Research Activities

Research Activities

Home › Research Activities › Principal Investigators › Haruhisa Inoue (Professor)

Principal Investigators

Dept. of Cell Growth and Differentiation 
Haruhisa Inoue (Professor)

Publications

Egawa N, Izumi Y, Suzuki H, Tsuge I, Fujita K, Shimano H, Izumikawa K, Takahashi N, Tsukita K, Enami T, Nakamura M, Watanabe A, Naitoh M, Suzuki S, Seki T, Kobayashi K, Tida T, Kaji R, Takahashi R, Inoue H.

TDP-43 regulates cholesterol biosynthesis by inhibiting sterol regulatory element-binding protein 2. Scientific Reports, 12:7988, 2022

Kondo T, Hara N, Koyama S, Yada Y, Tsukita K, Nagahashi A, Ikeuchi T, Ishii K, Asada T, Arai T, Yamada R, Alzheimer's Disease Neuroimaging Initiative (ADNI), Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI) & Inoue H.

Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer's disease patients. Nature Aging 2:125-139, 2022.

Kondo T, Yamamoto T, Okayama K, Narumi H, Inoue H.

Metabolites of soil microorganisms modulate amyloid β production in Alzheimer's neurons. Scientific Reports 12(1):2690, 2022

Suong D, Imamura K, Inoue I, Kabai R, Sakamoto S, Okumura T, Kato Y, Kondo T, Yada Y, Klein WL, Watanabe A, Inoue H.

Induction of inverted morphology in brain organoids by vertical-mixing bioreactors. Communications Biology 4(1):1213, 2021

Imamura K, Yada Y, Izumi Y, Morita M, Kawata A, Arisato T, Nagahashi A, Enami T, Tsukita K , Kawakami H, Nakagawa M, Takahashi R, Inoue H.

Prediction Model of Amyotrophic Lateral Sclerosis by Deep Learning with Patient Induced Pluripotent Stem Cells. Annals of Neurology 89(6):1226-1233, 2021.

Karagiannis P, Muotri A, Inoue H.

Reprogramming the brain in and out of diseased states. Molecular and Cellular Neuroscience 110:103571, 2020

Karagiannis P, Inoue H.

ALS, a cellular whodunit on motor neuron degeneration. Molecular and Cellular Neuroscience 107:103524, 2020

Hidaka T, Imamura K, Hioki T, Takagi T, Giga Y, Giga M, Nishimura Y, Kawahara Y, Hayashi S, Niki T, Fushimi M, Inoue H.

Prediction of Compound Bioactivities using Heat Diffusion Equation. Patterns 1(9) 100140, 2020 

Takeuchi H, Imamura K, Ji B, Tsukita K, Enami T, Takao K, Miyakawa T, Hasegawa M, Sahara N, Iwata N, Inoue M, Tabira T, Hara H, Ono M, Trojanowski J, Lee V, Takahashi R, Suhara T, Higuchi M, Inoue H.

Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice. NPJ Vaccines, 5(1):28,2020 

Tsuburaya N, Homma K, Higuchi T, Balia A, Yamakoshi H, Shibata N, Nakamura S, Nakagawa H, Ikeda SI, Umezawa N, Kato N, Yokoshima S, Shibuya M, Shimonishi M, Kojima H, Okabe T, Nagano T, Naguro I, Imamura K, Inoue H, Fujisawa T, Ichijo H.

A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model. Nature Communications 9(1):2668, 2018

Komatsu K, Imamura K, Yamashita H, Julien JP, Takahashi R, Inoue H

Overexpressed wild-type superoxide dismutase 1 exhibits amyotrophic lateral sclerosis-related misfolded conformation in induced pluripotent stem cell-derived spinal motor neurons. Neuroreport 29(1):25-29, 2018

Kondo T, Imamura K, Funayama M, Tsukita K, Miyake M, Ohta A, Woltjen K, Nakagawa M, Asada T,
Arai T, Kawakatsu S, Izumi Y, Kaji R, Iwata N, Inoue H.

iPSC-Based Compound Screening and In Vitro Trials Identify a Synergistic Anti-amyloid β Combination for Alzheimer's Disease. Cell Reports 21(8):2304-2312, 2017.

Matsuzono K, Imamura K, Murakami N, Tsukita K, Yamamoto T, Izumi Y, Kaji R, Ohta Y, Yamashita T,
Abe K, Inoue H.

Antisense Oligonucleotides Reduce RNA Foci in Spinocerebellar Ataxia 36 Patient iPSCs. Molecular Therapy - Nucleic Acids 8:211-219, 2017

Shi Y, Inoue H, Wu J, Yamanaka S.

Induced pluripotent stem cell technology: a decade of progress. Nature Reviews Drug Discovery, 16:115-130, 2017

Imamura K, Izumi Y, Watanabe A, Tsukita K, Woltjen K, Yamamoto T, Hotta A, Kondo T, Kitaoka S, Ohta A, Tanaka A, Watanabe D, Morita M, Takuma H, Tamaoka A, Kunath T, Wray S, Furuya H, Era T, Makioka K, Okamoto K, Fujisawa T, Nishitoh H, Homma K, Ichijo H, Julien JP, Obata N, Masato H, Akiyama H, Kaneko S, Ayaki T, Ito H, Kaji R, Takahashi R, Yamanaka S, Inoue H.

