Research Activities

Research Activities

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Principal Investigators

Dept. of Life Science Frontiers 
Takuya Yamamoto (Associate Professor)

Takuya Yamamoto Photo
Takuya Yamamoto Ph.D.
Research Overview

With iPS cell technology as a tool, our laboratory strives to open up new life science fields at the molecular and cellular level. In particular, we use cell fate-conversion processes, including iPS cell induction and senescence processes, as experimental systems. Using these systems, we aim to determine how information is extracted from DNA--the biological blueprint--and how the extracted information translates into cell functions and properties, with the ultimate goal of identifying the basic principles of life. Toward this goal, we employ various kind of technologies, including molecular biology, biochemistry, cellular biology, genetics, bioinformatics and imaging technologies, to perform integrated analysis of multilevel mechanisms regulating the expression and function of RNA transcribed from genomic DNA. We also seek to clarify relationships between multiple levels of regulatory mechanisms for chromosome higher-order structure, epigenetics, transcription, post-transcription modification, RNA secondary structure, and translation.

Multicellular organisms use intercellular communication to operate sophisticated cell regulation networks, which requires expression analysis supported by cell position data. The intracellular localization of RNA is thus also important in determining cell properties. We address these questions using a wide range of techniques to analyze gene expression while preserving intracellular spatial information.

Using comprehensive analysis technologies to clarify the multi-level
regulation mechanisms at work in cell fate-altering processes.

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