Research Activities

Research Activities

Home › Research Activities › Principal Investigators › Jun K. Yamashita (Professor)

Principal Investigators

Dept. of Cell Growth and Differentiation 
Jun K. Yamashita (Professor)

Publications

Takeda M, Kanki Y, Masumoto H, Funakoshi S, Hatani T, Fukushima H, Izumi-Taguchi A, Matsui Y, Shimamura T, Yoshida Y, Yamashita JK.

Identification of Cardiomyocyte-Fated Progenitors from Human-Induced Pluripotent Stem Cells Marked with CD82. Cell Rep, 2018 Jan 9;22(2):546-556. doi: 10.1016/j.celrep.2017.12.057. PMID:29320747

Kawatou M, Masumoto H, Fukushima H, Morinaga G, Sakata R, Ashihara T, Yamashita JK.

Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue. Nat Commun, 2017 Oct 20;8(1):1078. doi: 10.1038/s41467-017-01125-y.

Kanki Y, Nakaki R, Shimamura T, Matsunaga T, Yamamizu K, Katayama S, Suehiro JI, Osawa T, Aburatani H, Kodama T, Wada Y, Yamashita JK, Minami T.

Dynamically and epigenetically coordinated GATA/ETS/SOX transcription factor expression is indispensable for endothelial cell differentiation. Nucleic Acids Res, 2017 Mar 17. doi: 10.1093/nar/gkx159.

Nakagawa Y, Nishikimi T, Kuwahara K, Fujishima A, Oka S, Tsutamoto T, Kinoshita H, Nakao K, Cho K, Inazumi H, Okamoto H, Nishida M, Kato T, Fukushima H, Yamashita JK, Wijnen WJ, Creemers EE, Kangawa K, Minamino N, Nakao K, Kimura T.

MiR30-GALNT1/2 Axis-Mediated Glycosylation Contributes to the Increased Secretion of Inactive Human Prohormone for Brain Natriuretic Peptide (proBNP) From Failing Hearts. J Am Heart Assoc, 2017 Feb 10;6(2). pii: e003601. doi: 10.1161/JAHA.116.003601.

Masumoto H, Yamashita JK.

Untiring steps toward the maturation of human stem cell-engineered heart tissue. Ann Transl Med, Ann Transl Med. 2017;5(4):87. (Commentary)

Takeichiro Nakane, Hidetoshi Masumoto, Joseph P. Tinney, Fangping Yuan, William J. Kowalski, Fei Ye, Amanda J. LeBlanc, Ryuzo Sakata, Jun K. Yamashita, Bradley B. Keller

Impact of Cell Composition and Geometry on Human Induced Pluripotent Stem Cells-Derived Engineered Cardiac Tissue. Scientific Reports, 3;7:45641, 2017. doi: 10.1038/srep45641.

Takeshi Ikuno, Hidetoshi Masumoto, Kohei Yamamizu, Miki Yoshioka, Kenji Minakata, Tadashi Ikeda, Ryuzo Sakata, Jun K Yamashita

Efficient and robust differentiation of endothelial cells from human induced pluripotent stem cells via lineage control with VEGF and cyclic AMP. PLoS One, 13;12(3):e0173271, 2017. doi: 10.1371/journal.pone.0173271.

Tian Z, Miyata K, Kadomatsu T, Horiguchi H, Fukushima H, Tohyama S, Ujihara Y, Okumura T, Yamaguchi S, Zhao J, Endo M, Morinaga J, Sato M, Sugizaki T, Zhu S, Terada K, Sakaguchi H, Komohara Y, Takeya M, Takeda N, Araki K, Manabe I, Fukuda K, Otsu K, Wada J, Murohara T, Mohri S, Yamashita JK, Sano M, Oike Y.

ANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism. Nat Commun, 7:13016, 2016. doi: 10.1038/ncomms13016.

Masumoto H, Yamashita JK.

