発表論文

Masui A, Hashimoto R, Matsumura Y, Yamamoto T, Nagao M, Noda T, Takayama K^*, Gotoh S^*.

Micro-patterned culture of iPSC-derived alveolar and airway cells distinguishes SARS-CoV-2 variants. Stem Cell Reports, 2024 Mar; 19(4): 545-561

Ohnishi Y, Masui A, Suezawa T, Mikawa R, Hirai T, Hagiwara M, Gotoh S^*.

Screening of factors inducing alveolar type 1 epithelial cells using human pluripotent stem cells. Stem Cell Reports, 2024 Mar; 19(4): 529-544

Takeuchi K^*, Abo M, Date H, Gotoh S, Kamijo A, Kaneko T, Keicho N, Kodama S, Koinuma G, Kondo M, Masuda S, Mori E, Morimoto K, Nagao M, Nakano N, Nakatani K, Nishida N, Nishikido T, Ohara H, Okinaka Y, Fujieda S.

Practical guide for the diagnosis and management of primary ciliary dyskinesia. Auris Nasus Larynx, 2024 Mar; 51(3): 553-568

Mikawa R, Gotoh S^*

Past and future of alveolar organoids for lung regenerative medicine. Stem Cells, 2024 June; 42(6): 491-498

Shiratsuchi G, Konishi S, Yano T, Yanagihashi Y, Nakayama S, Katsuno T, Kashihara H, Tanaka H, Tsukita K, Suzuki K, Herawati E, Watanabe H, Hirai T, Yagi T, Kondoh G, Gotoh S, Tamura A^*, Tsukita S^*.

Dual-color live imaging unveils stepwise organization of multiple basal body arrays by cytoskeletons. EMBO Rep., 2024 Feb 5; Online ahead of print.

Niwa R, Sakai K*, Lung MSY, Matsumoto T, Mikawa R, Maehana S, Suzuki M, Yamamoto Y, Maurissen TL, Hirabayashi A, Noda T, Kubo M, Gotoh S^*, Woltjen K^*.

ACE2 knockout hinders SARS-CoV-2 propagation in iPS cell-derived airway and alveolar epithelial cells. Front Cell Dev Biol., 2023 Dec 8; 11: 1290876.

Yadav S, Fujimoto K, Takenaga T, Takahashi S, Muramoto Y, Mikawa R, Noda T, Gotoh S, Yokokawa R^*.

Isogenic iPSC-derived proximal and distal lung-on-chip models: Tissue and virus-specific immune responses in human lungs. bioRxiv, 2023 Nov 24.

Hosokawa M, Mikawa R, Hagiwara A, Okuno Y, Awaya T, Yamamoto Y, Takahashi S, Yamaki H, Osawa M, Setoguchi Y, Saito MK, Abe S, Hirai T, Gotoh S^*, Hagiwara M^*.

Cryptotanshinone is a candidate therapeutic agent for interstitial lung disease associated with a BRICHOS-domain mutation of SFTPC. iScience, 2023 Oct; 26(10): 107731.

Li R, Sone N, Gotoh S, Sun X, Hagood JS^*.

Contemporary and emerging technologies for research in children's rare and interstitial lung disease. Pediatr Pulmonol., 2023 May 19; Epub ahead of print.

Muramoto Y, Takahashi S, Halfmann PJ, Gotoh S, Noda T, Kawaoka Y

Omicron variants BA.5 and BQ.1.1 lack efficient replicative capacity at elevated temperatures. Lancet Microbe., 2023 Apr 24;S2666-5247(23)00100-3.

Xu Y, Feng G, Yano T, Masuda S, Nagao M, Gotoh S, Ikejiri M, Tanabe M, Takeuchi K

Characteristic genetic spectrum of primary ciliary dyskinesia in Japanese patients and global ethnic heterogeneity: population-based genomic variation database analysis. J Hum Gen., 2023 Mar 2. doi: 10.1038/s10038-023-01142-4.

