Dept. of Life Science Frontiers
Kazutoshi Takahashi (Associate Professor)
Kazutoshi Takahashi Ph.D.
Recent advances in technology have allowed us to detect things that have been overlooked in the past. As a result, the classical central dogma, which states "messenger RNA transcribed from DNA is translated into proteins that carry out cellular functions" has recently begun to be revised.
We are focusing on molecules that are not included in the dogma, such as unannotated small proteins and functional RNAs. These molecules are prime candidates for the "missing pieces" in explaining biological phenomena and molecular mechanisms.
With this new perspective, we aim to unravel the mysteries of cell fate determination using pluripotent stem cells as a model. Our current projects are listed below.
■ Understanding the role of translation regulators in the maintenance of pluripotency
■ Approaching the cellular functions played by non-canonical translation and small proteins
■ Elucidating the roles of functional RNAs expressed in pluripotent stem cells
■ Recapitulating the pluripotency networks by combining functional screening and bioinformatics