Publications

Watanabe Y, Kimura I, Hashimoto R, Sakamoto A, Yasuhara N, Yamamoto T, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Sato K, Takayama K

Virological characterization of the 2022 outbreak-causing monkeypox virus using human keratinocytes and colon organoids Journal of Medical Virology, 2023 Jun;95(6):e28827.

Tamura T, Ito J, Uriu K, Zahradnik J, Kida I, Anraku Y, Nasser H, Shofa M, Oda Y, Lytras S, Nao N, Itakura Y, Deguchi S, Suzuki R, Wang L, Begum MM, Kita S, Yajima H, Sasaki J, Sasaki-Tabata K, Shimizu R, Tsuda M, Kosugi Y, Fujita S, Pan L, Sauter D, Yoshimatsu K, Suzuki S, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Yamamoto Y, Nagamoto T, Schreiber G, Maenaka K, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Hashiguchi T, Ikeda T, Fukuhara T, Saito A, Tanaka S, Matsuno K, Takayama K, Sato K

Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants Nature Communications, 2023 May 16;14(1):2800.

Hashimoto R, Tamura T, Watanabe Y, Sakamoto A, Yasuhara N, Ito H, Nakano M, Fuse H, Ohta A, Noda T, Matsumura Y, Nagao M, Yamamoto T, Fukuhara T, Takayama K

Evaluation of broad anti-coronavirus activity of autophagy-related compounds using human airway organoids Molecular Pharmaceutics, 2023 Apr 3;20(4):2276-2287.

Deguchi S, Kosugi K, Hashimoto R, Sakamoto A, Yamamoto M, Rafal K, Gee P, Negoro R, Noda T, Yamamoto T, Torisawa Y, Nagao M, Takayama K

Elucidation of the liver pathophysiology of COVID-19 patients using liver-on-a-chips PNAS Nexus, 2023 Mar 7;2(3):pgad029.

Bodie NM., Hashimoto R., Connolly D., Chu J., Takayama K., Uhal BD.

Design of a chimeric ACE-2/Fc-silent fusion protein with ultrahigh affinity and neutralizing capacity for SARS-CoV-2 variants Antib Ther, 2023 Jan 20;6(1):59-74.

Morita M., Yoneda A., Tokunoh N., Masaki T., Shirakura K., Kinoshita M., Hashimoto R., Shigesada N., Takahashi J., Tachibana M., Tanaka S., Obana M., Hino N., Ikawa M., Tsujikawa K., Ono C., Matsuura Y., Kidoya H., Takakura N., Kubota Y., Doi T., Takayama K., Yoshioka Y., Fujio Y., Okada Y

Upregulation of Robo4 expression by SMAD signaling suppresses vascular permeability and mortality in endotoxemia and COVID-19 models Proc Natl Acad Sci U S A., 2023 Jan 17;120(3):e2213317120.

Deguchi S, Takayama K.

State-of-the-art liver disease research using liver-on-a-chip Inflamm Regen., 2022 Dec 9;42(1):62.

Yi R., Hashimoto R., Sakamoto A., Matsumura Y., Nagao M., Takahashi K., Takayama K.

Exocyst complex component 2 is a potential host factor for SARS-CoV-2 infection iScience., 2022 Nov 18;25(11):105427.

Saito A, Tamura T, Zahradnik J, Deguchi S, Tabata K, Kimura I, Ito J, Nasser H, Toyoda M, Nagata K, Uriu K, Kosugi Y, Fujita S, Yamasoba D, Shofa M, Begum MM, Oda Y, Suzuki R, Ito H, Nao N, Wang L, Tsuda M, Yoshimatsu K, Yamamoto Y, Nagamoto T, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Ueno T, Schreiber G, Takaori-Kondo A,G2P-Japan Consortium, Shirakawa K, Sawa H, Irie T, Takayama K, Matsuno K, Tanaka S, Ikeda T, Fukuhara T, Sato K

Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 Cell Host & Microbe, 2022 Nov 9;30(11):1540-1555.e15.

Wang M, Tsuda M, Deguchi S, Higuchi Y, So K, Torisawa Y, Takayama K, Yamashita F

Application of perfluoropolyether elastomers in microfluidic drug metabolism assays International Journal of Pharmaceutics, 2022 Nov 5;627:122253.

Hassan SS., Kodakandla V., Redwan EM., Lundstrom K., Choudhury PP., Serrano-Aroca Á., Azad GK., Aljabali AAA., Palu G., El-Aziz TMA., Barh D., Uhal BD., Adadi P., Takayama K., Bazan NG., Tambuwala M., Sherchan SP., Lal A.,Chauhan G., Baetas-da-Cruz W., Uversky VN.

Non-uniform aspects of the SARS-CoV-2 intraspecies evolution reopen question of its origin Int J Biol Macromol., 2022 Dec 1;222(Pt A):972-993.

Hashimoto R., Takahashi J., Shirakura K., Funatsu R., Kosugi K., Deguchi S., Yamamoto M., Tsunoda Y., Morita M., Muraoka K., Tanaka M., Kanbara T., Tanaka S., Tamiya S., Tokunoh N., Kawai A., Ikawa M., Ono C., Tachibana K., Kondoh M., Obana M., Matsuura Y., Ohsumi A., Noda T., Yamamoto T., Yoshioka Y., Torisawa YS., Date H., Fujio Y., Nagao M., Takayama K., Okada Y.

SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression Sci Adv., 2022 Sep 23;8(38):eabo6783.

Sasaki Y., Tatsuoka H., Tsuda M., Sumi T., Eguchi Y., So K., Higuchi Y., Takayama K., Torisawa Y., Yamashita F.

Intestinal permeability of drugs in Caco-2 cells cultured in microfluidic devices Biol. Pharm. Bull, 2022;45(9):1246-1253.

Bakshi HA., Faruck HL., Ravesh Z., Ansari P., Hannan JMA., Hashimoto R., Takayama K., Farzand R., Nasef MM., Mensah A.Aljabali AAA., Mishra V., Charbe NB., Goyal R., Negi P., Serrano-Aroca Á., Bahar B., El-Tanani M., Courtenay AJ., McCarron P., Jack IG., Tambuwala MM.

Therapeutic potential of cannabinoids on tumor microenvironment: a molecular switch in neoplasia transformation Integr Cancer Ther, 2022 Jan-Dec;21:15347354221096766.

Sano E., Suzuki T., Hashimoto R., Itoh Y., Sakamoto A., Sakai Y., Saito A., Okuzaki D., Motooka D., Muramoto Y., Noda T., Takasaki T., Sakuragi J., Minami S., Kobayashi T., Yamamoto T., Matsumura Y., Nagao M., Okamoto T.^*, Takayama K.^*

Cell response analysis in SARS-CoV-2 infected bronchial organoids Communications Biology, 2022 May 30; 5. 516.
*Corresponding author

Negoro R., Tasaka M., Deguchi S., Takayama K., Fujita T.

Generation of HepG2 cells with high expression of multiple drug-metabolizing enzymes for drug discovery research using a PITCh system Cells, 2022 May 18;11(10):1677.

Redwan EM, Elrashdy F, Aljabali AAA, Baetas-da-Cruz W, Barh D, Brufsky AM, Hassan SS, Lundstrom K, Serrano-Aroca Á, Takayama K, Tambuwala MM, Uhal BD, Uversky VN

Would new SARS-CoV-2 variants change the war against COVID-19? Epidemiologia, 2022 Apr 29;3(2):229-237.

Kojima H., Yagi H., Kushige H., Toba Y., Takayama K., Masuda S., Morisaku T., Tsuchida T., Kuroda K., Hirukawa K., Inui J., Nishi K., Nakano Y., Tanaka M., Hori S., Hasegawa Y., Abe Y., Kitago M., Adachi S., Tomi M., Matsuura K., Mizuguchi H., Kitagawa Y.

Decellularized organ-derived scaffold is a promising carrier for human induced pluripotent stem cells-derived hepatocytes Cells, 2022 Apr 7;11(8):1258.

Cano-Vicent A., Hashimoto R., Takayama K.^*, Serrano-Aroca Á.^*

Biocompatible films of calcium alginate inactivate enveloped viruses such as SARS-CoV-2 Polymers (Basel)., 2022 Apr 6;14(7):1483.
*Corresponding author

Hassan SS., Kodakandla V., Redwan EM., Lundstrom K., Pal Choudhury P., Abd El-Aziz TM., Takayama K., Kandimalla R., Lal A., Serrano-Aroca Á., Azad GK., Aljabali AAA., Palù G., Chauhan G., Adadi P., Tambuwala M., Brufsky AM., Baetas-da-Cruz W., Barh D., Azevedo V., Bazan NG., Andrade BS., Santana Silva RJ., Uversky VN.

An issue of concern: Unique truncated ORF8 protein variants of SARS-CoV-2 PeerJ, 2022 Mar 21;10:e13136.

Tsuji S., Minami S., Hashimoto R., Konishi Y., Suzuki T., Kondo T., Sasai M., Torii S., Ono C., Shichinohe S., Sato S., Wakita M., Okumura S., Nakano S., Matsudaira T., Matsudaira T., Matsumoto T., Kawamoto S., Yamamoto M., Watanabe T., Matsuura Y., Takayama K., Kobayashi T., Okamoto T., Hara E.

SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response Nature Aging, 2, pages 115-124 (2022)

Tanaka T., Saito A., Suzuki T., Miyamoto Y., Takayama K., Okamoto T., Moriishi K.

Establishment of a stable SARS-CoV-2 replicon system for application in high-throughput screening Antiviral Res., 2022 Mar 7;199:105268.

Shahcheraghi SH., Ayatollahi J., Lotfi M., Aljabali AAA., Al-Zoubi MS., Panda PK., Mishra V., Satija S., Charbe NB., Serrano-Aroca Á., Bahar B., Takayama K., Goyal R., Bhatia A., Almutary AG., Alnuqaydan AM., Mishra Y., Negi P., Courtney A., McCarron PA., Bakshi HA., Tambuwala MM.

Gene therapy for neuropsychiatric disorders: potential targets and tools CNS Neurol Disord Drug Targets, 2022 Mar 4. doi: 10.2174/1871527321666220304153719. (review)

Hassan SS., Choudhury PP., Dayhoff GW., Aljabali AAA., Uhal BD., Lundstrom K., Rezaei N., Pizzol D., Adadi P., Lal A., Soares A., Abd El-Aziz TM., Brufsky AM., Azad GK., Sherchan SP., Baetas-da-Cruz W., Takayama K., Serrano-Aroca Ã., Chauhan G., Palu G., Mishra YK., Barh D., Santana Silva RJ., Andrade BS., Azevedo V., Góes-Neto A., Bazan NG., Redwan EM., Tambuwala M., Uversky VN.