Human iPS Cell-Derived Cardiac Tissue Sheets: a Platform for Cardiac Regeneration. Curr Treat Options Cardiovasc Med, 2016;18(11):65. (Review)

Masumoto H, Yamashita JK.

Exploiting human iPS cell-derived cardiovascular cell populations toward cardiac regenerative therapy. Stem Cell Transl Investig, 2016; 3: e1226. (Review)

Masumoto H, Nakane T, Tinney JP, Yuan F, Ye F, Kowalski WJ, Minakata K, Sakata R, Yamashita JK, Keller BB.

The myocardial regenerative potential of three-dimensional engineered cardiac tissues composed of multiple human iPS cell-derived cardiovascular cell lineages. Sci Rep, 2016;6:29933.

Yamashita JK.

Expanding reprogramming to cardiovascular progenitors. Cell Stem Cell, 18: 299-301, 2016. (Preview)

Matsuo T, Masumoto H, Tajima S, Ikuno T, Katayama S, Minakata K, Ikeda T, Yamamizu K, Tabata Y, Sakata R, Yamashita JK*.

Efficient long-term survival of cell grafts after myocardial infarction with thick viable cardiac tissue entirely from pluripotent stem cells. Sci Rep, 5: 16842, 2015. doi: 10.1038/srep16842

Masumoto H, Ikuno T, Takeda M, Fukushima H, Marui A, Katayama S, Shimizu T, Ikeda T, Okano T, Sakata R, Yamashita JK*.

Human iPS cell-engineered cardiac tissue sheets with cardiomyocytes and vascular cells for cardiac regeneration. Sci Rep, 4:6716, 2014. doi: 10.1038/srep06716

Arita Y, Nakaoka Y, Matsunaga T, Kidoya H, Yamamizu K, Arima Y, Kataoka-Hashimoto T, Ikeoka K, Yasui T, Masaki T, Yamamoto K, Higuchi K, Park JS, Shirai M, Nishiyama K, Yamagishi H, Otsu K, Kurihara H, Minami T, Yamauchi-Takihara K, Koh GY, Mochizuki N, Takakura N, Sakata Y,Yamashita JK, Komuro I.

Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart. Nat Commun, 5:4552, 2014. doi: 10.1038/ncomms5552

Cho SW, Park JS, Heo HJ, Park SW, Song S, Kim I, Han YM, Yamashita JK, Youm JB, Han J, Koh GY.

Dual modulation of the mitochondrial permeability transition pore and redox signaling synergistically promotes cardiomyocyte differentiation from pluripotent stem cells. J Am Heart Assoc, 3:e000693, 2014. doi: 10.1161/JAHA113.000693.

Matsunaga T, Yamashita JK*.

Single-step generation of gene knockout-rescue system in pluripotent stem cells by promoter insertion with CRISPR/Cas9. Biochem Biophys Res Commun, 444:158-163, 2014. doi: 10.1016/bbrc2014.01.037.

Uosaki H*, Magadum A, Seo K, Fukushima H, Takeuchi A, Nakagawa Y, Moyes KW, Narazaki G, Kuwahara K, Laflamme M, Matsuoka S, Nakatsuji N, Nakao K, Kwon C, Kass DA, Engel FB, Yamashita JK*.

Identification of chemicals inducing cardiomyocyte proliferation in developmental stage-specific manner with pluripotent stem cells. Circ Cardiovasc Genet, 6:624-633, 2013. doi: 10.1161/CIRCGENETICS.113.000330

Yamamizu K, Furuta S, Hamada Y, Yamashita A, Kuzumaki N, Narita M, Doi K, Katayama S, Nagase H, Yamashita JK, Narita M.

k Opioids inhibit tumor angiogenesis by suppressing VEGF signaling. Sci Rep, 3:3213, 2013. doi: 10.1038/srep03213.

