Welcome to our HP

The goal of The Kaneko laboratory is to regenerate human immune system utilizing the iPSC technology.


Department of Cell Growth and Differentiation,
Center for iPS Cell Research and Application,
Kyoto University
SHiN KANEKO Laboratory

53 Kawahara-cho, Shogoin Yoshida,
Sakyo-ku, Kyoto 606-8507, Japan

Tel +81-75-366-7157
Fax +81-75-366-7158


Home > Publications


1) Publications

*corresponding author

  1. Minagawa A, *Kaneko S. Rise of iPSCs as a cell source for adoptive immunotherapy. Human Cell, 2014 Feb.
  2. Hirata S, Takayama N, Jono-Ohnishi R, Endo H, Nakamura S, Dohda T, Nishi M, Hamazaki Y, Ishii E, Kaneko S, Otsu M, Nakauchi H, Kunishima S, *Eto K. Congenital amegakaryocytic thrombocytopenia iPS cells exhibit defective MPL-mediated signaling. J Clin Invest. 2013 Sep 3;123(9):3802-14.
  3. *Kaneko S, *Yamanaka S. To be immunogenic, or not to be: that's the iPSC question. Cell Stem Cell. 2013 Apr 4;12(4):385-6.
  4. Nishimura T, *Kaneko S, Kawana A, Tajima Y, Gotoh H, Zhu D, Nakayama K, Iriguchi S, Uemura Y, Shimizu T, Takayama N, Yamada D, Nishimura K, Ohtaka M, Watanabe N, Takahashi S, Iwamoto A, Koseki H, Nakanishi M, Eto K, *Nakauchi H. Generation of rejuvenated antigen-specific T cells by pluripotency reprogramming and redifferentiation. Cell Stem Cell. 2013 Jan 3;12(1):114-26.
  5. Bondanza A, Hambach L, Aghai Z, Nijmeijer B, Kaneko S, Mastaglio S, Radrizzani M, Fleischhauer K, Ciceri F, Bordignon C, Bonini C, and *Goulmy E: IL-7 receptor expression identifies suicide gene-modified allospecific CD8+ T cells capable of self-renewal and differentiation into antileukemia effectors. Blood. 117:6469-78, (2011)
  6. Shimizu T, Sano S, Takayama N, *Kaneko S, Eto K, Takeuchi Y, Nakauchi H. Constitutive STAT5A activation enables erythropoiesis from human embryonic stem cell-derived primitive hematopoietic cells in the absence of erythropoietin. Kitasato Med. J. 41:42-49, (2011)
  7. Kaneko S, Otsu M, and *Nakauchi H: Reprogramming of adult hematopoietic cells. Curr. Opinion. in Hematol. 17:271-5, (2010)
  8. Kaneko S, Mastaglio S, *Bondanza A, Ponzoni M, Sanvito F, Aldrighetti L, Radrizzani M, La Seta-Catamancio S, Provasi E, Mondino A, Nagasawa T, Fleischhauer K, Russo V, Traversari C, Ciceri F, Bordignon C, and Bonini C: IL-7 and IL-15 allow the generation of suicide gene-modified alloreactive self-renewing central memory human T lymphocytes. Blood. 113: 1006-15, (2009)
  9. Sanuki S, Hamanaka S, Kaneko S, Otsu M, Karasawa S, Miyawaki A, Nakauchi H, Nagasawa T, and Onodera M: A new red fluorescent protein that allows efficient marking of murine hematopoietic stem cells. J Gene Med 10: 965-71, (2008)
  10. *Bonini C, Bondanza A, Perna SK, Kaneko S, Traversari C, Ciceri F and Bordignon C: The suicide gene therapy challenge: how to improve a successful gene therapy approach. Mol Ther 15:1248-52, (2007)
  11. Machino T, *Okoshi Y, Kaneko S, Obara N, Mukai HY, Suzukawa K, Hasegawa Y, Yamashita Y, Mori N, Kojima H, and Nagasawa T: Hepatosplenic alphabeta T-cell lymphoma successfully treated with allogeneic bone marrow transplantation. Bone Marrow Transplant 39:513-4, (2007)
  12. Muto H, *Kaneko S, Machino T, Okoshi Y, Mukai HY, Suzukawa K, Hasegawa Y, Imagawa S, Kojima H, Ishii Y, Hitomi S and Nagasawa T: Quinupristin/dalfopristin and voriconazole controlled Staphylococcus epidermidis pneumonia and chronic necrotizing aspergillosis in a patient with severe lung degradation consequent to multiple treatments for Hodgkin’s lymphoma. J Infect Chemother 12:391-5, (2006)