The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis. Science Translational Medicine 9(391):eaaf3962, 2017.

Murakami N, Imamura K, Izumi Y, Egawa N, Tsukita K, Enami T, Yamamoto T, Kawarai T, Kaji R, Inoue H.

Proteasome impairment in neural cells derived from HMSN-P patient iPSCs. Molecular Brain, 15;10(1):7, 2017

Goto K, Imamura K, Komatsu K, Mitani K, Aiba K, Nakatsuji N, Inoue M, Kawata A, Yamashita H, Takahashi R, Inoue H.

Simple derivation of spinal motor neurons from ESCs/iPSCs using Sendai virus vectors. Molecular Therapy - Methods & Clinical Development 10(4):115-125, 2017

Imamura K, Sahara N, Kanaan KM, Tsukita K, Kondo T, Kutoku Y, Ohsawa Y, Sunada Y, Kawakami K, Hotta A, Yawata S, Watanabe D, Hasegawa M, Trojanowski J, Q Lee, V MY, Suhara T, Higuchi M, Inoue H.

Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons. Scientific Reports 6:34904, 2016

Inoue H. Nagata N, Kurokawa H, Yamanaka S.

iPS cells: A game changer for future medicine. The EMBO Journal 33(5):409-417, 2014

Kondo T, Funayama M, Tsukita K, Hotta A, Yasuda A, Nori S, Kaneko S, Nakamura M, Takahashi R,
Okano H, Yamanaka S, Inoue H.

Focal transplantation of human iPSC-derived glial-rich neural progenitors improves lifespan of ALS mice. Stem Cell Reports 3:1-8, 2014.

Kondo T, Asai M, Tsukita K, Kutoku Y, Ohsawa Y, Sunada Y, Imamura K, Egawa N, Yahata N, Okita K, Takahashi K, Asaka I, Aoi T, Watanabe A, Watanabe K, Kadoya C, Nakano R, Watanabe D, Maruyama K, Hori O, Hibino S, Choshi T, Nakahata T, Hioki H, Kaneko T, Naitoh M, Yoshikawa K, Yamawaki S, Suzuki S, Hata R, Ueno S, Seki T, Kobayashi K, Toda T, Murakami K, Irie K, Klein WL, Mori H, Asada T, Takahashi R, Iwata N, Yamanaka S, Inoue H.

Modeling Alzheimer's Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness. Cell Stem Cell 12(4): 487-496, 2013

Egawa N, Kitaoka S, Tsukita K, Naitoh M, Takahashi K, Yamamoto T, Adachi F, Kondo T, Okita K, Asaka I, Aoi T, Watanabe A, Yamada Y, Morizane A, Takahashi J, Ayaki T, Ito H, Yoshikawa K, Yamawaki S, Suzuki S, Watanabe D, Hioki H, Kaneko T, Makioka K, Okamoto K, Takuma H, Tamaoka A, Hasegawa K, Nonaka T, Hasegawa M, Kawata A, Yoshida M, Nakahata T, Takahashi R, Marchetto MC, Gage FH, Yamanaka S, Inoue H.

Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells. Science Translational Medicine 4(145):145ra104, 2012

Wada T, Goparaju SK, Tooi N, Inoue H, Takahashi R, Nakatsuji N, Aiba K.

Amyotrophic Lateral Sclerosis Model Derived from Human Embryonic Stem Cells Overexpressing Mutant Superoxide Dismutase 1. Stem Cells Translational Medicine 1(5): 396-402, 2012

Yahata N, Asai M, Kitaoka S, Takahashi K, Asaka I, Hioki H, Kaneko T, Maruyama K, Saido TC,
Nakahata T, Asada T, Yamanaka S, Iwata N, Inoue H.

Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease. PLoS ONE 6(9): e25788, 2011

Inoue H, Yamanaka S.

The Use of Induced Pluripotent Stem Cells in Drug Development. Clinical Pharmacology & Therapeutics 89(5): 655-661, 2011

Takeuchi H, Iba M, Inoue H, Higuchi M, Takao K, Tsukita K, Karatsu Y, Iwamoto Y, Miyakawa T, Suhara T, Trojanowski JQ, Lee VMY, Takahashi R.

P301S Mutant Human Tau Transgenic Mice Manifest Early Symptoms of Human Tauopathies with Dementia and Altered Sensorimotor Gating. PLoS ONE 6(6), 2011

Murakami G, Inoue H, Tsukita K, Asai Y, Amagai Y, Aiba K, Shimogawa H, Uesugi M, Nakatsuji N, Takahashi R.

Chemical Library Screening Identifies a Small Molecule That Downregulates SOD1 Transcription for Drugs to Treat Amyotrophic Lateral Sclerosis. The Journal of Biomolecular Screening 16(4): 405-414, 2011

Inoue H, Tsukita K, Iwasato T, Suzuki Y, Tomioka M, Tateno M, Nagao M, Kawata A, Saido TC, Miura M, Misawa H, Itohara S, Takahashi R.

The crucial role of caspase-9 in the disease progression of transgenic ALS mouse model. EMBO J 22(24): 6665-6674, 2003

Chui DH, Tanahashi H, Ozawa K, Ikeda S, Checler F, Ueda O, Suzuki H, Araki W, Inoue H, Shirotani K, Takahashi K, Gallyas F, Tabira T.

Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation. Nature Medicine 5: 560-564, 1999
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