Tamai K, Sakai K, Yamaki H, Moriguchi K, Igura K, Maehana S, Suezawa T, Takehara K, Hagiwara M, Hirai T, Gotoh S

iPS cell-derived mesenchymal cells that support alveolar organoid development. Cell Rep Methods., 2022 Sep 19;2(10):100314.

Feng G, Xu Y, Saso S, Sasano S, Kondoh S, Itani H, Gotoh S, Nagao M, Ikejiri M, Tanabe M, Takeuchi K^*

A Novel Homozygous Variant in GAS2L2 in Two Sisters with Primary Ciliary Dyskinesia. Intern Med., 2022 Sep 15;61(18):2765-2769.

Masui A, Hirai T, Gotoh S

Perspectives of future lung toxicology studies using human pluripotent stem cells. Archives of Toxicology, 2022 Feb; 96(2):389-402. Review

Suezawa T, Kanagaki S, Moriguchi K, Masui A, Nakao K, Toyomoto M, Tamai K, Mikawa R, Hirai T, Murakami K, Hagiwara M, Gotoh S.

Disease modeling of pulmonary fibrosis using human pluripotent stem cell-derived alveolar organoids. Stem Cell Reports, 2021 Dec 14;16(12):2973-2987.

Suezawa T, Kanagaki S, Korogi Y, Nakao K, Hirai T, Murakami K, Hagiwara M, Gotoh S.

Modeling of lung phenotype of Hermansky-Pudlak syndrome type I using patient-specific iPSCs. Respiratory Research, 2021 Nov 4;22(1):284.

Kogo M, Matsumoto H*, Tanabe N, Chen-Yoshikawa TF, Nakajima N, Yoshizawa A, Oguma T, Sato S, Nomura N, Morimoto C, Sunadome H, Gotoh S, Ohsumi A, Date H, Hirai T.

The importance of central airway dilatation in patients with bronchiolitis obliterans. ERJ Open Res., 2021 Oct; 7(4):00123-2021.

Ikeo S, Yamamoto Y, Ikeda K, Sone N, Korogi Y, Tomiyama L, Matsumoto H, Hirai T, Hagiwara M,
Gotoh S.

Core-shell hydrogel microfiber-expanded pluripotent stem cell-derived lung progenitors applicable to lung reconstruction in vivo. Biomaterials, 2021 Sep; 276:121031.

Sone N, Konishi S, Igura K, Tamai K, Ikeo S, Korogi Y, Kanagaki S, Namba T, Yamamoto Y, Xu Y, Takeuchi K, Adachi Y, Chen-Yoshikawa TF, Date H, Hagiwara M, Tsukita S, Hirai T, Torisawa Y, Gotoh S^*.

Multicellular modeling of ciliopathy by combining iPS cells and microfluidic airway-on-a-chip technology. Sci Transl Med., 2021 Jul; 13(601): abb1298.

Kanagaki S, Suezawa T, Moriguchi K, Nakao K, Toyomoto M, Murakami K, Hagiwara M, Gotoh S.

Hydroxypropyl cyclodextrin improves amiodarone-induced aberrant lipid homeostasis of alveolar cells. Am J Resp Cell Mol., 2021 Apr; 64(4): 504-514.

Xu Y, Ogawa S, Adachi Y, Sone N, Gotoh S, Ikejiri M, Nakatani K, Takeuchi K^*.

A pediatric case of primary ciliary dyskinesia caused by novel copy number variation in PIH1D3. Auris Nasus Larynx, 2021 Mar; S0385-8146(21)00087-0.

Yin X, Riva L, Pu Y, Martin-Sancho L, Kanamune J, Yamamoto Y, Sakai K, Gotoh S, Miorin L, De Jesus PD, Yang CC, Herbert KM, Yoh S, Hultquist JF, Garcia-Sastre A, Chanda SK^*.

MDA5 governs the innate immune response to SARS-CoV-2 in lung epithelial cells. Cell Rep., 2021 Jan; 34: 108628.

Kanagaki S, Ikeo S, Suezawa T, Yamamoto Y, Seki M, Hirai T, Hagiwara M, Suzuki Y, Gotoh S.

