発表論文

Niuxin Yang, Masato Nakagawa, Aki Nishiura, Masahiro Yamada, Hidetoshi Morikuni, Yoshitomo Honda, Naoyuki Matsumoto

Identification of Senescent Cells in Peri-Implantitis and Prevention of Mini-Implant Loss Using Senolytics Int J Mol Sci., 24(3):2507 (2022)

Mio Iwasaki, Yuka Kawahara, Chikako Okubo, Tatsuya Yamakawa, Michiko Nakamura, Tsuyoshi Tabata, Yohei Nishi, Megumi Narita, Akira Ohta, Hirohide Saito, Takuya Yamamoto, Masato Nakagawa, Shinya Yamanaka, Kazutoshi Takahashi

Multi-omics approach reveals post-transcriptionally regulated genes are essential for human pluripotent stem cells. iScience, 11(1) 24254-24254 (2022)

Chiaki Akifuji, Mio Iwasaki, Yuka Kawahara, Chiho Sakurai, Yu-Shen Cheng, Takahiko Imai, Masato Nakagawa

MYCL promotes iPSC-like colony formation via MYC Box 0 and 2 domains. Scientific Reports, 11:24254 (2021)

Shihori Yokobayashi, Yukihiro Yabuta, Masato Nakagawa, Keisuke Okita, Bo Hu, Yusuke Murase, Tomonori Nakamura, Guillaume Bourque, Jacek Majewski, Takuya Yamamoto, Mitinori Saitou

Inherent genomic properties underlie the epigenomic heterogeneity of human induced pluripotent stem cells. Cell reports, 37(5) 109909-109909 (2021)

Akinori Yuzuriha, Sou Nakamura, Naoshi Sugimoto, Shunsuke Kihara, Masato Nakagawa, Takuya Yamamoto, Kiyotoshi Sekiguchi, Koji Eto

Extracellular laminin regulates hematopoietic potential of pluripotent stem cells through integrin β1-ILK-β-catenin-JUN axis. Stem cell research, 53:102287-102287 (2021)

Iwasaki M, Tabata T, Kawahara Y, Ishihama Y, Nakagawa M.

Removal of Interference MS/MS Spectra for Accurate Quantification in Isobaric Tag-Based Proteomics. Journal of proteome research, 18(6):2535-2544 (2019)

Terada Y, Jo N, Arakawa Y, Sakakura M, Yamada Y, Ukai T, Kabata M, Mitsunaga K, Mineharu Y, Ohta S, Nakagawa M, Miyamoto S, Yamamoto T, Yamada Y.

Human Pluripotent Stem Cell-Derived Tumor Model Uncovers the Embryonic Stem Cell Signature as a Key Driver in Atypical Teratoid/Rhabdoid Tumor. Cell Reports, 36(10):1552-1566 (2019)

Karagiannis P, Takahashi K, Saito M, Yoshida Y, Okita K, Watanabe A, Inoue H, Yamashita JK, Todani M, Nakagawa M, Osawa M, Yashiro Y, Yamanaka S, Osafune K.

Induced Pluripotent Stem Cells and Their Use in Human Models of Disease and Development. Physiological reviews, 99(1) 79-114 (2019)

Nakai R, Ohnuki M, Kuroki K, Ito H, Hirai H, Kitajima R, Fujimoto T, Nakagawa M, Enard W, Imamura M.

Derivation of induced pluripotent stem cells in Japanese macaque (Macaca fuscata). Scientific Reports, 8(1):12187 (2018)

Ito Y, Nakamura S, Sugimoto N, Shigemori T, Kato Y, Ohno M, Sakuma S, Ito K, Kumon H, Hirose H, Okamoto H, Nogawa M, Iwasaki M, Kihara S, Fujio K, Matsumoto T, Higashi N, Hashimoto K, Sawaguchi A, Harimoto KI, Nakagawa M, Yamamoto T, Handa M, Watanabe N, Nishi E, Arai F, Nishimura S, Eto K.

Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production. Cell, 147(3):636-648.e18 (2018)

Lee S, Huh JY, Turner DM, Lee S, Robinson J, Stein JE, Shim SH, Hong CP, Kang MS, Nakagawa M, Kaneko S, Nakanishi M, Rao MS, Kurtz A, Stacey GN, Marsh SGE, Turner ML, Song J.

