発表論文

Jo N, Hidaka Y, Kikuchi O, Fukahori M, Sawada T, Aoki M, Yamamoto M, Nagao M, Morita S, Nakajima T, Muto M, and Hamazaki Y^✝.

Impaired CD4⁺ T cell response in older adults is associated with reduced immunogenicity and reactogenicity of mRNA COVID-19 vaccination. Nature Aging, 2023 Jan 12; 3, 82-9. doi: 10.1038/s43587-022-00343-4
✝ Correspondence

Koike T, Fujii K, Kometani K, Butler NS, Funakoshi K, Yari S, Kikuta J, Ishii M, Kurosaki T, Ise W.

Progressive differentiation toward the long-lived plasma cell compartment in the bone marrow J Exp Med., 2022 Dec 14 220(2):e20221717

Sato Y, Oguchi A, Fukushima Y, Masuda K, Toriu N, Taniguchi K, Yoshikawa T, Cui X, Kondo M, Hosoi T, Komidori S, Shimizu Y, Fujita H, Jiang L, Kong Y, Yamanashi T, Seita J, Yamamoto T, Toyokuni S, Hamazaki Y, Hattori M, Yoshikai Y, Boor P, Floege J, Kawamoto H, Murakawa Y, Minato N, Yanagita M.

CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury. J Clin Invest., 2022 Jan 18;132(2):e146071. doi: 10.1172/JCI146071.

Konishi Y, Ichise H, Watabe T, Oki C, Tsukiji S, Hamazaki Y, Murakawa Y, Takaori-Kondo A, Terai K, Matsuda M.

Intravital Imaging Identifies the VEGF-TXA2 Axis as a Critical Promoter of PGE2 Secretion from Tumor Cells and Immune Evasion. Cancer Res., 2021 Aug 1;81(15):4124-4132. doi: 10.1158/0008-5472.CAN-20-4245.

Jo N, Zhang R, Ueno H, Yamamoto T, Weiskopf D, Nagao M, Yamanaka S, and Hamazaki Y^✝.

Aging and CMV Infection Affect Pre-existing SARS-CoV-2-Reactive CD8⁺ T Cells in Unexposed Individuals. Front. Aging, 2021 Aug, 2:719342. doi: 10.3389/fragi.2021.719342
✝ Correspondence

Nagatake T, Zhao Y, Ito T, Itoh M, Kometani K, Furuse M, Saika A, Node E, Kunisawa J, Minato N, Hamazaki Y^✝.

Selective expression of claudin-5 in thymic endothelial cells regulates the blood-thymus barrier and T-cell export. Int Immunol. 2020 Oct 10:dxaa069. doi: 10.1093/intimm/dxaa069. Online ahead of print.
✝ Correspondence

Ito T, Kometani K, Minato N, Hamazaki Y^✝.

Bone Marrow Endothelial Cells Take Up Blood-Borne Immune Complexes via Fcγ Receptor IIb2 in an Erythropoietin-Dependent Manner. J Immunol. 2020 Oct 15;205(8):2008-2015. doi: 10.4049/jimmunol.1901101. Epub 2020 Sep 9.
✝ Correspondence

Li H, Neelankal John A, Nagatake T, Hamazaki Y, Jiang FX.

Claudin 4 in pancreatic β cells is involved in regulating the functional state of adult islets. FEBS Open Bio, 2020 Jan 10(1):28-40

Kikuchi S, Noguchi K, Wakai K, Hamazaki Y, Tozawa K, Jomori T, Sasako M, Miwa H.

Propagermanium Induces NK Cell Maturation and Tends to Prolong Overall Survival of Patients With Refractory Cancer. Anticancer Res., 2019 Sep 39(9):4687-4698

Minato N, Hattori M, Hamazaki Y.

Physiology and pathology of T-cell aging. Int Immunol. 2020 Jan 22. pii: dxaa006. doi: 10.1093/intimm/dxaa006. [Epub ahead of print]

Sekai M, Wang J, Hamazaki Y^✝.

Clonogenic Culture of Mouse Thymic Epithelial Cells. Methods Mol Biol. 2019;2048:143-153. doi: 10.1007/978-1-4939-9728-2_15.
✝ Correspondence

Imai T, Tanaka H, Hamazaki Y, Minato N.

Rap1 signal modulators control the maintenance of hematopoietic progenitors in bone marrow and adult long-term hematopoiesis. Cancer Sci. 2019 Apr;110(4):1317-1330. doi: 10.1111/cas.13974.

Sekai M, Wang J, Minato N, Hamazaki Y^✝.

