Research Activities

Research Activities

Home › Research Activities › Principal Investigators › Shinya Yamanaka (Professor)

Principal Investigators

Dept. of Life Science Frontiers 
Shinya Yamanaka (Professor)

Shinya Yamanaka M.D., Ph.D

[ Lab Website ]

Research Overview

iPS cells can be differentiated into almost all cell types of the adult body and have the ability to grow nearly limitlessly. In other words, reprogramming allows us to take one somatic cell and make it into another. Currently, technical development aimed at the generation of iPS cells is moving forward not only at CiRA, but all over the world. Techniques for producing iPS cells have become quite diverse, such as transgenesis and the combination of derived tissue and induction factors. Differences in these production methods have given rise to differences in the nature, safety and efficient production of iPS cells. Therefore, to realize the application of iPS cells in drug discovery and regenerative medicine, we have been working to establish safe and effective iPS cells and designing evaluation techniques that can serve as a global standard. Until now, we established a method of iPS cell culture that poses little risk of malignant transformation and does not include animal-derived constituents. We have now begun to disseminate this method. In addition, we found that during reprogramming, cells go through a state resembling the primitive streak, which is an important process in development. The Department of Life Science Frontiers are engaged in research associated with elucidating the phenomenon of life and the mechanism of reprogramming somatic cells into iPS cells.

Chimera mice derived from Nanog-iPS cells
Progeny of chimeric mice derived from Nanog-iPS cells (F1)

Chimera mice derived from Nanog-iPS cells
Progeny of chimeric mice derived from Nanog-iPS cells (F1)

Human iPS cells
iPS cells derived from adult human dermal fibroblasts

Human iPS cells
iPS cells derived from adult human dermal fibroblasts

Chimeric mice derived from Myc-iPS cells
Chimeric mice obtained by blastocyst injection of Myc-iPS cells that are derived from mouse embryonic fibroblasts (left, green) or adult tail-tip fibroblasts (right, red)

Chimeric mice derived from Myc-iPS cells
Chimeric mice obtained by blastocyst injection of Myc-iPS cells that are derived from mouse embryonic fibroblasts (left, green) or adult tail-tip fibroblasts (right, red)

Cardiomyocytes differentiated from Human iPS cells (beating) Movie
Chimera mice derived from Nanog-iPS cells
Progeny of chimeric mice derived from Nanog-iPS cells (F1)
Nanog-iPS
Human iPS cells
iPS cells derived from adult human dermal fibroblasts
iPS
Chimeric mice derived from Myc-iPS cells
Chimeric mice obtained by blastocyst injection of Myc-iPS cells that are derived from mouse embryonic fibroblasts (left, green) or adult tail-tip fibroblasts (right, red)
Myc- iPS????????
go top