発表論文

Gao P, Inada Y, Hotta A, Sakurai H, Ikeya M.

iMSC-mediated delivery of ACVR2B-Fc fusion protein reduces heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva. Stem Cell Res Ther. 2024 Mar 18;15(1):83. doi: 10.1186/s13287-024-03691-7.
PMID: 38500216 Free PMC article.

Gao P, Kajiya M, Motoike S, Ikeya M, Yang J.

Application of mesenchymal stem/stromal cells in periodontal regeneration: Opportunities and challenges. Jpn Dent Sci Rev. 2024 Dec;60:95-108. doi: 10.1016/j.jdsr.2024.01.001. Epub 2024 Jan 25.
PMID: 38314143 Free PMC article. Review.

Aoi T, Tanaka A, Furuhashi K, Ikeya M, Shimizu A, Arioka Y, Kushima I, Ozaki N, Maruyama S.

Mesenchymal stem/stromal cells generated from induced pluripotent stem cells are highly resistant to senescence. Nagoya J Med Sci., 2023 Nov;85(4):682-690. doi: 10.18999/nagjms.85.4.682. PMID: 38155616 Free PMC article.

Mizuno K, Ohnishi H, Yoshimatsu M, Zhao C, Hayashi Y, Kuwata F, Kaba S, Okuyama H, Kawai Y, Hiwatashi N, Kishimoto Y, Sakamoto T, Ikeya M, Omori K.

Laryngeal Cartilage Regeneration of Nude Rats by Transplantation of Mesenchymal Stem Cells Derived from Human-Induced Pluripotent Stem Cells. Cell Transplant., 2023 Jan-Dec;32:9636897231178460. doi: 10.1177/09636897231178460.
PMID: 37278405

Zhao C, Inada Y, Sekiguchi K, Hino K, Nishio M, Yamada Y, Matsuda S, Toguchida J, Ikeya M.

Myelin protein zero (P0)- and Wnt1-Cre marked muscle resident neural crest-derived mesenchymal progenitor cells give rise to heterotopic ossification in mouse models Genes Dis., 2023 May 29:10(3)731-734. doi: 10.1016/j.gendis.2022.09.002. PMID: 37396524

Zujur D, Al-Akashi Z, Nakamura A, Zhao C, Takahashi K, Aritomi S, Theoputra W, Kamiya D, Nakayama K, Ikeya M*.

Enhanced chondrogenic differentiation of iPS cell-derived mesenchymal stem/stromal cells via neural crest cell induction for hyaline cartilage repair. Front Cell Dev Biol. 2023 May 10;11:1140717. doi: 10.3389/fcell.2023.1140717. eCollection 2023.
PMID: 37234772

Al-Akashi Z, Zujur D, Kamiya D, Kato T Jr, Kondo T, Ikeya M.

Selective vulnerability of human-induced pluripotent stem cells to dihydroorotate dehydrogenase inhibition during mesenchymal stem/stromal cell purification. Front Cell Dev Biol., 2023 Feb 6;11:1089945. doi: 10.3389/fcell.2023.1089945. eCollection 2023.
PMID: 36814599 Free PMC article.

Kamiya D, Takenaka-Ninagawa N, Motoike S, Kajiya M, Akaboshi T, Zhao C, Shibata M, Senda S,
Toyooka Y, Sakurai H, Kurihara H, Ikeya M^*.

Induction of functional xeno-free MSCs from human iPSCs via a neural crest cell lineage. NPJ Regen Med., 2022 Sep 15;7(1):47. doi: 10.1038/s41536-022-00241-8. PMID: 36109564

Ikeguchi R, Aoyama T, Tanaka M, Noguchi T, Ando M, Yoshimoto K, Sakamoto D, Iwai T, Miyazaki Y, Akieda S, Ikeya M, Nakayama K, Matsuda S.

Nerve regeneration using the Bio 3D nerve conduit fabricated with spheroids. J Artif Organs., 2022 Aug 15. doi: 10.1007/s10047-022-01358-9. Online ahead of print.
PMID: 35970971 Review.

Gao P, Liu S, Wang X, Ikeya M.