Repurposing the Cord Blood Bank for Haplobanking of HLA-Homozygous iPSCs and Their Usefulness to Multiple Populations. Stem Cell, 36(10):1552-1566 (2018)

Kondo T, Imamura K, Funayama M, Tsukita K, Miyake M, Ohta A, Woltjen K, Nakagawa M, Asada T, Arai T, Kawakatsu S, Izumi Y, Kaji R, Iwata N, Inoue H.

iPSC-Based Compound Screening and In Vitro Trials Identify a Synergistic Anti-amyloid β Combination for Alzheimer's Disease. Cell Reports, 21(8):2304-2312 (2017)

Ikeda T, Uchiyama I, Iwasaki M, Sasaki T, Nakagawa M, Okita K, Masui S.

Artificial acceleration of mammalian cell reprogramming by bacterial proteins. Genes to Cells, 22(10):918-928 (2017)

Kikuchi, T., Morizane, A., Doi, D., Magotani, H., Onoe, H., Hayashi, T., Mizuma, H., Takara, S., Takahashi, R., Inoue, H., Morita, S., Yamamoto, M., Okita, K., Nakagawa, M., Parmar, M. & Takahashi, J.

Human iPS cell-derived dopaminergic neurons function in a primate Parkinsons disease model. J Nature, 548(7669):592-596 (2017)

Kuang, Y., Miki, K., Parr, C. J. C., Hayashi, K., Takei, I., Li, J., Iwasaki, M., Nakagawa, M., Yoshida, Y. & Saito.

Efficient, Selective Removal of Human Pluripotent Stem Cells via Ecto-Alkaline Phosphatase-Mediated Aggregation of Synthetic Peptides. Cell Chemical Biology, 24(6):685-699 (2017)

Kikuchi, T., Morizane, A., Doi, D., Okita, K., Nakagawa, M., Yamakado, H., Inoue, H., Takahashi, R. & Takahashi, J.

Idiopathic Parkinson's disease patient-derived induced pluripotent stem cells function as midbrain dopaminergic neurons in rodent brains. J Neurosci Res., 95(9):1829-1837 (2017)

Yamamizu, K., Iwasaki, M., Takakubo, H., Sakamoto, T., Ikuno, T., Miyoshi, M., Kondo, T., Nakao, Y., Nakagawa, M., Inoue, H. & Yamashita.

In Vitro Modeling of Blood-Brain Barrier with Human iPSC-Derived Endothelial Cells, Pericytes, Neurons, and Astrocytes via Notch Signaling. Stem Cell Reports, 8(3):634-647 (2017)

Masamitsu Sone, Nobuhiro Morone, Tomonori Nakamura, Akito Tanaka, Keisuke Okita, Knut Woltjen, Masato Nakagawa, John E Heuser, Yasuhiro Yamada, Shinya Yamanaka and Takuya Yamamoto.

Hybrid Cellular Metabolism Coordinated by Zic3 and Esrrb Synergistically Enhances Induction of Naive Pluripotency. Cell Metabolism, 25(5), 1103-1117.e6, (2017).

Sugiyama, H., Takahashi, K., Yamamoto, T., Iwasaki, M., Narita, M., Nakamura, M., Rand, T. A., Nakagawa, M., Watanabe, A. & Yamanaka, S.

Nat1 promotes translation of specific proteins that induce differentiation of mouse embryonic stem cells. Proc Natl Acad Sci U S A 114, 340-345, doi:10.1073/pnas.1617234114 (2017).

Masato Nakagawa, Peter Karagiannis, Shinya Yamanaka.

When Myc's asleep, embryonic stem cells are dormant. EMBO. 2016. 35. 801-802. doi:10.15252/embj.201694095

Kim, S. I., Oceguera-Yanez, F., Sakurai, C., Nakagawa, M., Yamanaka, S. & Woltjen, K.

Inducible Transgene Expression in Human iPS Cells Using Versatile All-in-One piggyBac Transposons. Methods Mol Biol 1357, 111-131, doi:10.1007/7651_2015_251 (2016).

Sasaki, K., Yokobayashi, S., Nakamura, T., Okamoto, I., Yabuta, Y., Kurimoto, K., Ohta, H., Moritoki, Y., Iwatani, C., Tsuchiya, H., Nakamura, S., Sekiguchi, K., Sakuma, T., Yamamoto, T., Mori, T., Woltjen, K., Nakagawa, M., Yamamoto, T., Takahashi, K., Yamanaka, S. & Saitou, M.

Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells. Cell Stem Cell. 2015. doi:10.1016/j.stem.2015.06.014

Nakamura, T., Yabuta, Y., Okamoto, I., Aramaki, S., Yokobayashi, S., Kurimoto, K., Sekiguchi, K., Nakagawa, M., Yamamoto, T. & Saitou, M.

