Dept. of Life Science Frontiers
By researching cell behaviors at the molecular level using iPS cell technology, the goal of the Department of Life Science Frontiers is to create new platforms for medical therapies. For instance, researchers at the department are elucidating the pathogenesis of cancer and the mechanisms of the immune system and development. In addition, the department is creating new biotechnologies to explore fundamental questions about cell growth and development.
Head : Shinya Yamanaka
Dept. of Cell Growth and Differentiation
The Department of Cell Growth and Differentiation seeks to develop methods for inducing pluripotent cells, such as iPSCs and ESCs, toward specific cell fates, such as mesenchymal tissue (bone, etc.) cells, cardiovascular lineages, neurons, and liver and pancreatic cells. In addition, using model organisms, we conduct preclinical studies of the safety and efficacy of somatic cells differentiated from iPSCs for transplantation into various tissues in the hopes of contributing to the development of effective iPS cell therapies.
Head : Junya Toguchida
Dept. of Clinical Application
The Department of Clinical Applications generates iPSCs from somatic cells generously donated to CiRA by patients afflicted with various genetic conditions and use these cells to induce differentiation into various cell types as a platform for the study of disease etiology and mechanisms of pathology. We further use patient-derived iPSCs in the search for and testing of candidate drug compounds and therapies.
Head : Jun Takahashi
Dept. of Fundamental Cell Technology
The Department of Fundamental Cell Technology investigates issues regarding the regulation and oversight of research aimed towards future therapies using iPSCs. In addition to overseeing the operations of the Facility for iPS Cell Therapy (FiT), which maintains and provides clinical-grade iPSCs, we also work to develop culture methods for the generation of cells of assured quality. We further provide technical and facility support to other CiRA labs. The division both strives to establish reliable methods for iPS cell generation and maintenance within the institute, and to provide guidance for other researchers working with these cells around the world.
Head : Naoko Takasu
Drug Discovery Technology Development Office Head : Tatsutoshi Nakahata
Builds a platform for drug discovery using iPS cell and provides support for iPS cell drug screening
Common Equipment Management Office Head : Naoki Harada
Manages shared equipments at CiRA
Information Security Office Head : Koji Eto
Manages information security at CiRA
Uehiro Research Div. for iPS Cell Ethics
This division is devoted to the bioethics involving iPS cell research and application.