Saito MK, Osawa M, Tsuchida N, Shiraishi K, Niwa A, Woltjen K, Asaka I, Ogata K, Ito S, Kobayashi S, Yamanaka S
A disease-specific iPS cell resource for studying rare and intractable diseases.
Inflammation and Regeneration. 43(1):43
Takayama K, Yamanaka S
Pluripotent stem cell-based therapies and their path to the clinic.
Stem Cell Reports. 18(8): 1547-1548
Vasic I, Libby ARG, Maslan A, Bulger EA, Zalazar D, Krakora Compagno MZ, Streets A, Tomoda K, Yamanaka S, McDevitt TC
Loss of TJP1 disrupts gastrulation patterning and increases differentiation toward the germ cell lineage in human pluripotent stem cells.
Developmental Cell. 58(16):1477-1488.e5
2022
Sakuma K, Tsubooka-Yamazoe N, Hashimoto K, Sakai N, Asano S, Watanabe-Matsumoto S, Watanabe T, Saito B, Matsumoto H, Ueno H, Ito R, Toyoda T
CDK8/19 inhibition plays an important role in pancreatic β-cell induction from human iPSCs.
Stem Cell Research & Therapy. 14(1):1
Kunitomi A, Hirohata R, Arreola V, Osawa M, Kato TM, Nomura M, Kawaguchi J, Hara H, Kusano K, Takashima Y, Takahashi K, Fukuda K, Takasu N, Yamanaka S
Improved Sendai viral system for reprogramming to naive pluripotency.
Cell Rep Methods. 2(11):100317
Suzuki T, Aizawa K, Shibuya K, Yamanaka S, Anzai Y, Kurokawa K, Nagai R
Prevalence of Asymptomatic SARS-CoV-2 Infection in Japan.
JAMA Netw Open. 5(12):e2247704
Yoshida S, Kato TM, Sato Y, Umekage M, Ichisaka T, Tsukahara M, Takasu N, Yamanaka S
A clinical-grade HLA haplobank of human induced pluripotent stem cells matching approximately 40% of the Japanese population.
Med. 4(1):51-66.e10
Iwasaki M, Kawahara Y, Okubo C, Yamakawa T, Nakamura M, Tabata T, Nishi Y, Narita M, Ohta A, Saito H, Yamamoto T, Nakagawa M, Yamanaka S, Takahashi K
Multi-omics approach reveals posttranscriptionally regulated genes are essential for human pluripotent stem cells.
iScience. 25(5):104289
2021
Takahashi K, Okubo C, Nakamura M, Iwasaki M, Kawahara Y, Tabata T, Miyamoto Y, Woltjen K, Yamanaka S
A stress-reduced passaging technique improves the viability of human pluripotent cells.
Cell Reports Methods. 2(2):100155
Hashimoto R, Sakamoto A, Deguchi S, Yi R, Sano E, Hotta A, Takahashi K, Yamanaka S, Takayama K
Dual inhibition of TMPRSS2 and Cathepsin B prevents SARS-CoV-2 infection in iPS cells.
Molecular Therapy Nucleic Acids. 26:1107-1114
Takahashi K, Nakamura M, Narita M, Ueda M, Takashima Y, Watanabe A, Yamanaka S
The pluripotent stem cell-specific transcript ESRG is dispensable for human pluripotency.
PLoS Genetics. 17(5):e1009587
Karagiannis, P., and Yamanaka, S.
Konnichiwa: Japanese scientists and their struggle to speak English: More research careers in Japan need less English.
EMBO Reports. 22:e52558
2020
Shinya Yamanaka.
Pluripotent Stem Cell-Based Cell Therapy-Promise and Challenges.
Cell Stem Cell 27(4), 523-531
Takahashi, K., Jeong, D., Wang, S., Narita, M., Jin X., Iwasaki, M., Perli, S.D., Conklin, B.R., and Yamanaka, S.
Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells.
Cell Reports 31(9), 107715
2019
Araki, H., Miura, F., Watanabe, A., Morinaga, C., Kitaoka, F., Kitano, Y., Sakai, N., Shibata, Y., Terada, M., Goto, S., Yamanaka, S., Takahashi, M., Ito, T.
Base-Resolution Methylome of Retinal Pigment Epithelial Cells Used in the First Trial of Human Induced Pluripotent Stem Cell-Based Autologous Transplantation.
Stem Cell Reports 13(4), 761-774
Kime, C., Kiyonari, H., Ohtsuka, S., Kohbayashi, E., Asahi, M., Yamanaka, S., Takahashi, M., Tomoda, K.
Induced 2C Expression and Implantation-Competent Blastocyst-like Cysts from Primed Pluripotent Stem Cells.
Towards Precision Medicine With Human iPSCs for Cardiac Channelopathies.
Circulation research 125(6), 653-658
Suga, M., Kondo, T., Imamura, K., Shibukawa, R., Okanishi, Y., Sagara, Y., Tsukita, K., Enami, T., Furujo, M., Saijo, K., Nakamura, Y., Osawa, M., Saito, M.K., Yamanaka, S., Inoue, H.
Generation of a human induced pluripotent stem cell line, BRCi001-A, derived from a patient with mucopolysaccharidosis type I.
Stem Cell Research 36: 101406
Karagiannis, P., Yamanaka, S., Saito, M. K.
Application of induced pluripotent stem cells to primary immunodeficiency diseases.
Experimental Hematology 71, 43-50
Tsuji, O., Sugai, K., Yamaguchi, R., Tashiro, S., Nagoshi, N., Kohyama, J., Iida, T., Ohkubo, T., Itakura, G., Isoda, M., Shinozaki, M., Fujiyoshi, K., Kanemura, Y., Yamanaka, S., Nakamura, M., Okano, H.
Laying the Groundwork for a First-In-Human Study of an induced Pluripotent Stem Cell-Based Intervention for Spinal Cord Injury.
STEM CELLS 37(1): 6-13
2018
Karagiannis, P., Takahashi, K., Saito, M., Yoshida, Y., Okita, K., Watanabe, A., Inoue, H., Yamashita, J., Todani, M., Nakagawa, M., Osawa, M., Yashiro, Y., Yamanaka, S., and Osafune, K.