Kito T, Shibata R, Ishii M, Suzuki H, Himeno T, Kataoka Y, Yamamura Y, Yamamoto T, Nishio N, Ito S, Numaguchi Y, Tanigawa T, Yamashita JK, Ouchi N, Honda H, Isobe K, Murohara T.

iPS cell sheets created by a novel magnetite tissue engineering method for reparative angiogenesis. Sci Rep, 3:1418, 2013.

Masumoto H, Yamashita JK.

Pluripotent stem cells for cardiac cell therapy: The application of cell sheet technology. In Deepa Bhartiya and Nibedita Lenka. Pluripotent Stem Cells., Chaper 21, p459-p475. InTech, 2013 (Review).

Masumoto H, Yamashita JK*.

Strategies in cell therapy for cardiac regeneration. Inflammation and Regeneration, 33: 114-120, 2013 (Review)

Yamamizu K, Fujihara M, Tachibana M, Katayama S, Takahashi A, Hara E, Imai H, Shinkai Y, Yamashita JK*.

Protein kinase A determines timing of early differentiation through epigenetic regulation with G9a. Cell Stem Cell, 10: 759-770, 2012

Masumoto H, Matsuo T, Yamamizu K, Uosaki H, Narazaki G, Katayama S, Marui A, Shimizu T, Ikeda T, Okano T, Sakata R, Yamashita JK*.

Pluripotent stem cell-engineered cell sheets re-assembled with defined cardiovascular populations ameliorate reduction in infarct heart function with cardiomyocyte-mediated neovascularization. Stem Cells, 30: 1196-1205, 2012

Yamamizu K, Matsunaga T, Katayama S, Kataoka H, Takayama N, Eto K, Nishikawa SI, Yamashita JK*.

PKA/CREB signaling triggers initiation of endothelial and hematopoietic cell differentiation via Etv2 induction. Stem Cells, 30: 687-696, 2012

Kuzumaki N, Suzuki A, Narita M, Hosoya T, Nagasawa A, Imai S, Yamamizu K, Morita H, Nagase H, Okada Y, Okano HJ, Yamashita JK, Okano H, Suzuki T, Narita M.

Effect of κ-opioid receptor agonist on the growth of non-small cell lung cancer (NSCLC) cells. Br J Cancer, 106: 1148-1152, 2012

Uosaki H, Fukushima H, Takeuchi A, Matsuoka S, Nakatsuji N, Yamanaka S, Yamashita JK*.

Efficient and scalable purification of cardiomyocytes from human embryonic and induced pluripotent stem cells by VCAM1 surface expression. PLoS One, 6: e23657. 2011

Yamamizu K, Furuta S, Katayama S, Narita M, Kuzumaki N, Imai S, Nagase H, Suzuki T, Narita M*, Yamashita JK*.

The kappa opioid system regulates endothelial cell differentiation and pathfinding in vascular development. Blood, 118: 775-785, 2011 (Cover image)

Fujiwara M, Yan P, Otsuji TG, Narazaki G, Uosaki H, Fukushima H, Matsuda H, Matsuoka S, Okita K, Takahashi K, Nakagawa M, Ikeda T, Sakata R, Mummery CL, Nakatsuji N, Nakao K, Yamanaka S, Yamashita JK*.

Induction and enhancement of cardiac cell differentiation from mouse and human induced pluripotent stem cells with cyclosporin-A. PLoS One, 6: e16734, 2011

Uosaki H, Yamashita JK*.

Chemicals Regulating Cardiomyocyte Differentiation. In Craig Atwood. Embryonic Stem Cells: The Hormonal Regulation of Pluripotency and Embryogenesis. Chaper 24, p471-p486. InTech, 2011 (Review).

Yamamizu K, Yamashita JK*

Roles of cAMP signaling in endothelial cell differentiation and arterial-venous specification during vascular development. Circ J, 75: 253-260, 2011 (Review)

Yamashita JK.

ES and iPS cell research for cardiovascular regeneration. Exp Cell Res, 316:2555-2559,2010 (Review)

Yamamizu K, Matsunaga T, Uosaki H, Fukushima H, Katayama S, Hiraoka-Kanie M, Mitani K, Yamashita JK*.

