Dept. of Life Science Frontiers
Yoko Hamazaki (Professor)
Yoko Hamazaki Ph.D.
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The immune system protects our bodies against infectious diseases caused by pathogens. At the same time, it is responsible for immune rejection that occurs when organs are transplanted into a human body and is involved in the onset and pathology of various age-related diseases including cancers and lifestyle diseases.
Our laboratory studies the development and function of T cells, which act as the conductor of the immune system, and the thymic tissues, which is crucial for the differentiation and selection of T cells. We will strive to explore the fundamental principles of immunology and develop strategies for controlling immune reactions in order to advance medicine and medical applications.
- Development and functions of supporting cells for lymphohematopoietic tissues such as thymic epithelial cells, which play a central role in the differentiation and selection of T cells.
- Induction of thymic epithelial cells from iPS cells and reconstruction of thymic functions.
- Mechanisms of thymic involution and activation of thymic functions.
- Mechanism of immunosenescence and its association with age-related diseases.
- Regulation of the human immune system.