Dept. of Clinical Application
Makoto Ikeya (Associate Professor)
Makoto Ikeya Ph.D.
The medical applications of iPS cells include cell therapy, disease modeling, and drug discovery using healthy or patient-derived iPS cells. The development of an easy and reproducible induction method is indispensable for all applications.
Our laboratory has developed methods for inducing differentiation into cells that have been considered difficult to induce, or cells that require a simpler and more efficient induction method. In particular, we emphasize insights from developmental biology, i.e., the development of stepwise induction methods by recapitulating the in vivo environment, as well as the development of stem cell maintenance culture methods for each developmental stage. Currently, neural crest cells, somite cells, and mesenchymal stem cells are our focused cell types, and our interest ranges widely from basic to application. Our technologies have been applied to research of fibrodysplasia ossificans progressive (FOP), a rare and intractable disease in which ectopic bones are formed within muscle tissue.
Through these initiatives, we aim to develop new therapies, particularly for intractable diseases.
Keywords: developmental stem cells, mesenchymal stem cells, neural crest cells, somite, disease-specific iPS cells, ectopic bone formation, osteocyte, chondrocyte