Induced Pluripotent Stem Cells and Their Use in Human Models of Disease and Development.
Physiological Reviews 99(1): 79-114
Allison, TF., Andrews, PW., Avior, Y., Barbaric, I., Benvenisty, N., Bock, C., Brehm, J., Brüstle, O., Damjanov, I., Elefanty, A., Felkner, D., Gokhale, PJ., Halbritter, F., Healy, LE., Hu, TX., Knowles, BB., Loring, JF., Ludwig, TE., Mayberry, R., Micallef, S., Mohamed, JS., Müller, FJ., Mummery, CL., Nakatsuji, N., Ng, ES., Oh, SKW., O'Shea, O., Pera, MF., Reubinoff, B., Robson, P., Rossant, J., Schuldt, BM., Solter, D.,
Sourris, K., Stacey, G., Stanley, EG., Suemori, H., Takahashi, K., and Yamanaka, S.
Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells.
Nature Communications 9(1): 1925
Rand, TA., Sutou, K., Tanabe, K., Jeong, D., Nomura, M., Kitaoka, F., Tomoda, E., Narita, M., Nakamura, M., Nakamura, M., Watanabe, A., Rulifson, E., Yamanaka, S., and Takahashi, K.
MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition.
Cell Reports 23(2): 361-375
2017
Ikeda, H., Sone, M., Yamanaka, S., and Yamamoto, T.
Structural and spatial chromatin features at developmental gene loci in human pluripotent stem cells.
Nature Communications 8(1): 1616
Morizane, A., Kikuchi, T., Hayashi, T., Mizuma, H., Takara, S., Doi, H., Mawatari, A., Glasser, M.F., Shiina, T., Ishigaki, H., Itoh, Y., Okita, K., Yamasaki, E., Doi, D., Ono,e H., Ogasawara, K., Yamanaka, S., and Takahashi, .J.
MHC matching improves engraftment of iPSC-derived neurons in non-human primates.
Nature Communications 8(1): 385
Kawamura, M., Miyagawa, S., Fukushima, S., Saito, A., Miki, K., Funakoshi, S., Yoshida, Y., Yamanaka, S., Shimizu, T., Okano, T., Daimon, T., Toda, K., and Sawa, Y.
Enhanced Therapeutic Effects of Human iPS Cell Derived-Cardiomyocyte by Combined Cell-Sheets with Omental Flap Technique in Porcine Ischemic Cardiomyopathy Model.
Scientific Reports 7: 8824
Imamura, K., Izumi, Y., Watanabe, A., Tsukita, K., Woltjen, K., Yamamoto, T., Hotta, A., Kondo, T., Kitaoka, S., Ohta, A., Tanaka, A., Watanabe, D., Morita, M., Takuma, H., Tamaoka, A., Kunath, T., Wray, S., Furuya, H., Era, T., Makioka, K., Okamoto, K., Fujisawa, T., Nishitoh, H., Homma, K., Ichijo, H., Julien, J.P., Obata, N., Hosokawa, M., Akiyama, H., Kaneko, S., Ayaki, T., Ito, H., Kaji, R., Takahashi, R., Yamanaka, S., and Inoue, H.
The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis.
Science Translational Medicine 9(391): eaaf3962
Sone, M. Morone, N., Nakamura, T., Tanaka, A., Okita, K., Woltjen, K., Nakagawa, M., Heuser, J.E., Yamada, Y., Yamanaka, S., and Yamamoto, T.
Hybrid Cellular Metabolism Coordinated by Zic3 and Esrrb Synergistically Enhances Induction of Naive Pluripotency.
Cell Metabolism 25(5): 1103-111
Yagi, M., Yamanaka, S., Yamada, Y.
Epigenetic foundations of pluripotent stem cells that recapitulate in vivo pluripotency.
Laboratory Investigation 97, 1133-1141
Yoshida, Y., and Yamanaka, S.
Induced Pluripotent Stem Cells 10 Years Later: For Cardiac Applications.
Circulation Research 120: 1958-1968
Parr, C.J., Yamanaka, S., and Saito, H.
An update on stem cell biology and engineering for brain development.
Molecular Psychiatry 6: 808-819
Mandai, M., Watanabe, A., Kurimoto, Y., Hirami, Y., Morinaga, C., Daimon, T., Fujihara, M., Akimaru, H., Sakai, N., Shibata, Y., Terada, M., Nomiya, Y., Tanishima, S., Nakamura, M., Kamao, H., Sugita, S., Onishi, A., Ito, T., Fujita, K., Kawamata, S., Go, M.J., Shinohara, C., Hata, K., Sawada, M., Yamamoto, M., Ohta, S., Ohara, Y., Yoshida, K., Kuwahara, J., Kitano, Y., Amano, N., Umekage, M., Kitaoka, F., Tanaka, A., Okada, C., Takasu, N., Ogawa, S., Yamanaka, S., and Takahashi, M.
First-in-human Clinical Study of Transplantation of Autologous iPSC-Retinal Pigment Epithelial Cell Sheet for Wet Age Related Macular Degeneration.
The New England Journal of Medicine 376(11): 1038-1046
Karagiannis, P., Onodera, A., and Yamanaka, S.
New Models for Therapeutic Innovation from Japan.
EBioMedicine 18: 3-4
Shi, Y., Inoue, H., Wu, J.C., and Yamanaka, S.
Induced pluripotent stem cell technology: a decade of progress.
Nature Reviews Drug Discovery 16(2):115-130
Sugiyama, H., Takahashi, K., Yamamoto, T., Iwasaki, M., Narita, M., Nakamura, M., Rand, TA., Nakagawa, M., Watanabe, A., and Yamanaka, S.
Nat1 promotes translation of specific proteins that induce differentiation of mouse embryonic stem cells.
Proc Natl Acad Sci U S A 114(2), 340-345.
