Research Overview

Creating RNA-based synthetic biological systems
RNA-Protein (RNP) complexes regulate gene expression, subcellular localization, and cell fate determination, thus playing a central role in various vital cellular functions.

We, therefore, postulate that a better understanding of the essential factors that regulate RNP formation, such as RNA sequences and structures, would enable the manipulation of cell fates and other cellular functions via artificial RNP complexes.

To achieve this goal, we take on the challenge of developing new technologies to understand and control living systems through synthetic biology and directed evolution based on RNA and RNPs. In turn, we will use these novel technologies to elucidate the mechanisms of cell fate determination and manipulate cell functions.

By utilizing technologies we have developed, we are working on the following research themes to uncover new findings in life science and medical research:

We train master's and doctoral students affiliated with the Graduate School of Medicine at Kyoto University to work on unique research projects and acquire techniques from RNA-based synthetic biology, molecular biology, stem cell biology, and bioengineering. In addition, we encourage students to perform joint research with researchers from different fields, both domestically and internationally, and to present their work at scientific conferences, aiming to foster leading researchers in the fields of medicine, life sciences, and engineering. After graduation, we hope they will contribute to society as excellent young talents in academia and other sectors.