Dept. of Life Science Frontiers
Shinya Yamanaka (Professor)
Shinya Yamanaka M.D., Ph.D.
iPS cells are somatic cells in which certain factors were induced, thus converting them to a pluripotent state. Importantly, iPS cells can proliferate indefinitely and differentiate into just about any type of cell in the human body. Since the original creation of iPS cells, scientists have discovered multiple ways to generate them, but with these different methods come different levels of quality, safety and efficiency. Furthermore, even though we can make iPS cells, there is still much to learn about the fundamental mechanisms that lead to their creation.
These matters are crucial when considering global standards for the application of iPS cells to new medicines and therapies. As one example of this effort, we have established a generation method that lowers the risk of cancer and a feeder-free culture system.
The Department of Life Science Frontiers is focused on studying the reprogramming mechanisms and elucidating the phenomenon of life. In order to help realize regenerative medicine using pluripotent stem cells, our laboratory is researching post-transcriptional RNA regulation and protein translation regulation in the induction, proliferation, and differentiation of pluripotent stem cells. We also seek to elucidate the mechanisms of reprogramming somatic cells to pluripotent stem cells and the mechanisms determining differentiation potential and differentiation resistance.
Yamanaka Lab hosts graduate students enrolled in the Graduate School of Medicine, Kyoto University. For students who wish to apply to be accepted to the Yamanaka Lab, they must first obtain an approval from Dr. Shinya Yamanaka prior to applying for the entrance examination and be accepted into the Graduate School of Medicine, Kyoto University.
For more information about the procedures for acceptance of graduate students at Yamanaka Lab, please visit Graduate Program at CiRA.