2016
Hayashi, Y., Hsiao, E.C., Sami, S., Lancero, M., Schlieve, C.R., Nguyen, T., Yano, K, Nagahashi, A., Ikeya, M., Matsumoto, Y., Nishimura, K., Fukuda, A., Hisatake, K., Tomoda, K., Asaka, I., Toguchida, J., Conklin, B.R., and Yamanaka, S.
BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence.
Proc Natl Acad Sci U S A 113, 13057-13062.
Kime, C., Sakaki-Yumoto, M., Goodrich, L., Hayashi, Y., Sami, S., Derynck, R., Asahi, M., Panning, B., Yamanaka, S., and Tomoda, K.
Autotaxin-mediated lipid signaling intersects with LIF and BMP signaling to promote the naive pluripotency transcription factor program.
Proc Natl Acad Sci U S A 113, 12478-12483.
Funakoshi, S., Miki, K., Takaki, T., Okubo, C., Hatani, T., Chonabayashi, K., Nishikawa, M., Takei, I., Oishi, A., Narita, M., Hoshijima, M., Kimura, T., Yamanaka, S., and Yoshida, Y.
Enhanced engraftment, proliferation, and therapeutic potential in heart using optimized human iPSC-derived cardiomyocytes.
Scientific Reports 6, 19111.
2015
Kim, SI., Oceguera-Yanez, F., Hirohata., R., Linker, S., Okita, K., Yamada, Y., Yamamoto, T., Yamanaka, S., and Woltjen, K.
KLF4 N-Terminal Variance Modulates Induced Reprogramming to Pluripotency.
Stem Cell Reports 4, 727-743.
Hayashi, Y., Caboni, L., Das, D., Yumoto, F., Clayton, T., Deller, MC., Nguyen, P., Farr, CL., Chiu, HJ., Miller, MD., Elsliger, MA., Deacon, AM., Godzik, A., Lesley, SA., Tomoda, K., Conklin, BR., Wilson, IA., Yamanaka, S., and Fletterick, RJ.
Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.
Proc Natl Acad Sci U S A 112, 4666-4671.
Miki, K., Endo, K., Takahashi, S., Funakoshi, S., Takei, I., Katayama, S., Toyoda, T., Kotaka, M., Takaki, T., Umeda, M., Okubo, C., Nishikawa, M., Oishi, A., Narita, M., Miyashita, I., Asano, K., Hayashi, K., Osafune, K., Yamanaka, S., Saito, H., and Yoshida, Y.
Efficient Detection and Purification of Cell Populations Using Synthetic MicroRNA Switches.
Cell Stem Cell 16, 699-711.
Sasaki, K., Yokobayashi, S., Nakamura, T., Okamoto, I., Yabuta, Y., Kurimoto, K., Ohta, H., Moritoki, Y., Iwatani, C., Tsuchiya, H., Nakamura, S., Sekiguchi, K., Sakuma, T., Yamamoto, T., Mori, T., Woltjen, K., Nakagawa, M., Yamamoto, T., Takahashi, K., Yamanaka, S., and Saitou, M.
Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells.
Cell Stem Cell 17, 178-194.
Toyohara, T., Mae, SI., Sueta, SI., Inoue, T., Yamagishi, Y., Kawamoto, T., Kasahara, T., Hoshina, A., Toyoda, T., Tanaka, H., Araoka, T., Sato-Otsubo, A., Takahashi, K., Sato, Y., Yamaji, N., Ogawa, S., Yamanaka, S., and Osafune, K.
Cell Therapy Using Human Induced Pluripotent Stem Cell-Derived Renal Progenitors Ameliorates Acute Kidney Injury in Mice.
Stem Cells Translational Medicine 4, 980-992.
2014
Ohnuki, M., Tanabe, K., Sutou, K., Teramoto, I., Sawamura, Y., Narita, M., Nakamura, M., Tokunaga, Y., Nakamura, M., Watanabe, A., Yamanaka, S., and Takahashi, K.
Dynamic regulation of human endogenous retroviruses mediates factor-induced reprogramming and differentiation potential.
Proc Natl Acad Sci U S A 111, 12426-12431.
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Sasaki, A., Yamamoto, M., Nakamura, M., Sutou, K., Osafune, K., and Yamanaka, S.
Induction of pluripotency in human somatic cells via a transient state resembling primitive streak-like mesendoderm.
Nature Communications 5, 3678.
Shimamoto, R., Amano, N., Ichisaka, T., Watanabe, A., Yamanaka, S., and Okita, K.
Generation and Characterization of Induced Pluripotent Stem Cells from Aid-Deficient Mice.
PLoS ONE 9, e94735.
Nakagawa, M., Taniguchi, Y., Senda, S., Takizawa, N., Ichisaka, T., Asano, K., Morizane, A., Doi, D., Takahashi, J., Nishizawa, M., Yoshida, Y., Toyoda, T., Osafune, K., Sekiguchi, K., and Yamanaka, S.
A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cells.
Scientific Reports 4, 3594.
2013
Koyanagi-Aoi, M., Ohnuki, M., Takahashi, K., Okita, K., Noma, H., Sawamura, Y., Teramoto, I., Narita, M., Sato, Y., Ichisaka, T., Amano, N., Watanabe, A., Morizane, A., Yamada, Y., Sato, T., Takahashi, J., and Yamanaka, S.
Differentiation defective phenotypes revealed by large scale analysis of human pluripotent stem cells.
Proc Natl Acad Sci U S A 110, 20569-20574.
Tanabe, K., Nakamura, M., Narita, M., Takahashi, K., and Yamanaka, S.
Maturation, not initiation, is the major roadblock during reprogramming toward pluripotency from human fibroblasts.
Proc Natl Acad Sci U S A 110, 12172-12179.
Okita, K., Yamakawa, T., Matsumura, Y., Sato, Y., Amano, N., Watanabe, A., Goshima, N., and Yamanaka, S.
An Efficient Non-viral Method to Generate Integration-Free Human iPS Cells from Cord Blood and Peripheral Blood Cells.
Stem Cells 31, 458-466.
