Research Activities

Research Activities

Home › Research Activities › Principal Investigators › Yoshinori Yoshida (Associate Professor)

Principal Investigators

Dept. of Cell Growth and Differentiation 
Yoshinori Yoshida (Associate Professor)

Publications

Espinoza JL, Elbadry MI, Chonabayashi K, Yoshida Y, Katagiri T, Harada K, Nakagawa N, Zaimoku Y, Imi T, Hassanein HA, Khalifa A Noreldin A, Takenaka K, Akashi K, Hamana H, Kishi H, Akatsuka Y, Nakao S.

Hematopoiesis by iPSC-derived hematopoietic stem cells of aplastic anemia that escape cytotoxic T-cell attack. Blood Adv. 2018 Feb 27;2(4):390-400.

Takeda M, Kanki Y, Masumoto H, Funakoshi S, Hatani T, Fukushima H, Izumi-Taguchi A, Matsui Y, Shimamura T, Yoshida Y, Yamashita JK.

Identification of Cardiomyocyte-Fated Progenitors from Human-Induced Pluripotent Stem Cells Marked with CD82. Cell Rep. 2018 Jan 9;22(2):546-556.

Hayano M, Makiyama T, Kamakura T, Watanabe H, Sasaki K, Funakoshi S, Wuriyanghai Y, Nishiuchi S, Harita T, Yamamoto Y, Kohjitani H, Hirose S, Yokoi F, Chen J, Baba O, Horie T, Chonabayashi K, Ohno S, Toyoda F, Yoshida Y, Ono K, Horie M, Kimura T.

The Development of a Patient-Derived Induced Pluripotent Stem Cell Model for the Investigation of SCN5A-D1275N-Related Cardiac Sodium Channelopathy. Circ J. 2017 Nov 24;81(12):1783-1791.

Kawamura M, Miyagawa S, Fukushima S, Saito A, Miki K, Funakoshi S, Yoshida Y, Yamanaka S, Shimizu T, Okano T, Daimon T, Toda T, Sawa Y.

Enhanced Therapeutic Effects of Human iPS Cell Derived-Cardiomyocyte by Combined Cell-Sheets with Omental Flap Technique in Porcine Ischemic Cardiomyopathy Model. Sci Rep.. 2017 Aug 18;7(1):8824.

Yoshida Y, Yamanaka S.

Induced Pluripotent Stem Cells Ten Years Later: For Cardiac Applications. Circ Res. 2017 Jun 9;120(12):1958-1968.

Kuang Y, Miki K, Parr CJ, Hayashi K, Takei I, Li J, Iwasaki M, Nakagawa M, Yoshida Y, Saito H.

Efficient and Selective Removal of Human Pluripotent Stem Cells via Ecto-Alkaline Phosphatase-Mediated Aggregation of Synthetic Peptides. Cell Chemical Biology. 2017 Jun 22;24(6):685-694.e4.

Kuang Y, Miki K, Parr CJ, Hayashi K, Takei I, Li J, Iwasaki M, Nakagawa M, Yoshida Y, Saito H.

Efficient and Selective Removal of Human Pluripotent Stem Cells via Ecto-Alkaline Phosphatase-Mediated Aggregation of Synthetic Peptides. Cell Chemical Biology. in press

Nakanishi H, Miki K, Komatsu KR, Umeda M, Mochizuki M, Inagaki A, Yoshida Y, Saito H.

Monitoring and visualizing microRNA dynamics during live cell differentiation using microRNA-responsive non-viral reporter vectors. Biomaterials. 2017 Jun;128:121-135.

Yamamoto Y, Makiyama T, Harita T, Sasaki K, Wuriyanghai Y, Hayano M, Nishiuchi S, Kohjitani H, Hirose S, Chen J, Yokoi F, Ishikawa T, Ohno S, Chonabayashi K, Motomura H, Yoshida Y, Horie M, Makita N, Kimura T.

Allele-specific ablation rescues electrophysiological abnormalities in a human iPS cell model of long-QT syndrome with a CALM2 mutation. Hum Mol Genet. 2017 May 1;26(9):1670-1677.

Ueki J, Nakamori M, Nakamura M, Nishikawa M, Yoshida Y, Tanaka A, Morizane A, Kamon M, Araki T, Takahashi MP, Watanabe A, Inagaki N, Sakurai M.

