研究活動
Research Activities

研究活動
Research Activities

Home › 研究活動 › 主任研究者 › 川口 義弥 教授

主任研究者
Principal Investigators

未来生命科学開拓部門 川口 義弥 教授

発表論文

Sato A, Masui T, Nakano K, Sankoda N, Anazawa T, Takaori K, Kawaguchi Y, Uemoto S.

Abdominal contamination with Candida albicans after pancreaticoduodenectomy is related to hemorrhage associated with pancreatic fistulas. Pancreatology. (3):484-489, 2017

Goto T, Elbahrawy A, Furuyama K, Horiguchi M, Hosokawa , Aoyama Y, Tsuboi K, Sakikubo M, Hirata K, Masui T, Kubo H, Sakai Y, Uemoto S, Kawaguchi Y.

Liver-specific Prox1 inactivation causes hepatic injury and glucose intolerance in mice. FEBS Lett. ;591(4):624-635, 2017

Masui T, Doi R, Kawaguchi Y, Sato A, Nakano K, Ito T, Anazawa T, Takaori K, Uemoto S.

Concurrent gemcitabine+S-1 neoadjuvant chemotherapy contributes to the improved survival of patients with small borderline-resectable pancreatic cancer tumors. Surg Today. ;46(11):1282-9, 2016

Kiyoto Nishi, Yuichi Sato, Mikiko Ohno, Yoshinori Hiraoka, Sayaka Saijo, Jiro Sakamoto, Po-Min Chen, Yusuke Morita, Shintaro Matsuda, Kanako Iwasaki, Kazu Sugizaki, Norio Harada, Yoshiko Mukumoto, Hiroshi Kiyonari, Kenichiro Furuyama, Yoshiya Kawaguchi, Shinji Uemoto, Toru Kita, Nobuya Inagaki, Takeshi Kimura and Eiichiro Nishi.

Nardilysin Is Required for Maintaining Pancreatic β-Cell Function. Diabetes. ;65(10):3015-27, 2016

Nakano Y, Negishi N, Gocho S, Mine T, Sakurai Y, Yazawa M, Abe K, Yagita H, Habu S, Kageyama R, Kawaguchi Y, Hozumi K.

Disappearance of centroacinar cells in the Notch ligand-deficient pancreas. Gens to Cells, 20(6):500-11, 2015

Shinichi Hosokawa, Kenichiro Furuyama, Masashi Horiguchi, Yoshiki Aoyama, Kunihiko Tsuboi, Morito Sakikubo, Toshihiko Goto, Koji Hirata, Wataru Tanabe, Yasuhiro Nakano, Haruhiko Akiyama, Ryoichiro Kageyama, Shinji Uemoto, Yoshiya Kawaguchi.

Impact of Sox9 Dosage and Hes1-mediated Notch Signaling in Controlling the Plasticity of Adult Pancreatic Duct Cells in Mice. Scientific Reports. 5, Article number: 8518, 2015

Kawaguchi Y*

Sox9 and reprogramming of liver and pancreatic progenitors. J Clin Invest. 123(5):1881-1886, 2013

Nakanishi Y, Seno H, Fukuoka A, Ueo T, Yamaga Y, Maruno T, Nakanishi N, Kanda K, Komekado H, Kawada M, Isomura A,Kawada K, Sakai Y, Yanagita M, Kageyama R, Kawaguchi Y, Taketo MM, Yonehara S, Chiba T.

Dclk1 distinguishes between tumor and normal stem cells in the intestine. Nat Genet. 45(1):98-103, 2013

Furuyama K, Kawaguchi Y*, Akiyama H*, Horiguchi M, Kodama S, Kuhara T, Hosokawa S, Elbahrawy A, Soeda T, Koizumi M, Masui T, Kawaguchi M, Takaori K, Doi R, Nishi E, Kakinoki R, Deng JM, Behringer RR, Nakamura T, Uemoto S.

Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine Nat Genet. 43(1):34-41, 2011

Kawaguchi Y*, Takaori K, Uemoto S

Genetic lineage tracing, a powerful tool to investigate the embryonic organogenesis and adult organ maintenance of the pancreas J Hepatobiliary Pancreat Sci. 18(1):1-5, 2011

Nishda K, Hoshino M, Kawaguchi Y, Murakami F

Ptf1a directly controls expression of immunoglobulin superfamily molecules Nephrin and Neph3 in the developing central nervous system J Biol Chem. 285;373-80, 2010

Betley JN, Wright CVE, Kawaguchi Y, Erdelyi F, Szabo G, Jessell TM, Kaltschmidt JA

Stringent specificity in the construction of a GABAergic presynaptic inhibitory circuit Cell. 139(1): 161-74, 2009

Fujiyama T, Yamada M, Terao M, Terashima T, Hioki H, Inoue YU, Inoue T, Masuyama N, Obata K, Yanagawa Y, Kawaguchi Y, Nabeshima Y, Hoshino M

Inhibitory and excitatory subtypes of cochlear nucleus neurons are defined by distinct bHLH transcription factors, Ptf1a and Atoh1. Development. 136(12):2049-58, 2009

Obata K, Hirono M, Kume N, Kawaguchi Y, Itohara S and Yanagawa Y

GABA and synaptic inhibition of mouse cerebellum lacking glutamate decarboxylase 67. Biochem Biophys Res Commun. ;670(3) :429-33. 2008

Fukuda A, Kawaguchi Y*, Furuyama K, Kodama S, Horiguchi M, Kuhara T, Kawaguchi M, Terao M, Doi R, Wright CV, Hoshino M, Chiba T, Uemoto S

Reduction of Ptf1a gene dosage causes pancreatic hypoplasia and diabetes in mice Diabetes. 57 (9) : 2421-2431, 2008

Morton JP, Mongeau ME, Klimstra DS, Morris JP, Lee YC, Kawaguchi Y, Wright CV, Hebrok M and Lewis BC

Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis. Proc Natl Acad Sci U S A. 20;104(12):5103-8. 2007

Fujikura J, Hosoda K, Kawaguchi Y, Noguchi M, Iwakura H, Odori S, Mori E, Tomita T, Hirata M Ebihara K, Masuzaki H, Fukuda A, Furuyama K, Tanigaki K, Yabe D and Nakao K

Rbp-j regulates expansion of pancreatic epithelial cells and their differentiation into exocrine cells during mouse development. Dev Dyn. ;236(10):2779-91. 2007

YamadaM, Terao M, Terashima T, Fujiyama T, Kawaguchi Y, Nabeshima Y and Hoshino M

Origin of climbing fiber neurons and their developmental dependence on Ptf1a. J Neurosci. 27(41):10924-34. 2007

Fujitani Y, Fuijtani S, Boyer DF, Gannon M, Kawaguchi Y, Ray M, Shiota M, Stein RW, Magnuson MA and Wright CV

Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation Genes Dev. ;20(2):253-66. 2006

Fukuda A, Kawaguchi Y*, Furuyama K, Kodama S, Kuhara T, Horiguchi M, Koizumi M, Fujimoto K, Doi R, Wright CVE, Chiba T

Loss of the major duodenal papilla results in brown pigment biliary stone formation in pdx1 null mice Gastroenterology. ;130(3):855-67. 2006

Fukuda A, Kawaguchi Y*, Furuyama K, Kodama S, Horiguchi M, Kuhara T, Koizumi M, Boyer DF., Fujimoto K, Doi R, Kageyama R, Wright CVE, Chiba T

Ectopic pancreas formation in Hes1 -knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas. J Clin Invest. ;116(6):1484-93. 2006

Miyatsuka T, Kaneto H, Shiraiwa T, Matsuoka TA, Yamamoto K, Kato K, Nakamura Y, Akira S, Takeda K, Kajimoto Y, Yamasaki Y, Sandgren EP, Kawaguchi Y, Wright CV and Fujitani Y

Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation. Genes Dev. ;20(11):1435-40.2006

Koizumi M, Nagai K, Kida A, Kami K, Ito D, Fujimoto K, Kawaguchi Y and Doi R

Forced expression of PDX-1 induces insulin production in intestinal epithelia. Surgery. ;140:273-80. 2006

Fujitani Y, Fujitani S, Luo H, Qui F, Burlison J Long Q, Kawaguchi Y, Edlund H, MacDonald RJ, Furukawa T, Fujikado T, Magunuson MA, Xiang M and Wright CV

Ptf1a determines horizontal and amacrine cell fates during mouse retinal development. Development. ;133(22):4439-50. 2006

Hoshino M, Nakamura S, Mori K, Kawauchi T, Terao M, Nishimura YV, Fukuda A, Fuse T, Matsuo N, Sone M, Watanabe M, Bito H, Terashima T, Wright CV, Kawaguchi Y, Nakao K and Nabeshima Y

Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum. Neuron. ;47(2):201-13. 2005

Koizumi M, Doi R, Fujimoto K, Ito D, Toyoda E, Mori T, Kami K, Kawaguchi Y, Gittes GK and Imamura M