The importance of accessory protein variants in the pathogenicity of SARS-CoV-2. Arch Biochem Biophys., 2022 Mar 15;717:109124.

Hassan SS., Lundstrom K., Serrano-Aroca Á., Adadi P., Aljabali AAA., Redwan EM., Lal A., Kandimalla R., El-Aziz TMA., Pal Choudhury P., Azad GK., Sherchan SP., Chauhan G., Tambuwala M., Takayama K., Barh D., Palu G., Basu P., Uversky VN.

Emergence of unique SARS-CoV-2 ORF10 variants and their impact on protein structure and function Int J Biol Macromol., 2022 Jan 1;194:128-143.

Takayama K., Tuñón-Molina A., Cano-Vicent A., Muramoto Y., Noda T., Aparicio-Collado JL., Sabater I Serra R., Martí M., Serrano-Aroca Á.^*

Non-woven infection prevention fabrics coated with biobased cranberry extracts inactivates enveloped viruses such as SARS-CoV-2 and multidrug-resistant bacteria Int J Mol Sci., 2021 Nov 24;22(23):12719.
*Corresponding author

Tuñón-Molina A., Takayama K., Redwan EM., Uversky VN., Andrés J., Serrano-Aroca Á.

Protective face masks: current status and future trends ACS Appl Mater Interfaces., 2021 Dec 8;13(48):56725-56751. (review)

Hashimoto R., Sakamoto A., Deguchi S., Yi R., Sano E., Hotta A., Takahashi K., Yamanaka S., Takayama K.^*

Dual inhibition of TMPRSS2 and Cathepsin B prevents SARS-CoV-2 infection in iPS cells Mol Ther Nucleic Acids., 2021 Dec 3;26:1107-1114.
*Corresponding author

Barh D., Tiwari S., Gabriel Rodrigues Gomes L., Weener ME., Alzahrani KJ., Alsharif KF., Aljabali AAA., Tambuwala MM., Lundstrom K., Hassan SS., Serrano-Aroca Á., Takayama K., Ghosh P., Redwan EM., Silva Andrade B., Soares SC., Azevedo V., Uversky VN.

Potential molecular mechanisms of rare anti-tumor immune response by SARS-CoV-2 in isolated cases of lymphomas Viruses, 2021 Sep 25;13(10):1927. (review)

Hassan SS., Lundstrom K., Barh D., Silva RJS., Andrade BS., Azevedo V., Choudhury PP., Palu G., Uhal BD., Kandimalla R., Seyran M., Lal A., Sherchan SP., Azad GK., Aljabali AAA., Brufsky AM., Serrano-Aroca Á., Adadi P., Abd El-Aziz TM., Redwan EM., Takayama K., Rezaei N., Tambuwala M., Uversky VN.

Implications derived from S-protein variants of SARS-CoV-2 from six continents Int J Biol Macromol., 2021 Nov 30;191:934-955.

Hassan SS., Basu P., Redwan EM., Lundstrom K., Choudhury PP., Serrano-Aroca Á., Azad GK., Aljabali AAA., Palu G., Abd El-Aziz TM., Barh D., Uhal BD., Adadi P., Takayama K., Bazan NG., Tambuwala MM., Lal A., Chauhan G., Baetas-da-Cruz W., Sherchan SP., Uversky VN.

Periodically aperiodic pattern of SARS-CoV-2 mutations underpins the uncertainty of its origin and evolution Environ Res., 2022 Mar;204(Pt B):112092.

Sano E., Deguchi S., Matsuoka N., Tsuda M., Wang M., Kosugi K., Mori C., Yagi K., Wada A., Yamasaki S., Kawai T., Yodogawa M., Mizuguchi H., Nakazawa N., Yamashita F., Torisawa YS.^*, Takayama K.^*

Tetrafluoroethylene-propylene elastomer-based liver-on-a-chip resistant to drug absorption ACS Omega, 2021 Sep 15;6(38):24859-24865.
*Corresponding author

Elrashdy F., Tambuwala MM., Hassan SS., Adadi P., Seyran M., Abd El-Aziz TM., Rezaei N., Lal A., Aljabali AAA., Kandimalla R., Bazan NG., Azad GK., Sherchan SP., Choudhury PP., Serrano-Aroca Á., Takayama K., Chauhan G., Pizzol D., Barh D., Panda PK., Mishra YK., Palù G., Lundstrom K., Redwan EM., Uversky VN.

Autoimmunity roots of the thrombotic events after COVID-19 vaccination Autoimmun Rev., 2021 Nov;20(11):102941. (review)

Cano-Vicent A., Tuñón-Molina A., Martí M., Muramoto Y., Noda T., Takayama K.^*, Serrano-Aroca A.^*

Antiviral face mask functionalized with solidified hand soap: low-cost infection prevention clothing against enveloped viruses such as SARS-CoV-2 ACS Omega, 2021 Sep 2;6(36):23495-23503.
*Corresponding author

Tuñón-Molina A., Martí M., Muramoto Y., Noda T., Takayama K.*, and Serrano-Aroca A.^*

Antimicrobial face shield: next generation of facial protective equipment against SARS-CoV-2 and multidrug-resistant bacteria Int J Mol Sci., 2021 Sep 1;22(17):9518.
*Corresponding author

Aljabali AAA., Pal K., Serrano-Aroca A., Takayama K., Dua K., Tambuwala MM.