Dental applications of induced pluripotent stem cells and their derivatives. Jpn Dent Sci Rev., 2022 Nov;58:162-171. doi: 10.1016/j.jdsr.2022.03.002. Epub 2022 Apr 30.
PMID: 35516907. Review.

Kamiya D^†*, Yamashita T^†, Akaboshi T, Yamaguchi Y, Toyooka Y, Ikeya M.

Generation of human GAPDH knock-in reporter iPSC lines for stable expression of tdTomato in pluripotent and differentiated culture conditions. Stem Cell Res., 2022 Feb 8;60:102704. doi: 10.1016/j.scr.2022.102704. Online ahead of print.
PMID: 35176664

Yamashita T^†, Kamiya D^†, Kawaraichi N, Toyokawa H, Akaboshi T, Ikeya M, Toyooka Y^*.

Generation of a human SOX10 knock-in reporter iPSC line for visualization of neural crest cell differentiation. Stem Cell Res., 2022 Feb 1;60:102696. doi: 10.1016/j.scr.2022.102696. Online ahead of print.
PMID: 35144211

Harada A, Goto M, Kato A, Takenaka-Ninagawa N, Tanaka A, Noguchi S, Ikeya M, Sakurai H.

Systemic Supplementation of Collagen VI by Neonatal Transplantation of iPSC-Derived MSCs Improves Histological Phenotype and Function of Col6-Deficient Model Mice. Front Cell Dev Biol., 2021 Nov 23;9:790341. doi: 10.3389/fcell.2021.790341. eCollection 2021.
PMID: 34888314

Nakajima T, Nakahata A, Yamada N, Yoshizawa K, Kato TM, Iwasaki M, Zhao C, Kuroki H, Ikeya M.

Grafting of iPS cell-derived tenocytes promotes motor function recovery after Achilles tendon rupture. Nat Commun., 2021 Aug 18;12(1):5012. doi: 10.1038/s41467-021-25328-6. PMID: 34408142

Nakamura A, Murata D, Fujimoto R, Tamaki S, Nagata S, Ikeya M, Toguchida J, Nakayama K.

Bio-3D printing iPSCs-derived human chondrocytes for articular cartilage regeneration. Biofabrication., 2021 Aug 11. doi: 10.1088/1758-5090/ac1c99. Online ahead of print. PMID: 34380122

Takenaka-Ninagawa N, Kim J, Zhao M, Sato M, Jonouchi T, Goto M, Yoshioka CKB, Ikeda R, Harada A, Sato T, Ikeya M, Uezumi A, Nakatani M, Noguchi S, Sakurai H.

Collagen-VI supplementation by cell transplantation improves muscle regeneration in Ullrich congenital muscular dystrophy model mice. Stem Cell Res Ther. 2021 Aug 9;12(1):446. doi: 10.1186/s13287-021-02514-3. PMID: 34372931

Ventura F, Williams E, Ikeya M, Bullock AN, Ten Dijke P, Goumans MJ, Sanchez-Duffhues G.

Challenges and Opportunities for Drug Repositioning in Fibrodysplasia Ossificans Progressiva. Biomedicines. 2021 Feb 19;9(2):213. doi: 10.3390/biomedicines9020213. PMID: 33669809 Review.

Nakajima T, Ikeya M.

Development of pluripotent stem cell-based human tenocytes. Dev Growth Differ. 2020 Dec 3. doi: 10.1111/dgd.12702. Online ahead of print. PMID: 33270251 Review.

Yoshimatsu M, Ohnishi H, Zhao C, Hayashi Y, Kuwata F, Kaba S, Okuyama H, Kawai Y, Hiwatashi N, Kishimoto Y, Sakamoto T, Ikeya M, Omori K.

In vivo regeneration of rat laryngeal cartilage with mesenchymal stem cells derived from human induced pluripotent stem cells via neural crest cells. Stem Cell Res. 2021 Feb 11;52:102233. doi: 10.1016/j.scr.2021.102233. Online ahead of print. PMID: 33607469

Imhof BA, Ballet R, Hammel P, Jemelin S, Garrido-Urbani S, Ikeya M, Matthes T, Miljkovic-Licina M.