An improved clonogenic culture method for thymic epithelial cells. J Immunol Methods. 2019 Apr;467:29-36. doi: 10.1016/j.jim.2019.02.003.
✝Correspondence

Wang J, Sekai M, Matsui T, Fujii Y, Matsumoto M, Takeuchi O, Minato N, Hamazaki Y^✝.

Hassall's corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus. Int Immunol. 2018 Dec 10. doi: 10.1093/intimm/dxy073.
✝Correspondence

Konishi Y, Terai K, Furuta Y, Kiyonari H, Abe T, Ueda Y, Kinashi T, Hamazaki Y, Takaori-Kondo A, Matsuda M.

Live-Cell FRET Imaging Reveals a Role of Extracellular Signal-Regulated Kinase Activity Dynamics in Thymocyte Motility. iScience. 2018 Dec 21;10:98-113. doi: 10.1016/j.isci.2018.11.025.

Kato A, Takaori‐Kondo A, Minato N, Hamazaki Y^✝

CXCR3^high CD8⁺ T cells with naïve phenotype and high capacity for IFN‐γ production are generated during homeostatic T‐cell proliferation Eur. J. Immunol. 2018. 00: 1-16. doi: 10.1002/eji.201747431
^✝Correspondence

Suzuki H, Nagatake T, Nasu A, Lan H, Ikegami K, Setou M, Hamazaki Y, Kiyono H, Yagi K, Kondoh M, Kunisawa J.

Impaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice. Sci Rep. 2018 Feb 13;8(1):2904. doi: 10.1038/s41598-018-21120-7.

Sugie T, Suzuki E, Yamauchi A, Yamagami K, Masuda N, Gondo N, Sumi E, Ikeda T, Tada H, Uozumi R, Kanao S, Tanaka Y, Hamazaki Y, Minato N, Toi M.

Combined effects of neoadjuvant letrozole and zoledronic acid on γδT cells in postmenopausal women with early-stage breast cancer. Breast. 2018 Jan 5;38:114-119. doi: 10.1016/j.breast.2017.12.017.

Ito T, Hamazaki Y^✝, Takaori-Kondo A, Minato N.

Bone Marrow Endothelial Cells Induce Immature and Mature B Cell Egress in Response to Erythropoietin. Cell Struct Funct. 2017 Dec 12;42(2):149-157. doi: 10.1247/csf.17018.
✝Correspondence

Sato K, Kato A, Sekai M, Hamazaki Y, Minato N.

Physiologic Thymic Involution Underlies Age-Dependent Accumulation of Senescence-Associated CD4⁺ T Cells. J Immunol. 2017 Jul 1;199(1):138-148.

Ohigashi, I, Ohte, Y, Setoh, K, Nakase, H, Maekawa, A, Kiyonari, H, Hamazaki, Y, Sekai, M, Sudo, T, Tabara, Y, Sawai, H, Omae, Y, Yuliwulandari, R, Tanaka, Y, Mizokami, M, Inoue, H, Kasahara, M, Minato, N, Tokunaga, K, Tanaka, K, Matsuda, F, Murata, S, and Takahama, Y.

A human PSMB11 variant affects molecular processing of thymoproteasome and thymic　production of CD8⁺ T cells. JCI Insight. 2017 May 18;2(10). pii: 93664.

Ito K, Nakajima A, Fukushima Y, Suzuki K, Sakamoto K, Hamazaki Y, Ogasawara K, Minato N, Hattori M.

The potential role of Osteopontin in the maintenance of commensal bacteria homeostasis in the intestine. PLoS One. 2017 Mar 15;12(3):e0173629.

Shirakawa K, Yan X, Shinmura K, Endo J, Kataoka M, Katsumata Y, Yamamoto T, Anzai A, Isobe S, Yoshida N, Itoh H, Manabe I, Sekai M, Hamazaki Y, Fukuda K, Minato N, and Sano M.

Obesity accelerates T-cell senescence in visceral adipose tissue. J Clin Invest. 2016 Dec 1;126(12):4626-4639.

Sato Y, Mii A, Hamazaki Y, Fujita H, Nakata H, Masuda K, Nishiyama S, Shibuya S, Haga H, Ogawa O, Shimizu A, Narumiya S, Kaisho T, Arita M, Yanagisawa M, Miyasaka M, Sharma K, Minato N, Kawamoto H, and Yanagita M.

Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney. JCI. Insight. 2016 Jul 21;1(11):e87680.

Hamazaki Y^✝, Sekai M, Minato N.

Medullary thymic epithelial stem cells: role in thymic epithelial cell maintenance and thymic involution. Immunol Rev. 2016 May;271(1):38-55.
^✝Correspondence

Baik S, Sekai M, Hamazaki Y, Jenkinson WE, Anderson G.