Convergence of Notch and β-catenin signaling induces arterial fate in vascular progenitors. J Cell Biol, 189: 325-338, 2010

Suzuki H, Shibata R, Kito T, Ishii M, Li P, Yoshikai T, Nishio N, Ito S, Numaguchi Y, Yamashita JK, Murohara T, Isobe K.

Therapeutic angiogenesis by transplantation of induced pluripotent stem cell-derived Flk-1 positive cells. BMC Cell Biol, 11: 72, 2010

Matsuda M, Yamashita JK, Tsukita S, Furuse M.

abLIM3 is a novel component of adherens junctions with actin-binding activity Eur J Cell Biol, 89: 807-816, 2010

Yamamizu K, Kawasaki K, Katayama S, Watabe T, Yamashita JK*.

Enhancement of vascular progenitor potential by protein kinase A through dual induction of Flk-1 and Neuropilin-1. Blood, 114: 3707-3716, 2009

Narazaki G, Yamashita JK*.

Creations of biological Pacemaker. Inflammation and Regeneration, 29: 123-127, 2009 (Review).

Kuratomi S, Ohmori Y, Ito M, Shimazaki K, Muramatsu SI, Mizukami H, Uosaki H, Yamashita JK, Arai Y, Kuwahara K, Takano M.

The cardiac pacemaker-specific channel Hcn4 is a direct transcriptional target of MEF2. Cardiovasc Res, 83: 682-687, 2009

Sasaki D, Shimizu T, Masuda S, Kobayashi J, Itoga K, Tsuda Y, Yamashita JK, Yamato M, Okano T.

Mass preparation of size-controlled mouse embryonic stem cell aggregates and induction of cardiac differentiation by cell patterning method. Biomaterials, 30: 4384-4389, 2009.

Yan P, Nagasawa A, Uosaki H, Sugimoto A, Yamamizu K, Teranishi M, Matsuda H, Matsuoka S, Ikeda T, Komeda M, Sakata R, Yamashita JK*.

Cyclosporin-A potently induces highly cardiogenic progenitors from embryonic stem cells. Biochem Biophys Res Commun, 379: 115-120, 2009

Narazaki G, Uosaki M, Teranishi M, Okita K, Kim B, Matsuoka S, Yamanaka S, Yamashita JK*.

Directed and systematic differentiation of cardiovascular cells from mouse induced pluripotent stem cells. Circulation, 118: 498-506, 2008 (Circulation 2008, Best Paper Award in basic science)

Yamashita JK*

A linkage in the developmental pathway of vascular and hematopoietic cells. In Tanaka K, Davie EW. Recent Advances in Thrombosis and Hemostasis 2008. Part 5, p363-p373. Springer, Tokyo, 2008 (Review).

Nakao Y*, Narazaki G, Hoshino T, Maeda S, Yoshida M, Maejima H, Yamashita JK*.

Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells. Bioorg Med Chem Lett. 18: 2982-2984, 2008

Yamahara K, Sone M, Itoh H, Yamashita JK, Yurugi-Kobayashi T, Homma K, Chao TH, Miyashita K, Park K, Oyamada N, Sawada N, Taura D, Tamura N, Nakao K.

Augmentation of neovascularizaiton in hindlimb ischemia by combined transplantation of human embryonic stem cells-derived endothelial and mural cells. PLoS One, 3: e1666, 2008.

Matsuda M, Kobayashi Y, Masuda S, Adachi M, Watanabe T, Yamashita JK, Nishi E, Tsukita S, Furuse M.

Identification of adherens junction-associated GTPase activating proteins by the fluorescence localization-based expression cloning. Exp Cell Res, 314:939-49, 2008.

Shimizu N, Yamamoto K, Obi S, Kumagaya S, Masumura T, Shimano Y, Naruse K, Yamashita JK, Igarashi T, Ando J.