2012
Tomoda, K., Takahashi, K., Leung, K., Okada, A., Narita, M., Yamada, N.A., Eilertson, K.E., Tsang, P., Baba, S., White, M.P., Sami, S., Srivastava, D., Conklin, B.R., Panning, B., and Yamanaka, S.
Derivation conditions impact x-inactivation status in female human induced pluripotent stem cells.
Cell Stem Cell 11, 91-99.
Kajiwara, M., Aoi, T., Okita, K., Takahashi, R., Inoue, H., Takayama, N., Endo, H., Eto, K., Toguchida, J., Uemoto, S., and Yamanaka, S.
Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells.
Proc Natl Acad Sci U S A 109, 12538-12543.
Miki, K., Uenaka, H., Saito, A., Miyagawa, S., Sakaguchi, T., Higuchi, T., Shimizu, T., Okano, T., Yamanaka, S., and Sawa, Y.
Bioengineered myocardium derived from induced pluripotent stem cells improves cardiac function and attenuates cardiac remodeling following chronic myocardial infarction in rats.
Stem Cells Transl Med 1, 430-437.
2011
Nakamura, T., Nakagawa, M., Ichisaka, T., Shiota, A., and Yamanaka, S.
Essential roles of ECAT15-2/Dppa2 in functional lung development.
Mol Cell Biol 31, 4366-4378.
Maekawa, M., Yamaguchi, K., Nakamura, T., Shibukawa, R., Kodanaka, I., Ichisaka, T., Kawamura, Y., Mochizuki, H., Goshima, N., and Yamanaka, S.
Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1.
Nature 474, 225-229.
Iwabuchi, K., Yamakawa, T., Sato, Y., Ichisaka, T., Takahashi, K., Okita, K., and Yamanaka, S.
ECAT11/L1td1 is enriched in ESCs and rapidly activated during iPSC generation, but it is dispensable for the pluripotency.
PLoS ONE 6, e20461.
Okita, K., Matsumura, Y., Sato, Y., Okada, A., Morizane, A., Okamoto, S., Hong, H., Nakagawa, M., Tanabe, K., Tezuka, K., Shibata, T., Kunisada, T., Takahashi, M., Takahashi, J., Saji, H., and Yamanaka, S.
A more efficient method to generate integration-free human iPS cells.
Nature Methods 8, 409-412.
2010
Egusa, H., Okita, K., Kayashima, H., Yu, G., Fukuyasu, S., Saeki, M., Matsumoto, T., Yamanaka, S., and Yatani, H.
Gingival fibroblasts as a promising source of induced pluripotent stem cells.
PLoS One 5, e12743.
Nakagawa, M., Takizawa, N., Narita, M., Ichisaka, T., and Yamanaka, S.
Promotion of direct reprogramming by transformation-deficient Myc.
Proc Natl Acad Sci U S A 107, 14152-14157.
Tsuji, O., Miura, K., Okada, Y., Fujiyoshi, K., Mukaino, M., Nagoshi, N., Kitamura, K., Kumagai, G., Nishino, M., Tomisato, S., Higashi, H., Nagai, T., Katoh, H., Kohda, K., Matsuzaki, Y., Yuzaki, M., Ikeda, E., Toyama, Y., Nakamura, M., Yamanaka, S., and Okano, H. (2010).
Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury.
Proc Natl Acad Sci U S A 107, 12704-12709.
Saunders, L.R., Sharma, A.D., Tawney, J., Nakagawa, M., Okita, K., Yamanaka, S., Willenbring, H., and Verdin, E. (2010).
miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues.
Aging (Albany NY).
Tamaoki, N., Takahashi, K., Tanaka, T., Ichisaka, T., Aoki, H., Takeda-Kawaguchi, T., Iida, K., Kunisada, T., Shibata, T., Yamanaka, S., and Tezuka, K. (2010).
Dental Pulp Cells for Induced Pluripotent Stem Cell Banking.
J Dent Res.
Kaichi, S., Hasegawa, K., Takaya, T., Yokoo, N., Mima, T., Kawamura, T., Morimoto, T., Ono, K., Baba, S., Doi, H., Yamanaka, S., Nakahata, T., and Heike, T. (2010).
Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice.
Cardiovasc Res.
Yamanaka, S., and Blau, H.M. (2010).
Nuclear reprogramming to a pluripotent state by three approaches.
Nature 465, 704-712.
Okita, K., and Yamanaka, S. (2010).
Induction of pluripotency by defined factors.
Exp Cell Res.
Sato, S., Yagi, S., Arai, Y., Hirabayashi, K., Hattori, N., Iwatani, M., Okita, K., Ohgane, J., Tanaka, S., Wakayama, T., Yamanaka, S. & Shiota, K.
Genome-wide DNA methylation profile of tissue-dependent and differentially methylated regions (T-DMRs) residing in mouse pluripotent stem cells.
Genes Cells (2010).
Kazuki, Y., Hiratsuka, M., Takiguchi, M., Osaki, M., Kajitani, N., Hoshiya, H., Hiramatsu, K., Yoshino, T., Kazuki, K., Ishihara, C., Takehara, S., Higaki, K., Nakagawa, M., Takahashi, K., Yamanaka, S., and Oshimura, M.
Complete genetic correction of ips cells from Duchenne muscular dystrophy.
Mol Ther 18, 386-393. (2010)
Mizuno, Y., Chang, H., Umeda, K., Niwa, A., Iwasa, T., Awaya, T., Fukada, S.I., Yamamoto, H., Yamanaka, S., Nakahata, T., and Heike, T
Generation of skeletal muscle stem/progenitor cells from murine induced pluripotent stem cells.
FASEB J. (2010)
Okita, K., Hong, H., Takahashi, K., and Yamanaka, S.
Generation of mouse-induced pluripotent stem cells with plasmid vectors.
Nat Protoc 5, 418-428. (2010)
2009
Takahashi, K., Narita, M., Yokura, M., Ichisaka, T., and Yamanaka, S. (2009).
Human induced pluripotent stem cells on autologous feeders.
PLoS One 4, e8067.
