Research Activities

Research Activities

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Principal Investigators

Dept. of Life Science Frontiers 
Mio Iwasaki (Junior Associate Professor)

Publications

Mio Iwasaki, Yuka Kawahara, Chikako Okubo, Tatsuya Yamakawa, Michiko Nakamura, Tsuyoshi Tabata, Yohei Nishi, Megumi Narita, Akira Ohta, Hirohide Saito, Takuya Yamamoto, Masato Nakagawa, Shinya Yamanaka, Kazutoshi Takahashi

Multi-omics approach reveals post-transcriptionally regulated genes are essential for human pluripotent stem cells. iScience, 11(1) 24254-24254 (2022)

Takahashi K., Okubo C., Nakamura M., Iwasaki M., Kawahara Y., Tabata T., Miyamoto Y. Wolthen K., Yamanaka S.

A stress-reduced passaging technique improves the viability of human pluripotent cells. Cell Reports Methods, p100155. (2022).

Iwasaki M.

Development of Basic Proteomics Technology Using Monolithic Silica Columns and Its Application to Analysis of Pluripotent Stem Cells. Proteome Letters, 2021, Volume 6, Issue 2, p61-68, https://doi.org/10.14889/jpros.6.2_61 (2022)

Iwasaki M., Kawahara Y., Tabata Y., Nishi Y., Narita M., Ohta A., Saito H., Yamamoto T., Nakagawa M., Yamanaka S., Takahashi K.

Post-transcriptionally regulated genes are essential for pluripotent stem cell survival. bioRxiv, doi: https://doi.org/10.1101/2021.10.18.462967 (2021)

Nakajima T., Nakahata A., Yamada N., Yoshizawa K., Kato T.M., Iwasaki M., Zhao C., Kuroki H., Ikeya M.

Grafting of iPS cell-derived tenocytes promotes motor function recovery after Achilles tendon rupture. Nature communications, Vol. 12(1), 5012-5012 (2021)

Kimura A., Toyoda T., Iwasaki M., Hirama R., Osafune K.

Combined Omics Approaches Reveal the Roles of Non-canonical WNT7B Signaling and YY1 in the Proliferation of Human Pancreatic Progenitor Cells. Cell Chem Biol., Vol. 27(12), p1561-p1572.e7. (2020)

Takahashi K., Jeong D., Wang S., Narita M., Jin X., Iwasaki M., Perli S.D., Conklin B.R., Yamanaka S.

Critical roles of translation initiation and RNA uridylation in endogenous retroviral expression and neural differentiation in pluripotent stem cells. Cell Reports, 2020 Jun 2;31(9):107715. (2020)

Gee P., Lung M.S.Y., Okuzaki Y., Sasakawa N., Iguchi T., Makita Y., Hozumi H., Miura Y., Yang LF., Iwasaki M., Wang WH., Waller MA., Shirai N., Abe YO., Fujita Y., Watanabe K., Kagita A., Iwabuchi KA., Yasuda M., Xu H., Noda T., Komano J., Sakurai H., Inukai N., Hotta A.

Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping. Nature communications, Vol. 11, 1334 (2020)

Iwasaki M., Ishihama Y.

Proteomic analysis data of human induced pluripotent stem cells and human fibroblast cells. Journal of Proteome Data and Methods, Vol.1 p2 - 3 (2019)

Iwasaki M.*, Tabata T., Kawahara Y., Ishihama Y., Nakagawa M.

Removal of interference MS/MS spectra for accurate quantification in isobaric tag-based proteomics. Journal of proteome research, Vol. 18, p2535-p2544 (2019)

Moriya Y., Kawano S., Okuda S., Watanabe Y., Matsumoto M., Takami T., Kobayashi D., Yamanouchi Y., Araki N., Yoshizawa AC., Tabata T., Iwasaki M., Sugiyama N., Tanaka S., Goto S., Ishihama Y.

The jPOST environment: an integrated proteomics data repository and database. Nucleic acids research, Vol. 47, D1218-D1224 (2019)

Ito Y., Nakamura S., Sugimoto N., Shigemori T., Kato Y., Ohno M., Sakuma S., Ito K., Kumon H., Hirose H., Okamoto H., Nogawa M., Iwasaki M., Kihara S., Fujio K., Matsumoto T., Higashi N., Hashimoto K., Sawaguchi A., Harimoto K., Nakagawa M., Yamamoto T., Handa M., Watanabe N., Nishi E., Arai F., Nishimura S., Eto K.

Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production. Cell, Vol. 174, p636-p648 (2018)

Ikeda T., Uchiyama I., Iwasaki M., Sasaki T., Nakagawa M., Okita K., Masui S.

Artificial acceleration of mammalian cell reprogramming by bacterial proteins. Genes to Cells, Vol. 22, p918-p928 (2017)

Kuang Y., Miki K., Parr C.J.C., Hayashi K., Takei I., Li J., Iwasaki M., Nakagawa M., Yoshida Y., Saito H.

Efficient, Selective Removal of Human Pluripotent Stem Cells via Ecto-Alkaline Phosphatase-Mediated Aggregation of Synthetic Peptides. Cell chemical biology, Vol. 24, p685-p694 (2017)

Sugiyama H., Takahashi K., Yamamoto T., Iwasaki M., Narita M., Nakamura M., Rand TA., Nakagawa M., Watanabe A., Yamanaka S.

Nat1 promotes translation of specific proteins that induce differentiation of mouse embryonic stem cells. Proceedings of the National Academy of Sciences of the U. S. A., Vol. 114, p340-p345 (2017)

Mitchell C.J., Getnet D., Kim M.S., Manda S.S., Kumar P., Huang T.C., Pinto S.M., Nirujogi R.S., Iwasaki M. Shaw P.G., Wu X., Zhong J., Chaerkady R., Marimuthu A., Muthusamy B., Sahasrabuddhe N.A., Raju R., Bowman C., Danilova L., Cutler J., Kelkar D.S., Drake C.G., Prasad TS.K, Marchionni L., Murakami P.N., Scott A.F., Shi L., Thierry-Mieg J., Thierry-Mieg D., Irizarry R., Cope L., Ishihama Y., Wang C., Gowda H., Pandey A.

A multi-omic analysis of human naïve CD4+ T cells. Pandey A. BMC Systems Biology, Vol. 9:75, p1-p16 (2015)

Iwasaki M., Ishihama Y.

Challenges Facing Complete Human Proteome Analysis. Chromatography, Vol. 35(2), p73-p80, (2014)

Yamana R., Iwasaki M., Wakabayashi M., Nakagawa M., Yamanaka S., Ishihama Y.

Rapid and deep profiling of human induced pluripotent stem cell proteome by one-shot nanoLC-MS/MS analysis with meter-scale monolithic silica columns. Journal of Proteome Research, Vol. 12(1), p214-p221 (2013)

Iwasaki M., Sugiyama N., Tanaka N, Ishihama Y.

Human proteome analysis by using reversed phase monolithic silica capillary columns with enhanced sensitivity. Journal of Chromatography A, Vol. 1228, p292-p297 (2012)

Iwasaki M, Miwa S, Ikegami T, Tomita M, Tanaka N, Ishihama Y*.

One-dimensional capillary liquid chromatographic separation coupled with tandem mass spectrometry unveils the Escherichia coli proteome on a microarray scale. Analytical Chemistry, Vol. 82(7), p2616-p2620 (2010)

Iwasaki M, Masuda T, Tomita M, Ishihama Y.

Chemical cleavage-assisted tryptic digestion for membrane proteome analysis. Journal of Proteome Research, Vol. 8(6), p3169-p3175 (2009)
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