Relb acts downstream of medullary thymic epithelial stem cells and is essential for the emergence of RANK⁺ medullary epithelial progenitors. Eur J Immunol. 2016 Apr;46(4):857-62.

Hamazaki Y^✝.

Adult thymic epithelial cell (TEC) progenitors and TEC stem cells - Models and mechanisms for the development and maintenance of thymic epithelial cells. Eur J Immunol. 2015 Nov;45(11):2985-93.
^✝Correspondence

Ohigashi I, Zuklys S, Sakata M, Mayer CE, Hamazaki Y, Minato N, Hollander GA, Takahama Y.

Adult thymic medullary epithelium is maintained and regenerated by lineage-restricted cells rather than bipotent progenitors. Cell Rep. 2015 Nov 17;13(7):1432-43.

Tahir S, Fukushima Y, Sakamoto K, Sato K, Fujita H, Inoue J, Uede T, Hamazaki Y, Hattori M, Minato N.

A CD153+CD4+ T Follicular Cell Population with Cell-Senescence Features Plays a Crucial Role in Lupus Pathogenesis via Osteopontin Production. J Immunol. 2015 Jun 15;194(12):5725-35.

Doi K, Imai T, Kressler C, Yagita H, Agata Y, Vooijs M, Hamazaki Y, Inoue J, Minato N.

Crucial role of the Rap G protein signal in Notch activation and leukemogenicity of T-cell acute lymphoblastic leukemia. Sci Rep. 2015 Jan 23;5:7978.

Sekai M, Hamazaki Y^✝, Minato N.

Medullary thymic epithelial stem cells maintain a functional thymus to ensure lifelong central T cell tolerance. Immunity. 2014 Nov 14: 41(5), 753-761.
^✝Correspondence

Mizuno R, Kamioka Y, Kabashima K, Imajo M, Sumiyama K, Nakasho E, Ito T, Hamazaki Y, Okuchi Y, Sakai Y, Kiyokawa E, Matsuda M.

In vivo imaging reveals PKA regulation of ERK activity during neutrophil recruitment to inflamed intestines. J Exp Med. 2014 Jun 2;211(6):1123-36.

Nagatake T, Fujita H, Minato N, Hamazaki Y.^✝

Enteroendocrine cells are specifically marked by cell surface expression of claudin-4 in mouse small intestine. PLoS One. 2014 Mar 6;9(3):e90638.
^✝Correspondence

Fujita H, Hamazaki Y^✝, Noda Y, Oshima M, and Minato N.

Claudin-4 deficiency results in urothelial hyperplasia and lethal hydronephrosis. PLOS One. 2012 7(12):e52272.
^✝Correspondence

Kawai Y*, Hamazaki Y*^✝, Fujita H, Fujita A, Sato T, Furuse M, Fujimoto T, Jetten AM, Agata Y and Minato N.

Claudin-4 induction by E protein activity in later stages of CD4/8 double-positive thymocytes to increase positive selection efficiency. Proc Natl Acad Sci USA 2011 Mar 8;108(10):4075-80.
^✝Correspondence
* These authors contributed equally to this work.

Shimizu Y, Hamazaki Y, Hattori M, Doi K, Terada N, Kobayashi T, Toda Y, Yamasaki T, Inoue TA, Kajita Y, Maeno A, Kamba T, Mikami Y, Kamoto T, Yamada T, Kanno T, Yoshikawa K, Ogawa O, Minato N, Nakamura E.

SPA-1 controls the invasion and metastasis of human prostate cancer. Cancer Sci. 2011 Apr;102(4):828-36.

Tanaka H, Tamura A, Sekai M, Hamazaki Y, Minato N.

Increased c-Myc activity and DNA damage in hematopoietic progenitors precede myeloproliferative disease in Spa-1-deficiency. Cancer Sci. 2011 Apr;102(4):784-91.

Shimatani K, Nakashima Y, Hattori M, Hamazaki Y, Minato N.

PD-1⁺ memory phenotype CD4⁺ T cells expressing C/EBPα underlie T cell immunodepression in senescence and leukemia. Proc Natl Acad Sci USA 2009 Sep 15;106:15807-12.

Katayama Y, Sekai M, Hattori M, Miyoshi I, Hamazaki Y, Minato N.

Rap signaling is crucial for the competence of IL-7 response and the development of B-lineage cells. Blood. 2009 Aug 27;114(9):1768-75.

Adachi M, Hamazaki Y, Kobayashi Y, Itoh M, Tsukita S, Furuse M, Tsukita S.