Cyclic strain induces mouse embryonic stem cell differentiation into vascular smooth muscle cells by activating PDGF receptor {beta}. J Appl Physiol, 104: 766-772, 2008

Yanagi K, Takano M, Narazaki G, Uosaki H, Hoshino T, Ishii T, Misaki T, Yamashita JK*.

Hyperpolarization-activated cyclic nucleotide-gated channels and T-type calcium channels confer automaticity of embryonic stem cell-derived cardiomyocytes. Stem Cells, 25: 2712-2719, 2007.

Sone M, Itoh h, Yamahara K, Yamashita JK, Yurugi-Kobayashi T, Nonoguchi A, Suzuki Y, Chao TH, Sawada N, Fukunaga Y, Miyashita K, Park K, Oyamada N, Sawada N, Taura D, Tamura N, Kondo Y, Nito S, Suemori H, Nakatsuji N, Nishikawa SI, Nakao K.

Pathway for differentiation of human embryonic stem cells to vascular cell components and their potential for vascular regeneration. Arterioscler Thromb Vasc Biol, 27: 2127-2134, 2007.

Yamashita JK.

Differentiation of arterial, venous, and lymphatic endothelial cells from vascular progenitors. Trends Cardiovasc Med, 17: 59-63, 2007 (Review).

Kamo N, Yasuchika K, Fujii H, Hoppo T, Machimoto T, Ishii T, Fujita N, Tsuruo T, Yamashita JK, Kubo H, Ikai I.

Two populations of Thy1-positive mesenchymal cells regulate the in vitro maturation of hepatic progenitor cells. Am J Physiol Gastrointest Liver Physiol,292: G526-534, 2007.

Hiraoka-Kanie M, Miyagishi M, Yamashita JK*.

Differentiation stage-specific analysis of gene function with inducible short hair-pin RNA in differentiating embryonic stem cells. Biochem Biophys Res Commun, 351: 669-674, 2006.

Yurugi-Kobayashi T, Itoh H, Schroeder T, Nakano A, Narazaki G, Kita F, Yanagi K, Hiraoka-Kanie M, Inoue E, Ara T, Nagasawa T, Just U, Nakao K, Nishikawa SI, Yamashita JK*.

Adrenomedullin/cyclic AMP pathway induces Notch activation and differentiation of arterial endothelial cells from vascular progenitors. Arterioscler Thromb Vasc Biol, 26: 1977-1984, 2006.

Kono T, Kubo H*, Shimazu C, Ueda Y, Takahashi M, Yanagi K, Fujita N, Tsuruo T, Wada H, Yamashita JK*.

Differentiation of lymphatic endothelial cells from embryonic stem cells on OP9 stromal cells. Arterioscler Thromb Vasc Biol, 26: 2070-2076, 2006.

Nakao Y, Yoshida S, Matsunaga S, Shindoh N, Terada Y, Nagai K, Yamashita JK, Ganesan A, Soest van RW, Fusetani N.

Azumamides A-E: Histone Deacetylase Inhibitory Cyclic Tetrapeptides from the Marine Sponge Mycale izuensis. Angew Chem Int Ed, 45: 7553-7557, 2006. (cover image)

Watabe T, Yamashita JK, Mishima K, Miyazono K.

TGF-beta signaling in embryonic stem cell-derived endothelial cells. Methods Mol Biol, 330: 341-51, 2006.

Yamashita JK*, Takano M, Hiraoka-Kanie M, Shimazu C, Yan P, Yanagi K, Nakano A, Inoue E, Kita F, Nishikawa SI.

Prospective identification of cardiac progenitor potentials by a novel single cell-based cardiomyocyte induction. FASEB J, 19: 1534-1536, 2005.

Hisatsune H, Matsumura K, Ogawa M, Uemura A, Kondo N, Yamashita JK, Katsuda H, Nishikawa S, Chiba T, Nishikawa SI.

A high level of endothelial cell-specific gene expression by a combination of 5' flanking region and 5' half of the first intron of VE-cadherin gene. Blood, 105: 4657-4663, 2005.