Olfactomedin-like 3 promotes PDGF-dependent pericyte proliferation and migration during embryonic blood vessel formation. FASEB J. 2020 Sep 30. doi: 10.1096/fj.202000751RR. Online ahead of print. PMID: 32997357

Matsuda M, Hayashi H, Garcia-Ojalvo J, Yoshioka-Kobayashi K, Kageyama R, Yamanaka Y, Ikeya M, Toguchida J, Alev C, Ebisuya M.

Species-specific segmentation clock periods are due to differential biochemical reaction speeds. Science. 2020 Sep 18;369(6510):1450-1455. doi: 10.1126/science.aba7668. PMID: 32943519

Mitsuzawa S^†, Zhao C^†, Ikeguchi R^*, Aoyama T, Kamiya D, Ando M, Takeuchi H, Akieda S, Nakayama K, Matsuda S, Ikeya M^*.

Pro-angiogenic scaffold-free Bio three-dimensional conduit developed from human induced pluripotent stem cell-derived mesenchymal stem cells promotes peripheral nerve regeneration. Sci Rep. 2020 Jul 21;10(1):12034. doi: 10.1038/s41598-020-68745-1. PMID: 32694698

Zhao M, Tazumi A, Takayama S, Takenaka-Ninagawa N, Nalbandian M, Nagai M, Nakamura Y, Nakasa M, Watanabe A, Ikeya M, Hotta A, Ito Y, Sato T, Sakurai H.

Induced Fetal Human Muscle Stem Cells with High Therapeutic Potential in a Mouse Muscular Dystrophy Model. Stem Cell Reports. 2020 Jun 23. pii: S2213-6711(20)30225-3. doi: 10.1016/j.stemcr.2020.06.004.
[Epub ahead of print] PMID: 32619494

Matsuda M, Yamanaka Y, Uemura M, Osawa M, Saito MK, Nagahashi A, Nishio M, Guo L, Ikegawa S, Sakurai S, Kihara S, Maurissen TL, Nakamura M, Matsumoto T, Yoshitomi H, Ikeya M, Kawakami N, Yamamoto T, Woltjen K, Ebisuya M, Toguchida J, Alev C.

Recapitulating the human segmentation clock with pluripotent stem cells. Nature. 2020 Apr;580(7801):124-129. doi: 10.1038/s41586-020-2144-9.
Epub 2020 Apr 1. PMID: 32238941

Tsujimoto H, Kasahara T, Sueta SI, Araoka T, Sakamoto S, Okada C, Mae SI, Nakajima T, Okamoto N, Taura D, Nasu M, Shimizu T, Ryosaka M, Li Z, Sone M, Ikeya M, Watanabe A, Osafune K.

A Modular Differentiation System Maps Multiple Human Kidney Lineages from Pluripotent Stem Cells. Cell Rep. 2020 Apr 7;31(1):107476. doi: 10.1016/j.celrep.2020.03.040. PMID: 32268094

Mitsuzawa S, Ikeguchi R, Aoyama T, Ando M, Takeuchi H, Yurie H, Oda H, Noguchi T, Ohta S, Zhao C, Ikeya M, Matsuda S.

Induced pluripotent stem cell-derived mesenchymal stem cells prolong hind limb survival in a rat vascularized composite allotransplantation model. Microsurgery. 2019 Aug 31. doi: 10.1002/micr.30507. PMID: 31471984

Motoike S, Kajiya M, Komatsu N, Horikoshi S, Ogawa T, Sone H, Matsuda S, Ouhara K, Iwata T, Mizuno N, Fujita T, Ikeya M, Kurihara H.

Clumps of Mesenchymal Stem Cell/Extracellular Matrix Complexes Generated with Xeno-Free Conditions Facilitate Bone Regeneration via Direct and Indirect Osteogenesis. Int J Mol Sci. 2019 Aug 15;20(16). pii: E3970. doi: 10.3390/ijms20163970. PMID: 31443173

Katsuno T, Belyantseva IA, Cartagena-Rivera AX, Ohta K, Crump SM, Petralia RS, Ono K, Tona R, Imtiaz A, Rehman A, Kiyonari H, Kaneko M, Wang YX, Abe T, Ikeya M, Fenollar-Ferrer C, Riordan GP, Wilson EA, Fitzgerald TS, Segawa K, Omori K, Ito J, Frolenkov GI, Friedman TB, Kitajiri SI.