SC3-seq: a method for highly parallel and quantitative measurement of single-cell gene expression. Nucleic Acids Res. 2015. 43, e60, doi:10.1093/nar/gkv134

Kim, S. I., Oceguera-Yanez, F., Sakurai, C., Nakagawa, M., Yamanaka, S. & Woltjen, K.

Transgene Expression in Human iPS Cells Using Versatile All-in-One piggyBac Transposons. Methods Mol Biol. 2015. doi:10.1007/7651_2015_251

Samata B, Kikuchi T, Miyawaki Y, Morizane A, Mashimo T, Nakagawa M, Okita K, Takahashi J.

X-linked severe combined immunodeficiency (X-SCID) rats for xeno-transplantation and behavioral evaluation. J Neurosci Methods. 2015 Mar 30;243:68-77. doi: 10.1016/j.jneumeth.2015.01.027. Epub 2015 Feb 4. PubMed PMID: 25662444.

Fukuta M, Nakai Y, Kirino K, Nakagawa M, Sekiguchi K, Nagata S, Matsumoto Y, Yamamoto T, Umeda K, Heike T, Okumura N, Koizumi N, Sato T, Nakahata T, Saito M, Otsuka T, Kinoshita S, Ueno M, Ikeya M, Toguchida J.

Derivation of mesenchymal stromal cells from pluripotent stem cells through a neural crest lineage using small molecule compounds with defined media. PLoS One. 2014 Dec 2;9(12):e112291. doi: 10.1371/journal.pone.0112291. eCollection 2014. PubMed PMID: 25464501; PubMed Central PMCID: PMC4251837.

Nao Hirata, Masato Nakagawa, Yuto Fujibayashi, Kaori Yamauchi, Asako Murata, Itsunari Minami, Maiko Tomioka, Takayuki Kondo, Ting-Fang Kuo, Hiroshi Endo, Haruhisa Inoue3, Shin-ichi Sato1,2, Shin Ando1,2, Yoshinori Kawazoe, Kazuhiro Aiba, Koh Nagata, Eihachiro Kawase, Young-Tae Chang6,, Hirofumi Suemori, Koji Eto, Hiromitsu Nakauchi, Shinya Yamanaka, Norio Nakatsuji, Kazumitsu Ueda, and Motonari Uesugi.

A Chemical Probe that Labels Human Pluripotent Stem Cells. Cell Reports Published Online 7 March 2014 doi: 10.1016/j.celrep.2014.02.006

Daisuke Doi, Bumpei Samata, Mitsuko Katsukawa, Tetsuhiro Kikuchi, Asuka Morizane, Yuichi Ono, Kiyotoshi Sekiguchi, Masato Nakagawa, Malin Parmar, and Jun Takahashi.

Isolation of Human Induced Pluripotent Stem Cell-Derived Dopaminergic Progenitors by Cell Sorting for Successful Transplantation. Stem Cell Reports 2014 March 06 doi: 10.1016/j.stemcr.2014.01.013

Nakagawa M, Taniguchi Y, Senda S, Takizawa N, Ichisaka T, Asano K, Morizane A, Doi D, Takahashi J, Nishizawa M, Yoshida Y, Toyoda T, Osafune K, Sekiguchi K, YamanakaS.

A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cells. Scientific Reports 2014 Jan 8;4:3594. doi: 10.1038/srep03594

Yamana R, Iwasaki M, Wakabayashi M, Nakagawa M, Yamanaka S. & Ishihama Y.

Rapid and deep profiling of human induced pluripotent stem cell proteome by one-shot NanoLC-MS/MS analysis with meter-scale monolithic silica columns. Journal of proteome research 2013 Jan 4;12(1):214-21. doi: 10.1021/pr300837u. Epub 2012 Dec 4.

Wang YC, Nakagawa M, Garitaonandia I, Slavin I, Altun G, Lacharite RM, Nazor KL, Tran HT, Lynch CL, Leonardo TR, Liu Y, Peterson SE, Laurent LC, Yamanaka S, & Loring JF

Specific lectin biomarkers for isolation of human pluripotent stem cells identified through array-based glycomic analysis. Cell Res. 2011

Nakamura T, Nakagawa M, Ichisaka T, Shiota A, & Yamanaka S

Essential roles of ECAT15-2/Dppa2 in functional lung development. Mol Cell Biol. 2011

Hirano K, Nagata S, Yamaguchi S, Nakagawa M, Okita K, Kotera H, Ainscough J, & Tada T

Human and Mouse Induced Pluripotent Stem Cells Are Differentially Reprogrammed in response to Kinase Inhibitors. Stem Cells Dev. 2011

Okita K, Matsumura Y, Sato Y, Okada A, Morizane A, Okamoto S, Hong H, Nakagawa M, Tanabe K, Tezuka KI, Shibata T, Kunisada T, Takahashi M, Takahashi J, Saji H, Yamanaka S.