  13. Kaneko S, Nagasawa T, Nakauchi H and *Onodera M: An in vivo assay for retrovirally transduced human peripheral T lymphocytes using non-obese diabetic/ severe combined immunodeficiency mice. Exp. Hematol 33:35-41, (2005)
  14. Shinagawa A, *Kojima H, Berndt MC, Kaneko S, Suzukawa K, Hasegawa Y, Shigeta O, and Nagasawa T: Characterization of a myeloma patient with a life-threatening hemorrhagic diathesis: presence of a lambda dimer protein inhibiting shear-induced platelet aggregation by binding to the A1 domain of von Willebrand factor. Thromb Haemost. 93:889-96, (2005)
  15. *Kojima H, Hasegawa Y, Suzukawa K, Mukai HY, Kaneko S, Kobayashi T, Kamoshita M, Shinagawa A, Komeno T, Komatsu T, Mitsuhashi S, Kawachi Y, Yamashita Y, Mori N, and Nagasawa T: Clinicopathological features and prognostic factors of Japanese patients with "peripheral T-cell lymphoma, unspecified" diagnosed according to the WHO classification. Leuk Res. 28:1287-92, (2004)
  16. Yoshida C, *Kojima H, Ishigaki T, Katsura Y, Kaneko S, Suzukawa K, Hasegawa Y, Kawachi Y, Otsuka F, and Nagasawa T: Association of pyoderma gangrenosum and sterile osteomyelitis in a patient having myelodysplastic syndrome with der(1;7)(q10;q10). Eur J Haematol. 72:149-53, (2004)
  17. Suzuki A, Obi K, Urabe T, Hayakawa H, Yamada M, Kaneko S, Onodera M, Mizuno Y, and *Mochizuki H: Feasibility of ex vivo gene therapy for neurological disorders using the new retroviral vector GCDNsap packaged in the vesicular stomatitis virus G protein. J Neurochem. 82: 953-60, (2002)
  18. Osawa M, Yamaguchi T, Nakamura Y, Kaneko S, Onodera M, Sawada K, Jegalian A, Wu H, Nakauchi H, and *Iwama A: Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis. Blood 100:2769-2777.(2002)
  19. *Iwama A, Osawa M, Hirasawa R, Uchiyama N, Kaneko S, Onodera M, Shibuya K, Shibuya A, Vinson C, Tenen DG, and Nakauchi H: Reciprocal roles for CCAAT/enhancer binding protein (C/EBP) and PU.1 transcription factors in Langerhans cell commitment. J Exp Med 195:547-558, (2002)
  20. Suzuki A, Zheng YY, Kaneko S, Onodera M, Fukao K, Nakauchi H, and *Taniguchi H: Clonal identification and Characterization of self-renewing pluripotent stem cells in the developing liver. J Cell Biol 156:173-184, (2002)
  21. Kaneko S, *Onodera M, Fujiki Y, Nagasawa T, and Nakauchi H: The simplified retroviral vector GCsap with murine stem cell virus long terminal repeat allows high and continued expression of enhanced green fluorescent protein by human hematopoietic progenitors engrafted in non-obese diabetic/severe combined immunodeficiency mice. Hum Gene Ther12:35-44, (2001)
  22. *Yasukawa M, Hasegawa A, Sakai I, Ohminami H, Arai J, Kaneko S, Yakushijin Y, Maeyama K, Nakashima H, Arakaki R, and Fujita S: Down-regulation of CXCR4 by human herpesvirus 6 (HHV-6) and HHV-7. J Immunol 162:5417-5422, (1999)
  23. Ohminami H, *Yasukawa M, Kaneko S, Yakushijin Y, Abe Y, Kasahara Y, Ishida Y, and Fujita S: Fas-independent and nonapoptotic cytotoxicity mediated by a human CD4(+) T-cell clone directed against an acute myelogenous leukemia-associated DEK-CAN fusion peptide. Blood 93:925-935, (1999)
  24. *Yasukawa M, Ohminami H, Kaneko S, Yakushijin Y, Nishimura Y, Inokuchi K, Miyakuni T, Nakao S, Kishi K, Kubonishi I, Dan K, and Fujita S: CD4(+) cytotoxic T-cell clones specific for bcr-abl b3a2 fusion peptide augment colony formation by chronic myelogenous leukemia cells in a b3a2-specific and HLA-DR-restricted manner. Blood 92:3355-3361, (1998)
  25. Kaneko S, Nagata M, Takemura H, Yuhara T, Akama T, Suzuki H, *Yamane K, and Kashiwagi H: Gelatinous transformation of bone marrow with pancytopenia in an emaciated patient with systemic lupus erythematosus. Jpn J Rheumatol 8:167-173, (1998