TRIOBP-5 sculpts stereocilia rootlets and stiffens supporting cells enabling hearing. JCI Insight. 2019 June 20;4(12). pii: 128561. doi: 10.1172/jci.insight.128561. eCollection 2019 June 20. PMID: 31217345

Nakajima T, Ikeya M.

Insights into the biology of fibrodysplasia ossificans progressiva using patient-derived induced pluripotent stem cells. Regen Ther. 2019 May 10;11:25-30. doi: 10.1016/j.reth.2019.04.004. eCollection 2019 Dec. Review. PMID: 31193176

Kawai S, Yoshitomi H, Sunaga J, Alev C, Nagata S, Nishio M, Hada M, Koyama Y, Uemura M, Sekiguchi K, Maekawa H, Ikeya M, Tamaki S, Jin Y, Harada Y, Fukiage K, Adachi T, Matsuda S, Toguchida J.

In vitro bone-like nodules generated from patient-derived iPSCs recapitulate pathological bone phenotypes. Nat Biomed Eng. 2019 Jun 10. doi: 10.1038/s41551-019-0410-7. [Epub ahead of print] PMID: 31182836 [PubMed - as supplied by publisher]

Nakajima T^*, Sakurai H, Ikeya M^*.

In Vitro Generation of Somite Derivatives from Human Induced Pluripotent Stem Cells. J Vis Exp. 2019 Apr 25; 146: e59359, doi:10.3791/59359

Iwashita M, Ohta H, Fujisawa T, Cho M, Ikeya M, Kidoaki S, Kosodo Y.

Brain-stiffness-mimicking tilapia collagen gel promotes the induction of dorsal cortical neurons from human pluripotent stem cells. Sci Rep. 2019 Feb 28;9(1):3068. doi: 10.1038/s41598-018-38395-5. PMID: 30816128

Hino K, Zhao C, Horigome K, Nishio M, Okanishi Y, Nagata S, Komura S, Yamada Y, Toguchida J, Ohta A, Ikeya M*.

An mTOR Signaling Modulator Suppressed Heterotopic Ossification of Fibrodysplasia Ossificans Progressiva. Stem Cell Reports. 2018 Nov 1. pii: S2213-6711(18)30430-2. doi: 10.1016/j.stemcr.2018.10.007.

Nakajima T, Shibata M, Nishio M, Nagata S, Alev C, Sakurai H, Toguchida J, Ikeya M*

Modeling human somite development and fibrodysplasia ossificans progressiva with induced pluripotent stem cells Development. 2018 145: dev165431 doi: 10.1242/dev.165431 Published 23 August 2018.

Zhao C and Ikeya M.

Generation and Applications of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells. Stem Cells Int. 2018 Jul 31; 2018:9601623. doi: 10.1155/2018/9601623. (Review)

Hino K, Horigome K, Nishio M, Komura S, Nagata S, Zhao C, Jin Y, Kawakami K, Yamada Y, Ohta A, Toguchida J*, Ikeya M*.

Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva. J Clin Invest. 2017 Jul 31. pii: 93521. doi: 10.1172/JCI93521. [Epub ahead of print]

Chijimatsu R, Ikeya M, Yasui Y, Ikeda Y, Ebina K, Moriguchi Y, Shimamura K, Hart DA, Yoshikawa H and Nakamura N.

Characterization of Mesenchymal Stem Cell-Like Cells Derived From Human iPSCs via Neural Crest Development and Their Application for Osteochondral Repair. Stem Cells Int. 2017;2017:1960965. doi: 10.1155/2017/1960965. Epub 2017 May 10.

Horikiri T, Ohi H, Shibata M, Ikeya M, Ueno M, Sotozono C, Kinoshita S, Sato T.