Clinical utility of novel biosensing platform: Diagnosis of coronavirus SARS-CoV-2 at point of care Mater Lett., 2021 Dec 1;304:130612. (review)

Deguchi S., Serrano-Aroca Á., Tambuwala MM., Uhal BD., Brufsky AM., Takayama K.^*

SARS-CoV-2 research using human pluripotent stem cells and organoids Stem Cells Transl Med., 2021 Nov;10(11):1491-1499.
*Corresponding author (review)

Deguchi S., Tsuda M., Kosugi K., Sakamoto A., Mimura N., Negoro R., Sano E., Nobe T., Maeda K., Kusuhara H., Mizuguchi H., Yamashita F., Torisawa YS.^*, Takayama K.^*

Usability of polydimethylsiloxane-based microfluidic devices in pharmaceutical research using human hepatocytes ACS Biomater Sci Eng., 2021 Aug 9;7(8):3648-3657.
*Corresponding author

Shrivastava G., Aljabali AA., Shahcheraghi SH., Lotfi M., Shastri MD., Shukla SD., Chellappan DK., Jha NK., Anand K., Dureja H., Pabari RM., Mishra V., Almutary AG., Alnuqaydan AM., Charbe N., Prasher P., Negi P., Goyal R., Dua K., Gupta G., Serrano-Aroca Á., Bahar B., Barh D., Panda PK., Takayama K., Lundstorm K., McCarron P., Bakshi H., Tambuwala MM.

Targeting LIN28: a new hope in prostate cancer theranostics Future Oncol., 2021 Oct;17(29):3873-3880. (review)

Redwan EM., Alghamdi MF., El-Aziz TMA., Adadi P., Aljabali AAA., Attrish D., Azad GK., Baetas-da-Cruz W., Barh D., Bazan NG., Brufsky AM., Chauhan G., Hassan SKS., Kandimalla R., Lal A., Lundstrom K., Mishra YK., Choudhury PP., Palù G., Panda PK., Pizzol D., Rezaei N., Serrano-Aroca Á., Sherchan SP., Seyran M., Takayama K., Tambuwala MM., Uhal BD., Uversky VN.

The mechanism behind flaring/triggering of autoimmunity disorders associated with COVID-19 Autoimmun Rev., 2021 Oct;20(10):102909. (review)

Lundstrom K., Barh D., Uhal B., Takayama K., Aljabali A., El-Aziz T., Lal A., Redwan E., Adadi P., Chauhan G., Sherchan S., Azad G., Rezaei N., Serrano-Aroca A., Bazan N., Hassan S., Panda P., Choudhury P., Pizzol D., Kandimalla R., Baetas-da-Cruz W., Mishra Y., Palu G., Brufsky A., Tambuwala M., Uversky V.

COVID-19 vaccines and thrombosis - roadblock or dead-end street? Biomolecules, 2021 Jul 13;11(7):1020. (review)

Serrano-Aroca Á., Takayama K., Tuñón-Molina A., Seyran M., Hassan SS., Pal Choudhury P., Uversky VN., Lundstrom K., Adadi P., Palù G., Aljabali AAA., Chauhan G., Kandimalla R., Tambuwala MM., Lal A., Abd El-Aziz TM., Sherchan S., Barh D., Redwan EM., Bazan NG., Mishra YK., Uhal BD., Brufsky A.

Carbon-based nanomaterials: promising antiviral agents to combat COVID-19 in the microbial-resistant era. ACS Nano., 2021 May 25;15(5):8069-8086. (review)

Sano E., Deguchi S., Sakamoto A., Mimura N., Hirabayashi A., Muramoto Y., Noda T., Yamamoto T., Takayama K.^*

Modeling SARS-CoV-2 infection and its individual differences with ACE2-expressing human iPS cells. iScience, 2021 May 21;24(5):102428.
*Corresponding author

Shahcheraghi SH., Aljabali AAA., Al Zoubi MS., Mishra V., Charbe NB., Haggag YA., Shrivastava G., Almutary AG., Alnuqaydan AM., Barh D., Dua K., Chellappan DK., Gupta G., Lotfi M., Serrano-Aroca Á., Bahar B., Mishra YK., Takayama K., Panda PK., Bakshi HA., Tambuwala MM.

Overview of key molecular and pharmacological targets for diabetes and associated diseases Life Sci., 2021 May 18;278:119632. (review)

Hassan SS., Attrish D., Ghosh S., Choudhury PP., Uversky VN., Aljabali AAA., Lundstrom K., Uhal BD., Rezaei N., Seyran M., Pizzol D., Adadi P., Soares A., Abd El-Aziz TM., Kandimalla R., Tambuwala MM., Azad GK., Sherchan SP., Baetas-da-Cruz W., Lal A., Palù G., Takayama K., Serrano-Aroca Á., Barh D., Brufsky AM.

Notable sequence homology of the ORF10 protein introspects the architecture of SARS-CoV-2 Int J Biol Macromol., 2021 Jun 30;181:801-809.

Hassan SS., Aljabali AAA., Panda PK., Ghosh S., Attrish D., Choudhury PP., Seyran M., Pizzol D., Adadi P., Abd El-Aziz TM., Soares A., Kandimalla R., Lundstrom K., Lal A., Azad GK., Uversky VN., Sherchan SP., Baetas-da-Cruz W., Uhal BD., Rezaei N., Chauhan G., Barh D., Redwan EM., Dayhoff GW., Bazan NG., Serrano-Aroca Á., El-Demerdash A., Mishra YK., Palu G., Takayama K., Brufsky AM., Tambuwala MM.