Pancreatic epithelial cells can be converted into insulin-producing cells by GLP-1 in conjunction with virus-mediated gene transfer of pdx-1. Surgery. ;138:125-33. 2005

Nakajima S, Doi R, Toyoda E, Tsuji S, Wada M, Koizumi M, Tulachan S.S, Ito D, Kami K, Mori T, Kawaguchi Y, Fujimoto K, Hosotani R, and Imamura M

N-Cadherin Expression and Epithelial-Mesenchymal Transition in Pancreatic Carcinoma Clinical Caner Research 10: 4125-33, 2004

Koizumi M , Doi R, Toyoda E, Tulachan S.S, Kami K, Mori T, Ito D, Kawaguchi Y, Fujimoto K, Gittes G.K and Imamura M

Hepatic regeneration and enforced PDX-1 expression accelerate transdifferentiation in liver Surgery 136: 449-57, 2004

Tulachan S.S., Doi, R, Kawaguchi Y, Tsuji S, Nakajima S, Masui T, Koizumi M, Toyoda E, Mori T, Ito D, Kami K, Fujimoto K and Imamura M

All-Trans Retinoic Acid Induces Differentiation of Ducts and Endocrine Cells by Mesenchymal/Epithelial Interactions in Embryonic Pancreas Diabetes 52: 76-84, 2003

Hingorani S.R., Petricoin III E.F., Maitra A, Rajapakse V., King C., Jacobetz M. A., Ross S., Conrads T. P., Veenstra T. D., Hitt B. A., Kawaguchi Y., Johann D., Liotta L.A., Crawford H. C., Putt M. E., Jacks T., Wright C.V.E., Hruban R.H., Lowy A.M and Tuveson D.A

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse Cancer Cell 4:437-49, 2003

Koizumi M, Doi R, Toyoda E, Masui T, Tulachan SS, Kawaguchi Y, Fujimoto K, Gittes GK, Imamura M

Increased PDX-1 expression is associated with outcome in patients with pancreatic cancer. Surgery. 134:260-6, 2003

Kawaguchi Y, Cooper B, Gannon M, Ray M, MacDonald R. J and Wright C.V.E

The role of transcriptional regulator ptf1a in converting intestinal to pancreatic progenitors Nat.Genet. 32(1): 128-134, 2002

Kawaguchi Y*, Takebayashi H, Kakizuka A, Arii S, Kato M and Imamura M

Expression of Fas-estrogen receptor fusion protein induces cell deathin pancreatic cancer cell lines Cancer Lett. 116(1): 53-59, 1997

Nakamoto M, Takebayashi H, Kawaguchi Y, Nakamura S, Taniwaki M, Nakamura Y, Ishikawa Y, Akiguchi I, Kimura J and Kakizuka A

A CAG/CTG expansion in the normal population Nat. Genet. 17(4): 385-386, 1997

Okada N, Kubota A, Imamura T, Suwa H, Kawaguchi Y, Ohshio G, Seino Y, Imamura M

Evaluation of cholecystokinin, gastrin, CCK-A receptor, and CCK-B/gastrin receptor gene expressions in gastric cancer. Hum. Mol. Genet. 4: 807-812, 1995

Maruyama H, Nakamura S, Matusyama Z, Sakai T, Doyu M, Sobue G, Tsujibata M, Oh-I T, Nishino T, Sunahara N, Takahashi R, Hayashi M, Nishino I, Ohtake T, Oda T, Nishimura M, Saida T, Matsumoto H, Baba M, Kawaguchi Y, Kakizuka A and Kawakami H

Molecular features of the CAG repeats and clinical manifestations of Machado-Joseph disease Hum. Mol. Genet. 4: 807-812, 1995

Kawakami H, Maruyama H, Nakamura S, Kawaguchi Y, Kakizuka A, Doyu M and Sobue G

Unique features of the CAG repeats in Machado-Joseph disease Nat.Genet. 9(4): 344-345, 1995

Kawaguchi Y, Okamoto T, Taniwaki M, Aizawa M, Inoue M, Katayama S, Kawakami H, Nakamura S, Nishimura M, Akiguchi I, Kimura J, Narumiya S and Kakizuka A

CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1 Nat. Genet. 8(3): 221-228, 1994

Kawaguchi Y, Hoshimaru M, Nawa H and Nakanishi S

Sequence analysis of cloned cDNA for rat substance P precursor; existence of a third substance P precursor Biochem Biophys Res Commun. 139(3): 1040-1046, 1986
go top