Similar and distinct properties of MUPP1 and Patj, two homologous PDZ domain-containing tight-junction proteins. Mol Cell Biol. 2009 May;29(9):2372-89.

Sakata D, Taniguchi H, Yasuda S, Adachi-Morishima A, Hamazaki Y, NakayamaR, Miki T, Minato N, Narumiya S.

Impaired T lymphocyte trafficking in mice deficient in an actin-nucleating protein, mDia1. J. Exp. Med. 2007 Sep 3;204(9):2031-8.

Hamazaki Y, Fujita H, Kobayashi T, Choi Y, Scott HS, Matsumoto M, Minato N.

Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin. Nat. Immunol. 2007 Mar; 8(3):304-11.

Sugihara-Mizuno Y, Adachi M, Kobayashi Y, Hamazaki Y, Nishimura M, Imai T, Furuse M, Tsukita S.

Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties. Genes Cells. 2007 Apr;12(4):473-86.

Ishida D, Su L, Tamura A, Katayama Y, Kawai Y, Wang SF, Taniwaki M, Hamazaki Y, Hattori M, Minato N.

Rap1 signal controls B cell receptor repertoire and generation of self-reactive B1a cells. Immunity. 2006 Apr;24(4):417-27.

Harazaki M, Kawai Y, Su L, Hamazaki Y, Nakahata T, Minato N, Hattori M.

Specific recruitment of SPA-1 to the immunological synapse: involvement of actin-bundling protein actinin. Immunol Lett. 2004 Apr 15;92(3):221-6.

Hamazaki Y, Itoh M, Sasaki H, Furuse M, Tsukita S.

Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule. J Biol Chem. 2002 Jan 4;277(1):455-61.

Hamazaki Y, Kojima H, Mano H, Nagata Y, Todokoro K, Abe T, Nagasawa T.

Tec is involved in G protein-coupled receptor- and integrin-mediated signalings in human blood platelets. Oncogene 1998 May; 16(21): 2773-9.

Kojima H, Hamazaki Y, Nagata Y, Todokoro K, Nagasawa T, Abe T.

Modulation of platelet activation in vitro by thrombopoietin. Thromb Haemost 1995 Dec; 74(6): 1541-5.

日本語総説

城 憲秀、依光 隆哲、米谷 耕平、濱崎 洋子

【抗老化医療の未来をさぐる：哺乳類における老化・寿命制御の理解とその社会実装】高齢者のワクチン効果について教えてください. Geriatric Medicine（老年医学） 2023 Jan 01 61(1):75-79

濵﨑 洋子、湊 長博

Ｔ細胞の老化と免疫老化 ライフサイエンス　領域融合レビュー　7, e005 (2018) DOI: 10.7875/leading.author.7.e005

濵﨑 洋子

胸腺退縮とＴ細胞老化 アンチ・エイジング医学―日本抗加齢医学会雑誌　13(3) 020-027

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胸腺上皮幹細胞の早期活性低下に伴う胸腺退縮と免疫老化 実験医学　特集「臓器老化の本質に迫るステムセルエイジング」　35(8) 1309-1315 (2017) 羊土社

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免疫老化　―Ｔ細胞の加齢変化を中心に― 腎臓内科・泌尿器科　3(4) 393-401 (2016) 科学評論社

濵﨑 洋子

Ｔ細胞の中枢性自己寛容を保証する胸腺髄質上皮幹細胞の同定とその制御 感染・免疫・炎症 45(4) 28-35 (2015) 羊土社

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中枢性自己寛容を保証する胸腺髄質上皮幹細胞と自己免疫疾患におけるその制御 実験医学　増刊　「自己免疫疾患」　33(12), 134-139 (2015) 羊土社

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Ｔ細胞の中枢性自己寛容を生涯にわたり保証する胸腺髄質上皮幹細胞の同定 ライフサイエンス新着論文レビュー (2015) DOI: 10.7875/first.author.2015.003

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胸腺の発生 （皮質・髄質上皮細胞の起源と分化） メディカルバイオ、5(1), 24-31 (2008)　オーム社

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胸腺上皮細胞に発現するクローディン 感染・炎症、免疫,　38(1), 32-40 (2008)　医薬の門社

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教科書翻訳

エッセンシャル免疫学 （原著第二版）翻訳 メディカル・サイエンス・インターナショナル2007　監修　笹月健彦

エッセンシャル免疫学 （原著第三版）翻訳 メディカル・サイエンス・インターナショナル2010　監修　笹月健彦

免疫生物学 （原著第七版）翻訳 南江堂　2010　監修　笹月健彦