Yamamoto K, Sokabe T, Watabe T, Miyazono K, Yamashita JK, Obi S, Ohmura N, Matsushita A, Kamiya A, Ando J.

Fluid shear stress induces differentiation of Flk-1-positive embryonic stem cells into vascular endothelial cells in vitro. Am J Physiol Heart Circ Physiol, 288: H1915-1924, 2005.

Huang H, Nakayama Y, Qin K, Yamamoto K, Ando J, Yamashita J, Itoh H, Kanda K, Yaku H, Okamoto Y, Nemoto Y.

Differentiation from embryonic stem cells to vascular wall cells under in vitro pulsatile flow loading. J Artif Organ, 8: 110-118, 2005.

Saito T, Itoh H, Yamashita J, Doi K, Chun TH, Tanaka T, Inoue M, Masatsugu K, Fukunaga Y, Sawada N, Sakaguchi S, Arai H, Tojo K, Tajima N, Hosoya T, Nakao K.

Angiotensin II suppresses growth arrest specific homeobox (Gax) expression via redox-sensitive mitogen-activated protein kinase (MAPK). Regul Pept, 127: 159-167, 2005.

Tanaka T, Fukunaga Y, Itoh H, Doi K, Yamashita J, Chun TH, Inoue M, Masatsugu K, Saito T, Sawada N, Sakaguchi S, Arai H, Nakao K.

Therapeutic potential of thiazolidinedinoes in activation of peroxisome proliferator-activated receptor gamma for monocyte recruitment and endothelial regeneration. Eur J Pharmacol, 508: 255-265, 2005.

Yamashita J.

Cardiovascular cell differentiation from ES cells. In: Mori H, Matsuda H. Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches.Chapter 2. p67-p80. Springer-Verlag GmbH, Berlin, New Yolk, Tokyo. 2004 (Review).

Kobayashi T, Tahara Y, Matsumoto M, Iguchi M, Sano H, Maruyama T, Arai H, Oida H, Yurugi-Kobayashi T, Yamashita JK, Katagiri H, Majima M, Yokode M, Kita T, Narumiya S.

Roles of thromboxane A2 and prostacyclin in development of atherosclerosis in apoE-deficient mice. J Clin Invest 114: 784-794, 2004.

Yamashita JK.

Differentiation and diversification of vascular cells from ES cells. Int J Hematol 80: 1-6, 2004 (Review).

Yamashita J, Nishikawa SI.

Embryonic stem cell-derived endothelial cells. In: Augustin H. Springer Lab Manual. Methods in Endothelial Cell Biology Chapter 4. p33-p45. Springer-Verlag GmbH, Berlin, New Yolk, Tokyo. 2004 (Review).

Suzuki Y, Komi Y, Ashino H, Yamashita J, Inoue J, Yoshiki A, Eichmann A, Amanuma H, Kojima S.

Retinoic acid controls blood vessel formation by modulating endothelial and mural cell interaction via suppression of TIE2 signaling in vascular progenitor cells. Blood 104: 166-169, 2004.

Fraser ST, Yamashita J, Jakt LM, Okada M, Ogawa M, Nishikawa S, Nishikawa SI.

In vitro differentiation of mouse embryonic stem cells: Hematopoietic and vascular cell types. Methods Enzymol 365: 59-72, 2003 (Review).

Watabe T, Nishihara A, Mishima K, Yamashita J, Shimizu K, Miyazawa K, Nishikawa SI, Miyazono K.

TGF-beta receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells. J Cell Biol 163: 1303-1311, 2003.

Fujita M, Nakao Y, Matsunaga S, Seiki M, Itoh Y, Yamashita J, Soest van RW, Fusetani N.

Ageladine A: an anti-angiogenic matrixmetalloproteinase inhibitor from the marine sponge Agelas nakamurai. J Am Chem Soc 125: 15700-15701, 2003.