A unique view of SARS-COV-2 through the lens of ORF8 protein Comput Biol Med., 2021 Jun;133:104380.

Ichikawa M., Akamine H., Murata M., Ito S., Takayama K., Mizuguchi H.

Generation of tetracycline-controllable CYP3A4-expressing Caco-2 cells by the piggyBac transposon system Sci Rep., 2021 Jun 3;11(1):11670.

Deguchi S., Shintani T., Harada K., Okamoto T., Takemura A. Hirata K., Ito K., Takayama K.^*, Mizuguchi H.^*

In vitro model for a drug assessment of cytochrome P450 family 3 subfamily a member 4 substrates using human induced pluripotent stem cells and genome editing technology Hepatol Commun., 2021 May 5;5(8):1385-1399.
*Corresponding author

Yamashita T., Takayama K.^*, Mizuguchi H.

Generation of hepatocytes from human ES/iPS cells for regenerative medicine Springer Book: Cell-Inspired Materials and Engineering (edited by Dr. Daniel Packwood), 2021 Apr pp 3-26 (review).
*corresponding author

Inoue C., Negoro R., Takayama K., Mizuguchi H., Sakurai F.

Asymmetric profiles of infection and innate immunological responses in human iPS cell-derived small intestinal epithelial-like cell monolayers following infection with mammalian reovirus Virus Research, 2021 Apr 15;296:198334.

Takayama K., Ito K., Matsui A., Yamashita T., Kawakami K., Hirayama D., Kishimoto W., Nakase H., Mizuguchi H.

In vivo gene expression profile of human intestinal epithelial cells: from the viewpoint of drug metabolism and pharmacokinetics Drug Metab Dispos., 2021 Mar;49(3):221-232.

Ichikawa M., Negoro R., Kawai K., Yamashita T., Takayama K., Mizuguchi H.

Vinblastine treatment enhances the intestinal functions and decreases the undifferentiated cell contamination of human iPS cell-derived intestinal epithelial-like cells Mol Ther Methods Clin Dev., 2021 Jan 20;20:463-472.

Martí M., Tuñón-Molina A., Aachmann F., Muramoto Y., Noda T., Takayama K.^*, Serrano-Aroca A.^*

Protective face mask filter capable of inactivating SARS-CoV-2, and methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis Polymers, 2021 Jan 8;13(2):207.
*corresponding author

Hassan SS., Ghosh S., Attrish D., Choudhury P., Uversky V., Uhal B., Lundstrom K., Rezaei N., Aljabali A., Seyran M., Pizzol D., Adadi P., Soares A., Mohamed T., Kandimalla R., Tambuwala M., Azad G., Sherchan S., Baetas-da-Cruz W., Takayama K., Serrano-Aroca A., Chauhan G., Palu G., Brufsky A.

Possible transmission flow of SARS-CoV-2 based on ACE2 features Molecules. 2020 Dec 13;25(24):5906.

Seyran M., Takayama K., Lal A., Uversky V., Lundstrom K, Palù G., Sherchan S., Attrish D., Rezaei N., Aljabali A., Ghosh S., Pizzol D., Chauhan G., Adadi O., El-Aziz T., Soares A., Kandimalla R., Tambuwala M., Hassan S., Azad G., ChoudhuryP., Baetas-da-Cruz W., Serrano-Aroca A., Brufsky A., Uhal B.

The Structural Basis of Accelerated Host Cell Entry by SARS-CoV-2 FEBS Journal, 2020 Dec 2;10.1111/febs.15651.

Takayama K., Weaver L., Rocha E., Sardo V., Gehart H., Vu L.

Introductions to the Community: Early-Career Researchers in the Time of COVID-19 Cell Stem Cell. 2020 Dec 3;27(6):853-855. (Voices)

Takayama K.^*

In vitro and Animal Models for SARS-CoV-2 research Trends Pharmacol Sci. 2020 Aug;41(8):513-517.
*corresponding author

Hagihara Y., Sakamoto A., Tokuda T., Yamashita T., Ikemoto S., Kimura A., Haruta M., Sasagawa K., Ohta J., Takayama K.^*, Mizuguchi H.^*

Photoactivatable oncolytic adenovirus for optogenetic cancer therapy Cell Death Dis. 2020 Jul 23;11(7):570.
*corresponding author

Suzuki T., Itoh Y., Sakai Y., Saito A., Okuzaki D., Motooka D., Minami S., Kobayashi T., Yamamoto T., Okamoto T., Takayama K.