Myotonic dystrophy type 1 patient-derived iPSCs for the investigation of CTG repeat instability. Sci Rep. 2017 Feb 13;7:42522.

Sasaki K, Makiyama T, Yoshida Y, Wuriyanghai Y, Kamakura T, Nishiuchi S, Hayano M, Harita T, Yamamoto Y, Kohjitani H, Hirose S, Chen J, Itoh H, Kawamura M, Ohno S, Takeuchi A, Matsuoka S, Miura M, Sumitomo N, Horie M, Yamanaka S, Kimura T.

Patient-specific Human Induced Pluripotent Stem Cell Model Assessed with Electrical Pacing Validates S107 as a Potential Therapeutic Agent for Catecholaminergic Polymorphic Ventricular Tachycardia. PLoS One. 2016 Oct 20;11(10):e0164795

Parr CJ, Katayama S, Miki K, Kuang Y, Yoshida Y, Morizane A, Takahashi J, Yamanaka S, Saito H.

MicroRNA-302 switch to identify and eliminate undifferentiated human pluripotent stem cells. Sci Rep. 2016 Sep 9;6:32532.

Nishizawa M, Chonabayashi K, Nomura M, Tanaka A, Nakamura M, Inagaki A, Nishikawa M, Takei I, Oishi A, Tanabe K, Ohnuki M, Yokota H, Koyanagi-Aoi M, Okita K, Watanabe A, Takaori-Kondo A, Yamanaka S, Yoshida Y.

Epigenetic variation between human induced pluripotent stem cell lines is an indicator of differentiation capacity. Cell Stem Cell. 2016 Sep 1;19(3):341-54.

Oceguera-Yanez F, Kim SI, Matsumoto T, Tan GW, Xiang L, Hatani T, Kondo T, Ikeya M, Yoshida Y, Inoue H, Woltjen K.

Engineering the AAVS1 locus for consistent and scalable transgene expression in human iPSCs and their differentiated derivatives. Methods. 2016 May 15;101:43-55.

Kawamura T, Miyagawa S, Fukushima S, Maeda A, Kashiyama N, Kawamura A, Miki K, Okita K, Yoshida Y, Shiina T, Ogasawara K, Miyagawa S, Toda K, Okuyama H, Sawa Y.

Cardiomyocytes Derived from MHC-Homozygous Induced Pluripotent Stem Cells Exhibit Reduced Allogeneic Immunogenicity in MHC-Matched Non-human Primates. Stem Cell Reports. 2016 Mar 8;6(3):312-20

Morita Y, Andersen P, Hotta A, Tsukahara Y, Sasagawa N, Hayashida N, Koga C, Nishikawa M, Saga Y, Evans SM, Koshiba-Takeuchi K, Nishinakamura R, Yoshida Y, Kwon C, Takeuchi JK.

Sall1 transiently marks undifferentiated heart precursors and regulates their fate. J Mol Cell Cardiol. 2016 Mar;92:158-62

Yoshida Y, Yamanaka S.

Understanding Intracellular Signaling Advances Cardiac Reprogramming Technology Toward Clinical Applications. Circ Res. 2016 Feb 5;118(3):377-8.

Funakoshi S, Miki K, Takaki T, Okubo C, Hatani T, Chonabayashi K, Nishikawa M, Takei I, Oishi A, Narita M, Hoshijima M, Kimura T, Yamanaka S, Yoshida Y.

Enhanced engraftment, proliferation, and therapeutic potential in heart using optimized human iPSC-derived cardiomyocytes. Sci Rep. 2016 Jan 8;6:19111.

Miki K, Endo K, Takahashi S, Funakoshi S, Takei I, Katayama S, Toyoda T, Kotaka M, Takaki T, Umeda M, Okubo C, Nishikawa M, Oishi A, Narita M, Miyashita I, Asano K, Hayashi K, Osafune K, Yamanaka S, Saito H, Yoshida Y.

Efficient detection and purification of cell populations using synthetic microRNA switches.Cell Stem Cell. 2015 Jun 4;16(6):699-711

Tokunaga K, Saitoh N, Goldberg I, Sakamoto C, Yasuda Y, Yoshida Y, Yamanaka S, Nakao M.