Sone M, Itoh H, Yamashita J, Yurugi-Kobayashi T, Suzuki Y, Kondo Y, Nonoguchi A, Sawada N, Yamahara K, Miyashita K, Park K, Nito S, Shibuya M, Nishikawa SI, Nakao K.

Different differentiation kinetics of vascular progenitor cells in primate and mouse embryonic stem cells. Circulation 107: 2085-2088, 2003.

Yurugi-Kobayashi T, Itoh H, Yamashita J, Yamahara K, Hirai H, Kobayashi T, Ogawa M, Nishikawa S, Nishikawa SI, Nakao K.

Effective contribution of transplanted vascular progenitor cells derived from embryonic stem cells to adult neovascularization in proper differentiation stage. Blood 101: 2675-2678, 2003.

Yamahara K, Itoh H, Chun TH, Ogawa Y, Yamashita J, Sawada N, Fukunaga Y, Sone M, Yurugi-Kobayashi T, Miyashita K, Tsujimoto H, Kook H, Feil R, Garbers DL, Hofmann F, NakaoK.

Significance and therapeutic potential of the natriuretic peptides/cGMP/cGMP-dependent protein kinase pathway in vascular regeneration. Proc Natl Acad Sci USA 100: 3404-3409, 2003.

Masatsugu K, Itoh H, Chun TH, Saito T, Yamashita J, Doi K, Inoue M, Sawada N, Fukunaga Y, Sakaguchi S, Sone M, Yamahara K, Yurugi T, Nakao K.

Shear stress attenuates endothelin and endothelin-converting enzyme expression through oxidative stress. Regul Pept 111: 1-3, 2003.

Ohono N, Itoh H, Ikeda T, Ueyama K, Yamahara K, Doi K, Yamashita J, Inoue M, Masatsugu K, Sawada N, Fukunaga Y, Sakaguchi S, Sone M, Yurugi T, Kook H, Komeda M, Nakao K.

Anccelerated reendothelialization with suppressed thrombogenic property and neointimal hyperplasia of rabbit juglar vein grafts by adenovirus-mediated gene transfer of C-type atriuretic peptide. Circulation 105: 1623-1626, 2002.

Doi K, Ikeda T, Itoh H, Ueyama K, Hosoda K, Ogawa Y, Yamashita J, Chun TH, Inoue M, Masatsugu K, Sawada N, Fukunaga Y, Saito T, Sone M, Yamahara K, Kook H, Komeda M, Ueda M, Nakao K.

C-type natriuretic peptide induces redifferentiation of vascular smooth muscle cells with accelerated reendothelialization. Arterioscler Thromb Vasc Biol 21: 930-936, 2001.

Sawada N, Itoh H, Yamashita J, Doi K, Inoue M, Masatsugu K, Fukunaga Y, Sakaguchi S, Sone M, Yamahara K, Yurugi T, Nakao K.

cGMP-dependent protein kinase phosphorylates and inactivates RhoA. Biochem Biophys Res Commun 280: 798-805, 2001.

Saito T, Itoh H, Chun TH, Fukunaga Y, Yamashita J, Doi K, Tanaka T, Inoue M, Masatsugu K, Sawada N, Sakaguchi S, Arai H, Mukoyama M, Tojo K, Hosoya T, Nakao K.

Coordinate regulation of endothelin and adrenomedullin secretion by oxidative stress in endothelial cells. Am J Physiol Heart Circ Physiol 281:H1364-71, 2001.

Fukunaga Y, Itoh H, Doi K, Tanaka T, Yamashita J, Chun TH, Inoue M, Masatsugu K, Sawada N, Saito T, Hosoda K, Kook H, Ueda M, Nakao K.

Thiazolidinediones, peroxisome proliferator-activated receptor gamma agonists, regulate endothelial cell growth and secretion of vasoactive peptides. Atherosclerosis 158:113-9, 2001

Yamashita J*, Itoh H, Hirashima M, Ogawa M, Nishikawa S, Yurugi T, Naito M, Nakao K and Nishikawa SI.

