Dept. of Clinical Application
Koji Eto (Professor)
Koji Eto M.D. Ph.D.
Multicellular organisms develop by producing a variety of cell types through asymmetric division. Hematopoietic stem cells and various blood lineage progenitor cells produce many types of blood cells this way to supply blood for a lifetime. To recapitulate this phenomenon in vitro, it is necessary to establish hematopoietic cells that can maintain self-renewal and differentiation abilities while also understanding the molecular mechanisms driving maturation of the cell types. We are performing research to establish technology that efficiently induces various blood cells, such as platelets and erythrocytes, from human pluripotent stem cells, which would lead to a blood transfusion system that greatly reduces the dependency on blood donors. We are also developing novel drug delivery systems (DDS) based on this research approach.
Overall, we are conducting basic and clinical research on iPS cell-derived platelet products (iPS platelets). In 2019, we began the world's first clinical study on iPS platelet transfusion.
Currently, we are analyzing the immune properties of universal iPS platelets that are effective for treating platelet transfusion refractoriness. These platelets are made from iPS cells supplied by the CiRA Foundation. In another part of this project, we are working on their large-scale manufacturing. In a separate project, we are studying the molecular mechanisms for deriving and maintaining non-platelet blood cell lineages from human pluripotent stem cells.