Nagata, S., Toyoda, M., Yamaguchi, S., Hirano, K., Makino, H., Nishino, K., Miyagawa, Y., Okita, H., Kiyokawa, N., Nakagawa, M., Yamanaka, S., Akutsu, H., Umezawa, A., and Tada, T. (2009)
Efficient reprogramming of human and mouse primary extra-embryonic cells to pluripotent stem cells.
Genes Cells 14, 1395-1404.
Kazuki, Y., Hiratsuka, M., Takiguchi, M., Osaki, M., Kajitani, N., Hoshiya, H., Hiramatsu, K., Yoshino, T., Kazuki, K., Ishihara, C., Takehara, S., Higaki, K., Nakagawa, M., Takahashi, K., Yamanaka, S., and Oshimura, M. (2009).
Complete Genetic Correction of iPS Cells From Duchenne Muscular Dystrophy.
Mol Ther.
Nagata, S., Toyoda, M., Yamaguchi, S., Hirano, K., Makino, H., Nishino, K., Miyagawa, Y., Okita, H., Kiyokawa, N., Nakagawa, M., Yamanaka, S., Akutsu, H., Umezawa, A., and Tada, T. (2009)
Efficient reprogramming of human and mouse primary extra-embryonic cells to pluripotent stem cells.
Genes Cells.
Yoshida, Y., Takahashi, K., Okita, K., Ichisaka, T., and Yamanaka, S. (2009).
Hypoxia enhances the generation of induced pluripotent stem cells.
Cell Stem Cell 5, 237-241.
Hong, H., Takahashi, K., Ichisaka, T., Aoi, T., Kanagawa, O., Nakagawa, M., Okita, K., and Yamanaka, S. (2009)
Suppression of induced pluripotent stem cell generation by the p53-p21 pathway.
Nature 460, 1132-1135.
Nishimura, K., Nakagawa, T., Ono, K., Ogita, H., Sakamoto, T., Yamamoto, N., Okita, K., Yamanaka, S., and Ito, J. (2009).
Transplantation of mouse induced pluripotent stem cells into the cochlea.
Neuroreport.
Miura, K., Okada, Y., Aoi, T., Okada. A., Takahashi, K., Okita, K., Nakagawa, M., Koyanagi, M., Tanabe, K., Ohnuki, M., Ogawa, D., Ikeda, E., Okano, H., Yamanaka, S. (2009).
Variation in the safety of induced pluripotent stem cell lines.
Nat Biotechnol 27, 743-745.
Niwa, A., Umeda, K., Chang, H., Saito, M., Okita, K., Takahashi, K., Nakagawa, M., Yamanaka, S., Nakahata, T., Heike, T. (2009).
Orderly hematopoietic development of induced pluripotent stem cells via Flk-1+ hemoangiogenic progenitors.
J Cell Phys, Epub ahead of print.
Ohnuki, M., Takahashi, K., and Yamanaka, S. (2009).
Generation and characterization of human induced pluripotent stem cells.
Curr Protoc Stem Cell Biol Chapter 4, Unit 4A 2.
Yamanaka, S. (2009).
A fresh look at iPS cells.
Cell 137, 13-17.
Tsubooka, N., Ichisaka, T., Okita, K., Takahashi, K., Nakagawa, M., and Yamanaka, S. (2009).
Roles of Sall4 in the generation of pluripotent stem cells from blastocysts and fibroblasts.
Genes Cells.
Taura, D., Sone, M., Homma, K., Oyamada, N., Takahashi, K., Tamura, N., Yamanaka, S., and Nakao, K. (2009a)
Induction and Isolation of Vascular Cells From Human-Induced Pluripotent Stem Cells.
Arterioscler Thromb Vasc Biol.
Taura, D., Noguchi, M., Sone, M., Hosoda, K., Mori, E., Okada, Y., Takahashi, K., Homma, K., Oyamada, N., Inuzuka, M., Sonoyama, T., Ebihara, K., Tamura, N., Itoh, H., Suemori, H., Nakatsuji, N., Okano, H., Yamanaka, S., and Nakao, K. (2009b).
Adipogenic differentiation of human induced pluripotent stem cells: comparison with that of human embryonic stem cells.
FEBS Lett 583, 1029-1033.
Tanaka, T., Tohyama, S., Murata, M., Nomura, F., Kaneko, T., Chen, H., Hattori, F., Egashira, T., Seki, T., Ohno, Y., Koshimizu, U., Yuasa, S., Ogawa, S., Yamanaka, S., Yasuda, K., and Fukuda, K. (2009).
In vitro pharmacologic testing using human induced pluripotent stem cell-derived cardiomyocytes.
Biochem Biophys Res Commun.
Senju, S., Haruta, M., Matsunaga, Y., Fukushima, S., Ikeda, T., Takahashi, K., Okita, K., Yamanaka, S., and Nishimura, Y. (2009)
Characterization of Dendritic Cells and Macrophages Generated by Directed Differentiation from Mouse Induced Pluripotent Stem Cells.
Stem Cells 27, 1021-1031.
Hirami, Y., Osakada, F., Takahashi, K., Okita, K., Yamanaka, S., Ikeda, H., Yoshimura, N., and Takahashi, M. (2009).
Generation of retinal cells from mouse and human induced pluripotent stem cells.
Neurosci Lett.
Daley, G.Q., Lensch, M.W., Jaenisch, R., Meissner, A., Plath, K., and Yamanaka, S. (2009).
Broader implications of defining standards for the pluripotency of iPSCs.
Cell Stem Cell 4, 200-201; author reply 202.
Aoyama, Y., Nomura, M., Yamanaka, S., Ogawa, Y., and Kitajima, Y. (2009).
Subcutaneous phaeohyphomycosis caused by Exophiala xenobiotica in a non-Hodgkin lymphoma patient.
Med Mycol 47, 95-99.
Aiba, K., Nedorezov, T., Piao, Y., Nishiyama, A., Matoba, R., Sharova, L.V., Sharov, A.A., Yamanaka, S., Niwa, H., and Ko, M.S. (2009).
Defining developmental potency and cell lineage trajectories by expression profiling of differentiating mouse embryonic stem cells.
