Research Activities

Research Activities

Home › Research Activities › Principal Investigators › Yasuhiro Takashima (Junior Associate Professor)

Principal Investigators

Dept. of Life Science Frontiers 
Yasuhiro Takashima (Junior Associate Professor)

Publications

Io S, Iemura Y, Takashima Y*.

Optimized protocol for naive human pluripotent stem cell-derived trophoblast induction. STAR Protocols 2021; 2(4), 100921 DOI:10.1016/j.xpro.2021.100921

Kishimoto K, Shimada A, Shinohara H, Takahashi T, Yamada Y, Higuchi Y, Yoneda N, Suemizu H, Kawai K, Kurotaki Y, Hanazawa K, Takashima Y, Sasaki E.

Establishment of novel common marmoset embryonic stem cell lines under various conditions. Stem Cell Res 2021; 53 102252 DOI: 10.1016/j.scr.2021.102252

Takahashi K, Nakamura M, Okubo C, Kliesmete Z, Ohnuki M, Narita M, Watanabe A Ueda M,
Takashima Y, Hellmann I, Yamanaka S.

The pluripotent stem cell-specific transcript ESRG is dispensable for human pluripotency. PLoS Genet, 2021; 17(5) e1009587 DOI: 10.1371/journal.pgen.1009587

Io, S., Kabata, M., Iemura, Y., Semi, K., Morone, N., Minagawa, A., Wang, B., Okamoto, I., Nakamura, T., Kojima, Y., Iwatani,C., Tsuchiya, H., Kaswandy, B., Kondoh, E., Kaneko, S., Woltjen, K., Saitou, M., Yamamoto, T., Mandai, M., Takashima, Y*.

Capturing human trophoblast development with naive pluripotent stem cells in vitro. Cell Stem Cell. 2021; 28(6) 1023-1039. DOI: 10.1016/j.stem.2021.03.013
*corresponding author

Semi, K., and Takashima, Y*.

Pluripotent stem cells for the study of early human embryology. Dev Growth Differ, 2021; 63, 104-115. DOI: 10.1111/dgd.12715
*corresponding author

Huang M, Tailor J, Zhen Q, Gillmor AH, Miller ML, Weishaupt H, Chen J, Zheng T, Nash EK, McHenry LK, An Z, Ye F, Takashima Y, Clarke J, Ayetey H, Cavalli FMG, Luu B, Moriarity BS, Ilkhanizadeh S, Chavez L, Yu C, Kurian KM, Magnaldo T, Sevenet N, Koch P, Pollard SM, Dirks P, Snyder MP, Largaespada DA,
Cho YJ, Phillips JJ, Swartling FJ, Morrissy AS, Kool M, Pfister SM, Taylor MD, Smith A, Weiss WA.

Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis. Cell Stem Cell., 2019; 25(3) 433-446, DOI: 10.1016/j.stem.2019.05.013

Stefano BD, Ueda M, Sabri S, Brumbaugh J, Huebner A, Sahakyan A, Clement K, Clowers KJ, Erickson A, Shioda K, Gygi SP, Gu H, Shioda T, MeissnerA, Takashima Y, Kathrin Plath, Hochedlinger K.

Reduced MEK inhibition confers a growth advantage and improves genomic stability in naïve human ES cells. Nature Methods 2018; 15(9) 732-740 DOI: 10.1038/s41592-018-0104-1

Yu L, Li J, Hong J, Takashima Y, Fujimoto N, Nakajima M, Yamamoto A, Dong X, Dang Y, Hou Y, Yang W, Minami I, Okita K, Tanaka M, Luo C, Tang F, Chen Y, Tang C, Kotera H, Liu L.

Low Cell-Matrix Adhesion Reveals Two Subtypes of Human Pluripotent Stem Cells. Stem Cell Reports 2018; 11(1) 142-156, DOI: 10.1016/j.stemcr.2018.06.003

Karagiannis P, Takashima Y*.

Surface markers guide the journey towards naïve pluripotency Cell Stem Cell 2017; 20(6) 237-238
*corresponding author

Honda A, Kawano Y, Izu H, Choijookhuu N, Honsho K, Nakamura T, Yabuta Y, Yamamoto T, Takashima Y, Hirose M, Sankai T, Hishikawa Y, Ogura A, Saitou M.

Stem Cell Status after Subjecting Cynomolgus Monkey Pluripotent Stem Cells to Naïve Conversion.Scientific Reports . 28;7:45285. 2017

Takashima Y, Guo G, Loos R, Nichols J, Ficz G, Krueger F, Oxley D, Santos F, Clarke J, Mansfield W, Reik W, Bertone P and Smith A.