Generation of human bronchial organoids for SARS-CoV-2 research bioRxiv, doi:10.1101/2020.05.25.115600

Negoro R.¹, Kawai K.¹, Ichikawa M., Deguchi S., Takayama K.^*, Mizuguchi H.^*

Establishment of MDR1/ABCB1-knockout human induced pluripotent stem cell line Drug Metab Pharmacokinet. 2020 Jun;35(3):288-296.
*corresponding author, 1equally contributed

Deguchi S., Takayama K.^*, Mizuguchi H.^*

Generation of human iPS cell-derived hepatocyte-like cells for cellular medicine Biol Pharm Bull. 2020;43(4):608-615. (review)
^*corresponding author

Toba Y., Deguchi S., Mimura N., Sakamoto A., Harada K., Hirata K., Takayama K.^*, Mizuguchi H.^*

Comparison of commercially available media for hepatic differentiation and hepatocyte maintenance PLoS One. 2020 Feb 27;15(2):e0229654.
^*corresponding author

Kiso A.¹, Toba Y.¹, Tsutsumi S., Deguchi S., Igai K., Koshino S., Tanaka Y., Takayama K.^*, Mizuguchi H.^*

Tolloid‐like 1 negatively regulates hepatic differentiation of human induced pluripotent stem cells through transforming growth factor beta signaling Hepatol Commun. 2020 Jan 2;4(2):255-267.
^*corresponding author, ¹equally contributed

Kawai K., Negoro R., Ichikawa M., Yamashita T., Deguchi S., Harada K., Hirata K., Takayama K.^*,
Mizuguchi H.^*

Establishment of SLC15A1/PEPT1-knockout human induced pluripotent stem cell line for intestinal drug absorption studies Molecular Therapy - Methods & Clinical Development, 2019 Nov 21;17:49-57.
^*corresponding author

Takayama K.^1,*, Negoro R.¹, Yamashita T., Kawai K, Ichikawa M, Mori T, Nakatsu N, Harada K, Ito S, Yamada H, Yamaura Y, Hirata K, Ishida S, Mizuguchi H.^*

Generation of human iPS cell-derived intestinal epithelial cell monolayers by CDX2 transduction Cellular and Molecular Gastroenterology and Hepatology, 2019 Jun 19;8(3):513-526.
^*corresponding author, ¹equally contributed

Deguchi S., Yamashita T., Igai K., Harada K., Toba Y., Hirata K., Takayama K.^*, Mizuguchi H.^*

Modeling of hepatic drug metabolism and responses in CYP2C19 poor metabolizer using genetically manipulated human iPS cells Drug Metabolism and Disposition, 2019 Jun;47(6):632-638.
^*corresponding author

Toba Y., Kiso A., Nakamae S., Sakurai F., Takayama K.^*, Mizuguchi H.^*

FGF signal is not required for hepatoblast differentiation of human iPS cells Scientific Reports, 2019 Mar 6;9(1):3713.
^*corresponding author

Yamashita T., Takayama K.^*, Hori M., Harada-Shiba M., Mizuguchi H.

Pharmaceutical research for inherited metabolic disorders of the liver using human induced pluripotent stem cell and genome editing technologies Biol. Pharm. Bull.,2019;42(3):312-318. (review)
^*corresponding author

Negoro R., Takayama K.^*, Kawai K., Harada K., Sakurai F., Hirata K., Mizuguchi H.^*

Efficient generation of small intestinal epithelial-like cells from human iPS cells for drug absorption and metabolism studies Stem Cell Reports, 2018 Dec 11;11(6):1539-1550.
^*corresponding author

Matoba N.¹, Yamashita T.¹, Takayama K.^*, Sakurai F., Mizuguchi H.^*

Optimal human iPS cell culture method for efficient hepatic differentiation Differentiation, 2018 Sep 24;104:13-21.
¹equally contributed, ^*corresponding author

Takayama K.^*, Hagihara Y., Toba Y., Sekiguchi K., Sakurai F., Mizuguchi H^*.

Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research Biomaterials. 2018 Apr;161:24-32.
^*corresponding author

Nakamae S.¹, Toba Y.¹, Takayama K.^*, Sakurai F., Mizuguchi H^*.

Nanaomycin A treatment promotes hepatoblast differentiation from human iPS cells Stem Cells Dev., 2018 Mar 15;27(6):405-414.
^*corresponding author, ¹equally

Okamoto R.¹, Takayama K.¹, Akita N.¹, Nagamoto Y., Hosokawa D., Iizuka S., Sakurai F., Suemizu H., Ohashi K., Mizuguchi H.

Human iPS cell-based liver-like tissue engineering at extrahepatic sites in mice as a new cell therapy for Hemophilia B Cell Transplant. 2018 Feb;27(2):299-309.
¹equally contributed

Yamashita T., Takayama K.^*, Sakurai F., Mizuguchi H^*.

Billion-scale production of hepatocyte-like cells from human induced pluripotent stem cells Biochem Biophys Res Commun. 2018 Feb 19;496(4):1269-1275.
^*corresponding author

Takayama K.^*, Mizuguchi H^*.

Generation of optogenetically modified adenovirus vector for spatiotemporally controllable gene therapy ACS Chem Biol., 2018 Feb 16;13(2):449-454.
^*corresponding author

Nakamori D.¹, Akamine H.¹, Takayama K.¹, Sakurai F., Mizuguchi H.

Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction Scientific Reports, 2017 Nov 30;7(1):16675.
¹equally contributed

Takayama K.¹, Akita N.¹, Mimura N., Akahira R., Taniguchi Y., Ikeda M., Sakurai F., Ohara O., Morio T., Sekiguchi K., Mizuguchi H.

Generation of safe and therapeutically effective human induced pluripotent stem cell-derived hepatocyte-like cells for regenerative medicine Hepatology Communications, 2017 Oct 12;1(10):1058-1069.
¹equally contributed

Sakurai F., Kunito T., Takayama K., Hashimoto R., Tachibana M., Sakamoto N., Wakita T., Mizuguchi H.