SOX10-Nano-Lantern Reporter Human iPS Cells; A Versatile Tool for Neural Crest Research. PLoS One. 2017 Jan 20;12(1):e0170342.

Hayashi Y, Hsiao EC, Sami S, Lancero M, Schlieve CR, Nguyen T, Yano K, Nagahashi A, Ikeya M, Matsumoto Y, Nishimura K, Fukuda A, Hisatake K, Tomoda K, Asaka I, Toguchida J, Conklin BR, Yamanaka S.

BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence. Proc Natl Acad Sci U S A. 2016 Oct 28. pii: 201603668. [Epub ahead of print]

Oceguera-Yanez F, Kim SI, Matsumoto T, Tan GW, Xiang L, Hatani T, Kondo T, Ikeya M, Yoshida Y, Inoue H, Woltjen K.

Engineering the AAVS1 locus for consistent and scalable transgene expression in human iPSCs and their differentiated derivatives. Methods. 2015 Dec 18. [Epub ahead of print]

Hino K, Ikeya M*, Horigome K, Matsumoto Y, Ebise H, Nishio M, Sekiguchi K, Shibata M, Nagata S, Matsuda S, Toguchida J*.

Neofunction of ACVR1 in fibrodysplasia ossificans progressiva. Proc Natl Acad Sci U S A. 2015 Nov 30.

Tamaki S, Fukuta M, Sekiguchi K, Jin Y, Nagata S, Hayakawa K, Hineno S, Okamoto T, Watanabe M, Woltjen K, Ikeya M, Kato T Jr, Toguchida J.

SS18-SSX, the Oncogenic Fusion Protein in Synovial Sarcoma, Is a Cellular Context-Dependent Epigenetic Modifier. PLoS One. 2015 Nov 16;10(11):e0142991.

Jin Y, Elalaf H, Watanabe M, Tamaki S, Hineno S, Matsunaga K, Woltjen K, Kobayashi Y, Nagata S, Ikeya M, Kato T Jr, Okamoto T, Matsuda S, Toguchida J.

Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes. PLoS One. 2015 Jul 10;10(7):e0131998.

Matsumoto Y†, Ikeya M†*, Hino K, Horigome K, Fukuta M, Watanabe M, Nagata S, Yamamoto T, Otsuka T, Toguchida J*.

New Protocol to Optimize iPS Cells for Genome Analysis of Fibrodysplasia Ossificans Progressiva. Stem Cells. 2015 Mar 13. Stem Cells. 2015 Jun;33(6):1730-42.

Yokoyama K, Ikeya M, Umeda K, Oda H, Nodomi S, Nasu A, Matsumoto Y, Izawa K, Horigome K, Kusaka T, Tanaka T, Saito MK, Yasumi T, Nishikomori R, Ohara O, Nakayama N, Nakahata T, Heike T, Toguchida J.

Enhanced chondrogenesis of iPS cells from neonatal-onset multisystem inflammatory disease occurs via the caspase-1-independent cAMP/PKA/CREB pathway. Arthritis Rheumatol. 2015 Jan;67(1):302-314.

Fukuta M, Nakai Y, Kirino K, Nakagawa M, Sekiguchi K, Nagata S, Matsumoto Y, Yamamoto T, Umeda K, Heike T, Okumura N, Koizumi N, Sato T, Nakahata T, Saito M, Otsuka T, Kinoshita S, Ueno M*, Ikeya M*, Toguchida J*.

Derivation of Mesenchymal Stromal Cells from Pluripotent Stem Cells through a Neural Crest Lineage using Small Molecule Compounds with Defined Media. PloS One. 2014 Dec 2;9(12):e112291

Matsumoto Y, Hayashi Y, Schlieve CR, Ikeya M*, Kim H, Nguyen TD, Sami S, Baba S, Barruet E, Nasu A, Asaka I, Otsuka T, Yamanaka S, Conklin BR, Toguchida J*, Hsiao EC*

Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation. Orphanet J Rare Dis. 2013 Dec 9;8(1):190.