Flk1 positive cells derived from embryonic stem cells serve as vascular progenitors. Nature 408: 92-96, 2000.

Sawada N, Itoh H, Ueyama K, Yamashita J, Doi K, Chun TH, Inoue M, Masatsugu K, Saito T, Fukunaga Y, Sakaguchi S, Arai H, Ohno N, Komeda M and Nakao K.

Inhibition of rho-associated kinase results in suppression of neointimal formation of balloon-injured arteries. Circulation 101: 2030-2033, 2000.

Fukunaga Y, Itoh H, Hosoda K, Doi K, Matsuda J, Son C, Yamashita J, Chun TH, Tanaka T, Inoue M, Masatsugu K, Saito T, Sawada N and Nakao K.

Altered gene expression of uncoupling protein-2 and -3 in stroke-prone spontaneously hypertensive rats. J Hypertens 18: 1233-1238, 2000.

Chun TH, Itoh H, Saito T, Yamahara K, Doi K, Mori Y, Ogawa Y, Yamashita J, Tanaka T, Inoue M, Masatsugu K, Sawada N, Fukunaga Y and Nakao K.

Oxidative stress augments secretion of endothelium-derived relaxing peptides, C-type natriuretic peptide and adrenomedullin. J Hypertens 18: 575-580, 2000.

Tanaka T, Itoh H, Doi K, Fukunaga Y, Hosoda K, Shintani M, Yamashita J, Chun TH, Inoue M, Masatsugu K, Sawada N, Saito T, Inoue G, Nishimura H, Yoshimasa Y and Nakao K.

Down regulation of peroxisome proliferator-activated receptor gamma expression by inflammatory cytokines and its reversal by thiazolidinediones. Diabetologia, 42: 702-710, 1999.

Yamashita J, Yoshimasa T, Arai H, Hiraoka J, Takaya K, Miyamoto Y, Ogawa Y, Itoh H and Nakao K.

Identification of cis-elements of the human endothelin-A receptor gene and inhibition of the gene expression by the decoy strategy. J Biol Chem, 273: 15993-15999, 1998.

Inoue M, Itoh H, Ueda M, Naruko T, Kojima A, Komatsu R, Doi K, Ogawa Y, Tamura N, Takaya K, Igaki T, Yamashita J, Chun TH, Masatsugu K, Becker AE and Nakao.

Vascular endothelial growhth factor (VEGF) expression in human coronary artery atherosclerotic lesions: possible pathophysiological significance of VEGF in progression of atherosclerosis. Circulation, 98: 2108-2116, 1998.

Suga SI, Itoh H, Komatsu Y, Ishida H, Igaki T, Yamashita J, Doi K, Chun TH, Yoshimasa T, Tanaka I and Nakao K.

Regulation of endothelial production of C-type natriuretic peptide by interaction between endothelial cells and macrophages. Endocrinology, 139: 1920-1926, 1998.

Saito T, Itoh H, Chun T, Igaki T, Mori Y, Yamashita J, Doi K, Tanaka T, Inoue M, Masatsugu K, Fukunaga Y, Sawada N, Tojo K, Saito Y, Hosoya T, Nakao K.

Oxidative stress suppresses the endothelial secretion of endothelin. J Cardiovasc Pharmacol, 31 Suppl 1: 345-7, 1998.

Masatsugu K, Itoh H, Chun TH, Ogawa Y, Tamura N, Yamashita J, Doi K, Inoue M, Fukunaga Y, Sawada N, Saito T, Korenaga R, Ando J, Nakao K.

Phiysiologic shear stress suppresses endothelin-converting enzyme-1 expression in vascular endothelial cells. J Cardiovasc Pharmacol, 31 Suppl 1: 42-5, 1998.

Igaki T, Itoh H, Suga SI, Hama N, Ogawa Y, Komatsu Y, Yamashita J, Doi K, Chun TH, Nakao K.

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