Hepatitis C virus-induced innate immune responses in human iPS cell-derived hepatocyte-like cells Virus Research, 2017 Oct 15;242:7-15.

Lim J., Sakai E., Takayama K., Sakurai F., Mizuguchi H.

Overexpression of miR-27b negatively regulates expression of pluripotency-associated genes and hepatic differentiation in human induced pluripotent stem cells. Stem Cell Research & Therapeutics, 2018; 2(1): 88-97.

Mitani S.¹, Takayama K.¹, Nagamoto Y., Imagawa K., Sakurai F., Tachibana M., Sumazaki R., Mizuguchi H.

Human ESC/iPSC-Derived Hepatocyte-like Cells Achieve Zone-Specific Hepatic Properties by Modulation of WNT Signaling Molecular Therapy, 2017 Jun 7;25(6):1420-1433.
¹equally contributed

Sakurai F., Mitani S., Yamamoto T., Takayama K., Tachibana M., Watashi K., Wakita T., Iijima S., Tanaka Y., Mizuguchi H.

Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection Scientific Reports, 2017 Apr 4;7:45698.

Fukuda T., Takayama K., Hirata M., Liu Y., Yanagihara K., Suga M., Mizuguchi H., Furue M.

Isolation and expansion of human pluripotent stem cell-derived hepatic progenitor cells by growth factor defined serum-free culture conditions. Exp Cell Res., 2017 Mar 15;352(2):333-345.

Takayama K., Igai K., Hagihara Y., Hashimoto R., Hanawa M., Sakuma T., Tachibana M., Sakurai F., Yamamoto T., Mizuguchi H.

Highly efficient biallelic genome editing of human ES/iPS cells using a CRISPR/Cas9 or TALEN system Nucleic Acids Research, 2017 May 19;45(9):5198-5207.

Machitani M., Sakurai F., Wakabayashi K., Nakatani K., Takayama K., Tachibana M., Mizuguchi H.

Inhibition of CRISPR/Cas9-mediated genome engineering by a Type I interferon-induced reduction in guide RNA expression. Biol Pharm Bull, 2017;40(3):272-277.

Hanawa M., Takayama K., Sakurai F., Tachibana M., Mizuguchi H.

Hepatocyte Nuclear Factor 4 Alpha Promotes Definitive Endoderm Differentiation from Human Induced Pluripotent Stem Cells Stem Cells Reviews & Reports, 2017 Aug;13(4):542-551.

Imagawa K.¹, Takayama K.¹, Isoyama S., Tanikawa K., Shinkai M., Harada K., Tachibana M., Sakurai F., Noguchi E., Hirata K., Kage M., Kawabata K., Sumazaki R., Mizuguchi H.

Generation of a bile salt export pump deficiency model using patient-specific induced pluripotent stem cell-derived hepatocyte-like cells. Scientific Reports, 2017 Feb 2;7:41806. ¹equally contributed

Takayama K.^*, Mizuguchi H^*.

Generation of human pluripotent stem cell-derived hepatocyte-like cells for drug toxicity screening Drug Metabolism and Pharmacokinetics, 2017 Feb;32(1):12-20. (review)
^*corresponding author

Yanagihara K., Liu Y., Kanie K., Takayama K., Kokunugi M., Hirata M., Fukuda T., Suga M., Nikawa H., Mizuguchi H., Kato R., Furue M.

Prediction of Differentiation Tendency Toward Hepatocytes from Gene Expression in Undifferentiated Human Pluripotent Stem Cells Stem Cells Dev., 2016 Dec 15;25(24):1884-1897.

Takayama K.¹, Mitani S.¹, Nagamoto Y., Sakurai F., Tachibana M., Taniguchi Y., Sekiguchi K., Mizuguchi H.

Laminin 411 and 511 promote the cholangiocyte differentiation of human induced pluripotent stem cells Biochem Biophys Res Commun., 2016 May 20;474(1):91-6.
¹equally contributed

Negoro R.¹, Takayama K.¹, Nagamoto Y, Sakurai F., Tachibana M, Mizuguchi H.

Modeling of drug-mediated CYP3A4 induction by using human iPS cell-derived enterocyte-like cells Biochem Biophys Res Commun. 2016 Apr 15;472(4):631-636.
¹equally contributed

Nagamoto Y., Takayama K., Ohashi K., Okamoto R., Sakurai F., Tachibana M., Kawabata K., Mizuguchi M.

Transplantation of a human iPSC-derived hepatocyte sheet increases survival in mice with acute liver failure Journal of Hepatology, 2016 May;64(5):1068-1075.

Nakamori D.¹, Takayama K.¹, Nagamoto Y., Mitani S., Sakurai F., Tachibana M., Mizuguchi H.

Hepatic maturation of human iPS cell-derived hepatocyte-like cells by ATF5, c/EBPα, and PROX1 transduction Biochem Biophys Res Commun. 2016 Jan 15;469(3):424-429.
¹equally contributed

Ozawa T.¹, Takayama K.¹, Okamoto R., Negoro R., Sakurai F., Tachibana M., Kawabata K., Mizuguchi H.

Generation of enterocyte-like cells from human induced pluripotent stem cells for drug absorption and metabolism studies in human small intestine Scientific Reports, 2015 Nov 12;5:16479.
¹equally contributed

Minami H., Tashiro K., Okada A., Hirata N., Yamaguchi T., Takayama K., Mizuguchi H., Kawabata K.