Tanaka A, Woltjen K, Miyake K, Hotta A, Ikeya M, Yamamoto T, Nishino T, Shoji E, Sehara-Fujisawa A, Manabe Y, Fujii N, Hanaoka K, Era T, Yamashita S, Isobe K, Kimura E, Sakurai H

Efficient and Reproducible Myogenic Differentiation from Human iPS Cells: Prospects for Modeling Miyoshi Myopathy In Vitro PLoS One. 2013;8(4)e61540

Hayakawa K, Ikeya M, Fukuta M, Woltjen K, Tamaki S, Takahara N, Kato T Jr, Sato S, Otsuka T, Toguchida J.

Identification of target genes of synovial sarcoma-associated fusion oncoprotein using human pluripotent stem cells. Biochem Biophys Res Commun. 2013 Mar 22;432(4):713-9.

Nasu A, Ikeya M, Yamamoto T, Watanabe A, Jin Y, Matsumoto Y, Hayakawa K, Amano N, Sato S, Osafune K, Aoyama T, Nakamura T, Kato T, Toguchida J.

Genetically matched human iPS cells reveal that propensity for cartilage and bone differentiation differs with clones, not cell type of origin. PLoS One. 2013;8(1):e53771. Epub 2013 Jan 31.

Ikeya M*, Fukushima K, Kawada M, Onishi S, Furuta Y, Yonemura S, Kitamura T, Nosaka T, Sasai Y.

Cv2, Functioning as a Pro-BMP Factor via Twisted Gastrulation, is Required for Early Development of Nephron Precursors. Dev. Biol. 337, 405-414 (2010)

Ikeya M*, Nosaka T, Fukushima K, Kawada M, Furuta Y, Kitamura T, Sasai Y.

Twisted gastrulation mutation suppresses skeletal defect phenotypes in Crossveinless 2 mutant mice. Mech. Dev. 125, 832-842 (2008)

Arakawa A, Matsuo-Takasaki M, Takai A, Inomata H, Matsumura M, Ikeya M, Takahashi K, Miyachi Y, Sasai N, Sasai Y.

The secreted EGF-Discoidin factor xDel1 is essential for dorsal development of the Xenopus embryo. Dev. Biol. 306, 160-169 (2007)

Ikeya M, Kawada M, Kiyonari H, Sasai N, Nakao K, Furuta Y, Sasai Y.

Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis. Development 133, 4463-4473 (2006)

Sakuragi M, Sasai N, Ikeya M, Kawada M, Onai T, Katahira T, Nakamura H, Sasai Y.

Functional analysis of chick ONT1 reveals distinguishable activities among olfactomedin-related signaling factors. Mech. Dev. 123, 114-123 (2006)

Ikeya M*, Kawada M, Nakazawa Y, Sakuragi M, Sasai N, Ueno M, Kiyonari H, Nakao K, Sasai Y.

Gene disruption/knock-in analysis of mONT3: vector construction by employing both in vivo and in vitro recombinations. Int. J. Dev. Biol. 49, 807-823 (2005)

Mizuseki K, Sakamoto T, Watanabe K, Muguruma K, Ikeya M, Nishiyama A, Arakawa A, Suemori H, Nakatsuji N, Kawasaki H, Murakami F, Sasai Y.

Generation of neural crest-derived peripheral neurons and floor plate cells from mouse and primate embryonic stem cells. Proc. Natl. Acad. Sci. U S A. 100, 5828-5833 (2003)

Muroyama Y, Fujihara M, Ikeya M, Kondoh H, Takada S.

Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord. Genes Dev. 16, 548-553 (2002)

Nomi M, Oishi I, Kani S, Suzuki H, Matsuda T, Yoda A, Kitamura M, Itoh K, Takeuchi S, Takeda K, Akira S, Ikeya M, Takada S, Minami Y.

Loss of mRor1 enhances the heart and skeletal abnormalities in mRor2-deficient mice: redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinases. Mol. Cell. Biol. 21, 8329-8335 (2001)

Kawauchi T, Ikeya M, Takada S, Ueda K, Shirai M, Takihara Y, Kioka N, Amachi T.

Expression of vinexin alpha in the dorsal half of the eye and in the cardiac outflow tract and atrioventricular canal. Mech. Dev. 106, 147-150 (2001)

Matsuda T, Nomi M, Ikeya M, Kani S, Oishi I, Terashima T, Takada S, Minami Y.