Computational image analysis of colony and nuclear morphology to evaluate human induced pluripotent stem cells.Sci Rep. 2014 Nov 11;4:6996.

Nakagawa M, Taniguchi Y, Senda S, Takizawa N, Ichisaka T, Asano K, Morizane A, Doi D, Takahashi J, Nishizawa M, Yoshida Y, Toyoda T, Osafune K, Sekiguchi K, Yamanaka S.

A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cells.Sci Rep. 2014 Jan 8;4:3594.

Miki K, Yoshida Y, Yamanaka S.

Making Steady Progress on Direct Cardiac Reprogramming Toward Clinical Application.Circ Res. 2013 Jun 21;113(1):13-5.

Kamakura T, Makiyama T, Sasaki K, Yoshida Y, Wuriyanghai Y, Chen J, Hattori T, Ohno S, Kita T, Horie M, Yamanaka S, Kimura T.

Ultrastructural Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes in a Long-Term Culture.Circ J. 2013 Apr 25;77(5):1307-14.

Yoshida Y, Yamanaka S.

An emerging strategy of gene therapy for cardiac disease.Circ Res. 2012 Oct 12;111(9):1108-10.

Yoshida Y, Yamanaka S.

Labor pains of new technology: direct cardiac reprogramming.Circ Res. 2012 Jun 22;111(1):3-4.

Yoshida Y, Yamanaka S.

iPS cells : A source of cardiac regeneration.J Mol Cell Cardiol. 2011 Feb;50(2):327-32.

Yoshida Y, Yamanaka S

Induced pluripotent stem cells for disease modeling and stem cell-based regeneration.Circulation. 2010 Jul 6;122(1):80-87.

Yoshida, Y., Takahashi, K., Okita, K., Ichisaka, T., and Yamanaka, S.

Hypoxia enhances the generation of induced pluripotent stem cells.Cell Stem Cell. 2009 5, 237-241.

Nakashima Y, Ono K, Yoshida Y, Kojima Y, Kita T, Tanaka M, Kimura T.

The search for Nkx2-5-regulated genes using purified embryonic stem cell-derived cardiomyocytes with Nkx2-5 gene targeting.Biochem Biophys Res Commun. 2009 Dec 18;390(3):821-826.

Kojima Y, Ono K, Inoue K, Takagi Y, Kikuta K, Nishimura M, Yoshida Y, Nakashima Y, Matsumae H, Furukawa Y, Mikuni N, Nobuyoshi M, Kimura T, Kita T, Tanaka M.

Progranulin expression in advanced human atherosclerotic plaque.Atherosclerosis. 2009 Sep;206(1):102-8.

Matsumae H, Yoshida Y, Ono K, Togi K, Inoue K, Furukawa Y, Nakashima Y, Kojima Y, Nobuyoshi M, Kita T, Tanaka M.

CCN1 knockdown suppresses neointimal hyperplasia in a rat artery balloon injury model.Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1077-83.

Yoshida Y, Togi K, Matsumae H, Nakashima Y, Kojima Y, Yamamoto H, Ono K, Nakamura T, Kita T, Tanaka M.

CCN1 protects cardiomyocytes from oxidative stress via beta1 integrin-Akt pathway.Biochem Biophys Res Commun. 2007 Apr 13; 355(3):611-8.

Kawamoto T, Togi K, Yamauchi R, Yoshida Y, Nakashima Y, Kita T, Tanaka M.

Endothelin-1 activates Homer 1alpha expression via mitogen-activated protein kinase in cardiac myocytes.Int J Mol Med. 2006 Jul;18(1):193-6.

Togi K, Yoshida Y, Matsumae H, Nakashima Y, Kita T, Tanaka M.

Essential role of Hand2 in interventricular septum formation and trabeculation during cardiac development.Biochem Biophys Res Commun. 2006 Apr 28; 343 (1):144-51.

Togi K, Kawamoto T, Yamauchi R, Yoshida Y, Kita T, Tanaka M.

Role of Hand1/eHAND in the dorso-ventral patterning and interventricular septum formation in the embryonic heart.Mol Cell Biol. 2004 Jun; 24(11):4627-35.
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