Generation of brain microvascular endothelial-like cells from human induced pluripotent stem cells by co-culture with C6 glioma cells. PLoS One, 2015 Jun 10; 10(6): e0128890.

Tashiro K., Hirata N., Okada A., Yamaguchi T., Takayama K., Mizuguchi H., Kawabata K.

Expression of coxsackievirus and adenovirus receptor separates hematopoietic and cardiac progenitor cells in Flk1-expressing mesoderm. STEM CELL Transl Med., 2015 May;4(5):424-36.

Nagamoto Y., Takayama K., Tashiro K., Tateno C., Sakurai F., Tachibana M., Kawabata K., Ikeda K.,
Tanaka Y., Mizuguchi H.

Efficient Engraftment of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells in uPA/SCID Mice by Overexpression of FNK, a Bcl-xL Mutant Gene Cell Transplantation, 2015;24(6):1127-38.

Takayama K., Morisaki Y., Kuno S., Nagamoto Y., Harada K., Furukawa N., Ohtaka M., Nishimura K., Imagawa K., Sakurai F., Tachibana M., Sumazaki R., Noguchi E., Nakanishi M., Hirata K., Kawabata K., Mizuguchi H.

Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes Proc Natl Acad Sci U S A., 2014 Nov 25;111(47):16772-7.

Watanabe H.¹, Takayama K.¹, Inamura M., Tachibana M., Mimura N., Katayama K., Tashiro K.,
Nagamoto Y., Sakurai F., Kawabata K., Furue MK., Mizuguchi H.

HHEX promotes hepatic-lineage specification through the negative regulation of eomesodermin PLoS One, 2014 Mar 20;9(3):e90791. ¹equally contributed

Takayama K., Kawabata K., Nagamoto Y., Inamura M., Ohashi K., Okuno H., Yamaguchi T., Tashiro K., Sakurai F., Hayakawa T., Okano T., Furue MK., Mizuguchi H.

CCAAT/enhancer binding protein-mediated regulation of TGFβ receptor 2 expression determines the hepatoblast fate decision Development, 2014 Jan;141(1):91-100.

Takayama K., Nagamoto Y., Mimura N., Tashiro K., Sakurai F., Tachibana M., Hayakawa T., Kawabata K., Mizuguchi H.

Long-term self-renewal of human ES/iPS-derived hepatoblast-like cells on human laminin 111-coated dishes Stem Cell Reports, 2013 Oct 3;1(4):322-35.

Takayama K., Kawabata K., Nagamoto Y., Kishimoto K., Tashiro K., Sakurai F., Tachibana M., Kanda K., Hayakawa T., Furue MK., Mizuguchi H.

3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing Biomaterials, 2013 Feb;34(7):1781-9.

Takayama K., Inamura M., Kawabata K., Sugawara M., Kikuchi K., Higuchi M., Nagamoto Y., Watanabe H., Tashiro K., Sakurai F., Hayakawa T., Furue MK., Mizuguchi H.

Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction Journal of Hepatology, 2012 Sep;57(3):628-36.

Nagamoto Y., Tashiro K., Takayama K., Ohashi K., Kawabata K., Sakurai F., Tachibana M., Hayakawa T., Hayakawa H., Furue MK., Mizuguchi H.

The promotion of hepatic maturation of human pluripotent stem cells in 3D co-culture using type I collagen and Swiss 3T3 cell sheets Biomaterials, 2012 Jun;33(18):4526-34.

Kawabata K., Takayama K., Nagamoto Y., Saldon M.S., Higuchi M., Mizuguchi H.

Endodermal and hepatic differentiation from human embryonic stem cells and human induced pluripotent stem cells. J Stem Cell Res Ther., 2012 S10:002.doi: 10.4172/2157-7633.S10-002 (review)

Takayama K., Inamura M., Kawabata K., Katayama K., Higuchi M., Tashiro K., Nonaka A., Sakurai F., Hayakawa T., Furue MK., Mizuguchi H.

Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4α transduction Molecular Therapy, 2012 Jan;20(1):127-37.

Yoshida T.¹, Takayama K.¹, Kondoh M., Sakurai F., Tani H., Sakamoto N., Matsuura Y., Mizuguchi H.,
Yagi K.

Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for hepatocytes in hepatitis C virus infection Biochem Biophys Res Commun., 2011 Dec 9;416(1-2):119-24.
¹equally contributed

Takayama K., Inamura M., Kawabata K., Tashiro K., Katayama K., Hayakawa T., Furue MK., Mizuguchi H.

Efficient and directive generation of two distinct endoderm lineages from human ESCs and iPSCs by differentiation stage-specific SOX17 transduction PLoS One, 2011;6(7):e21780.

Inamura M., Kawabata K., Takayama K., Tashiro K., Sakurai F., Katayama K., Toyoda M., Akutsu H., Miyagawa Y., Okita H., Kiyokawa N., Umezawa A., Hayakawa T., Furue MK., Mizuguchi H.

Efficient generation of hepatoblasts from human ES cells and iPS cells by transient overexpression of homeobox gene HEX. Molecular Therapy, 2011 Feb;19(2):400-7.

Tashiro K., Kawabata K., Inamura M., Takayama K., Furukawa N., Sakurai F., Katayama K., Hayakawa H., Furue MK., Mizuguchi H.

Adenovirus vector-mediated efficient transduction into human embryonic and induced pluripotent stem cells Cell Reprogram., 2010 Oct;12(5):501-7.