Uemoto S, Yamanaka S.

Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells. Proc Natl Acad Sci U S A. 109(31):12538-43. (2012)

Hirano K, Nagata S, Yamaguchi S, Nakagawa M, Okita K, Kotera H, Ainscough J, Tada T.

Human and mouse induced pluripotent stem cells are differentially reprogrammed in response to kinase inhibitors. Stem Cells Dev. 21(8):1287-98. (2011)

Iwabuchi KA, Yamakawa T, Sato Y, Ichisaka T, Takahashi K, Okita K, Yamanaka S.

ECAT11/L1td1 is enriched in ESCs and rapidly activated during iPSC generation, but it is dispensable for the maintenance and induction of pluripotency. PLoS One. 6(5):e20461. (2011)

Okita K, Matsumura Y, Sato Y, Okada A, Morizane A, Okamoto S, Hong H, Nakagawa M, Tanabe K, Tezuka KI, Shibata T, Kunisada T, Takahashi M, Takahashi J, Saji H, Yamanaka S.

A more efficient method to generate integration-free human iPS cells. Nat Methods. 8(5):409-12. (2011)

Fujiwara M, Yan P, Otsuji TG, Narazaki G, Uosaki H, Fukushima H, Kuwahara K, Harada M, Matsuda H, Matsuoka S, Okita K, Takahashi K, Nakagawa M, Ikeda T, Sakata R, Mummery CL, Nakatsuji N, Yamanaka S, Nakao K, Yamashita JK.

Induction and enhancement of cardiac cell differentiation from mouse and human induced pluripotent stem cells with cyclosporin-A. PLoS One. 6(2):e16734. (2011)

Egusa H, Okita K, Kayashima H, Yu G, Fukuyasu S, Saeki M, Matsumoto T, Yamanaka S, Yatani H.

Gingival fibroblasts as a promising source of induced pluripotent stem cells. PLoS One. 5(9):e12743. (2010)

Espejel S, Roll GR, McLaughlin KJ, Lee AY, Zhang JY, Laird DJ, Okita K, Yamanaka S, Willenbring H.

Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice. J Clin Invest. 120(9):3120-6. (2010)

Laura R. Saunders, Amar Deep Sharma, Jaime Tawney, Masato Nakagawa, Keisuke Okita, Shinya Yamanaka, Holger Willenbring, Eric Verdin.

miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues. Aging. 2(7):415-31. (2010)

Okita K, Hong H, Takahashi K, Yamanaka S.

Generation of mouse-induced pluripotent stem cells with plasmid vectors. Nat Protoc. 5(3):418-28. (2010)

Sato S, Yagi S, Arai Y, Hirabayashi K, Hattori N, Iwatani M, Okita K, Ohgane J, Tanaka S, Wakayama T, Yamanaka S, Shiota K.

Genome-wide DNA methylation profile of tissue-dependent and differentially methylated regions (T-DMRs) residing in mouse pluripotent stem cells. Genes Cells. 15(6):607-18. (2010)

Yoshida Y, Takahashi K, Okita K, Ichisaka T, Yamanaka S.

Hypoxia enhances the generation of induced pluripotent stem cells Cell Stem Cell 5, 237-41. (2009)

Hyenjong Hong, Kazutoshi Takahashi, Tomoko Ichisaka, Takashi Aoi, Osami Kanagawa, Masato Nakagawa, Keisuke Okita and Shinya Yamanaka.

Suppression of induced pluripotent stem cell generation by the p53–p21 pathway Nature 460, 1132-5. (2009)

Senju, S., Haruta, M., Matsunaga, Y., Fukushima, S., Ikeda, T., Takahashi, K., Okita, K., Yamanaka, S., and Nishimura, Y.

Characterization of Dendritic Cells and Macrophages Generated by Directed Differentiation from Mouse Induced Pluripotent Stem Cells Stem Cells 27, 1021–1031. (2009)

Tsubooka, N., Ichisaka, T., Okita, K., Takahashi, K., Nakagawa, M., and Yamanaka, S.

Roles of Sall4 in the generation of pluripotent stem cells from blastocysts and fibroblasts Genes Cells 14, 683-94. (2009)

Niwa, A., Umeda, K., Chang, H., Saito, M., Okita, K., Takahashi, K., Nakagawa, M., Yamanaka, S., Nakahata, T., Heike, T.

Orderly hematopoietic development of induced pluripotent stem cells via Flk-1+ hemoangiogenic progenitors J Cell Phys 221, 367-77. (2009)

Hirami, Y., Osakada, F., Takahashi, K., Okita, K., Yamanaka, S., Ikeda, H., Yoshimura, N., and Takahashi, M.

Generation of retinal cells from mouse and human induced pluripotent stem cells Neurosci Lett 458, 126–31. (2009)

Nishimura, K., Nakagawa, T., Ono, K., Ogita, H., Sakamoto, T., Yamamoto, N., Okita, K., Yamanaka, S., and Ito, J.

