Research Activities

Research Activities

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Principal Investigators

Dept. of Clinical Application 
Shimpei Gotoh (Professor)

Publications

Muramoto Y, Takahashi S, Halfmann PJ, Gotoh S, Noda T, Kawaoka Y

Omicron variants BA.5 and BQ.1.1 lack efficient replicative capacity at elevated temperatures. Lancet Microbe., 2023 Apr 24;S2666-5247(23)00100-3.

Xu Y, Feng G, Yano T, Masuda S, Nagao M, Gotoh S, Ikejiri M, Tanabe M, Takeuchi K

Characteristic genetic spectrum of primary ciliary dyskinesia in Japanese patients and global ethnic heterogeneity: population-based genomic variation database analysis. J Hum Gen., 2023 Mar 2. doi: 10.1038/s10038-023-01142-4.

Tamai K, Sakai K, Yamaki H, Moriguchi K, Igura K, Maehana S, Suezawa T, Takehara K, Hagiwara M, Hirai T, Gotoh S

iPS cell-derived mesenchymal cells that support alveolar organoid development. Cell Rep Methods., 2022 Sep 19;2(10):100314.

Masui A, Hirai T, Gotoh S

Perspectives of future lung toxicology studies using human pluripotent stem cells. Archives of Toxicology, 2022 Feb; 96(2):389-402. Review

Suezawa T, Kanagaki S, Moriguchi K, Masui A, Nakao K, Toyomoto M, Tamai K, Mikawa R, Hirai T, Murakami K, Hagiwara M, Gotoh S.

Disease modeling of pulmonary fibrosis using human pluripotent stem cell-derived alveolar organoids. Stem Cell Reports, 2021 Dec 14;16(12):2973-2987.

Suezawa T, Kanagaki S, Korogi Y, Nakao K, Hirai T, Murakami K, Hagiwara M, Gotoh S.

Modeling of lung phenotype of Hermansky-Pudlak syndrome type I using patient-specific iPSCs. Respiratory Research, 2021 Nov 4;22(1):284.

Ikeo S, Yamamoto Y, Ikeda K, Sone N, Korogi Y, Tomiyama L, Matsumoto H, Hirai T, Hagiwara M,
Gotoh S.

Core-shell hydrogel microfiber-expanded pluripotent stem cell-derived lung progenitors applicable to lung reconstruction in vivo. Biomaterials, 2021 Sep; 276:121031.

Sone N, Konishi S, Igura K, Tamai K, Ikeo S, Korogi Y, Kanagaki S, Namba T, Yamamoto Y, Xu Y, Takeuchi K, Adachi Y, Chen-Yoshikawa TF, Date H, Hagiwara M, Tsukita S, Hirai T, Torisawa Y, Gotoh S.

Multicellular modeling of ciliopathy by combining iPS cells and microfluidic airway-on-a-chip technology. Science Translational Medicine, 2021 Jul 7; 13(601): eabb1298.

Kanagaki S, Suezawa T, Moriguchi K, Nakao K, Toyomoto M, Murakami K, Hagiwara M, Gotoh S.

Hydroxypropyl cyclodextrin improves amiodarone-induced aberrant lipid homeostasis of alveolar cells. American Journal of Respiratory Cell and Molecular Biology, 2021 Apr; 64(4): 504-514.

Kanagaki S, Ikeo S, Suezawa T, Yamamoto Y, Seki M, Hirai T, Hagiwara M, Suzuki Y, Gotoh S.

Directed induction of alveolar type I cells derived from pluripotent stem cells via Wnt signaling inhibition. Stem Cells, 2020 Feb; 39(2): 156-169.

Korogi Y, Gotoh S, Ikeo S, Yamamoto Y, Sone N, Tamai K, Konishi S, Nagasaki T, Matsumoto H, Ito I, Chen-Yoshikawa TF, Date H, Hagiwara M, Asaka I, Hotta A, Mishima M, Hirai T.

In vitro disease modeling of Hermansky-Pudlak Syndrome type 2 using human induced pluripotent stem cell-derived alveolar organoids. Stem Cell Reports, 2019 Mar 5; 12: 431-440.

Yamamoto Y, Gotoh S, Korogi Y, Seki M, Konishi S, Ikeo S, Sone N, Nagasaki T, Matsumoto H, Muro S, Ito I, Hirai T, Kohno T, Suzuki Y, Mishima M.

Long-term expansion of alveolar stem cells derived from human iPS cells in organoids. Nature Methods, 2017 Nov; 14(11):1097-1106.

Konishi S, Gotoh S, Tateishi K, Yamamoto Y, Korogi Y, Nagasaki T, Matsumoto H, Muro S, Hirai T, Ito I, Tsukita S, Mishima M.

Directed induction of functional multi-ciliated cells in proximal airway epithelial spheroids from human pluripotent stem cells. Stem Cell Reports, 2016 Jan; 6(1): 18-25.

Gotoh S, Ito I, Nagasaki T, Yamamoto Y, Konishi S, Korogi Y, Matsumoto H, Muro S, Hirai T, Funato M, Mae S, Toyoda T, Sato-Otsubo A, Ogawa S, Osafune K, Mishima M.

Generation of alveolar epithelial spheroids via isolated progenitor cells from human pluripotent stem cells. Stem Cell Reports, 2014 Sep 9; 3(3): 394-403.
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