DNA Res 16, 73-80.
2008
Aoi, T., Yae, K., Nakagawa, M., Ichisaka, T., Okita, K., Takahashi, K., Chiba, T., and Yamanaka, S. (2008).
Generation of pluripotent stem cells from adult mouse liver and stomach cells.
Science 321, 699-702.
Nakagawa, M., Koyanagi, M., Tanabe, K., Takahashi, K., Ichisaka, T., Aoi, T., Okita, K., Mochiduki, Y., Takizawa, N., and Yamanaka, S. (2008).
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts.
Nat Biotechnol 26, 101-106.
Narazaki, G., Uosaki, H., Teranishi, M., Okita, K., Kim, B., Matsuoka, S., Yamanaka, S., and Yamashita, J.K. (2008).
Directed and systematic differentiation of cardiovascular cells from mouse induced pluripotent stem cells.
Circulation 118, 498-506.
Okita, K., Nakagawa, M., Hyenjong, H., Ichisaka, T., and Yamanaka, S. (2008).
Generation of mouse induced pluripotent stem cells without viral vectors.
Science 322, 949-953.
Yamanaka, S. (2008).
Induction of pluripotent stem cells from mouse fibroblasts by four transcription factors.
Cell Prolif 41 Suppl 1, 51-56.
2007
Hyun, I., Hochedlinger, K., Jaenisch, R., and Yamanaka, S. (2007).
New advances in iPS cell research do not obviate the need for human embryonic stem cells.
Cell Stem Cell 1, 367-368.
Okita, K., Ichisaka, T., and Yamanaka, S. (2007).
Generation of germline-competent induced pluripotent stem cells.
Nature 448, 313-317.
Takahashi, K., Okita, K., Nakagawa, M., and Yamanaka, S. (2007a).
Induction of pluripotent stem cells from fibroblast cultures.
Nat Protoc 2, 3081-3089.
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., and Yamanaka, S. (2007b)
Induction of pluripotent stem cells from adult human fibroblasts by defined factors.
Cell 131, 861-872.
Yamanaka, S. (2007).
Strategies and new developments in the generation of patient-specific pluripotent stem cells.
Cell Stem Cell 1, 39-49.
Lewitzky M, Yamanaka S.
Reprogramming somatic cells towards pluripotency by defined factors.
Curr Opin Biotechnol. 2007 Oct;18(5):467-73.
Yoshikane N, Nakamura N, Ueda R, Ueno N, Yamanaka S, Nakamura M.
Drosophila NAT1, a homolog of the vertebrate translational regulator NAT1/DAP5/p97, is required for embryonic germband extension and metamorphosis.
Dev Growth Differ. 2007 Sep;49(7):623-34.
Uemoto, Y., Suzuki, S., Terada, N., Ohno, N., Ohno, S., Yamanaka S., and Komada, M.
Specific role of the truncated betaIV-spectrin Sigma6 in sodium channel clustering at axon initial segments and nodes of Ranvier.
J Biol Chem 282:6548-6555, 2007
2006
Nimura, K., Ishida, C., Koriyama, H., Hata, K., Yamanaka S., Li, E., Ura, K., and Kaneda, Y.
Dnmt3a2 targets endogenous Dnmt3L to ES cell chromatin and induces regional DNA methylation.
Genes Cells 11:1225-1237, 2006.
Takahashi K, Yamanaka S.
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
Cell, 126:663-676, 2006.
Tanaka TS, Lopez de Silanes I, Sharova LV, Akutsu H, Yoshikawa T, Amano H, Yamanaka S, Gorospe M, Ko MS.
Esg1, expressed exclusively in preimplantation embryos, germline, and embryonic stem cells, is a putative RNA-binding protein with broad RNA targets.
Dev Growth Differ. 48: 381-90, 2006.
Imamura M, Miura K, Iwabuchi K, Ichisaka T, Nakagawa M, Lee J, Kanatsu-Shinohara M, Shinohara T, Yamanaka S.
Transcriptional repression and DNA hypermethylation of a small set of ES cell marker genes in male germline stem cells.
BMC Dev Biol. 6: 34, 2006
Takahashi K, Ichisaka T, Yamanaka S.
Identification of genes involved in tumor-like properties of embryonic stem cells.
Methods Mol Biol. 329: 449-58, 2006.
Amano H., Itakura K., Maruyama M., Ichisaka T., Nakagawa M. and Yamanaka STokuzawa Y, Maruyama M, Yamanaka S.
Utilization of digital differential display to identify novel targets of Oct3/4.
Methods Mol Biol. 329: 223-31, 2006.
Identification and targeted disruption of the mouse gene encoding ESG1 (PH34/ECAT2/DPPA5).
BMC Developmental Biology, 6: 11 , 2006.
Okita K. and Yamanaka S.
Intracellular signaling pathways regulating pluripotency of embryonic stem cells.
Cur. Stem Cell Res. Ther., 1: 103-11, 2006
2005
Takahashi K., Murakami M. and Yamanaka S.
Role of the phosphoinositide 3-kinase pathway in mouse embryonic stem (ES) cells.
Biochem Soc Trans. 33: 1522-5, 2005
Takahashi K., Nakagawa M., Young S.G. and Yamanaka S.
Differential membrane localization of ERas and Rheb, Two Ras-related proteins involved in the PI3 kinase / mTOR pathway.
J. Biol. Chem. 280: 32768-74, 2005
Maruyama M., Ichisaka T., Nakagawa M. and Yamanaka S.
Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells.
J. Biol. Chem. 280: 24371-9, 2005
Wang X, Beugnet A., Murakami M., Yamanaka S. and Proud C.G.
Distinct signaling events downstream of mTOR co-operate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins.
Mol. Cell. Biol. 25: 2558-72, 2005
Takahashi K., Maruyama M., Tokuzawa Y, Murakami M, Oda Y, Yoshikane N, Makabe KW, Ichisaka T, Yamanaka S. (The first two authors equally contributed)
Evolutionarily Conserved Non-AUG Translation Initiation in NAT1/p97/DAP5 (EIF4G2),
Genomics 85:360-71, 2005
2004
Hamazaki T., Oka M., Yamanaka S. & Terada N.
