Dept. of Life Science Frontiers
Mio Iwasaki (Junior Associate Professor)
Mio Iwasaki Ph.D.
The human body is composed of cells with various functions. Where do the different functions originate? In cells, proteins are produced from RNA, which is transcribed from DNA. Proteins play the most important role in cells. However, since RNA is much easier to study experimentally than proteins, cell characteristics have traditionally been explained based on information about the type and amount of RNA. However, it is now known that there is not necessarily a proportional relationship between the amount of RNA and protein, and that the cellular position and modification state of proteins differ depending on the cell type. We are working on technological development of proteome analysis to comprehensively measure and analyze proteins in cells. We are also using this technique to focus on protein dynamics in stem cells.
We are working on the following research topics.
1: Elucidation of a gene cluster that differ significantly in RNA and protein amount
2: Elucidation of novel protein amount control mechanism
3: Better methods for comprehensive identification and quantification of proteins
In the future, we aim to understand the cells and tissues based on the network information of all molecules, such as DNA, RNA, proteins, and metabolites.