Transplantation of mouse induced pluripotent stem cells into the cochlea Neuroreport 20, 1250-4. (2009)

Miura, K., Okada, Y., Aoi, T., Okada. A., Takahashi, K., Okita, K., Nakagawa, M., Koyanagi, M., Tanabe, K., Ohnuki, M., Ogawa, D., Ikeda, E., Okano, H., Yamanaka, S.

Variation in the safety of induced pluripotent stem cell lines Nature Biotechnology 27, 743–745. (2009)

Okita, K., Nakagawa, M., Hyenjong, H., Ichisaka, T., and Yamanaka, S.

Generation of mouse induced pluripotent stem cells without viral vectors Science 322, 949-953. (2008)

Aoi, T., Yae, K., Nakagawa, M., Ichisaka, T., Okita, K., Takahashi, K., Chiba, T., and Yamanaka, S.

Generation of pluripotent stem cells from adult mouse liver and stomach cells Science 321, 699-702. (2008)

Nakagawa, M., Koyanagi, M., Tanabe, K., Takahashi, K., Ichisaka, T., Aoi, T., Okita, K., Mochiduki, Y., Takizawa, N., and Yamanaka, S.

Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts Nat Biotechnol 26, 101-106. (2008)

Narazaki, G., Uosaki, H., Teranishi, M., Okita, K., Kim, B., Matsuoka, S., Yamanaka, S., and Yamashita, J.K.

Directed and systematic differentiation of cardiovascular cells from mouse induced pluripotent stem cells Circulation 118, 498-506. (2008)

Takahashi K, Okita K, Nakagawa M, Yamanaka S.

Induction of pluripotent stem cells from fibroblast cultures Nat Protoc 2, 3081-9. (2007)

Okita, K., Ichisaka, T., and Yamanaka, S.

Generation of germline-competent induced pluripotent stem cellsNature 448, 313-7

Okita K. and Yamanaka S.(2006).

Intracellular signaling pathways regulating pluripotency of embryonic stem cells Cur. Stem Cell Res. Ther., 1: 103-11. (2007)

Ikuo Nobuhisa, Reiko Kato, Hirofumi Inoue, Makiko Takizawa, Keisuke Okita, Akihiko Yoshimura,Tetsuya Taga.

Spred–2 suppresses aorta–gonad–mesonephros hematopoiesis by inhibiting MAP kinase activation. J Exp Med.199,737–742. (2004)

Keisuke Okita, Hiroshi Kiyonari, Ikuo Nobuhisa, Naoki Kimura, Shinichi Aizawa, Tetsuya Taga.

Targeted disruption of the mouse ELYS gene results in embryonic lethality at peri-implantation development. Genes Cells. 11, 1083-1091. (2004)

Hirofumi Inoue, Ikuo Nobuhisa, Keisuke Okita, Makiko Takizawa, Pebusque Marie-Josephe, Tetsuya Taga.

Negative regulation of hematopoiesis by the fused in myeloproliferative disorders gene product. Biochem Biophys Res Commun. 313, 125–128. (2004)

Keisuke Okita, Ikuo Nobuhisa, Makiko Takizawa, Masaya Ueno, Naoki Kimura, Tetsuya Taga.

Genomic organization and characterization of the mouse ELYS gene. Biochem Biophys Res Commun. 305, 327–332. (2003)

Ikuo Nobuhisa, Makiko Takizawa, Satoshi Takaki, Hirofumi Inoue, Keisuke Okita, Masaya Ueno, Kiyoshi Takatsu, Tetsuya Taga.

Regulation of Hematopoietic Development in the Aorta–Gonad–Mesonephros Region Mediated by Lnk Adaptor Protein. Mol Cell Biol.23, 8486–8494. (2003)

Naoki Kimura, Makiko Takizawa, Keisuke Okita, Osamu Natori, Katsuhide Igarashi, Masaya Ueno, Kin-ichi Nakashima, Ikuo Nobuhisa, Tetsuya Taga.

Identification of a novel transcription factor, ELYS, expressed predominantly in mouse foetal haematopoietic tissues. Genes Cells. 7, 435-446. (2002)

Hiroshi Kitamura, Keisuke Okita, Daisuke Fujikura, Koshi Mori, Toshihiko Iwanaga, Masayuki Saito.

Induction of Src-suppressed C kinase substrate (SSeCKS) in vascular endothelial cells by bacterial lipopolysaccharide. J Histochem Cytochem. 50, 245–255. (2002)

Masaya Ueno, Katsuhide Igarashi, Naoki Kimura, Keisuke Okita, Makiko Takizawa, Ikuo Nobuhisa, Tetsuo Kojima, Toshio Kitamura, Ulrike Samulowitz, Dietmar Vestweber, Taizo Shimomura, Toshio Suda, Kinichi Nakashima, Tetsuya Taga.

Endomucin is expressed in embryonic dorsal aorta and is able to inhibit cell adhesion. Biochem Biophys Res Commun. 287, 501–506. (2001)

Hiroshi Kitamura, Katsushi Kanehira, Keisuke Okita, Masami Morimatsu, Masayuki Saito.

MAIL, a novel nuclear I kappa B protein that potentiates LPS-induced IL-6 production. FEBS Lett.485, 53-56. (2000)
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