Aggregation of Embryonic Stem Cells Induces Nanog Repression and Primitive Endoderm Differentiation.
J. Cell Sci. 117: 5681-5686, 2004
Tomoda K., Kato-Yoneda N., Fukumoto A., Yamanaka S. & Kato J.Y.
Multiple Functions of Jab1 Are Required for Early Embryonic Development and Growth Potential in Mice.
J. Biol. Chem. 279: 43013-8, 2004
Murakami M., Ichisaka T., Maeda M., Oshiro N., Hara K., Edenhofer F., Kiyama H., Yonezawa K. & Yamanaka S.
mTOR is essential for Growth and Proliferation in Early Mouse Embryos and Embryonic Stem Cells.
Mol. Cell. Biol. 24: 6710-6718, 2004
Matsuda E., Shigeoka , Iida R., Tocharus C., Yamanaka S., Kawaichi M. & Ishida Y.
Expression Profiling with Arrays of Randomly Disrupted Genes in Mouse ES Cells Leads to in Vivo Functional Analysis.
Proc. Natl. Acad. Sci. U S A 101:4170-4, 2004
Mak W., Nesterova TB., de Napoles M., Appanah R., Yamanaka S., Otte AP, and Neil Brockdorff N.
Reactivation of the Paternal X Chromosome in Early Mouse Embryos.
Science 303: 666-669, 2004
2003
Mitsui K, Tokuzawa Y, Itoh H., Segawa K, Murakami M, Takahashi K, Maruyama M, Maeda M and Yamanaka S.
The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cell.
Cell 113: 631-642, 2003
Takahashi K, Mitusi K. and Yamanaka S.
Role of ERas in promoting tumor-like properties in mouse embronic stem cells.
Nature 423: 541-545, 2003
Tokuzawa Y., Kaiho E., Maruyama M., Takahashi K., Mitsui K., Maeda M., Niwa H., and Yamanaka S.
Fbx15 is a novel target of Oct3/4 but is dispensable for ES cell self-renewal and mouse development.
Mol. Cell. Biol. 23: 2699-2708, 2003
~2002
Taniguchi, M., Miura, K., Iwao, H., and Yamanaka S.
Quantitative Assessment of DNA Microarrays – Comparison with Northern Blot Analyses.
Genomics 71: 34-39, 2001
Yamanaka S., Zhang, X. Y., Maeda, M., Miura, K., Wang, S., Farese, R. V. Jr., Iwao, H., and Innerarity. T. L.
Essential role of NAT1/p97/DAP5 in embryonic differentiation and retinoic acid pathway.
EMBO 19: 5533-5541, 2000
Nakamura, Y., Miura, K., Fujino, Y., Iwao, H., Ogita S. and Yamanaka S.
Evolution, Structure, and Expression of GNPI/Oscillin Orthologous Genes.
Genomics 68: 179-186, 2000
~1999
Yamanaka S., Zhang, X. Y., Miura, K., Kim, S. and Iwao, H.
The human gene encoding the lectin-type oxidized LDL receptor (OLR1) is a novel member of the natural killer gene complex with a unique expression profile.
Genomics 54: 191-199, 1998.
Qian, X., Balestra, M. E., Yamanaka S., Boren, J., Lee, I. and Innerarity, T. L.
Low expression of the apolipoprotein B mRNA-editing transgene in mice reduces LDL levels but does not cause liver dysplasia or tumors.
Arterioscler Thromb Vasc Biol 18:1013-1020, 1998.
Yamanaka S., Poksay, K.S., Arnold, K.S., and Innerarity, T.L.
A novel translational repressor mRNA is extensively edited in livers containing tumors caused by the transgene expression of an apoB mRNA editing enzyme.
Genes Dev.11: 321-333, 1997.
Yamanaka S., Poksay, K.S., Driscoll, D.M., and Innerarity, T.L.
Hyperediting of multiple cytidines of apolipoprotein B mRNA by APOBEC-1 requires auxiliary protein(s) but not a mooring sequence motif.
Cloning and mutagenesis of the rabbit apoB mRNA editing protein: A zinc motif is essential for catalytic activity, and non-catalytic auxiliary factor(s) of the editing complex are widely distributed.
J. Biol. Chem. 269:21725-21734, 1994.
Yamanaka S., K. Miura, T. Yukimura, and K. Yamamoto.
11-Dehydro thromboxane B2: a reliable parameter of thromboxane A2 production in dogs.
Prostaglandins 45: 221-8, 1993.
Yamanaka S., H. Iwao, T. Yukimura, S. Kim, and K. Miura.
Effect of NG-nitro-L-arginine on effective vascular stiffness in dogs.
Jpn J Pharmacol 63: 41-5, 1993.
Yamanaka S., H. Iwao, T. Yukimura, S. Kim, and K. Miura.
Effect of the platelet-activating factor antagonist, TCV-309, and the cyclo-oxygenase inhibitor, ibuprofen, on the haemodynamic changes in canine experimental endotoxic shock.
Br J Pharmacol 110: 1501-7, 1993.
Yamanaka S., K. Miura, T. Yukimura, M. Okumura, and K. Yamamoto.
Putative mechanism of hypotensive action of platelet-activating factor in dogs.
Circ Res 70: 893-901, 1992.
その他の発表論文
Tamada S., Nakatani T., Asai T., Tashiro T., Komiya T., Sumi T., Okamura M., Kim S., Iwao H., Kishimoto T., Yamanaka S., and Miura K.
Inhibition of NF-κB activation by pyrrolidine dithiocarbamate prevents chronic FK506 nephropathy.
Kidney International. 63: 306-314, 2003
Asai, T., Nakatani T., Yamanaka S., Tamada S., Kishimoto T., Tashiro K., Nakao N., Okamura M., Kim S., Iwao H. & Miura K.
Magnesium supplementation prevents experimental chronic cyclosporine a nephrotoxicity via renin-angiotensin system independent mechanism.