A more efficient method to generate integration-free human iPS cells. Nat Methods. 2011

Fujiwara M, Yan P, Otsuji TG, Narazaki G, Uosaki H, Fukushima H, Kuwahara K, Harada M, Matsuda H, Matsuoka S, Okita K, Takahashi K, Nakagawa M, Ikeda T, Sakata R, Mummery CL, Nakatsuji N, Yamanaka S, Nakao K, Yamashita JK

Induction and enhancement of cardiac cell differentiation from mouse and human induced pluripotent stem cells with cyclosporin-A. PLoS One. 2011

Masato Nakagawa, Nanako Takizawa, Megumi Narita, Tomoko Ichisaka and Shinya Yamanaka.

Promotion of Direct Reprogramming by Transformation-deficient Myc. Proceedings of the National Academy of Sciences Published online before print July 26, 2010, doi: 10.1073/pnas.1009374107

Miura, K., Okada, Y., Aoi, T., Okada. A., Takahashi, K., Okita, K., Nakagawa, M., Koyanagi, M., Tanabe, K., Ohnuki, M., Ogawa, D., Ikeda, E., Okano, H., Yamanaka, S. (2009).

Variation in the safety of induced pluripotent stem cell lines. Nature Biotechnology Published online: 9 July 2009 | doi:10.1038/nbt.1554.

Niwa, A., Umeda, K., Chang, H., Saito, M., Okita, K., Takahashi, K., Nakagawa, M., Yamanaka, S., Nakahata, T., Heike, T. (2009).

Orderly hematopoietic development of induced pluripotent stem cells via Flk-1+ hemoangiogenic progenitors. J Cell Phys, Epub ahead of print.

Taura, D., Noguchi, M., Sone, M., Hosoda, K., Mori, E., Okada, Y., Takahashi, K., Homma, K., Oyamada, N., Inuzuka, M., Sonoyama, T., Ebihara, K., Tamura, N., Itoh, H., Suemori, H., Nakatsuji, N., Okano, H., Yamanaka, S., and Nakao, K. (2009b).

Adipogenic differentiation of human induced pluripotent stem cells: comparison with that of human embryonic stem cells. FEBS Lett 583, 1029-1033.

Aoi, T., Yae, K., Nakagawa, M., Ichisaka, T., Okita, K., Takahashi, K., Chiba, T., and Yamanaka, S. (2008).

Generation of pluripotent stem cells from adult mouse liver and stomach cells. Science 321, 699-702.

Nakagawa, M., Koyanagi, M., Tanabe, K., Takahashi, K., Ichisaka, T., Aoi, T., Okita, K., Mochiduki, Y., Takizawa, N., and Yamanaka, S. (2008).

Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat Biotechnol 26, 101-106. >>> Paper citation ranking: 4th (cited in 2007-2008, by Tomson Reuters)

Okita, K., Nakagawa, M., Hyenjong, H., Ichisaka, T., and Yamanaka, S. (2008).

Generation of mouse induced pluripotent stem cells without viral vectors. Science 322, 949-953.

Imamura M, Miura K, Iwabuchi K, Ichisaka T, Nakagawa M, Lee J, Kanatsu-Shinohara M, Shinohara T, Yamanaka S.

Transcriptional repression and DNA hypermethylation of a small set of ES cell marker genes in male germline stem cells. BMC Dev Biol. 6: 34, 2006

Amano H., Itakura K., Maruyama M., Ichisaka T., Nakagawa M. and Yamanaka STokuzawa Y, Maruyama M, Yamanaka S.

Utilization of digital differential display to identify novel targets of Oct3/4. Methods Mol Biol. 329: 223-31, 2006.

Takahashi K., Nakagawa M., Young S.G. and Yamanaka S.

Differential membrane localization of ERas and Rheb, Two Ras-related proteins involved in the PI3 kinase / mTOR pathway. J. Biol. Chem. 280: 32768-74, 2005

Maruyama M., Ichisaka T., Nakagawa M. and Yamanaka S.

Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells. J. Biol. Chem. 280: 24371-9, 2005

著作物

中川 誠人

iPS細胞誘導におけるMYCの機能（特集：再発見！MYCの多機能性） 実験医学, 36, 534-538, (2018)