Directed induction of alveolar type I cells derived from pluripotent stem cells via Wnt signaling inhibition. Stem Cells, 2020 Nov; 39(2): 156-169.

Yamamoto Y, Korogi Y, Hirai T, Gotoh S^*.

A method of generating alveolar organoids using human pluripotent stem cells. Methods Cell Biol., 2020 Mar; 159:115-141.

Takeuchi K^*, Xu Y, Kitano M, Chiyonobu K, Abo M, Ikegami K, Ogawa S, Ikejiri M, Kondo M, Gotoh S, Nagao M, Fujisawa T, Nakatani K.

Copy number variation in DRC1 is the major cause of primary ciliary dyskinesia in the Japanese population. Mol Genet Genomic Med, 2020 Jan; e1137.

Konishi S, Yano T, Tanaka H, Mizuno T, Kanoh H, Tsukita K, Namba T, Tamura A, Yonemura S, Gotoh S, Matsumoto H, Hirai T, Tsukita S^*.

Vinculin is critical for the robustness of the epithelial cell sheet paracellular barrier for ions. Life Sci Alliance, 2019 Aug; 2(4): e201900414.

Okuyama H, Ohnishi H, Nakamura R, Yamashita M*, Kishimoto Y, Tateya I, Suehiro A, Gotoh S, Takezawa T, Nakamura T, Omori K.

Transplantation of multiciliated airway cells derived from human iPS cells using an artificial tracheal patch into rat trachea. J Tissue Eng Regen Med., 2019 Feb; 13(6):1019-1030.

Korogi Y, Gotoh S, Ikeo S, Yamamoto Y, Sone N, Tamai K, Konishi S, Nagasaki T, Matsumoto H, Ito I, Chen-Yoshikawa TF, Date H, Hagiwara M, Asaka I, Hotta A, Mishima M, Hirai T.

In vitro disease modeling of Hermansky-Pudlak Syndrome type 2 using human induced pluripotent stem cell-derived alveolar organoids. Stem Cell Reports, 2019 Feb; 12: 431-440.

Yamamoto Y, Gotoh S, Korogi Y, Seki M, Konishi S, Ikeo S, Sone N, Nagasaki T, Matsumoto H, Muro S, Ito I, Hirai T, Kohno T, Suzuki Y, Mishima M.

Long-term expansion of alveolar stem cells derived from human iPS cells in organoids. Nature Methods, 2017 Oct; 14(11):1097-1106.

Konishi S, Gotoh S, Tateishi K, Yamamoto Y, Korogi Y, Nagasaki T, Matsumoto H, Muro S, Hirai T, Ito I, Tsukita S, Mishima M.

Directed induction of functional multi-ciliated cells in proximal airway epithelial spheroids from human pluripotent stem cells. Stem Cell Reports, 2016 Jan; 6(1): 18-25.

Gotoh S, Ito I, Nagasaki T, Yamamoto Y, Konishi S, Korogi Y, Matsumoto H, Muro S, Hirai T, Funato M, Mae S, Toyoda T, Sato-Otsubo A, Ogawa S, Osafune K, Mishima M.

Generation of alveolar epithelial spheroids via isolated progenitor cells from human pluripotent stem cells. Stem Cell Reports, 2014 Sep 9; 3(3): 394-403.

Gotoh S^*, Chohnabayashi N.

Infection 57 years after plombage. N Engl J Med, 2009; 360:e29.

Gotoh S^*, Nishimura N, Takahashi O, Shiratsuka H, Horinouchi H, Ono H, Uchiyama N, Chohnabayashi N.

Adrenal function in patients with community-acquired pneumonia. Eur Respir J, 2008;31:1268-1273.

Nitta T, Hata M, Gotoh S, Seo Y, Sasaki H, Hashimoto N, Furuse M, Tsukita S^*.

Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol, 2003; 161: 653-60.

Kiuchi-Saishin Y, Gotoh S, Furuse M, Takasuga A, Tano Y, Tsukita S^*.

Differential expression pattern of claudins, tight junction membrane proteins, in mouse nephron segments. J Am Soc Nephrol, 2002; 13 : 875-886.