Expression of the receptor tyrosine kinase genes, Ror1 and Ror2, during mouse development. Mech. Dev. 105, 153-156 (2001)

Ikeya M, Takada S.

Wnt-3a is required for somite specification along the anteroposterior axis of the mouse embryo and for regulation of cdx-1 expression. Mech. Dev. 103, 27-33 (2001)

Takeuchi S, Takeda K, Oishi I, Nomi M, Ikeya M, Itoh K, Tamura S, Ueda T, Hatta T, Otani H, Terashima T, Takada S, Yamamura H, Akira S, Minami Y.

Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation. Genes Cells. 5, 71-78 (2000)

Ikeya M, Takada S.

Wnt signaling from the dorsal neural tube is required for the formation of the medial dermomyotome. Development 125, 4969-4976 (1998)

Ikeya M, Lee SM, Johnson JE, McMahon AP, Takada S.

Wnt signalling required for expansion of neural crest and CNS progenitors. Nature 389, 966-970 (1997)

著作物

戸口田淳也、日野恭介、池谷　真

特集：遺伝性疾患治療の最前線　7．進行性骨化性線維異形成症（FOP） 遺伝子医学 32号　2020年4月1日 vol. 10 No. 2, 55-61, メディカルドゥ（2020）

中島大輝、池谷　真

腱・人体研究のフロンティア　（４）iPS細胞と腱・靱帯研究 整形・災害外科　vol. 63 No. 4, 443-448, 金原出版株式会社 (2020)

川井俊介、日野恭介、池谷　真、戸口田淳也

骨芽細胞に関する最新のトピック（2）―FOPの発症メカニズムと分子治療薬への展開― THE BONE 2019年5月20日 Vol.33 No.1, 45-50, メディカルレビュー社

中島大輝、池谷　真

「iPS創薬×ドラッグリポジショニング」による進行性骨化性線維異形成症の治療薬開発 ファルマシア 2019年3月1日 vol. 55 No. 3, 199- 203, 公益社団法人日本薬学会 (2019)

池谷　真

進行性骨化性線維異形成症の発症機構の解明 日本再生医療学会雑誌　再生医療　vol. 17 No. 4, 77-82, メディカルレビュー社 (2018)

日野恭介、戸口田淳也、池谷　真

FOP患者由来iPS細胞を用いた創薬 医学のあゆみ 2018年9月8日 vol. 266 No. 10, 796-797, 医歯薬出版株式会社 (2018)

日野恭介、池谷　真

患者特異的iPS細胞由来間葉系細胞を用いた創薬スクリーニング 創薬のための細胞利用技術の最新動向と市場, 第II編 第1章 6, 株式会社シーエムシー･リサーチ (2018)

戸口田淳也、日野恭介、池谷　真

疾患特異的iPS細胞を用いた筋・骨格系疾患に対するアプローチ 血液フロンティア 3月号 Vol.28 No.3, 79-86, 医薬ジャーナル (2018)

池谷　真、日野恭介、松本佳久、福田誠、戸口田淳也

間葉系幹細胞疾患としての進行性骨化性線維異形成症 実験医学増刊 Vol.34 No.17, 145(2913)-151(2919), 羊土社 （2016）

日野恭介、池谷　真、戸口田淳也

患者由来iPS細胞を用いた進行性骨化性線維異形成症（FOP）の病態解明 感染　炎症　免疫, 第46巻　第1号, 55‐58, 鳥居薬品株式会社（2016）

松本佳久、日野恭介、池谷　真、戸口田淳也

iPS細胞を用いた進行性骨化性線維異形成症の病態解明 バイオサイエンスとインダストリー, 第74巻　第4号, 324‐326,
一般財団法人バイオインダストリー協会（2016）

戸口田淳也、日野恭介、池谷　真

疾患特異的iPS細胞を活用した難病研究 ～病態解明から創薬へ CLINICAL CALCIUM, Vol.26 No.4: 593-600,株式会社医薬ジャーナル社（2016）