Transplantation 74:784-791, 2002
Miura,K., Nakatani,T., Asai,T., Yamanaka S., Tamada,S., Tashiro,K., Kim,S., Okamura, M. & Iwao, H.
Role of hypomagnesemia in chronic cyclosporine A nephropathy.
Transplantation 73: 340-7, 2002
Miura, K., Yamanaka S., Ebara T., Okumura, M., Imanishi M., Kim, S., Nakatani T. & Iwao, H.
Effects of Nitric Oxide Scavenger, Carboxy-PTIO on endotoxin-induced alterations in systemic hemodyamics in rats.
Jpn J Pharmacol 82: 261-4, 2000
Miura, K., Yamanaka S., Ebara T., Okumura, M., Imanishi M., Kim, S., Nakatani T. & Iwao, H.
Effects of Nitric Oxide Scavenger, Carboxy-PTIO on endotoxin-induced alterations in systemic hemodyamics in rats.
Jpn J Pharmacol 82: 261-4, 2000
Miura, K., Okumura, M., Yamanaka S., Kim, S. & Iwao, H.
No participation of Adenosine A1 receptor in acute nephrotoxicity by 4-pentenoic acid administration in dogs.
Jpn J Pharmacol 80: 223-8, 1999
Miura, K., Okumura, M., Yamanaka S., Kim, S. and Iwao, H.
Effects of activation of renal adenosine A2 receptor on renal function and renin release in dogs.
Jpn J Pharmacol 80: 173-176, 1999.
Hamaguchi A, Kim S, Izumi Y, Zhan Y, Yamanaka S, and Iwao H.
Contribution of extracellular signal-regulated kinase to angiotensin II-induced transforming growth factor-beta1 expression in vascular smooth muscle cells.
Hypertension 34:126-31, 1999.
Yano, M., Kim, S., Izumi, Y., Yamanaka S. and Iwao, H.
Differential activation of cardiac c-jun amino-terminal kinase and extracellular signal-regulated kinase in angiotensin II-mediated hypertension.
Circ Res 83: 752-760, 1998.
Seto, M., Kim, S., Yoshifusa, H., Nakamura, Y., Masuda, T., Hamaguchi, A., Yamanaka S. and Iwao, H.
Effects of prednisolone on glomerular signal transduction cascades in experimental glomerulonephritis.
J Am Soc Nephrol 9: 1367-1376, 1998.
Izumi, Y., S. Kim, T. Murakami, S. Yamanaka, and H. Iwao.
Cardiac mitogen-activated protein kinase activities are chronically increased in stroke-prone hypertensive rats.
Hypertension 31: 50-6, 1998.
Kim, S., Y. Izumi, M. Yano, A. Hamaguchi, K. Miura, S. Yamanaka, H. Miyazaki, and H. Iwao.
Angiotensin blockade inhibits activation of mitogen-activated protein kinases in rat balloon-injured artery.
Circulation 97: 1731-7, 1998.
Hamaguchi, A., S. Kim, M. Yano, S. Yamanaka, and H. Iwao.
Activation of glomerular mitogen-activated protein kinases in angiotensin II-mediated hypertension.
J Am Soc Nephrol 9: 372-80, 1998.
Uchida, J., K. Miura, S. Yamanaka S. Kim, H. Iwao, T. Nakatani, and T. Kishimoto.
Renal endothelin in FK506-induced nephrotoxicity in spontaneously hypertensive rats.
Jpn J Pharmacol 76: 39-49, 1998.
Kim, S., H. Wanibuchi, A. Hamaguchi, K. Miura, S. Yamanaka, and H. Iwao.
Angiotensin blockade improves cardiac and renal complications of type II diabetic rats.
Hypertension 30: 1054-61, 1997.
Matsuura, T., K. Miura, T. Ebara, T. Yukimura, S. Yamanaka S. Kim, and H. Iwao.
Renal vascular effects of the selective endothelin receptor antagonists in anaesthetized rats.
Br J Pharmacol 122: 81-6, 1997.
Kim, S., T. Murakami, Y. Izumi, M. Yano, K. Miura, S. Yamanaka, and H. Iwao.
Extracellular signal-regulated kinase and c-Jun NH2-terminal kinase activities are continuously and differentially increased in aorta of hypertensive rats.
Biochem Biophys Res Commun 236: 199-204, 1997.
Kim, S., T. Sada, M. Mizuno, M. Ikeda, M. Yano, K. Miura, S. Yamanaka, H. Koike, and H. Iwao.
Effects of angiotensin AT1 receptor antagonist on volume overload- induced cardiac gene expression in rats.
Hypertens Res 20: 133-42, 1997.
Yukimura, T., Y. Yamashita, K. Miura, M. Okumura, S. Yamanaka, and K. Yamamoto.
Renal effects of the nitric oxide synthase inhibitor, L-NG- nitroarginine, in dogs.
Am J Hypertens 5: 484-7, 1992.
Yukimura, T., K. Miura, Y. Yamashita, T. Shimmen, M. Okumura, S. Yamanaka, M. Saito, and K. Yamamoto.
Effects of the calcium channel antagonist nicardipine on renal action of endothelin in dogs.
Contrib Nephrol 90: 105-10, 1991.
Yamashita, Y., T. Yukimura, K. Miura, M. Okumura, S. Yamanaka, and K. Yamamoto.
Effects of NG-nitro-L-arginine on renal hemodynamic responses to endothelin-3 in anesthetized dogs.
J Cardiovasc Pharmacol 17: S332-4, 1991.
Miura, K., T. Yukimura, Y. Yamashita, T. Shimmen, M. Okumura, S. Yamanaka, M. Imanishi, and K. Yamamoto.
Renal and femoral vascular responses to endothelin-1 in dogs: role of prostaglandins.
J Pharmacol Exp Ther 256: 11-7, 1991.
Miura, K., T. Yukimura, Y. Yamashita, K. Shichino, T. Shimmen, M. Saito, M. Okumura, M. Imanishi, S. Yamanaka, and K. Yamamoto
Effects of endothelin on renal hemodynamics and renal function in anesthetized dogs.