Resetting transcription factor control circuitry towards ground state pluripotency in human. Cell, 2014; 158(6):1254-69

Mohsen-Kanson T, Hafner AL, Wdziekonski B, Takashima Y, Villageois P, Carrière A, Svensson M, Bagnis C, Chignon-Sicard B, Svensson PA, Casteilla L, Smith A and Dani C.

Differentiation of human induced pluripotent stem cells into brown and white adipocytes: Role of Pax3.Stem Cells, 2014; 32(6):1459-67

Stricker S, Feber A, Engstrom PG, Caren H, Kurian KM, Takashima Y, Watts C, Way M, Dirks P, Bertone P, Smith A, Beck S, and Pollard SM.

Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner.Genes and Dev, 2013; 27(6):654-69

Falk A, Koch P, Kesavan J, Takashima Y, Ladewig J, Alexander M, Wiskow O, Tailor J, Trotter T, Pollard S, Smith A, Brüstle O.

Capture of neuroepithelial-like stem cells from pluripotent stem cells provides a versatile system for in vitro production of human neurons.PLOS ONE, 2012; 7:e29597

Camnasio S, Carri DA, Lombardo A, Grad I, Mariotti C, Castucci A, Rozell B, Riso PL, Castiglioni V, Zuccato C, Rochon C, Takashima Y, Diaferia G, Biunno I, Gellera C, Jaconi M, Smith A, Hovatta O, Naldini L, Donato SD, Feki A, Cattaneo E.

The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity.Neurobiol Dis. , 2012; 46(1):41-51

Nagare T, Sakaue H, Matsumoto M, Cao Y, Inagaki K, Sakai M, Takashima Y, Nakamura K, Mori T, Okada Y, Matsuki Y, Watanabe E, Ikeda K, Taguchi R, Kamimura N, Ohta S, Hiramatsu R, Kasuga M.

Overexpression of KLF15 Transcription Factor in Adipocytes of Mice Results in Down-regulation of SCD1 Protein Expression in Adipocytes and Consequent Enhancement of Glucose-induced Insulin Secretion. J Biol Chem., 2011; 286(43):37458-69

Moretti A, Bellin M, Jung CB, Thies TM, Takashima Y, Bernshausen A, Schiemann M, Fischer S, Moosmang S, Smith AG, Lam JT, Laugwitz KL.

Mouse and human induced pluripotent stem cells as a source for multipotent Isl1+ cardiovascular progenitors.FASEB J., 2010; 24(3):700-11

Zaragosi LE, Wdziekonski B, Villageois P, Keophiphath M, Maumus M, Tchkonia T, Bourlier V, Mohsen-Kanson T, Ladoux A, Elabd C, Scheideler M, Trajanoski Z, Takashima Y, Amri EZ, Lacasa D, Sengenes C, Ailhaud G, Clèment K, Bouloumie A, Kirkland JL, Dani C.

Activin a plays a critical role in proliferation and differentiation of human adipose progenitors.Diabetes., 2010; 59(10):2513-21

Takashima Y, Era T, Nakao K, Kondo S, Kasuga K, Smith AG, Nishikawa S.

Neuroepithelial cells supply an initial transient wave of MSC differentiation.Cell, 2007; 129(7): 1377 -88

Hikichi T, Wakayama S, Mizutani E, Takashima Y, Kishigami S, Van Thuan N, Ohta H, Bui HT, Nishikawa SI, Wakayama T.

Differentiation Potential of Parthenogenetic Embryonic Stem Cells is Improved by Nuclear Transfer. Stem Cells., 2007; 25(1): 46-53

Mori T, Sakaue H, Iguchi H, Gomi H, Okada Y, Takashima Y, Nakamura K, Nakamura T, Yamauchi T, Kubota N, Kadowaki T, Matsuki Y, Ogawa W, Hiramatsu R, Kasuga M.

Role of Kruppel-like factor 15 (KLF15) in transcriptional regulation of adipogenesis.J Biol Chem., 2005; 280(13):12867-75.

Sakaue H, Nishizawa A, Ogawa W, Teshigawara K, Mori T, Takashima Y, Noda T, Kasuga M.

Requirement for 3-phosphoinositide-kependent dinase-1 (PDK-1) in insulin-induced glucose uptake in immortalized brown adipocytes.J Biol Chem., 2003; 278(40):38870-4.

Takashima Y, Koide M, Fukunaga H, Iwai M, Miura M, Yoneda R, Fukuda T, Kobayashi K, Saheki T.

Recovery from marked altered consciousness in a patient with adult-onset type II citrullinemia diagnosed by DNA analysis and treated with a living related partial liver transplantation. Intern Med., 2002; 41(7):555-60
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