松本佳久、池谷　真、横山宏司、大塚隆信、戸口田淳也

iPS細胞を用いた難治性骨軟骨性疾患への取り組み 日本整形外科学会雑誌, 第89巻　第12号, 1005‐1009, 公益社団法人　日本整形外科学会（2015）

戸口田淳也、横山宏司、池谷　真、平家俊男、西小森隆太

慢性自己炎症性疾患における成長軟骨板の病態 臨床免疫・アレルギー科, 64(2): 205-211, 科学評論社（2015）

戸口田淳也、横山宏司、池谷　真、平家俊男、西小森隆太

疾患特異的iPS細胞を活用した筋骨格系難病研究 日本臨牀73巻　増刊号5 再生医療、416-422、日本臨牀社（2015）

戸口田淳也、池谷　真、西小森隆太

疾患特異的iPS細胞を活用した骨軟骨疾患研究 病理と臨床 2015年6月号 （33巻6号）病理医を誘うiPS細胞を使った疾患研究, 599-606, 文光堂（2015）

戸口田淳也、池谷　真

患者由来iPS細胞を用いた疾患モデル作製研究：骨軟骨疾患 医学のあゆみ　Vol.252 No.12、iPS細胞研究最前線ー疾患モデルから臓器再生まで、1245-1250、医歯薬出版（2015）

池谷　真、松本佳久、戸口田淳也

進行性骨化性線維異形成症 遺伝子医学MOOK 27号, 203-207, メディカルドゥ（2015）

戸口田淳也、池谷　真、西小森隆太、松本佳久、横山宏司

疾患特異的iPS細胞を用いた難治性骨軟骨疾患の病態解析・創薬 実験医学増刊　Vol.33 No.2、再生医療2015 幹細胞と疾患iPS細胞の研究最前線、147-151、羊土社（2015）

戸口田淳也、福田誠、池谷　真

Special Review　間葉系幹細胞を巡る最近の進歩について 細胞工学　Vol.33 No.12、1282-1287、秀潤社 (2014)

松本佳久、池谷　真、戸口田淳也

骨への分化誘導
実験医学別冊　ES・iPS細胞実験スタンダード、246-257、羊土社（2014）

松本佳久、福田　誠、池谷　真、戸口田淳也

iPS細胞の基礎と応用(第3回)iPS細胞を使う : 骨の研究へ 整形外科 64(9)、1017-1019、南江堂（2013）

池谷　真、松本佳久、横山宏司、戸口田淳也

iPS細胞ーその基礎と臨床応用に向けた展望ー 整形・災害外科 第56巻第5号、４月臨時増刊号、507-514、金原出版株式会社（2013）

戸口田淳也、池谷　真（編集）

最新疾患モデルと病態解明、創薬応用研究、細胞医薬創製研究の最前線 遺伝子医学MOOK 22号、メディカルドゥ（2012）

松本佳久、池谷　真、戸口田淳也

難治性骨軟骨疾患罹患者由来iPS細胞を用いた病態再現と治療薬開発の試み 遺伝子医学MOOK 22号, 190-194, メディカルドゥ（2012）

池谷　真、川田正子

Multisite Gatewayを用いたノックアウトベクターの効率的作製法（EG construction法） Gatewayを用いた遺伝子導入マニュアル,75-86, シュプリンガー・ジャパン (2009)

池谷　真、高田慎治

脊椎動物の原腸形成期におけるWntシグナルの役割 細胞工学 第19巻 第11号, 1644-1649, 秀潤社 (2000)

池谷　真、高田慎治

脊椎動物の神経管から分泌されるWnt遺伝子と形態形成 生化学 第71巻 第10, 1243-1247, 日本生化学会 (1999)

Ikeya M, Lee SM, McMahon AP, and Takada S.

The role of Wnt signaling in the Developing Dorsal Neural Tube Keio University Symposia for Life Science and Medicine, Vol.2 Neural Development,37-41, Springer-Verlag Tokyo (1999)

池谷　真

神経系の発生におけるWntシグナルの役割 脳の科学 第20巻 第11号, 1245-1248, 星和書店 (1998)